For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESFSAQGYHAVSMETIAAKVGVSAPALY RHYAGKYELFRGAVLALSQQLVDCTQLDDSDDPAQLLARLIASLIEVTLDNRLSGGLYRWQSRYLRAEDQ AAVADVLKVVNRRIQKPLTVIRASLRPAQRWMLSAGVLSVIGSIVDHPARLAADEIRALLGEAASAIVCA ELPEPGDVAVRKASWRIFAEDASVYETLLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIYRYFSGKCEI LATGLRRAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERANLTPADQMLLHNIQ LSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVDLGRMVDPQDSAGQSAYVQACVRELMELTLFGPTP AQADAAPPPPPGRRRRGSSNPGHVARR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3597 | - | - | 100% (447) | putative regulatory protein |
| M. ulcerans Agy99 | MUL_2880 | mce3R | 1e-33 | 30.56% (373) | TetR family transcriptional regulator |
| M. ulcerans Agy99 | MUL_1163 | - | 4e-12 | 31.76% (148) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 7e-36 | 30.61% (379) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0186 | - | 1e-110 | 54.64% (377) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 7e-36 | 30.61% (379) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_02568 | - | 9e-12 | 28.50% (193) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 3e-10 | 27.71% (166) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 0.0 | 99.11% (447) | putative regulatory protein |
| M. avium 104 | MAV_0110 | - | 1e-114 | 53.49% (415) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 1e-111 | 51.20% (418) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 3e-97 | 48.35% (395) | PUTATIVE transcriptional regulator, TetR family protein |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 1e-109 | 51.97% (406) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3597|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5559|M.marinum_M --------------------------------------------------
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
MUL_3597|M.ulcerans_Agy99 ----MAGTDSGYGEVMSAASVSP-GAAADGIRRRPKDRKAQIARAAAESF
MMAR_5559|M.marinum_M ----MAGTDSGYGEVMSAASVSP-GAAADGIRRRPKDRKAQIARAAAESF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu ---------------MSAAG----SDAHRNGRHRPKNRKALIARASADAF
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MAST------ADDHGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MUL_3597|M.ulcerans_Agy99 SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MMAR_5559|M.marinum_M SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
MUL_3597|M.ulcerans_Agy99 QLDD-------SDDPAQLLARLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MMAR_5559|M.marinum_M QLDD-------SDDPAQLLDGLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MAV_0110|M.avium_104 AFADDLP---ADADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVD---PAEDPHGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
Mflv_0186|M.gilvum_PYR-GCK AGID-------GDDPEVVLDRLVSALIDIALANRSSGGLYRWERRYLRGD
Mvan_0719|M.vanbaalenii_PYR-1 AGIE-------GDDPQVVLDRLVSALTDTALANRGSGGLYRWEGRYLRGD
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
MUL_3597|M.ulcerans_Agy99 DQAAVADVLKVVNRRIQKPLTVIRASLRPAQRWMLSAGVLSVIGSIVDHP
MMAR_5559|M.marinum_M DQAAVADVLKVVNRRIQKPLTVIRPSLRPAQRWMLSAGVLSVIGSIVDHP
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
Mflv_0186|M.gilvum_PYR-GCK DQAELLQQLRTVHHRLQTPVSILRPELTARQRSTLSTAVLSIVGSIVDHR
Mvan_0719|M.vanbaalenii_PYR-1 DQATLLQQIHTVHHRIHRPLSALRPELTARQRSTLSTAALSIVGSIVDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
MUL_3597|M.ulcerans_Agy99 ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MMAR_5559|M.marinum_M ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVLKAELP--TQRGRGSEPARAPTLTSAAGSYE
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLLAADLP--TPRRRRAPDPPPPRVTLAAGIYE
Mflv_0186|M.gilvum_PYR-GCK AKLPAAQIHRVLTQVARAILSTELPDAAPPATPAPAAERIRSAAESSKYE
Mvan_0719|M.vanbaalenii_PYR-1 AKLPAAQVHALIAQISRAVLGAELS-ADPPRYP-PDVVPARPTAEPSKYE
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVLAADLP--ELPELGAAAAPATTPVVSAAKYE
MAB_4541|M.abscessus_ATCC_1997 ---------------------------MTNLIPESETPNKRERAKADRRD
MLBr_02568|M.leprae_Br4923 -----------------------------------MAGGAKRIPRAVREQ
:
Mb1998c|M.bovis_AF2122/97 TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
