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MPRQAGRWSPTALRILGAAAELIALRGYSSTSTRDIAAAVGVEQPAIYKHFSAKRDILAALVRLAVEWPL ELFGHITAMPVPAVVKLHRWLTESLDHLHASPYVLVSILITPDLHQESFVAERELVAEMERALVGLIETG QGEGDVRAMHPLSAARLVQALFDALALPEFAVSPDEIVEFAMTALLSDPDRLAEIRAAADALEIQTAPPD RGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3185c | - | - | 100% (213) | TetR family transcriptional regulator |
| M. bovis AF2122 / 97 | Mb3587c | - | 2e-08 | 31.07% (103) | TetR family transcriptional regulator |
| M. bovis AF2122 / 97 | Mb1711c | - | 3e-07 | 36.71% (79) | hypothetical protein Mb1711c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4599 | - | 4e-11 | 34.46% (148) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3160c | - | 1e-117 | 100.00% (213) | TetR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4089c | - | 8e-15 | 38.53% (109) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2873 | mce3R | 2e-07 | 26.26% (179) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2588 | - | 1e-08 | 37.35% (83) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4300 | - | 8e-18 | 35.35% (215) | transcription regulator AmtR |
| M. thermoresistible (build 8) | TH_2975 | - | 3e-12 | 34.51% (142) | PUTATIVE putative transcription regulator AmtR |
| M. ulcerans Agy99 | MUL_2880 | mce3R | 7e-08 | 26.82% (179) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2232 | - | 1e-07 | 36.78% (87) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2873|M.marinum_M --------------MDSVVAPVRRRPKDRKQQILEQAVGLFIDRGFHSVK
MUL_2880|M.ulcerans_Agy99 --------------MDSVVAPVRRRPKDRKQQILEQAVGLFIDRGFHSVK
Mb3185c|M.bovis_AF2122/97 ---------------MPRQAGRWSPTALR---ILGAAAELIALRGYSSTS
Rv3160c|M.tuberculosis_H37Rv ---------------MPRQAGRWSPTALR---ILGAAAELIALRGYSSTS
MAB_4089c|M.abscessus_ATCC_199 -------MS-----GRPRRISPIREGNSTRDEILDASAELFTTDGFAATT
MSMEG_4300|M.smegmatis_MC2_155 -------MTTTSGRGRPRLEQPRRPGQTAREEILDAAAELFTTHGYGSTS
TH_2975|M.thermoresistible__bu VTAGGHPAAAPVTCGRPRSQERRRPGATARDEVLDAAAELFTTLGVAATS
Mflv_4599|M.gilvum_PYR-GCK -------------MNKVVVAGRTRVGGERRERILASATELIAERGYHAVS
MAV_2588|M.avium_104 -MARTPDKLRRSGYAPAANHGVGRRGLHTRERILGSAAEVFLANGFHATS
Mvan_2232|M.vanbaalenii_PYR-1 ------------MGRKGWRGAPPADDREARQRILDAALASIERRGPRLTT
:* : : * ..
MMAR_2873|M.marinum_M LEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGEQEP
MUL_2880|M.ulcerans_Agy99 LEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGEQEP
Mb3185c|M.bovis_AF2122/97 TRDIAAAVGVEQPAIYKHFSAKRDILAALVRLAVEWPLELFGHITAMPVP
Rv3160c|M.tuberculosis_H37Rv TRDIAAAVGVEQPAIYKHFSAKRDILAALVRLAVEWPLELFGHITAMPVP
MAB_4089c|M.abscessus_ATCC_199 TRRIAESVGIQQASLYYHFKTKDDILDALLAMTIDQPLHYAALIADRPEA
MSMEG_4300|M.smegmatis_MC2_155 TRRIADEVGVRQASLYHHFATKDDILDALLAGTVDEPLELAHGLLGESGP
TH_2975|M.thermoresistible__bu TRQIAESVGVRQASLYHHFRTKDEILATLLDATVAPSVTAARRLRGRPEP
Mflv_4599|M.gilvum_PYR-GCK MADIGVASGVVGPAIYRHFNSKSDLLAALFERVVDKLLKRATAIVEQSRD
MAV_2588|M.avium_104 LDAIAKTAGASRATVYQYFAGKEEIFRELSALAERDVLAHGEHLGELGPT
Mvan_2232|M.vanbaalenii_PYR-1 LTEVAADLGITRPTIYRHFTSSEDLLAAAAEIALDHWTARIGEMSGH---
:. * ::* :: . ::
MMAR_2873|M.marinum_M TPRPLSVDLPDLIAAAVASRSLTVLWQREARYLNDADRIEVRRRINAIVA
MUL_2880|M.ulcerans_Agy99 TPRPLSVDLPDLIAAAVASRSLTVLSQREARYLNDADRIEVRRRINAIVA
Mb3185c|M.bovis_AF2122/97 A-----------------------------------------------VV
Rv3160c|M.tuberculosis_H37Rv A-----------------------------------------------VV
MAB_4089c|M.abscessus_ATCC_199 P-----------------------------------------------VV
MSMEG_4300|M.smegmatis_MC2_155 A-----------------------------------------------AP
TH_2975|M.thermoresistible__bu P-----------------------------------------------AV
Mflv_4599|M.gilvum_PYR-GCK E------------------------------------------------A
MAV_2588|M.avium_104 VDGVDALHRWLVAWADIYDAHAAVFAEFPG------------------IG
Mvan_2232|M.vanbaalenii_PYR-1 ------------------------------------------------FT
MMAR_2873|M.marinum_M GMRESVLLEVPGLSPAHSELRAWAV----SSTLTSLGRHSLTLPAEELKE
MUL_2880|M.ulcerans_Agy99 GMRESVLLEVPGLSPAHSELRAWAV----SSTLTSLGRHSLTLPAEELKE
Mb3185c|M.bovis_AF2122/97 KLHRWLTESLDHLHASPYVLVSILI----TPDLHQESFVAERELVAEMER
Rv3160c|M.tuberculosis_H37Rv KLHRWLTESLDHLHASPYVLVSILI----TPDLHQESFVAERELVAEMER
MAB_4089c|M.abscessus_ATCC_199 RLYALALGDAAQLAASRWNLGALYL----LPDLRAERFSAFRRKRDQLRT
MSMEG_4300|M.smegmatis_MC2_155 RLHALVIYDASQLCAGRWNLGALYL----LPELRTDRFAPFRRRRAELRS
TH_2975|M.thermoresistible__bu LLHALVWLDARLLWDSPHNLGILYL----LPEVRDRRFGGFHRRRSELRA
Mflv_4599|M.gilvum_PYR-GCK EALTLLVSDQVALVMDQRELAMVYYR--EVHNLSDQHQSRLRRKQRLYLE
MAV_2588|M.avium_104 TATGLAVIDASSAAAQFHQTVTDRLRRTRLRDLEADDAAAALGRIPHMVH
Mvan_2232|M.vanbaalenii_PYR-1 DATDLLVEAVAYLIERLPDEPLLGL----LLETDRMRVMSRKMVMPAAVA
MMAR_2873|M.marinum_M RLYQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRYETLLATGA----
MUL_2880|M.ulcerans_Agy99 RLYQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRYETLLATGA----
Mb3185c|M.bovis_AF2122/97 ALVGLIETGQGEGDVRAMH-----------PLSAARLVQALFDA------
Rv3160c|M.tuberculosis_H37Rv ALVGLIETGQGEGDVRAMH-----------PLSAARLVQALFDA------
MAB_4089c|M.abscessus_ATCC_199 HYQELAAAACRASMLRAGV-----------ERLPFRLVESVIM-------
MSMEG_4300|M.smegmatis_MC2_155 AYRSLAAAVIAECGGPPEA-----------DDLPFRLVESVIN-------
TH_2975|M.thermoresistible__bu AYRDLAERVAAAGATPSSVPD-----VVIDPDVVFRLVETLPN-------
Mflv_4599|M.gilvum_PYR-GCK EWVHLVGELRPAVDEIELR------------AMVHGAIGAIQS-------
MAV_2588|M.avium_104 LYRYRDMLPLPARATVTWSLTG-ALQLMLFPETPADVLQVVAPARDGCAR
Mvan_2232|M.vanbaalenii_PYR-1 RSRTMLEHTGIDWSAMGFTG-----------RRMDDLVEFLLR-------
:
MMAR_2873|M.marinum_M RLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRS
MUL_2880|M.ulcerans_Agy99 RLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRS
Mb3185c|M.bovis_AF2122/97 --LALPEFAVSPDE------------------------------------
Rv3160c|M.tuberculosis_H37Rv --LALPEFAVSPDE------------------------------------
MAB_4089c|M.abscessus_ATCC_199 --LRADGDSIAPEA------------------------------------
MSMEG_4300|M.smegmatis_MC2_155 --SRSDDAVVPPEQPW----------------------------------
TH_2975|M.thermoresistible__bu --LRMDG-LGEPDQPR----------------------------------
Mflv_4599|M.gilvum_PYR-GCK -ILHYRGTGLAPEQTS----------------------------------
MAV_2588|M.avium_104 TTPRALDYAAATPAAVEASGSPIPQDVLSVSSALFAERGYYAIGMEEIAA
Mvan_2232|M.vanbaalenii_PYR-1 ---MIQSMVIAPSNP-----------------------------------
.
MMAR_2873|M.marinum_M LECIRALRANRQAAQRLRGLVEGHVRISLDAPDLVAVCVTELNHASGDVR
MUL_2880|M.ulcerans_Agy99 LECIRALRANRQAAQRLRGLVEGHVRISLDAPDLVAVCATELNHASGDVR
Mb3185c|M.bovis_AF2122/97 ---------IVEFAMTALLSDPDRLAEIRAAADALEIQTAPPDRGL----
Rv3160c|M.tuberculosis_H37Rv ---------IVEFAMTALLSDPDRLAEIRAAADALEIQTAPPDRGL----
MAB_4089c|M.abscessus_ATCC_199 ---------LADATLRVVGVTGDAGEIEGAARVLLGQLGWPVAIPKR---
MSMEG_4300|M.smegmatis_MC2_155 --------VIGEGALRVLGFDGDFAELAAATASRLGVR--PPGRAAR---
TH_2975|M.thermoresistible__bu --------RTADLAVHVLGWRGDWPRLRSESATVAAAVG-----DCR---
Mflv_4599|M.gilvum_PYR-GCK -------ALLVAMGHAVLGVPASSHQVRGVNTEPSCPRPGTPQH------
MAV_2588|M.avium_104 AADVSRATLYRYFSTKDKILAELTRRAVAEIEKHAAALPAKAADSLTEWM
Mvan_2232|M.vanbaalenii_PYR-1 ----------ARSAAALRGYLRQWIGPVMSAGAGDLS-------------
MMAR_2873|M.marinum_M DGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIEDVARTWHL
MUL_2880|M.ulcerans_Agy99 DGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIEDVARTWHL
Mb3185c|M.bovis_AF2122/97 --------------------------------------------------
Rv3160c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4089c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4300|M.smegmatis_MC2_155 --------------------------------------------------
TH_2975|M.thermoresistible__bu --------------------------------------------------
Mflv_4599|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2588|M.avium_104 LGYVRFHRTYRGVIRAWFDGAVAEQLSNADVDHGIGAIFQAVAALLSTVD
Mvan_2232|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2873|M.marinum_M TRYAAVADEITAIALSILTSRS----------------------------
MUL_2880|M.ulcerans_Agy99 TRYAAVADEITEIALSILTSRS----------------------------
Mb3185c|M.bovis_AF2122/97 --------------------------------------------------
Rv3160c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4089c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4300|M.smegmatis_MC2_155 --------------------------------------------------
TH_2975|M.thermoresistible__bu --------------------------------------------------
Mflv_4599|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2588|M.avium_104 LPPGIDADVAGAVFVAVLGRMSEPTGASGPNSDEQAAELMVKLLRRSLLR
Mvan_2232|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2873|M.marinum_M --
MUL_2880|M.ulcerans_Agy99 --
Mb3185c|M.bovis_AF2122/97 --
Rv3160c|M.tuberculosis_H37Rv --
MAB_4089c|M.abscessus_ATCC_199 --
MSMEG_4300|M.smegmatis_MC2_155 --
TH_2975|M.thermoresistible__bu --
Mflv_4599|M.gilvum_PYR-GCK --
MAV_2588|M.avium_104 EA
Mvan_2232|M.vanbaalenii_PYR-1 --