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VPDQLDLDAADLRISRGSVPASTQLAEALKAAIVKQRLPRGARLPTERELVDRTRVSRVTVRAAVGLLER QGWLVRRQGLGTFVANPVKQELGPGVRTITEVLAASGITPNVDVLSHRVEDAPQRIAETLHLTKVLCVHR RFRDGEQPLALMIAYLPPGLGEAVEPLLKSATDTQTGRAMESTYTMWERRLDTPIARASYEIHAAGASVE VAGALNLPLGSPVLVLERTSYGHDDTPLEVVEFHYRPERYRFSVTLPRTVPGPGAGIVERSG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0738 | - | - | 100% (273) | mercuric reductase/transcriptional regulator, fusion |
| M. avium 104 | MAV_1744 | - | 7e-16 | 30.28% (251) | transcriptional regulator, GntR family protein |
| M. avium 104 | MAV_3402 | - | 2e-13 | 27.39% (241) | GntR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0816c | - | 1e-106 | 71.91% (267) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2603 | - | 5e-16 | 29.23% (260) | UbiC transcription regulator-associated domain-containing |
| M. tuberculosis H37Rv | Rv0792c | - | 1e-106 | 71.91% (267) | GntR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0953 | - | 2e-13 | 29.13% (254) | GntR family transcriptional regulator |
| M. marinum M | MMAR_2560 | - | 4e-82 | 60.15% (266) | GntR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_4659 | - | 5e-18 | 30.99% (242) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4188 | - | 1e-16 | 30.40% (250) | PUTATIVE transcriptional regulator, GntR family |
| M. ulcerans Agy99 | MUL_3201 | - | 3e-81 | 59.02% (266) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0220 | - | 1e-17 | 30.92% (249) | regulatory protein GntR, HTH |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0816c|M.bovis_AF2122/97 MTSVK----LDLDAADLRISRGSVPASTQLAEALKAQIIQQRLPRGGRLP
Rv0792c|M.tuberculosis_H37Rv MTSVK----LDLDAADLRISRGSVPASTQLAEALKAQIIQQRLPRGGRLP
MAV_0738|M.avium_104 MVPDQ----LDLDAADLRISRGSVPASTQLAEALKAAIVKQRLPRGARLP
MMAR_2560|M.marinum_M MTSDEDSPRHDLADADLRVTRGSVPASVQLAELLRTQILERALSPGSRLP
MUL_3201|M.ulcerans_Agy99 MTSDEDSPRHDLADADLRVTRGSVPASVQLAELLRTQILERALSPGSRLP
TH_4188|M.thermoresistible__bu --------------------VRPRPAYQVLRDRLRDDIAAGRYRDGTRLP
Mvan_0220|M.vanbaalenii_PYR-1 ---------------------MP-PAYQVLRERLRDDIAAGRYPDGTRLP
Mflv_2603|M.gilvum_PYR-GCK ---------MP--LTVELDRSSPVPLYYQLAQAIEAAIRDGELAPGDRFE
MSMEG_4659|M.smegmatis_MC2_155 ---------MTPTLSVELDRSSPVPLYFQVAQVFEKAILDGQLKPGDRFE
MAB_0953|M.abscessus_ATCC_1997 -----------------MEESEGGPVAEDVRRRILSMLAQGTLHPGSRLG
* : : : * *:
