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TTPDAGSSGASARERVLTAAYELFSRRGIRAVGTDEVIARAGVARATLYRHFATKNDLVLAVLQRREELW TYGLIEEQSRLRGATPEEQLLAIFDVMDEWFRQGDRYEGCSFINVLLELGPEHPAGKACIAHIDRVRDIV RRRAVAAGLTDVEDFASSWHILMKGAIVLAAVGDLDAARRARRMARTLIEEHRPPLVSDTGEAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3517 | - | - | 100% (205) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1243 | - | 5e-17 | 31.96% (194) | transcriptional regulator |
| M. avium 104 | MAV_2097 | - | 4e-16 | 31.75% (189) | transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3198c | - | 9e-18 | 33.33% (195) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4672 | - | 3e-10 | 37.96% (108) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3173c | - | 9e-18 | 33.33% (195) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 2e-08 | 34.58% (107) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2458c | - | 1e-12 | 28.92% (204) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2062 | - | 1e-84 | 78.87% (194) | hypothetical protein MMAR_2062 |
| M. smegmatis MC2 155 | MSMEG_6244 | - | 5e-23 | 40.00% (195) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3775 | - | 2e-22 | 39.44% (180) | PUTATIVE TetR-family protein transcriptional regulator |
| M. ulcerans Agy99 | MUL_4890 | - | 6e-09 | 27.41% (197) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4792 | - | 7e-19 | 33.55% (155) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3517|M.avium_104 ---------------------------MTTPDAGSSGASARERVLTAAYE
MMAR_2062|M.marinum_M ---------------------------MAIPEATTAAVPARERILGAAYD
MSMEG_6244|M.smegmatis_MC2_155 ---------------------------------MLDPDAARERVLAAAEE
TH_3775|M.thermoresistible__bu ---------------------------------MAETDD-KNRVLATATT
Mb3198c|M.bovis_AF2122/97 ----------------------MPPVTRTTEPPRRGGRGARQRILKAAAE
Rv3173c|M.tuberculosis_H37Rv ----------------------MPPVTRTTEPPRRGGRGARQRILKAAAE
Mvan_4792|M.vanbaalenii_PYR-1 ----------------------MP------------AEDPRQRAIDAAVE
Mflv_4672|M.gilvum_PYR-GCK MSELAKTAPRRGGQPAN-GTGSSGAAR---RGNRLPRDERRGQLLAAASE
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
MAB_2458c|M.abscessus_ATCC_199 -------------------MSSATVPTAADSARTARVLGPADRLLQTATD
MUL_4890|M.ulcerans_Agy99 -------------------------MESKRRTQEERSAATREALITAARK
: .*
MAV_3517|M.avium_104 LFSRRGIRAVGTDEVIARAGVARATLYRHFATKNDLVLAVLQRREELWTY
MMAR_2062|M.marinum_M LFSRRGIRAVGTDEVIERAGVARATLYRHFATKDDLVLAVLQRREELWTF
MSMEG_6244|M.smegmatis_MC2_155 LFYARGIQAVGMDAVRTASGVSLKRLYQMFPSKEDLVVSFLQQRDSRWLG
TH_3775|M.thermoresistible__bu LFNERGVQAVGMDAIRDAAGISLKRLYSCFRSKADLVAAVLEQRDADVRR
Mb3198c|M.bovis_AF2122/97 LFYCEGINATGVELIANKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGE
Rv3173c|M.tuberculosis_H37Rv LFYCEGINATGVELIANKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGE
Mvan_4792|M.vanbaalenii_PYR-1 LFHREGFGAVGIDRLTTSIGMSKRTLYKYFDSKDDLLLAVLDSCEGMA-L
Mflv_4672|M.gilvum_PYR-GCK VFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKVELYLAVLQRHVDNLVS
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
MAB_2458c|M.abscessus_ATCC_199 LFATQGIRSVGIDQILREAGVAKASLYSSFGSKDALVVAYLEELDQRDRN
MUL_4890|M.ulcerans_Agy99 LWGSRGYAEVGTPEIAAEAGVTRGAMYHQFADKAALFGEVVEAVEQDVMT
:: .* .* : .:: :* * * * :
MAV_3517|M.avium_104 GLIEEQSRLRGATPEEQLLAIFDVMDEWFRQGDRYEGCSFINV--LLELG
MMAR_2062|M.marinum_M GLIEQKSRARGNTPEEQLLAIFDVLHEWFQSRDGYEGCSFINV--LLELG
MSMEG_6244|M.smegmatis_MC2_155 RLTAAVE-AHS-DPRERIPAVFDWLYSWF-SEPDYRGCAFINS--FGELG
TH_3775|M.thermoresistible__bu AMTEYVQ-SRAADPRDRILAVFDFLAHWF-AESDFRGCMFINT--IGELG
Mb3198c|M.bovis_AF2122/97 ADKMPKA-SNA-TPRERLLALFDRPNR---GDGRMRGCPFHNA--AVEAA
Rv3173c|M.tuberculosis_H37Rv ADKMPKA-SNA-TPRERLLALFDRPNR---GDGRMRGCPFHNA--AVEAA
Mvan_4792|M.vanbaalenii_PYR-1 RDLPDED-DDS-SPRDRILAVFDAQAKYC-TDPDFAGCFFVNI--ATEFR
Mflv_4672|M.gilvum_PYR-GCK GVRQALR--TTTDNRQRVRAAVQAFFDFIEHDSQGYRLIFEND--YVTEP
MLBr_00815|M.leprae_Br4923 SVQQALR--TTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFEND--NITEP
MAB_2458c|M.abscessus_ATCC_199 RWNAAVA--AQRDPIAKVLTFFDLAATAA-ESRNFRGCLYANA--ATEFP
MUL_4890|M.ulcerans_Agy99 RMATSVTTSGAATPADAIRAAVDAWLEVS-GDPEVRQLILLDAPAVLGWA
: : .: :
MAV_3517|M.avium_104 -PEHPAGKACIAHIDRVRDIVRRRAVAAGLTDVEDFASSWHILMKGAIVL
MMAR_2062|M.marinum_M -ADHPAGRACIGHIDHVRGIVRERAVAAGLHDVEDFAWSWHILMKGAIIL
MSMEG_6244|M.smegmatis_MC2_155 GISPAVADQARHHKREFHAYLTELVGAA--GYPAELAAHLALLAEGAIVN
TH_3775|M.thermoresistible__bu GTSTDVRRIARLHKTAVRDYLADLVAAA--ELPSELAEQLAILADGAIVA
Mb3198c|M.bovis_AF2122/97 GEMPGVERIVHSHKRDYIKGLARLAREAGAAHPRSLGNQLAVLFEGAAAL
Rv3173c|M.tuberculosis_H37Rv GEMPGVERIVHSHKRDYIKGLARLAREAGAAHPRSLGNQLAVLFEGAAAL
Mvan_4792|M.vanbaalenii_PYR-1 DPDHRAVRIAADHKAKLTQFLVRQARLAGVAAPDDLAEQLTVLHTGAADY
Mflv_4672|M.gilvum_PYR-GCK QVAAQVKVATESCTDAVFDLISHDSGLEPHRARMIAVGLVSISVDSARYW
MLBr_00815|M.leprae_Br4923 RVAAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVGISVDCARYW
MAB_2458c|M.abscessus_ATCC_199 GLQLEP---VRTHREWFRATVAALLREAGLARPDSIARQVQLLYDGALTG
MUL_4890|M.ulcerans_Agy99 GFCDVAQRYSLGMTEQLITEAIRAGQLDRHPVRPLAHVLIGALDEAAMFI
*
MAV_3517|M.avium_104 AAVGDLDAARRARRMARTLIEEHRPPLVSDTGEAV-
MMAR_2062|M.marinum_M AAVGDPDSARRAQRMAQVLIEQHR-----AAGAAAC
MSMEG_6244|M.smegmatis_MC2_155 SAIFGT-PDPATRAKQAALTLMQASGG---------
TH_3775|M.thermoresistible__bu ATIWGDGTDAAAAARRAAATLISAS-----------
Mb3198c|M.bovis_AF2122/97 STSLDDAGPWAHARAAAEVLIDQATARPV-------
Rv3173c|M.tuberculosis_H37Rv STSLDDAGPWAHARAAAEVLIDQATARPV-------
Mvan_4792|M.vanbaalenii_PYR-1 ALLYGHYP--DSTRTAVAALLTAAGL----------
Mflv_4672|M.gilvum_PYR-GCK LNNERPIDKDDAVEGTVQFIWGGLSHVPLTRS----
MLBr_00815|M.leprae_Br4923 LDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL----
MAB_2458c|M.abscessus_ATCC_199 SKIDKSVVPITLARRLTRQLIG--------------
MUL_4890|M.ulcerans_Agy99 ATADDPKRARRESRQVLRRLIDGMLND---------