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TVQAVLDDIRKRPGTGDVIAVIDPATEEKITEFTDCGAEAVDEAAARAKASFESGVWSQLPGRERAKILW RIGDLIDEHAEEFAQLDSLNTGMPLLQAQLQMSTCSEFFRYYAGWCSKINGTAYDVKTDGIATDTFVNMH AYTLKEPYSVVGLIFPWNGPIFNASAKLAPALAAGCSLLVKPAEETPLSALLLDRLVHEAGVPEGVVNLL TGYGHTAGAAITAHPDVEKVAFTGSTEVGKEIVRASAGNLKKVTLELGGKSPVLIFDDADLDKAILMASL GIFVHSGQGCVCGSRIFVQRGVYDRVVEGIAMMANTFKLGAPSEEGCVSGPLISQKQLNRVMGFIDEGKN DGVEVVTGGYRLDRKGYFVHPTVLTNVDPGMRLYQQEIFGPVVAILPFDDEDEAVAMANDTTYGLAATAW TENLGRAHRIVKRLQAGSVQVNCQLVFDHDVPFGGYKQSGWGHEFGKEGLEIYLKTKSVWAQL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2765 | - | - | 100% (484) | P-cumic aldehyde dehydrogenase |
| M. avium 104 | MAV_2101 | - | e-147 | 53.76% (465) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | e-107 | 44.06% (463) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 2e-88 | 38.91% (460) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0428 | - | 2e-99 | 42.13% (470) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 7e-93 | 39.83% (472) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-65 | 32.25% (462) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-92 | 40.43% (470) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 6e-90 | 39.36% (470) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6297 | - | 1e-105 | 42.51% (447) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2957 | - | 3e-97 | 40.08% (474) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 1e-89 | 39.15% (470) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 1e-100 | 42.98% (470) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6297|M.smegmatis_MC2_155 ----MTVTTFRPSDVATLTNPDAASDVADLSMFIAGEAVSAADGATFDSY
TH_2957|M.thermoresistible__bu ----MTSTLERP----------------EVTLRIGGEKRRTASGGTFDHI
Mflv_0428|M.gilvum_PYR-GCK MTQSTAFRTEWD------------------KLFIGGKWVEPASSEVIEVR
Mvan_0240|M.vanbaalenii_PYR-1 MTQSTTFRTEWD------------------KLFIGGKWVEPATSDVIEVH
MMAR_0472|M.marinum_M ----MGEKTEYD------------------KLFIGGKWTEPSTSEVIEVH
MUL_1122|M.ulcerans_Agy99 ----MGEKTEYD------------------KLFIGGRWTEPSTSEVIEVH
Rv0223c|M.tuberculosis_H37Rv ---MSDSATEYD------------------KLFIGGKWTKPSTSDVIEVR
MAB_4484|M.abscessus_ATCC_1997 -------MTNYD------------------KLFIGGVWTEPATDQVIEVI
MAV_2765|M.avium_104 ----MTVQAVLD-----------------------DIRKRPGTGDVIAVI
Mb2883c|M.bovis_AF2122/97 -------------------------------------------MSTTQLI
MLBr_02573|M.leprae_Br4923 --------------------------------------------MSIATI
MSMEG_6297|M.smegmatis_MC2_155 EPRSGRVWARLPRANSTDIDRAVRAARAAFEGP-WGAVSPADRGRFLMKI
TH_2957|M.thermoresistible__bu NPCTGAPDAAIPLAGPAEIDDAVKAAHDAFHS--WRQTNPAERRRLLFRL
Mflv_0428|M.gilvum_PYR-GCK SPATGDVVGKVPLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRA
Mvan_0240|M.vanbaalenii_PYR-1 SPATGELVGKVPLASAADVDAACAAAREAFDNGPWPHMSPAERGEILGRA
MMAR_0472|M.marinum_M CPATGEYVGKVPLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANA
MUL_1122|M.ulcerans_Agy99 CPATGEYVGKVPLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANA
Rv0223c|M.tuberculosis_H37Rv CPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAA
MAB_4484|M.abscessus_ATCC_1997 SPATGQKVGQCPLASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKA
MAV_2765|M.avium_104 DPATEEKITEFTDCGAEAVDEAAARAKASFESGVWSQLPGRERAKILWRI
Mb2883c|M.bovis_AF2122/97 NPATEEVLASVDHTDANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAF
MLBr_02573|M.leprae_Br4923 NPATGETVKTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANAT
* : :: * * : :*
MSMEG_6297|M.smegmatis_MC2_155 AAVVDRHRDQLTVIESRDNGKPVREVRAEIDAVVR-YFEYFAGVCQTTVG
TH_2957|M.thermoresistible__bu AELIEQHTDDFVRLGTFDNGTPVGLVAGLVAMSAE-WTRYYAGWADKITS
Mflv_0428|M.gilvum_PYR-GCK VKLMEERADELKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFT
Mvan_0240|M.vanbaalenii_PYR-1 VKIMEERADELKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFT
MMAR_0472|M.marinum_M LKLLEERKDHFAKLLADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVR
MUL_1122|M.ulcerans_Agy99 LKLLEERKDHFAKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVR
Rv0223c|M.tuberculosis_H37Rv VKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVT
MAB_4484|M.abscessus_ATCC_1997 VSLLESRKDEICKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVK
MAV_2765|M.avium_104 GDLIDEHAEEFAQLDSLNTGMP-LLQAQLQMSTCSEFFRYYAGWCSKING
Mb2883c|M.bovis_AF2122/97 AAAVQAHLDELAALEVANSGHP-IVSAEWEAGHVRDVLAFYAASPERLSG
MLBr_02573|M.leprae_Br4923 ADLLEAEANQSAALMTLEMGKT-LQSAKDEAMKCAKGFRYYAEKAETLLA
: . : : * . ::*
MSMEG_6297|M.smegmatis_MC2_155 --ETHPQAATA-------FSYTRREPVGVVGAIVPWNSPLLMLAWKLSPA
TH_2957|M.thermoresistible__bu --EVSGTYGTTGE-----FSYTLSQPYGVIGVIITWNGPLISLAMKVPAA
Mflv_0428|M.gilvum_PYR-GCK --WQDIRDGVYG------QTLVVREPVGVVGAVTAWNVPFFLAANKLGPA
Mvan_0240|M.vanbaalenii_PYR-1 --WQDIRDGVYG------QTLVVREPVGVVGAVTAWNVPFFLAANKLGPA
MMAR_0472|M.marinum_M --WKEIRNGSYG------QTIVHREPIGVVGAIVAWNVPLFLAINKLGPA
MUL_1122|M.ulcerans_Agy99 --WKEIRNGSYG------QTIVHREPIGVVGAIVAWNVPLFLAINKLGPA
Rv0223c|M.tuberculosis_H37Rv --WTETRTGSYG------QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPA
MAB_4484|M.abscessus_ATCC_1997 --WKELRNGAYG------QTLVTREPAGVVAAIAAWNVPLFLALNKIGPA
MAV_2765|M.avium_104 TAYDVKTDGIATDTFVNMHAYTLKEPYSVVGLIFPWNGPIFNASAKLAPA
Mb2883c|M.bovis_AF2122/97 --RQIPVAGGVD--------VTFNEPMGVVGVITPWNFPMVIASWAIAPA
MLBr_02573|M.leprae_Br4923 DEPAEAAAVGAS------KALARYQPLGVVLAVMPWNFPLWQTVRFAAPA
. :* .*: : .** *: .*
MSMEG_6297|M.smegmatis_MC2_155 LAGGNTIILKPAEETSVSAVVFAQLIAEVGLPDGVFNVVTGIGEEAGAAL
TH_2957|M.thermoresistible__bu LAAGNTVVVKPSELTPFSATLFADLAAEAGIPDGVINVVPGTG-DAGAAL
Mflv_0428|M.gilvum_PYR-GCK LLAGCTVVLKPAAETPLSVFAMAEMFVEAGLPEGVLSIVPGGP-ETGQAL
Mvan_0240|M.vanbaalenii_PYR-1 LLAGCTVVLKPAAETPLSVFAMAEMFVEAGLPEGVLSIVPGGP-ETGQAL
MMAR_0472|M.marinum_M LLAGCTVVLKPAAETPLTANALAEVFAEAGLPEGVLSVVPGGV-ETGQAL
MUL_1122|M.ulcerans_Agy99 PLAGCTVVLKPAAETPLTANALAEVFAEAGLPEGVLSVVPGGV-ETGQAL