Mb0816c|M.bovis_AF2122/97 SERELIDRSGLSRVTVRAAVGMLQRQGWLVRRQG--LGT-FVADPVEQEL
Rv0792c|M.tuberculosis_H37Rv SERELIDRSGLSRVTVRAAVGMLQRQGWLVRRQG--LGT-FVADPVEQEL
MAV_0738|M.avium_104 TERELVDRTRVSRVTVRAAVGLLERQGWLVRRQG--LGT-FVANPVKQEL
MMAR_2560|M.marinum_M TEQELIARSGVSRSTVRAAVGILEDEGWLVRRQG--LGT-FVAEPVKQDL
MUL_3201|M.ulcerans_Agy99 TEQELIARSGVSRSTVRAAVGILEDEGWLVRRQG--LGT-FVAEPVEQDL
TH_4188|M.thermoresistible__bu TESELMAQYGVSRQTVRRAFQDLVAEGSVYRVPG--RGT-YAAD---RYL
Mvan_0220|M.vanbaalenii_PYR-1 TESELVARHGLSRQTVRRAFQDLVAEGTVYRVPG--RGS-YASEQGRRYL
Mflv_2603|M.gilvum_PYR-GCK NELALAKRLTLSRPTTRRAIQELVDKGLLVRKRG--VGTQVVQNPVHRRV
MSMEG_4659|M.smegmatis_MC2_155 NELALASRLNLSRPTTRRAIQELVDKGLLVRKRG--VGTQVVQTPVHRPV
MAB_0953|M.abscessus_ATCC_1997 SEREMAERFAVSRATVRSALVPLSRAGILERQTGRGGGTFVRADVVQRNV
.* : : :** *.* *. * * : * * *: : :
Mb0816c|M.bovis_AF2122/97 SCGVRTITEVLLS-CGVTPQVDVLSHQTGPAPQRISETLG-LVEVLCIRR
Rv0792c|M.tuberculosis_H37Rv SCGVRTITEVLLS-CGVTPQVDVLSHQTGPAPQRISETLG-LVEVLCIRR
MAV_0738|M.avium_104 GPGVRTITEVLAA-SGITPNVDVLSHRVEDAPQRIAETLH-LTKVLCVHR
MMAR_2560|M.marinum_M ESGVRTITEVLLS-RGVTPRVEVLSHAVVAAPQSVGAALG-RSEVLRIQR
MUL_3201|M.ulcerans_Agy99 ESGVRTITEVLLS-RGVTPRVEVLAHAVVAAPQSVGAALG-RSEVLRIQR
TH_4188|M.thermoresistible__bu RQFGSIEDLMALS-DDTTMEVRSGLRRRVDVDAASRLRLD-DDVVHTVVF
Mvan_0220|M.vanbaalenii_PYR-1 RQLGSIEDLMSLS-DDTTMEVVDGLRRRVDIEAASRLRLD-GDVVYSVQF
Mflv_2603|M.gilvum_PYR-GCK ELTSLFDDLARAG-QEPTTRLLKYHIGPPDEDVARELNLAEGREVASIQR
MSMEG_4659|M.smegmatis_MC2_155 ELTSLYDDLARAG-QEPATEVLEYTRRPAQADIAERLSIEPGSEIAYMRR
MAB_0953|M.abscessus_ATCC_1997 AELVGLPTRLHIGGHTSDTRVLGTSRRPATAAERAALEIAEGAEVFDVRR
. .: : : :
Mb0816c|M.bovis_AF2122/97 RIRTGDQPLALVTAYLPPGVG---PAVEPLLSGSADTET------TYAMW
Rv0792c|M.tuberculosis_H37Rv RIRTGDQPLALVTAYLPPGVG---PAVEPLLSGSADTET------TYAMW
MAV_0738|M.avium_104 RFRDGEQPLALMIAYLPPGLG---EAVEPLLKSATDTQTGRAMESTYTMW
MMAR_2560|M.marinum_M RYSESDQPLAIVTCYLPADLPH--DAVEPLLSATSATAT------TYTMW
MUL_3201|M.ulcerans_Agy99 RYSESDQPLAIVTCYLPTDLPH--DAVEPLLSATSVTAT------TYTMW
TH_4188|M.thermoresistible__bu RRLHAGAPFVSTVVHLPDRAAHHLHGCAELRTGAVSTHT------VIGLL
Mvan_0220|M.vanbaalenii_PYR-1 RRLHGGIAFGHTTVALPPAVATSVLTSPHLVTGATSTHT------VIGLL
Mflv_2603|M.gilvum_PYR-GCK LRCANGEPLALMTNHLPADIAP--DAEELGNIGLYQALR-----------
MSMEG_4659|M.smegmatis_MC2_155 LRSSNGQPLALMTNYLPAALAP--DEDELARSGLYQSLR-----------
MAB_0953|M.abscessus_ATCC_1997 LRYADGVPLSVDTAYFPAELVP--DLLEQPLGGSLYELC-----------
.: :* .