Rv1963c|M.tuberculosis_H37Rv TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
MUL_3597|M.ulcerans_Agy99 TLLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIYRYFSGKCEILATGLR
MMAR_5559|M.marinum_M TLLHASMVLFKDRGYAQTSMAQIASASGVPVSGIYRYFSGKCEILATGLR
MAV_0110|M.avium_104 LLLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYR
TH_2795|M.thermoresistible__bu CVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASLR
Mflv_0186|M.gilvum_PYR-GCK ALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIYKYFSGKNDILAAIFR
Mvan_0719|M.vanbaalenii_PYR-1 ALLTASMQLFDRNGYRDTTMEDIASAVGMPTSGIYKYFSGKSDILATIFR
MSMEG_0815|M.smegmatis_MC2_155 ALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFR
MAB_4541|M.abscessus_ATCC_1997 QLLRAAARLLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLT
MLBr_02568|M.leprae_Br4923 QMLDAAVQMFSVNGYHKTSMDAIAAEAQISKPMLYLYYGSKEDLFGACLN
:* . :: .*: . :. :. . :* : .* ::
Mb1998c|M.bovis_AF2122/97 RLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELS
Rv1963c|M.tuberculosis_H37Rv RLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELS
MUL_3597|M.ulcerans_Agy99 RAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERA
MMAR_5559|M.marinum_M RAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERA
MAV_0110|M.avium_104 RAADQLSADLSSILATSSDPEQALARLIEAYVTRSFANPELACVYYTERH
TH_2795|M.thermoresistible__bu RAVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPALAYVQHTERR
Mflv_0186|M.gilvum_PYR-GCK RASDRVSAETAEIVSTVPDPQEALAAVIDAYVTRAFGQPEMESLYYSERL
Mvan_0719|M.vanbaalenii_PYR-1 RAADRVSAELASVVATMSDPEEALTAVIDGYVQRSFDQPELECVYYSERL
MSMEG_0815|M.smegmatis_MC2_155 RAADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPELEHVYYTERL
MAB_4541|M.abscessus_ATCC_1997 DVSRRLLEGGMTVAAAASSPAEALDGLIDFHLDFALNESDLIRVQDRDLD
MLBr_02568|M.leprae_Br4923 REMSRFIAMVRADIDFTQSPKDLLRNTIVSFLRYIDANRASWIVMYIQAM
.. * : .: : :
Mb1998c|M.bovis_AF2122/97 HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Rv1963c|M.tuberculosis_H37Rv HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
MUL_3597|M.ulcerans_Agy99 NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MMAR_5559|M.marinum_M NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MAV_0110|M.avium_104 NLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAVD
TH_2795|M.thermoresistible__bu NLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVTD
Mflv_0186|M.gilvum_PYR-GCK NMSPSDQRIVRDLQRSTVESWVELVAAVRPDWTPGEARFAVHAAMALVID
Mvan_0719|M.vanbaalenii_PYR-1 NMSAADQRIVRDLQRSTVESWVELVVAVRPEWSAAEARFAVHAAMALVVD
MSMEG_0815|M.smegmatis_MC2_155 NMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVID
MAB_4541|M.abscessus_ATCC_1997 SLPENARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAFGLMNS
MLBr_02568|M.leprae_Br4923 SLPAFAQTVR--EARDQITELVAGLMRVGTRSSRPDHEYEIMAGALVGAG
. . .. . .
Mb1998c|M.bovis_AF2122/97 VARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA-----------
Rv1963c|M.tuberculosis_H37Rv VARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA-----------
MUL_3597|M.ulcerans_Agy99 LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MMAR_5559|M.marinum_M LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MAV_0110|M.avium_104 IGRLVYPNTGA----PASTTVRRLMEVTVLGRPAAASRDGLRGAGRQRR-
TH_2795|M.thermoresistible__bu LGRLTDSHASP----SAQAAVQHLMEVVLLGG------------------
Mflv_0186|M.gilvum_PYR-GCK VGRLVHYAASD----EARDTVEGLVDAALRGSYRLRATLPSM--------
Mvan_0719|M.vanbaalenii_PYR-1 LGRLMRYENSE----EARETVSGLVDMTLLGRYRLRATLPAK--------
MSMEG_0815|M.smegmatis_MC2_155 LGRLMGYRNSE----QARAVVSTMVDLVLLGRYRLRTALPAR--------
MAB_4541|M.abscessus_ATCC_1997 TPYSAGRSAPS----QTRTVLRQMVVAALRS-------------------
MLBr_02568|M.leprae_Br4923 EAMATRLTTGDIAVDEAAELMINLFWHGLKGAPADRDFGPSIVAG-----
. : : : .
Mb1998c|M.bovis_AF2122/97 -----------
Rv1963c|M.tuberculosis_H37Rv -----------
MUL_3597|M.ulcerans_Agy99 GSSNPGHVARR
MMAR_5559|M.marinum_M GSSNPGHVARR
MAV_0110|M.avium_104 -----------
TH_2795|M.thermoresistible__bu -----------
Mflv_0186|M.gilvum_PYR-GCK -----------
Mvan_0719|M.vanbaalenii_PYR-1 -----------
MSMEG_0815|M.smegmatis_MC2_155 -----------
MAB_4541|M.abscessus_ATCC_1997 -----------
MLBr_02568|M.leprae_Br4923 -----------