Rv0223c|M.tuberculosis_H37Rv LLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVPGGI-ETGQAL
MAB_4484|M.abscessus_ATCC_1997 FLAGCAVVLKPAAETPLSSFILAEVFAEAGVPEGVLSVVPGGA-ETGRAL
MAV_2765|M.avium_104 LAAGCSLLVKPAEETPLSALLLDRLVHEAGVPEGVVNLLTGYGHTAGAAI
Mb2883c|M.bovis_AF2122/97 LAAGNAVLVKPAELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERF
MLBr_02573|M.leprae_Br4923 LMAGNVGLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISA-NGVEAI
.* ::* : .. : : . *. :. .. : :
MSMEG_6297|M.smegmatis_MC2_155 VAHPDVDKIAFTGSTEVGKQIAATAASDLKLVTFELGGKSPTVIFDDADL
TH_2957|M.thermoresistible__bu VAHPLVKKVTFTGGPDTARKILQSCAEHIKPSVMELGGKSGNIIFEDANL
Mflv_0428|M.gilvum_PYR-GCK TANPNLDKYTFTGSSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADL
Mvan_0240|M.vanbaalenii_PYR-1 TANPNLDKYTFTGSSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADL
MMAR_0472|M.marinum_M TSNPGVDLFTFTGSSAVGKEIGRRAAEMLKPCTLELGGKSAAILLEDVDL
MUL_1122|M.ulcerans_Agy99 TSNPGVDLFTFTGSSAVGKEIGRRAAEMLKPCTLELGGKSAAILLEDVDL
Rv0223c|M.tuberculosis_H37Rv TSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDL
MAB_4484|M.abscessus_ATCC_1997 TNNPDVDVFSFTGSTAVGKEIAEIAAKNLKKVTLELGGKSAAIVLEDADL
MAV_2765|M.avium_104 TAHPDVEKVAFTGSTEVGKEIVRASAGNLKKVTLELGGKSPVLIFDDADL
Mb2883c|M.bovis_AF2122/97 VTHPDIRKIVFTGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDL
MLBr_02573|M.leprae_Br4923 LRDPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADL
.* : :**. ..: : .. :* .:****.. ::: . :*
MSMEG_6297|M.smegmatis_MC2_155 DAAVHR-TAYGIFSAAGQTCQAASRIFVQDTIHDEFLDRFAALARRIRVG
TH_2957|M.thermoresistible__bu DTACSVGTLMSVGMMSGQGCAFPTRMIVARPLYDEVLTRVSALAPMVKVG
Mflv_0428|M.gilvum_PYR-GCK DSTLPMLVFSGLMNS-GQACVGQTRILAPRSRYDEVIEKLGEAVRNMAPG
Mvan_0240|M.vanbaalenii_PYR-1 DSTLPMLVFSGLMNS-GQACVGQTRILAPRSRYDEVVEKLAAAAAGMAPG
MMAR_0472|M.marinum_M STAVPMMVFSGIMNT-GQACVGQTRILAPRSRYEEIVEAVSAFVQALPVG
MUL_1122|M.ulcerans_Agy99 STAVPMMVFSGIMNT-GQACVGQTRILAPRSRYEEIVEAVSAFVQTLPVG
Rv0223c|M.tuberculosis_H37Rv AAAIPMMVFSGVMNA-GQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVG
MAB_4484|M.abscessus_ATCC_1997 AAALPMLVFSGLMNA-GQGCVNQTRVLAPRSRYDEVVDGIVGMVSLMGVG
MAV_2765|M.avium_104 DKAILMASLGIFVHS-GQGCVCGSRIFVQRGVYDRVVEGIAMMANTFKLG
Mb2883c|M.bovis_AF2122/97 ERAATTAPAGVFDNA-GQDCCARSRILVQRSVYDRFMELLEPAVHSIVVG
MLBr_02573|M.leprae_Br4923 DAAVATAVTGRVQNN-GQSCIAAKRFIAHADIYDEFVEKFVARMETLRVG
: . ** * .*.:. ::..: . . *
MSMEG_6297|M.smegmatis_MC2_155 DPLSERTQMGAQISAQHRERIAGYVASGIQEGANLVCGGTQPTEAPLAQ-
TH_2957|M.thermoresistible__bu DPLEPDTVAGPVVNEAALQRILGMIERAKQDGARLLTGGER-LGGDLAD-
Mflv_0428|M.gilvum_PYR-GCK LPDNPAAMIGPLISEKQRDRVEGYIKKGIEEGARVITGGGR--PEGLDS-
Mvan_0240|M.vanbaalenii_PYR-1 LPDNPAAMIGPLISEKQRDRVEGYIKKGIEEGARVVTGGGR--PEGLDS-
MMAR_0472|M.marinum_M PPSDPAAQIGSLISEKQRARVEGYIAKGIEEGARLVSGGGR--PEGLDN-
MUL_1122|M.ulcerans_Agy99 PPSDPAAQIGSLISEKQRARVEGYIAKGIEEGARLVSGGGR--PESLDN-
