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SEQSKHSVKRPLIPRMVRVLAVPIVVFWAIVAVTTNTFVPHVEDVAEELAGPMIPHYAPSQRAMLHIGEK FQESTSTSLTMLVLEADRPLDGSDHQYYDDLVRRLKSDTEHVQYVMDTWGKPITAAGAQSLDGKSAFVLL RLAGDIGQTQANKSVEAIKETIDKDTPPRGLKVYVSGAAPLASDTLSVANSSLNNITIVTIFLIIFMLLM VYRSVTTMLVPLFGVLVEMLVARGVVATLGHFGYIELSSFAVNIVIALTLGAGTDYGIFLLGRYHEARNA GLDREDAFYSAYRGVSHVIIGSGLTIAGAGLCLSFARLNYFHTMGPAVAIAMLLTIAAALTLGPALLHLG SLFGLFDPKRRVKARLYRRIGASVVRWPKPILVASAAAVLVGAVFVPTYQVNYDDRAYQPPDAPAKQGFA AADRHFPPSKLFTEMLMVESDHDMRNSADFISLDRVSKSLVRLPGVAMVQSITRPMGRALEHASLPYLFT TQGSGNGQQLPFTKAQNANTDRQAQIMAHSVAVLRQTTDLTQQLADEMHNTVVTMEDMQQVTQDMNEKVS NLDDFMRPLRNYFYWEPHCFDIPVCQSFRSLFDMLDSIDKLAADIKDAVGSLEVVDRLLPQMVALLKLTA NDQEALQALIVNTYGQTNLQATATDQTFDDMINVGNDFDASRSDDFFYIPHEAFDNEDIKTGMTLMMSPD GKAARFIVTHMGNAMGPEGIEHVNDFPDAITTALKETSLAGAQVYIGGAGSNNKDIKQYAASDLLIAAIA AFTLIFLIMMVITRSLVAPFVIIGTVAFSFAGAFGLSVLIWQHLVGLPLHWLILPLTFIILVAVGSDYNL LLIARLKEETDAGLNTGLIRALGSTGGVVTSAGLVFAFTMLAMLASDLRTIGQVGTTVCIGLLLDTLIVR SFIVPALVRLLGTWFWWPTRVLARPRREPVRS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_4768c | - | - | 100% (943) | putative membrane protein, MmpL |
M. abscessus ATCC 19977 | MAB_3562c | - | 0.0 | 80.24% (931) | MmpL family protein |
M. abscessus ATCC 19977 | MAB_2037 | - | 0.0 | 56.55% (932) | putative membrane protein MmpL |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0458c | mmpL4 | 0.0 | 49.09% (931) | transmembrane transport protein MmpL4 |
M. gilvum PYR-GCK | Mflv_4418 | - | 0.0 | 48.91% (918) | transport protein |
M. tuberculosis H37Rv | Rv0450c | mmpL4 | 0.0 | 49.19% (931) | transmembrane transport protein MmpL4 |
M. leprae Br4923 | MLBr_02378 | - | 0.0 | 47.79% (927) | hypothetical protein MLBr_02378 |
M. marinum M | MMAR_0771 | mmpL5_2 | 0.0 | 48.87% (931) | transmembrane transport protein MmpL5_2 |
M. avium 104 | MAV_3863 | - | 0.0 | 49.20% (933) | MmpL4 protein |
M. smegmatis MC2 155 | MSMEG_0185 | - | 0.0 | 75.16% (938) | MmpL6 protein |
M. thermoresistible (build 8) | TH_3260 | - | 0.0 | 45.34% (933) | PUTATIVE MmpL4 protein |
M. ulcerans Agy99 | MUL_3688 | mmpL4_1 | 0.0 | 48.88% (937) | transmembrane transport protein MmpL4_1 |
M. vanbaalenii PYR-1 | Mvan_1936 | - | 0.0 | 48.70% (920) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb0458c|M.bovis_AF2122/97 ---MSTKFANDSN------------------TNARPEKPFIARMIHAFAV Rv0450c|M.tuberculosis_H37Rv ---MSTKFANDSN------------------TNARPEKPFIARMIHAFAV MMAR_0771|M.marinum_M ---MTVKYANDPD------------------TRTHTEKPFLARMIHAFAV MLBr_02378|M.leprae_Br4923 ---MTVKCANDLD------------------THTKP--PFVARMIHRFAV Mflv_4418|M.gilvum_PYR-GCK --------------------------------MADAGRSGIGRIIRVLAV Mvan_1936|M.vanbaalenii_PYR-1 --------------------------------MADAGRSGIGRIIHLLAV TH_3260|M.thermoresistible__bu ---MTANPGHVRTDEAPTDRLDI--------KVSTHGPSFISTWIRRLSL MAV_3863|M.avium_104 ----------------------M--------TTDQATRSVVAQTIRRLSV MUL_3688|M.ulcerans_Agy99 ---MSESNSGASISTEDTGPIEIGAATGGAPNRERGHRPVIPHTIRILAV MAB_4768c|M.abscessus_ATCC_199 ---MSEQ------------------------SKHSVKRPLIPRMVRVLAV MSMEG_0185|M.smegmatis_MC2_155 MPGQVRM------------------------SAHRAGRPFFARTVRVLAV . . :: ::: Mb0458c|M.bovis_AF2122/97 PIILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFK Rv0450c|M.tuberculosis_H37Rv PIILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFK MMAR_0771|M.marinum_M PIILAWVAVCVALSVFIPSLEVVGQERSVSLSPKDAPSYEAMKRIGAAFN MLBr_02378|M.leprae_Br4923 PIILVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVFN Mflv_4418|M.gilvum_PYR-GCK PIVLGWVLLTVLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSMKRVGANFE Mvan_1936|M.vanbaalenii_PYR-1 PIVLGWIALTVLTNVAVPSLEKVGEEHTVGMSANDAPSMMSMERVGANFD TH_3260|M.thermoresistible__bu PIIVGWIALIALLNITVPQLEVVGEMRAVSMSPDEAPSMVAMKRVGELFD MAV_3863|M.avium_104 PILLVWVAVAAISNIAVPNLEDVAKAHNVSLNTPAAPSFQAMQHIGKVFH MUL_3688|M.ulcerans_Agy99 PIILGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAMMRLGHNFR MAB_4768c|M.abscessus_ATCC_199 PIVVFWAIVAVTTNTFVPHVEDVAEELAGPMIPHYAPSQRAMLHIGEKFQ MSMEG_0185|M.smegmatis_MC2_155 PIIVFWGLLAVTTNTFIPQVEHVADELAGPMIPNYAPSQVALLHIGEKFQ **:: * : . . :* :* *.. : . *** :: ::* * Mb0458c|M.bovis_AF2122/97 EGDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDP Rv0450c|M.tuberculosis_H37Rv EGDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDP MMAR_0771|M.marinum_M EGNSDSQAMIVLEGKDALGDDAHKYYDVLIRKLRADPRHVQSVQDFWGDP MLBr_02378|M.leprae_Br4923 EGNSDSVIMIVLEGDKPLGDDAHRFYDGLIRKLRAD-KHVQSVQDFWGDP Mflv_4418|M.gilvum_PYR-GCK EFDSDSSAMVVLEGEQPLGDAAHRYYDQLIDELEADTANVQHIADFWGDP Mvan_1936|M.vanbaalenii_PYR-1 EFDSDSSAMVVLEGEQPLGDAAHRYYDELIGKLEADTANVQHVADFWGDP TH_3260|M.thermoresistible__bu EGSSDSQVMIVLEGEEPLGADARAFYDELVKRLEADDAHVENVQDLWSDP MAV_3863|M.avium_104 EYDSDSAAMIVLEGDKPLGDDAHRFYDALVGKLEHDTKHVEHVQNFWGDP MUL_3688|M.ulcerans_Agy99 EFDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLRQDPEHIQHIQDFWGDR MAB_4768c|M.abscessus_ATCC_199 ESTSTSLTMLVLEADRPLDGSDHQYYDDLVRRLKSDTEHVQYVMDTWGKP MSMEG_0185|M.smegmatis_MC2_155 ESDSTNLTMLVFEADRPLDDGDHRYYDDLVRRLQADTEHVQYVMDLWGKP * * . *:::*.. *. : :** *: .*. * ::: : : *.. Mb0458c|M.bovis_AF2122/97 LTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVEST---PAPP Rv0450c|M.tuberculosis_H37Rv LTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVEST---PAPP MMAR_0771|M.marinum_M LTAAGAQSNDGKAAYVQLNLAGNQGEPLANESVEAVRKIVKET---PAPP MLBr_02378|M.leprae_Br4923 LTAPGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQT---PAPP Mflv_4418|M.gilvum_PYR-GCK LTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDRT---PAPP Mvan_1936|M.vanbaalenii_PYR-1 LTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDQT---PAPP TH_3260|M.thermoresistible__bu LTATGVQSPDGKSAYVQVKLAGNQGEALANESVETVREMIATVSEEMAPE MAV_3863|M.avium_104 LTAAGSQSKDGKAAYVQVYLAGNQGDALANESVDAIRNIVEHT---PPPP MUL_3688|M.ulcerans_Agy99 LTAAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINRT---HEPA MAB_4768c|M.abscessus_ATCC_199 ITAAGAQSLDGKSAFVLLRLAGDIGQTQANKSVEAIKETIDKD---TPPR MSMEG_0185|M.smegmatis_MC2_155 ITAAGAQSVDGKASFVLLRLAGNIGQLEANESVDAVRDIIADD---APPQ :**.* ** ***:::* : * *: * *:::: :::. : * Mb0458c|M.bovis_AF2122/97 GIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVV Rv0450c|M.tuberculosis_H37Rv GIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVV MMAR_0771|M.marinum_M GVTTYVTGAAALVSDMHSSGDKSMIKITVTTVAVIFIMLLLVYRSVITVV MLBr_02378|M.leprae_Br4923 GITAWVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITVI Mflv_4418|M.gilvum_PYR-GCK GIKAYVTGGAPLVADQHSAGDTSVLRVTLITIGVIAVMLLIVFRSVATMV Mvan_1936|M.vanbaalenii_PYR-1 GLKAYVTGGAPLVADQHNAGDKSVFRVTLITIGVIAVMLLLVFRSVATMV TH_3260|M.thermoresistible__bu GVQAFVTGGAAMSADQQEAGDSSLRVIEALTFLVITTMLLFVYRSVITVL MAV_3863|M.avium_104 GVKAYVTGAAPLVTDQFEVGSKGIFKVTVITVLVILAMLLWVYRS-VTAV MUL_3688|M.ulcerans_Agy99 GVKAYVTGPAALSDDMHLIGNASLATITMFTLGAIAVMLLLVYRSIVTTV MAB_4768c|M.abscessus_ATCC_199 GLKVYVSGAAPLASDTLSVANSSLNNITIVTIFLIIFMLLMVYRSVTTML MSMEG_0185|M.smegmatis_MC2_155 GLKVYVSGAAPLASDTLSTANSSLNNITIFTIILIVVMLLLVYRSAACLL *: .:*:* :.: * .. .: : :. * ** *:** : Mb0458c|M.bovis_AF2122/97 LLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIF Rv0450c|M.tuberculosis_H37Rv LLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIF MMAR_0771|M.marinum_M VLLLTVGVELTAARGVVALLGHSGAIGLSTFAVSLLTSLAIAAGTDYGIF MLBr_02378|M.leprae_Br4923 LLLFTVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGIF Mflv_4418|M.gilvum_PYR-GCK LILFMVFAELGAARGIVAFLADAEIIGLSTFATSLLTLMVIAAGTDYAIF Mvan_1936|M.vanbaalenii_PYR-1 LILFMVFAELGAARGIVAFLANAEIIGLSTFATSLLTLMVIAAGTDYAIF TH_3260|M.thermoresistible__bu IALFMVLIGLLTTRGVVAFLGYHNIIGLSTFATSLLVTLAIAIAVDYAIF MAV_3863|M.avium_104 FVLVTVIVEMAAARGIVAFLGSVGLIGLSTYATNLLTLLVIAAGTDYAIF MUL_3688|M.ulcerans_Agy99 IQLFMTGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIAAGTDYGIF MAB_4768c|M.abscessus_ATCC_199 VPLFGVLVEMLVARGVVATLGHFGYIELSSFAVNIVIALTLGAGTDYGIF MSMEG_0185|M.smegmatis_MC2_155 VPLPAVLIEMLVAKGVIATLGHFGLIPLSSFAVNVVVALTLGAGTDYGIF . * . ::*::* *. : *:::*..:: :.:. ..**.** Mb0458c|M.bovis_AF2122/97 IIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTITGATFCLSFARMP Rv0450c|M.tuberculosis_H37Rv IIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMP MMAR_0771|M.marinum_M IFGRYQEARQAGEDKETAFYTMYRGTAHVILGSGLTIAGATFCLKFARMP MLBr_02378|M.leprae_Br4923 ITGRYQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARMP Mflv_4418|M.gilvum_PYR-GCK AIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRLP Mvan_1936|M.vanbaalenii_PYR-1 AIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRLP TH_3260|M.thermoresistible__bu LIGRYQEARSVGADRATAYHTMFGGTAHVILASGLTIAGATFCLSFTRLP MAV_3863|M.avium_104 FVGRYHEARHEGQDRETAYYTMYRGTTHVVLGSGLTVAGAVLCLRFTRLN MUL_3688|M.ulcerans_Agy99 LVGRYQEARQAGEDRQDAYYTTFRGVAPVVLGSGLTIAGATYCLSFARLP MAB_4768c|M.abscessus_ATCC_199 LLGRYHEARNAGLDREDAFYSAYRGVSHVIIGSGLTIAGAGLCLSFARLN MSMEG_0185|M.smegmatis_MC2_155 LLGRYHEARQSGESREDAYFTAYRSVAPIIIGSGLTIAGACFCLSLARLD ***:*** . .: *:.: : .. :::.****::** ** ::*: Mb0458c|M.bovis_AF2122/97 YFQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFGLFDPKRLLKV-RGWR Rv0450c|M.tuberculosis_H37Rv YFQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFGLFDPKRLLKV-RGWR MMAR_0771|M.marinum_M YFETLGIPCAVGMLVAVMVALTLGPAVLTVGSRFGLFDPKRLIKV-RGWR MLBr_02378|M.leprae_Br4923 YFQTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFGLFEPKRLIKV-RGWR Mflv_4418|M.gilvum_PYR-GCK YFQTMGVPCAVGTFVAVIAALTLGPAVIVIGSRFGLFDPKRAISS-RGWR Mvan_1936|M.vanbaalenii_PYR-1 YFQTMGVPCAVGTFVAVMAALTLGPAVVAIGSRFGLFDPKRAISS-RGWR TH_3260|M.thermoresistible__bu YFQSLGPPLAIGMIVLIVTSLTMGPAIITVATRFGLLEPKRAARV-RFWR MAV_3863|M.avium_104 YFQSLGIPAAIGIGVALAAALSLTPAVITVGSLFGLFDPKRQMAT-RGWR MUL_3688|M.ulcerans_Agy99 WFNTMGAPVAIGMLVVVLAGLTLGPAVVFVGSRFHPFESKRAANRGRLWR MAB_4768c|M.abscessus_ATCC_199 YFHTMGPAVAIAMLLTIAAALTLGPALLHLGSLFGLFDPKRRVKA-RLYR MSMEG_0185|M.smegmatis_MC2_155 YFHTMGPAVAISMLFTIAAALTLAPALLTLGSLLALFDPKRPTRG-HLYR :*.::* . *:. . : ..*:: **:: :.: : ::.** : :* Mb0458c|M.bovis_AF2122/97 RVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQG Rv0450c|M.tuberculosis_H37Rv RVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQG MMAR_0771|M.marinum_M RVGTVVVRWPLPVLAATLAVALVGLLALPGYRTNYNDRDYLPNFIPANQG MLBr_02378|M.leprae_Br4923 RIGTVVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQG Mflv_4418|M.gilvum_PYR-GCK RIGVSVVRWPGPVLAATLALALVGLVTLPGYKTNYDARDYLPEDIPANVG Mvan_1936|M.vanbaalenii_PYR-1 RIGVSVVRWPGPVLAATLALALVGLVALPGYKTNYDSRDYLPEDVPANVG TH_3260|M.thermoresistible__bu KVGASVVRWPGPIMVTTVAVTLVGLLALPGYRTNYNDRNYLPASFPSNAG MAV_3863|M.avium_104 RIGTAIVRWPGPILVVATGVALVGLLALPGYRTNYDARPYMPASAPANTG MUL_3688|M.ulcerans_Agy99 RVGTAVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYLPASAPSNLG MAB_4768c|M.abscessus_ATCC_199 RIGASVVRWPKPILVASAAAVLVGAVFVPTYQVNYDDRAYQPPDAPAKQG MSMEG_0185|M.smegmatis_MC2_155 RIGTSVVRWPKPIFVASAAVVMVGAVFVPSYRVNYDDRAYQPVDAAANLG ::*. :**** *:: : . .:** : :* ::..*. * * * .:: * Mb0458c|M.bovis_AF2122/97 YAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISR Rv0450c|M.tuberculosis_H37Rv YAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISR MMAR_0771|M.marinum_M FTAAERHFSQARMKPDILMIQSDHDMRNPADFLVLDRLAKGIFHVPGISR MLBr_02378|M.leprae_Br4923 FAAADRHFPQARMKPEILMIESDHDMRNPADFLILDKLARGIFRVPGISR Mflv_4418|M.gilvum_PYR-GCK YAVADQHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKSVFRVPGVAR Mvan_1936|M.vanbaalenii_PYR-1 YAVADRHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKAIFRVPGVAR TH_3260|M.thermoresistible__bu YEAAERHFDPARLNPELLLIESDHDLRNPADFLVIEKIAKAVFQVEGISR MAV_3863|M.avium_104 YTAAERHFSQARLNPELLMIETDHDMRNPADMINLERVAKAIAHLPGIAQ MUL_3688|M.ulcerans_Agy99 EAAADRHFSHARMNPDMLMVEAEHDMRNPADMLVLDKVAKNVIRTVGIAM MAB_4768c|M.abscessus_ATCC_199 FAAADRHFPPSKLFTEMLMVESDHDMRNSADFISLDRVSKSLVRLPGVAM MSMEG_0185|M.smegmatis_MC2_155 FQAADRHFNQSKLFSEMLMIETDHDMRNSADFISLDRVAKALIRLPGVAM .*::** ::: .::*:::::**:**.**:: :::::: : : *:: Mb0458c|M.bovis_AF2122/97 VQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMA Rv0450c|M.tuberculosis_H37Rv VQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMA MMAR_0771|M.marinum_M VQAITRPDGTAMDHTSIPFQISMQNAGQIQTLKYQRDRMNDMLTQAEEMA MLBr_02378|M.leprae_Br4923 VQAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENMA Mflv_4418|M.gilvum_PYR-GCK VQTITRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQDRMADMLVQADAMQ Mvan_1936|M.vanbaalenii_PYR-1 VQTITRPDGKPIKHTTIPFQMSMRSTTSRLNEKYMQDRMADMLVQADAMQ TH_3260|M.thermoresistible__bu VQGITRPEGTPIEHSSIPFMISQQGTLQILNQQYMQDRMADMLVQADEMQ MAV_3863|M.avium_104 VQSMTRPLGTPIEHTSLAFQISAGSIGSIENLQYQKERAEDLLKQADNLK MUL_3688|M.ulcerans_Agy99 IQDITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMADMTKMADEMQ MAB_4768c|M.abscessus_ATCC_199 VQSITRPMGRALEHASLPYLFTTQGSGNGQQLPFTKAQNANTDRQAQIMA MSMEG_0185|M.smegmatis_MC2_155 VQSITRPLGRPLEHATIPYLFTTQGSTNGQQLPFSEQANENTDRQAEIQA :* :*** * .:.*:::.: : . : . : *: Mb0458c|M.bovis_AF2122/97 TTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRP Rv0450c|M.tuberculosis_H37Rv TTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRP MMAR_0771|M.marinum_M KTIALMRRMYGLMTQLANNTHKMVGDTIEMQQITKELRDHIANFDDFFRP MLBr_02378|M.leprae_Br4923 ETIASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWRP Mflv_4418|M.gilvum_PYR-GCK TNVDTMTRMQSLMGQMSATTHEMVLKTKKTEIDIIEVRDNLADFDDFFRP Mvan_1936|M.vanbaalenii_PYR-1 TNVDTMTKMQSLMTQMSAATHDMVTKTKKTAVDIVEVRDYLANLDDFVRP TH_3260|M.thermoresistible__bu LMIDTMDKMIALMEEMVETTDNMVRDMDEMAAHVAEMRDSISEFDDFFRP MAV_3863|M.avium_104 DTIGILNQQYALQKQLAASTHDETQSFHDTIAIINDLRDKIANFDDFFRP MUL_3688|M.ulcerans_Agy99 VLIDTTERMYAVMRELDTTTTDMARVTAETSTITDELRDHLAEFDDFWRP MAB_4768c|M.abscessus_ATCC_199 HSVAVLRQTTDLTQQLADEMHNTVVTMEDMQQVTQDMNEKVSNLDDFMRP MSMEG_0185|M.smegmatis_MC2_155 RSVEVLQHVITITQQMSAELHSTVLTFENLKEVTDEVNEGISNLDDFLRP : : : : . .:.: ::::*** ** Mb0458c|M.bovis_AF2122/97 IRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRL Rv0450c|M.tuberculosis_H37Rv IRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRL MMAR_0771|M.marinum_M IRSYFYWEKHCYDIPICSSFRSIFDALDGIDQIDEKLDNLVVDIKELDRL MLBr_02378|M.leprae_Br4923 IRSYFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDLL Mflv_4418|M.gilvum_PYR-GCK VRNYFYWEPHCYDIPVCWTMRSVFDTLDGINPLTDDISELIPDLERLDEL Mvan_1936|M.vanbaalenii_PYR-1 VRNYFYWEPHCYNIPVCATMRSVFDTLDGINPLTDDIQELIPDLERLDAL TH_3260|M.thermoresistible__bu IRNYFYWEPHCYNIPVCWAMRSVFDTLDGINTMTDDIQNMLPHMHRLNDL MAV_3863|M.avium_104 VRSYFYWEKHCFDIPACFAFRSVFDALDGIDELSAQFEKLTASLDKLDAG MUL_3688|M.ulcerans_Agy99 MRSYFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELTEDIQRTAGL MAB_4768c|M.abscessus_ATCC_199 LRNYFYWEPHCFDIPVCQSFRSLFDMLDSIDKLAADIKDAVGSLEVVDRL MSMEG_0185|M.smegmatis_MC2_155 LKNYFYWEPHCFDIPVCFAMRSLFDSLDGIDSLDEQIGNAVVSFEAIDRL ::.***** **:.:* * ::**:** **.:: : : : Mb0458c|M.bovis_AF2122/97 MPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAF Rv0450c|M.tuberculosis_H37Rv MPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAF MMAR_0771|M.marinum_M MPQMIETFPPMIETMESMRLMMLTMHSTMSGLYDQMSEMSENANAMGKAF MLBr_02378|M.leprae_Br4923 MPQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKAF Mflv_4418|M.gilvum_PYR-GCK MPQLIALLPSQIETMRSMQAMMLRQYQTQKGQLDQNAAMSEDADAMGEAF Mvan_1936|M.vanbaalenii_PYR-1 MPQLIALLPSQIESMRNMQSMMLTMYQSQKGLQDQMASQSEDADAMGEAF TH_3260|M.thermoresistible__bu MPQMLTLLPTTVATMKTMRSMLLTMQATNAGLQDQMAEMQENANAMGEAF MAV_3863|M.avium_104 QQKLVTLLPPQIADQEKNLALTLSNYATNLGINAQTRANTDTATALGQAY MUL_3688|M.ulcerans_Agy99 TSQMLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSNTAIVMGQSF MAB_4768c|M.abscessus_ATCC_199 LPQMVALLKLTANDQEALQALIVNTYGQTNLQATATDQTFDDMINVGNDF MSMEG_0185|M.smegmatis_MC2_155 LPQMITQLERMIADSRALLGVITNNYGPAHLQSTQTDQTYYDQINVGNDF ::: : . : :*: : Mb0458c|M.bovis_AF2122/97 DAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPE Rv0450c|M.tuberculosis_H37Rv DAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPE MMAR_0771|M.marinum_M DAAKNDDSFYLPPEVFKNEDFKRAMKSFLSPDGHAARFIILHRGDPQSAQ MLBr_02378|M.leprae_Br4923 DTAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASVA Mflv_4418|M.gilvum_PYR-GCK DDSMNDDSFYLPPEAFDNDDFKRGMENFISPDGRSVRFIISHEGDPATVE Mvan_1936|M.vanbaalenii_PYR-1 DDSMNDDSFYLPPEAFDNDDFKRGIENFISPDGKSVRFIIAHEGDPATVE TH_3260|M.thermoresistible__bu DQARNDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAVRFIISHQGDPMTPE MAV_3863|M.avium_104 DAAKNDDSFYLPPEAFTNPEFKRGLKLFLSPDGKAARMIISHEGDPATPE MUL_3688|M.ulcerans_Agy99 DASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFITHQGDPMTPE MAB_4768c|M.abscessus_ATCC_199 DASRSDDFFYIPHEAFDNEDIKTGMTLMMSPDGKAARFIVTHMGNAMGPE MSMEG_0185|M.smegmatis_MC2_155 DAARSDDFFYIPHEAFDNDDVKTGMKLLMSPDGKAARFIITHEGNAMAPE * : .** **:* *.* * :.: .: ::*.**::.*::: * *:. Mb0458c|M.bovis_AF2122/97 GIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAA Rv0450c|M.tuberculosis_H37Rv GIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAA MMAR_0771|M.marinum_M GIASIDQIRTAAEESLKGTPLEDAKIYVAGTASVFKDISEGADWDLLIAG MLBr_02378|M.leprae_Br4923 GIASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIAG Mflv_4418|M.gilvum_PYR-GCK GISEVVPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMSDGAFYDLLIAG Mvan_1936|M.vanbaalenii_PYR-1 GISRVLPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMRDGANYDLLIAG TH_3260|M.thermoresistible__bu GLAKIEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFKDMSDGTKYDLIIAA MAV_3863|M.avium_104 GISHIEPIRNAAKQAVKNTPLGDSNIYLAGTAATYKDIAEGAKYDLLIAG MUL_3688|M.ulcerans_Agy99 GISRVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADGEKYDLMIAV MAB_4768c|M.abscessus_ATCC_199 GIEHVNDFPDAITTALKETSLAGAQVYIGGAGSNNKDIKQYAASDLLIAA MSMEG_0185|M.smegmatis_MC2_155 GIEHVEQFPDAIKMALKETSLAGAKIYIGGAASNNLDIKTYAASDLLIVA *: : * .:* :.* .: :*:.*:.: *: **:*. Mb0458c|M.bovis_AF2122/97 ISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIH Rv0450c|M.tuberculosis_H37Rv ISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIH MMAR_0771|M.marinum_M ISSLCLIFIIMLILTRAFVAAAVIVGTVALSLGASFGMSVLLWQHILNID MLBr_02378|M.leprae_Br4923 ISSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGIE Mflv_4418|M.gilvum_PYR-GCK IAAVTLIFVIMLVITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGLA Mvan_1936|M.vanbaalenii_PYR-1 IAAVTLIFVIMLIITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGLA TH_3260|M.thermoresistible__bu IAAVCLIFIIMLILTRAVVAAAVIVGTVTLSLAASFGVSVLIWQYIVGLE MAV_3863|M.avium_104 IAALSLILLIMVLITRSLVAAIVIVGTVALSLGASFGLSVLVWQDILGIK MUL_3688|M.ulcerans_Agy99 VSALTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVLIWQDLFGIK MAB_4768c|M.abscessus_ATCC_199 IAAFTLIFLIMMVITRSLVAPFVIIGTVAFSFAGAFGLSVLIWQHLVGLP MSMEG_0185|M.smegmatis_MC2_155 IAAFVLIFLIMLYLTRSLVAALVIPGTVAFSFAGAFGLSVMMWQHLIGLP :::. **::**: :**:.:*. ** **. *:..:**:**::** :. : Mb0458c|M.bovis_AF2122/97 LHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKV Rv0450c|M.tuberculosis_H37Rv LHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKV MMAR_0771|M.marinum_M LHYMVLAMSVIVLLAVGSDYNLLLVSRFKEEIPAGLKTGIIRAMGGTGKV MLBr_02378|M.leprae_Br4923 LHYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGKV Mflv_4418|M.gilvum_PYR-GCK LHWMVLPMAVILLLAVGSDYNLLLVSRFKEELSGGLKTGIIRAMAGTGSV Mvan_1936|M.vanbaalenii_PYR-1 LHWMVLPMAVILLLAVGSDYNLLLVSRFKEELAGGLKTGIIRSMAGTGSV TH_3260|M.thermoresistible__bu MHWMVFPMALIILLAVGADYNLLVVARLREEIPAGLNTGMIRAMGGSGSV MAV_3863|M.avium_104 LYWICLALSVIILLAVGSDYNLLLISRFREEIHAGLNTGIIRSMAGSGAV MUL_3688|M.ulcerans_Agy99 IHWIVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGIIRSMAGTGGV MAB_4768c|M.abscessus_ATCC_199 LHWLILPLTFIILVAVGSDYNLLLIARLKEETDAGLNTGLIRALGSTGGV MSMEG_0185|M.smegmatis_MC2_155 LHWLILPLSFIILVAVGSDYNLLLISRVKEETGAGLNTGLIRALGSTGAV :::: .::.*:*:***:*****:::*.::* .**:**:**::..:* * Mb0458c|M.bovis_AF2122/97 VTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIA Rv0450c|M.tuberculosis_H37Rv VTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIA MMAR_0771|M.marinum_M VTNAGLVFAFTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRAFMTPSIA MLBr_02378|M.leprae_Br4923 VTNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSIA Mflv_4418|M.gilvum_PYR-GCK VTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAVA Mvan_1936|M.vanbaalenii_PYR-1 VTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAVA TH_3260|M.thermoresistible__bu VTAAGLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLFDTFVVRSFMMPSIA MAV_3863|M.avium_104 VTSAGLVFAFTMASFVSASLLVLGQIGTTIALGLLFDTLIVRSFMTPSVA MUL_3688|M.ulcerans_Agy99 VTAAGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIVRTLLMPSIA MAB_4768c|M.abscessus_ATCC_199 VTSAGLVFAFTMLAMLASDLRTIGQVGTTVCIGLLLDTLIVRSFIVPALV MSMEG_0185|M.smegmatis_MC2_155 VTSAGLVFAFTMLSMLVSDLRTIGQLGTTVCIGLLLDTMIVRSLVVPCLL ** *****..** : :.* .:.*.*:*: :***:**::**::: *.: Mb0458c|M.bovis_AF2122/97 ALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG-------- Rv0450c|M.tuberculosis_H37Rv ALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG-------- MMAR_0771|M.marinum_M ALLGRWFWWPMRVRTRPARTPSSPTADPEPDRALAMSGER---------- MLBr_02378|M.leprae_Br4923 ALLGRWFWWPQQGRTRPLLTVAAPVG-LPPDRSLVYSD------------ Mflv_4418|M.gilvum_PYR-GCK ALLGRWFWWPQKFRSAASERRLARIGVQ-PATAGR--------------- Mvan_1936|M.vanbaalenii_PYR-1 ALLGRWFWWPQKVRSHASQRRLAALNH----------------------- TH_3260|M.thermoresistible__bu TLLGRWFWWPQFVRKRPVPQPWPSVPPRGPATTDRVSV------------ MAV_3863|M.avium_104 ALLGRWFWWPQRVRPRPASTMLRPYGPRPAVRQLLLWEDGDPAVAPETPS MUL_3688|M.ulcerans_Agy99 TLLGRWFWWPQVVHPRGDNARPRVAAPTH--------------------- MAB_4768c|M.abscessus_ATCC_199 RLLGTWFWWPTRVLARPRREPVRS-------------------------- MSMEG_0185|M.smegmatis_MC2_155 RLLGPWFWWPTFIRQRPLRQAVRQRERADVV------------------- *** ***** Mb0458c|M.bovis_AF2122/97 ------- Rv0450c|M.tuberculosis_H37Rv ------- MMAR_0771|M.marinum_M ------- MLBr_02378|M.leprae_Br4923 ------- Mflv_4418|M.gilvum_PYR-GCK ------- Mvan_1936|M.vanbaalenii_PYR-1 ------- TH_3260|M.thermoresistible__bu ------- MAV_3863|M.avium_104 AARHSRG MUL_3688|M.ulcerans_Agy99 ------- MAB_4768c|M.abscessus_ATCC_199 ------- MSMEG_0185|M.smegmatis_MC2_155 -------