Mb0816c|M.bovis_AF2122/97 ERRLGVRIAQATHEIHAAGASPDVADALGLAVGSPVLVVDRTSYTNDGKP
Rv0792c|M.tuberculosis_H37Rv ERRLGVRIAQATHEIHAAGASPDVADALGLAVGSPVLVVDRTSYTNDGKP
MAV_0738|M.avium_104 ERRLDTPIARASYEIHAAGASVEVAGALNLPLGSPVLVLERTSYGHDDTP
MMAR_2560|M.marinum_M EQRLGVRISSATHEIQAAGASPEIAAALGLSEGAPVLVLRRTSYTDGDKP
MUL_3201|M.ulcerans_Agy99 EQRLGVRISSATHEVQAAGASPEIASALGLSEGAPVLVLRRTSYTDGDKP
TH_4188|M.thermoresistible__bu EPHLEEPIDQAAQSITVAPADDDTADAVGVEPGHPMLRIDRLYSDRTGRP
Mvan_0220|M.vanbaalenii_PYR-1 EPHLEKPIAEAAQSITVAAADEAAAAAVACPPGHPMLRVDRLYADDEGHP
Mflv_2603|M.gilvum_PYR-GCK --ARGVHIRLARQRIGARSATRAEAHLLDEKPNAPLLTMARTAFDDSGAA
MSMEG_4659|M.smegmatis_MC2_155 --ARGVHIRLARQRIGAKAADREEARLLDEKPKAPLLVMERTAFDDSGRI
MAB_0953|M.abscessus_ATCC_1997 QVRYGLQADSSTETIEVVSANPREAEWLDVPHRRPLLAITRVTRNTDGRP
: : . * * : *:* : * .
Mb0816c|M.bovis_AF2122/97 LEVVVFHHRPERYQFSVTLPRTLPGSGAGIIEKRDFA-------------
Rv0792c|M.tuberculosis_H37Rv LEVVVFHHRPERYQFSVTLPRTLPGSGAGIIEKRDFA-------------
MAV_0738|M.avium_104 LEVVEFHYRPERYRFSVTLPRTVPGPGAGIVERSG---------------
MMAR_2560|M.marinum_M LEVVLFHHRPERYEFCVTLPRTMPGQRAGMTER-----------------
MUL_3201|M.ulcerans_Agy99 LEVVLFHHRPERYEFCVTLPRTMPGQRAGMTER-----------------
TH_4188|M.thermoresistible__bu VELSVSHFLPEQYTYRVTLRRE----------------------------
Mvan_0220|M.vanbaalenii_PYR-1 VELAVSQFLPEQYTYRVTLRRSS---------------------------
Mflv_2603|M.gilvum_PYR-GCK VEFGNHCYRASRYYFDTTLVDR----------------------------
MSMEG_4659|M.smegmatis_MC2_155 VEYGSHAYRASRYYFDTTLVDR----------------------------
MAB_0953|M.abscessus_ATCC_1997 FEFSYDLFRADRVRLTATMTSAVAQESRGVDGKVERVVSRLAAHRRPDDT
.* . ..: .*:
Mb0816c|M.bovis_AF2122/97 ---
Rv0792c|M.tuberculosis_H37Rv ---
MAV_0738|M.avium_104 ---
MMAR_2560|M.marinum_M ---
MUL_3201|M.ulcerans_Agy99 ---
TH_4188|M.thermoresistible__bu ---
Mvan_0220|M.vanbaalenii_PYR-1 ---
Mflv_2603|M.gilvum_PYR-GCK ---
MSMEG_4659|M.smegmatis_MC2_155 ---
MAB_0953|M.abscessus_ATCC_1997 LLA