Rv0223c|M.tuberculosis_H37Rv PPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGR--PEGLDN-
MAB_4484|M.abscessus_ATCC_1997 LPDDPATQVGPLITEKQRTRVEGYIAKGIAEGARLAYGGKR--PEGLDG-
MAV_2765|M.avium_104 APSEEGCVSGPLISQKQLNRVMGFIDEGKNDGVEVVTGGYR-----LDRK
Mb2883c|M.bovis_AF2122/97 DPGSRATEMGPLVSRAHRDKVAGYVPDDAPVAFRGTAPAGR---------
MLBr_02573|M.leprae_Br4923 DPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKR-----PDRP
* . *. . :: : . . :
MSMEG_6297|M.smegmatis_MC2_155 GYYYSPTILDGVNRDMRMIREEIFGPVTGVMSFTDEADAVAKANDTEYGL
TH_2957|M.thermoresistible__bu EYFVAPTVFADVDPYSELAQKEVFGPVLSIIPFDTEEQAVEIANSTPYGL
Mflv_0428|M.gilvum_PYR-GCK GWFVEPTVFADVDNSMTIAQEEIFGPVLSVIPYEDEDDAVRIANDSVYGL
Mvan_0240|M.vanbaalenii_PYR-1 GWYVQPTVFADVDNSMTIAQEEIFGPVLAVIPYEDEDDAVRIANDSVYGL
MMAR_0472|M.marinum_M GFFVQPTVFADVDNKMTIAQEEIFGPVLVVIPYDTEEDAIKIANDSVYGL
MUL_1122|M.ulcerans_Agy99 GFFVQPTVFADVDNKMTIAQEEIFGPVLVVIPYDTKEDAIKIANDSVYGL
Rv0223c|M.tuberculosis_H37Rv GFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGL
MAB_4484|M.abscessus_ATCC_1997 GYFVQPTIFADVDNSMTIAQEEIFGPVLSIIAYDSVDEAVKIANDSNYGL
MAV_2765|M.avium_104 GYFVHPTVLTNVDPGMRLYQQEIFGPVVAILPFDDEDEAVAMANDTTYGL
Mb2883c|M.bovis_AF2122/97 GFWFPPTVLTPKR-GDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGL
MLBr_02573|M.leprae_Br4923 GWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGL
:: **:: .*:**** : :*: ** : :**
MSMEG_6297|M.smegmatis_MC2_155 AGSVWTRDVSRAHRVAASIAAGLIWVNTTRTINHLVPFGGYKQSGYGREG
TH_2957|M.thermoresistible__bu SGYVFTNDLKRAHRVAEQLETGEVLINGAAPLTVHRPFGGFGISGIGKEG
Mflv_0428|M.gilvum_PYR-GCK AGSVYTTDNDRALKIARRIRTGTYAVN-MYAFDPCAPFGGYKNSGIGREN
Mvan_0240|M.vanbaalenii_PYR-1 AGSVYTTDNDRALKIARRIRTGTYAVN-MYAFDPCAPFGGFKNSGIGREN
MMAR_0472|M.marinum_M AGSVWTSNVPKGIEISEKIRTGTYAIN-WYAFDPCCPFGGYKNSGIGREN
MUL_1122|M.ulcerans_Agy99 AGSVWTSNVPKGIEISEKIRTGTYAIN-WYAFDPCCPFGGYKNSGIGREN
Rv0223c|M.tuberculosis_H37Rv AGSVWTTDVPKGIKISQQIRTGTYGIN-WYAFDPGSPFGGYKNSGIGREN
MAB_4484|M.abscessus_ATCC_1997 AGSVWTTDVQKGLEVAAQIRTGTYGIN-WYAFDPSCPFGGYKQSGIGREN
MAV_2765|M.avium_104 AATAWTENLGRAHRIVKRLQAGSVQVNCQLVFDHDVPFGGYKQSGWGHEF
Mb2883c|M.bovis_AF2122/97 SGSIWTDDLSRALRVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGREL
MLBr_02573|M.leprae_Br4923 GSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGREL
.. :* : . .. : :* :* **** ** *:*
MSMEG_6297|M.smegmatis_MC2_155 GQAVMEHYTRIKSVWVDMQDDLPNWYAD
TH_2957|M.thermoresistible__bu GREGLAEFLRTKSVSIA-----------
Mflv_0428|M.gilvum_PYR-GCK GWEGIEAYCEQKSILLPFGYTPPAS---
Mvan_0240|M.vanbaalenii_PYR-1 GWEGIEAYCEPKSILLPFGYTPAT----
MMAR_0472|M.marinum_M GPEGVEHFTQQKSVLMPMGYTLES----
MUL_1122|M.ulcerans_Agy99 GPEGVEHFTQQKSVLMPMGYTLES----
Rv0223c|M.tuberculosis_H37Rv GPEGVEHFTQQKSVLLPMGYTVA-----
MAB_4484|M.abscessus_ATCC_1997 GPEGIEEYCELKSVLLPMGYTLESI---
MAV_2765|M.avium_104 GKEGLEIYLKTKSVWAQL----------
Mb2883c|M.bovis_AF2122/97 GPDAPLQFTETKNVFIAVGEEM------
MLBr_02573|M.leprae_Br4923 STHGIREFCNIKTVWIA-----------
. : . *.: