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M. marinum M MMAR_0771 (mmpL5_2)

annotation: transmembrane transport protein MmpL5_2
coordinates: 926142 - 929039
length: 965

TVKYANDPDTRTHTEKPFLARMIHAFAVPIILAWVAVCVALSVFIPSLEVVGQERSVSLSPKDAPSYEAM
KRIGAAFNEGNSDSQAMIVLEGKDALGDDAHKYYDVLIRKLRADPRHVQSVQDFWGDPLTAAGAQSNDGK
AAYVQLNLAGNQGEPLANESVEAVRKIVKETPAPPGVTTYVTGAAALVSDMHSSGDKSMIKITVTTVAVI
FIMLLLVYRSVITVVVLLLTVGVELTAARGVVALLGHSGAIGLSTFAVSLLTSLAIAAGTDYGIFIFGRY
QEARQAGEDKETAFYTMYRGTAHVILGSGLTIAGATFCLKFARMPYFETLGIPCAVGMLVAVMVALTLGP
AVLTVGSRFGLFDPKRLIKVRGWRRVGTVVVRWPLPVLAATLAVALVGLLALPGYRTNYNDRDYLPNFIP
ANQGFTAAERHFSQARMKPDILMIQSDHDMRNPADFLVLDRLAKGIFHVPGISRVQAITRPDGTAMDHTS
IPFQISMQNAGQIQTLKYQRDRMNDMLTQAEEMAKTIALMRRMYGLMTQLANNTHKMVGDTIEMQQITKE
LRDHIANFDDFFRPIRSYFYWEKHCYDIPICSSFRSIFDALDGIDQIDEKLDNLVVDIKELDRLMPQMIE
TFPPMIETMESMRLMMLTMHSTMSGLYDQMSEMSENANAMGKAFDAAKNDDSFYLPPEVFKNEDFKRAMK
SFLSPDGHAARFIILHRGDPQSAQGIASIDQIRTAAEESLKGTPLEDAKIYVAGTASVFKDISEGADWDL
LIAGISSLCLIFIIMLILTRAFVAAAVIVGTVALSLGASFGMSVLLWQHILNIDLHYMVLAMSVIVLLAV
GSDYNLLLVSRFKEEIPAGLKTGIIRAMGGTGKVVTNAGLVFAFTMASMAVSDLRVIGQVGTTIGLGLLF
DTLIVRAFMTPSIAALLGRWFWWPMRVRTRPARTPSSPTADPEPDRALAMSGER*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_0771mmpL5_2-100% (965)transmembrane transport protein MmpL5_2
M. marinum MMMAR_0255mmpL5_40.079.05% (945) transmembrane transport protein, MmpL5_4
M. marinum MMMAR_4429-0.075.77% (937) transmembrane transport protein, MmpL

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0458cmmpL40.081.66% (965) transmembrane transport protein MmpL4
M. gilvum PYR-GCKMflv_3435-0.064.66% (931) transport protein
M. tuberculosis H37RvRv0450cmmpL40.081.76% (965) transmembrane transport protein MmpL4
M. leprae Br4923MLBr_02378-0.080.67% (962) hypothetical protein MLBr_02378
M. abscessus ATCC 19977MAB_2301-0.063.10% (954) putative membrane protein, mmpL
M. avium 104MAV_2510-0.065.41% (928) MmpL4 protein
M. smegmatis MC2 155MSMEG_3496-0.063.89% (947) MmpL4 protein
M. thermoresistible (build 8)TH_3056-0.062.55% (940) PUTATIVE Mmp14a protein
M. ulcerans Agy99MUL_0757mmpL50.064.48% (946) transmembrane transport protein, MmpL5
M. vanbaalenii PYR-1Mvan_3189-0.064.98% (931) transport protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb0458c|M.bovis_AF2122/97           MSTKFANDSNTN------ARPEKPFIARMIHAFAVPIILGWLAVCVVVTV
Rv0450c|M.tuberculosis_H37Rv        MSTKFANDSNTN------ARPEKPFIARMIHAFAVPIILGWLAVCVVVTV
MMAR_0771|M.marinum_M               MTVKYANDPDTR------THTEKPFLARMIHAFAVPIILAWVAVCVALSV
MLBr_02378|M.leprae_Br4923          MTVKCANDLDTH------TKP--PFVARMIHRFAVPIILVWLAIAVTVSV
Mflv_3435|M.gilvum_PYR-GCK          MSAPVSDARTDEFPAA--HGPHRSFIPRMIRLFAVPIILGWIALIVVVNV
Mvan_3189|M.vanbaalenii_PYR-1       MSAPVSDARTDEFPAA--RQPHRPFIPRMIRLFAVPIILGWIALIVILNV
MUL_0757|M.ulcerans_Agy99           MTATTTDTPTDVVPPA--EHPPRPFIPRMIRTFAVPLILGWVLLIAVLNS
MAV_2510|M.avium_104                MSTTFDDTRTDAIPVV--KEPVREKIPRFIRAFAVPIIIGWIALIAVLNV
MSMEG_3496|M.smegmatis_MC2_155      MSNPSHDAPTDAMGVSGPKHARPGGIAKWIRVLAVPIILVWVAIIAVLNT
MAB_2301|M.abscessus_ATCC_1997      MSGSHAGR----------SAAEPTFLAKWIRRLSIPIVIGWLAIVFALNT
TH_3056|M.thermoresistible__bu      MSVLDRVG----------VEPRRPRVASFIRRYSVLIILGWVALTVLATV
                                    *:                  .    :.  *:  :: ::: *: :    . 

Mb0458c|M.bovis_AF2122/97           FVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFAMVIIEGN
Rv0450c|M.tuberculosis_H37Rv        FVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFAMVIIEGN
MMAR_0771|M.marinum_M               FIPSLEVVGQERSVSLSPKDAPSYEAMKRIGAAFNEGNSDSQAMIVLEGK
MLBr_02378|M.leprae_Br4923          FIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVFNEGNSDSVIMIVLEGD
Mflv_3435|M.gilvum_PYR-GCK          TVPQLETVGEAQAVSMSPNDAPSMISMKKVGELFEEGDSDSSVMIVFEGD
Mvan_3189|M.vanbaalenii_PYR-1       TVPQLEAVGEARAVSMSPNEAPSLISMKKVGELFREGDSDSSVMIVFEGD
MUL_0757|M.ulcerans_Agy99           VVPQLEVVGQMQAVSMSPDAAPSMISMKHIGKVFREGDSDSAAMIVLEGQ
MAV_2510|M.avium_104                VVPQLDEVGKMRSVEMTPDDAQSVVATKRMGAVFNEYKSNSSVMIVLEGQ
MSMEG_3496|M.smegmatis_MC2_155      VVPQLDVVGEMRSVSMSPDDAPSVIAMKRVGEVFEEFKSNSSVMIVLEGE
MAB_2301|M.abscessus_ATCC_1997      FVPQLEQVGKEHTVSLSPQSAPSMQAMKHMGKMFKESDSDSVVMIVLEGQ
TH_3056|M.thermoresistible__bu      AVPPLEAVEREKSLSLIPYDAPAFAAMHRMGELFDEPDSESIAIIVLEGQ
                                     :* *: * . :::.: *  * :  :  ::*  * * .*:*  ::::**.

Mb0458c|M.bovis_AF2122/97           QPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQSNDGKAAY
Rv0450c|M.tuberculosis_H37Rv        QPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQSNDGKAAY
MMAR_0771|M.marinum_M               DALGDDAHKYYDVLIRKLRADPRHVQSVQDFWGDPLTAAGAQSNDGKAAY
MLBr_02378|M.leprae_Br4923          KPLGDDAHRFYDGLIRKLRAD-KHVQSVQDFWGDPLTAPGAQSNDGKAAY
Mflv_3435|M.gilvum_PYR-GCK          QPLGDEAHAWYDELVDRLEADTAHVQSVQDFWSDPLTASGSQSNDGKAAY
Mvan_3189|M.vanbaalenii_PYR-1       QPLGDEAHAWYDELVERLRADTKHVQSVQDFWSDPLTASGSQSNDGKAAY
MUL_0757|M.ulcerans_Agy99           EPLGAAAHKFYDKMITKLRADTKHVQSVQDFWGDPLTATGAQSGDGKAAY
MAV_2510|M.avium_104                QPLGADAHAYYDEIVRRLNADTKHVEHVQDMWSDPLTGAGAQSNDGKASY
MSMEG_3496|M.smegmatis_MC2_155      QPLGDEAHKYYDEIVDKLEADPAHVEHVQDFWGDPLTASGAQSPDGLASY
MAB_2301|M.abscessus_ATCC_1997      ERLGPGSHKFYDEMVARLRADTKHVQHVQDFWGDPLTEAGAQSTDGKATY
TH_3056|M.thermoresistible__bu      EPLGLEAHEYYDQLISQLREHPQYVQHIRDFWGDPLTAGAAQSDDGKAAF
                                    . **  :* :** :: :*. .  :*: ::*:*.****  . ** ** *::

Mb0458c|M.bovis_AF2122/97           VQLSLAGNQGTPLANESVEAVRSIVESTPA---------PPGIKAYVTGP
Rv0450c|M.tuberculosis_H37Rv        VQLSLAGNQGTPLANESVEAVRSIVESTPA---------PPGIKAYVTGP
MMAR_0771|M.marinum_M               VQLNLAGNQGEPLANESVEAVRKIVKETPA---------PPGVTTYVTGA
MLBr_02378|M.leprae_Br4923          VQLSLAGNQGELLAQESIDAVRKIVVQTPA---------PPGITAWVTGA
Mflv_3435|M.gilvum_PYR-GCK          VQVKLSGNQGEALANESVKAVQQTVSSLEP---------PPGVRAFVTGP
Mvan_3189|M.vanbaalenii_PYR-1       VQVKLAGNQGESLANESVQAAQEIVRSLEP---------PPGVRAFVTGP
MUL_0757|M.ulcerans_Agy99           VQVKLAGNQGESLANESVEAVKTIVDSLQA---------PPGVKVYVTGS
MAV_2510|M.avium_104                VQVYLAGNQGEALANESVESVQNIVKSVQA---------PNGVKAYVTGP
MSMEG_3496|M.smegmatis_MC2_155      VQVYTRGNQGEALANESVEAVQDIVESVPA---------PPGVKAYVTGP
MAB_2301|M.abscessus_ATCC_1997      VQVNLAGNMGETLSNESTEAARNIVKQLEADWTKDGNKLPDGLTVYVTGP
TH_3056|M.thermoresistible__bu      VQVNLVGRFGQAKVNEAVRAVQEIVERTPA---------PEGVETFVTGP
                                    **:   *. *    :*:  :.:  *    .         * *: .:***.

Mb0458c|M.bovis_AF2122/97           SALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVLLLITVGVE
Rv0450c|M.tuberculosis_H37Rv        SALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVLLLITVGVE
MMAR_0771|M.marinum_M               AALVSDMHSSGDKSMIKITVTTVAVIFIMLLLVYRSVITVVVLLLTVGVE
MLBr_02378|M.leprae_Br4923          SALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITVILLLFTVGIE
Mflv_3435|M.gilvum_PYR-GCK          AALAADQHIAGDRSMRLIEAATFTVIIVMLLLVYRSIVTVLITLVMVVMS
Mvan_3189|M.vanbaalenii_PYR-1       AALAADQHIASDRSVRVIELVTFAVIIVMLLLVYRSIVTVLLTLVMVVLS
MUL_0757|M.ulcerans_Agy99           AALVADQQLAGDRSLQLIEMVTFTVIIVMLLLVYRSIITAAIMLTMVVLG
MAV_2510|M.avium_104                AALSADQHTAGDRSLQLITAATFTVIIGMLLLVYRSVITVLLTLVMVVLE
MSMEG_3496|M.smegmatis_MC2_155      AALSADQHVASDRSVRVIEALTFAVIITMLLLVYRSIVTVILTLVMVVLS
MAB_2301|M.abscessus_ATCC_1997      GALQTDMNHAGDGSLQLITGLTFLVIVVMLLFFYRSIFTVIMVFMLVGIQ
TH_3056|M.thermoresistible__bu      AALGADAGDSGTATVILITLVTVAVIFLMLLFFFRSFLTVIVLLLTVAVE
                                    .** :*   :.  ::  *   :. **.  **:.:**..*. : :  * : 

Mb0458c|M.bovis_AF2122/97           LTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRYQEAR
Rv0450c|M.tuberculosis_H37Rv        LTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRYQEAR
MMAR_0771|M.marinum_M               LTAARGVVALLGHSGAIGLSTFAVSLLTSLAIAAGTDYGIFIFGRYQEAR
MLBr_02378|M.leprae_Br4923          SAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGIFITGRYQEAR
Mflv_3435|M.gilvum_PYR-GCK          LATARGVVAFLGHHEIIGLSTFATNLLVTLAIAAATDYAIFLIGRYQEAR
Mvan_3189|M.vanbaalenii_PYR-1       LATARGVVAFLGWHEIIGLSLFATNLLVTLAIAAATDYAIFLIGRYQEAR
MUL_0757|M.ulcerans_Agy99           LLATRGGVAFLGYHRIIGLSTFATNLLVVLAIAAATDYAIFLIGRYQEAR
MAV_2510|M.avium_104                LSAARGMVAFLGYYKIIGLSTFATNLLVTLAIAAATDYAIFLIGRYQEAR
MSMEG_3496|M.smegmatis_MC2_155      LSAARGMIAFLGYHEIIGLSVFATNLLTTLAIAAATDYAIFLIGRYQEAR
MAB_2301|M.abscessus_ATCC_1997      LSAARGVIAFLGNTEIIGLSTFAVNLLVMLSIAAGTDYAIFLIGRYQEAR
TH_3056|M.thermoresistible__bu      LQVARGLVAYLGLQGWVGLTTYVVNLLVSVGIAAGTDYGIFFFGRYQEAR
                                      .:** :* **    :**: :...**. :.***.***.**: *******

Mb0458c|M.bovis_AF2122/97           QAGEDKEAAYYTMYRGTAHVILGSGLTITGATFCLSFARMPYFQTLGIPC
Rv0450c|M.tuberculosis_H37Rv        QAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMPYFQTLGIPC
MMAR_0771|M.marinum_M               QAGEDKETAFYTMYRGTAHVILGSGLTIAGATFCLKFARMPYFETLGIPC
MLBr_02378|M.leprae_Br4923          QANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARMPYFQTLGVPC
Mflv_3435|M.gilvum_PYR-GCK          TAGEDKETAYYTMFHGTAHVVLGSGLTIAGATFCLSFTRLPYFQTMGVPL
Mvan_3189|M.vanbaalenii_PYR-1       TNGEDKESAYYTMFHGTAHVVLGSGLTIAGATYCLSFTRLPYFQTLGVPL
MUL_0757|M.ulcerans_Agy99           GLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYFQTLGVPL
MAV_2510|M.avium_104                AVGESREDAYYTMYKGTAHVVAGSGMTIAGATFCLHFTNLPYFQTLGIPL
MSMEG_3496|M.smegmatis_MC2_155      SVGEDREQSYYTMFHSTAHVVLGSGMTIAGATLCLHFTRMPYFQSLGIPL
MAB_2301|M.abscessus_ATCC_1997      AMGADKEAAYYEMFHGTAHVILGSGMTIAGAMYCLSFTRMPYFQTLGVPC
TH_3056|M.thermoresistible__bu      EAGEDRDSAYFTTYRSVAKVVLASGLTIAGAIACLSFTRLPHFQPLGIPG
                                      . .:: :::  : .. :*: .**:**:**  ** *:.:*:*:.:*:* 

Mb0458c|M.bovis_AF2122/97           AVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVRGWRRVGTVVVRW
Rv0450c|M.tuberculosis_H37Rv        AVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVRGWRRVGTVVVRW
MMAR_0771|M.marinum_M               AVGMLVAVMVALTLGPAVLTVGSRFG-LFDPKRLIKVRGWRRVGTVVVRW
MLBr_02378|M.leprae_Br4923          AVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKRLIKVRGWRRIGTVVVRW
Mflv_3435|M.gilvum_PYR-GCK          AIGMFVVVMAGVVLMVACISVATRFGKLLEPKRAMRIRGWRKIGAAIVRW
Mvan_3189|M.vanbaalenii_PYR-1       AIGMFVVVMAGVILMVAMISVATRFGKLLEPKRAMRIRGWRKIGAAVVRW
MUL_0757|M.ulcerans_Agy99           AIGMVIVVATALTLGPALIAVMSRFGKLLEPKRMARVRGWRKIGAAIVRW
MAV_2510|M.avium_104                AIGMVVVVAAALTLGPAVISVASRFRQTLEPRRTQRIRGWRKVGTVVVRW
MSMEG_3496|M.smegmatis_MC2_155      AIGMSVVVLASLTMGAAIISVASRFGKTFEPKRAMRTRGWRKLGAAVVRW
MAB_2301|M.abscessus_ATCC_1997      SVGLLVGVLVSLTLGPALITIGSRFG-LFEPKRAMRIRSWRKIGTTIVRW
TH_3056|M.thermoresistible__bu      AVGLLVAVAVALTLVPATIALGSRFG-LFEPKRRVMTHRWRRIGTAVVRW
                                    ::*: : * ..: :  * : : :**   ::*:*    : **::*:.:***

Mb0458c|M.bovis_AF2122/97           PLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYAAADRHFS
Rv0450c|M.tuberculosis_H37Rv        PLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYAAADRHFS
MMAR_0771|M.marinum_M               PLPVLAATLAVALVGLLALPGYRTNYNDRDYLPNFIPANQGFTAAERHFS
MLBr_02378|M.leprae_Br4923          PLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQGFAAADRHFP
Mflv_3435|M.gilvum_PYR-GCK          PGPILVATMAITLVGLLALPGYKTNYNDRDYLPADLPANQGYAVADEHFD
Mvan_3189|M.vanbaalenii_PYR-1       PGPILVATLAITLVGLLALPGYKTNYNDRTYLPADLPANEGYAVADRHFD
MUL_0757|M.ulcerans_Agy99           PGPILIGAVALALVGLLTLPGYKTNYNDRNYLPADLPANEGYSAAERHFS
MAV_2510|M.avium_104                PGPILVLTIGVALVGLLTLPGYRTNYNDRNYLPTDLPANEGYAAADRHFS
MSMEG_3496|M.smegmatis_MC2_155      PAPILVTTIALSVVGLLALPGYQTNYNDRRYLPQDLPANTGYAAADRHFS
MAB_2301|M.abscessus_ATCC_1997      PGPVLAAAMAIAIIGLAALPGYRTSYDDKKYIPKDIPANAGFQAADRHFS
TH_3056|M.thermoresistible__bu      PVPILTAAVALSLVGLLTLPGYNPSYSDQEFIPDDIPASEGYKAAARHFP
                                    * *:*  : .::::** :****...*.*: ::*  :**. *: .* .** 

Mb0458c|M.bovis_AF2122/97           QARMK-PEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRVQAITRPE
Rv0450c|M.tuberculosis_H37Rv        QARMK-PEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRVQAITRPE
MMAR_0771|M.marinum_M               QARMK-PDILMIQSDHDMRNPADFLVLDRLAKGIFHVPGISRVQAITRPD
MLBr_02378|M.leprae_Br4923          QARMK-PEILMIESDHDMRNPADFLILDKLARGIFRVPGISRVQAITRPD
Mflv_3435|M.gilvum_PYR-GCK          QARMN-PELLMIESDHDLRNSADFLVIDKIAKALFRVEGIARVQAITRPD
Mvan_3189|M.vanbaalenii_PYR-1       QARMN-PELLMIESDHDLRNSADFLVIDKIAKAIFKVEGIARVQAITRPD
MUL_0757|M.ulcerans_Agy99           QARMN-PEVLMVESDHDMRNSSDFLVINKIAKAIFGVEGISRVQAITRPD
MAV_2510|M.avium_104                QARMN-PEVLMIESDHDLRNSADFLVIDKIAKTVFRVPGIGRVQAITRPQ
MSMEG_3496|M.smegmatis_MC2_155      QARMN-PELLMIESDHDLRNSADFLVVDRIAKRVFQVPGISRVQAITRPQ
MAB_2301|M.abscessus_ATCC_1997      QARMN-PEMLLIESDHDMRNSADFLVIDKIAKAVFRVPGIARVQAITRPQ
TH_3056|M.thermoresistible__bu      ASAMSVPDVVLIEADRDMRNPADLLVLNKVAKKIFEVPGVANVQSVTRPE
                                     : *. *:::::::*:*:**.:*:*:::::*: :* * *:..**::***:

Mb0458c|M.bovis_AF2122/97           GTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMATTIAVLTR
Rv0450c|M.tuberculosis_H37Rv        GTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMATTIAVLTR
MMAR_0771|M.marinum_M               GTAMDHTSIPFQISMQNAGQIQTLKYQRDRMNDMLTQAEEMAKTIALMRR
MLBr_02378|M.leprae_Br4923          GTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENMAETIASMRR
Mflv_3435|M.gilvum_PYR-GCK          GKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMADMLVQADEMANTIKTMEK
Mvan_3189|M.vanbaalenii_PYR-1       GKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMADMLVQADEMANTIATMEK
MUL_0757|M.ulcerans_Agy99           GKPIEHTSIPFLISMQGTSQKLTEKYNQDLTTSMLQQVNDIQTNIDQMER
MAV_2510|M.avium_104                GTPIEHTSIPFQISMQGVTQQMNQKYQQDQMADMLHQADMMQTTIDSMEK
MSMEG_3496|M.smegmatis_MC2_155      GTPIEHTSIPFQISMSGTTQMMNMKYMQDRMADMLVMADEMQKSVDTMEE
MAB_2301|M.abscessus_ATCC_1997      GTPIEHSSIPFLISMQSVGQRQNMKLMKDRMADMKVQADKMGENVVIMKR
TH_3056|M.thermoresistible__bu      GRQIEHTTIPFMLSMSQASQRLALPFQRARMDDMLKQADELTETIALMRR
                                    *  :.*::*** :**. . *       :    .:   .: :  .:  : .

Mb0458c|M.bovis_AF2122/97           MHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPIRSYFYWE
Rv0450c|M.tuberculosis_H37Rv        MHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPIRSYFYWE
MMAR_0771|M.marinum_M               MYGLMTQLANNTHKMVGDTIEMQQITKELRDHIANFDDFFRPIRSYFYWE
MLBr_02378|M.leprae_Br4923          MHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWRPIRSYFYWE
Mflv_3435|M.gilvum_PYR-GCK          MSGLTAQMADITHSMVTKMEGMVVDIEDLRDSIANFDDFFRPIRNYFYWE
Mvan_3189|M.vanbaalenii_PYR-1       MSNLTAQMADITHSMVSKMENMLTDIEDLRDSIANFDDFFRPIRNYFYWE
MUL_0757|M.ulcerans_Agy99           MHDLTQQMADVTHQMVIQMKGMVVDVEELRNHIADFDDFFRPIRSYFYWE
MAV_2510|M.avium_104                MQSITVQMSNDMHVMVQKMHDMTIDINDLRNKMADFEDFFRPMRSYFYWE
MSMEG_3496|M.smegmatis_MC2_155      MLKITREMSDTTHSMVGKMHGMVEDIKELRDHIADFDDFLRPIRNYFYWE
MAB_2301|M.abscessus_ATCC_1997      TLANMTTMAGITHSLVGDMHTLQGTIHEMRDSISNFDDWFRPIRNYLYWE
TH_3056|M.thermoresistible__bu      MQSLMEKMVATTHSMVGTTHELLDTTRDLRDHIADFDDFFRPIRNYFHWE
                                           :    * ::     :     .:*: :::*:*: **:*.*::**

Mb0458c|M.bovis_AF2122/97           KHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQMVAQI
Rv0450c|M.tuberculosis_H37Rv        KHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQMVAQI
MMAR_0771|M.marinum_M               KHCYDIPICSSFRSIFDALDGIDQIDEKLDNLVVDIKELDRLMPQMIETF
MLBr_02378|M.leprae_Br4923          RHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDLLMPQMLEQF
Mflv_3435|M.gilvum_PYR-GCK          PHCYNIPVCWALRSVFDTLDGINIMTDDFKAIIPDMKRLDTLMPQMVALM
Mvan_3189|M.vanbaalenii_PYR-1       PHCYNIPVCWALRSVFDTLDGINVMTDDFREILPDMKRLDSLMPQMVALM
MUL_0757|M.ulcerans_Agy99           KHCFDIPVCWSLRSVFDTLDGVDLMTEDINNLLPLMERLDTLMPQMTAMM
MAV_2510|M.avium_104                KHCYDIPVCWSLRSVFDALDGIDTMTDDIQSLLPIMDHLDTLMPQMVALM
MSMEG_3496|M.smegmatis_MC2_155      PHCDSIPVCQSIRSIFDTLDGIDVMTDDIQRLMPDMDRLDELMPQMLTIM
MAB_2301|M.abscessus_ATCC_1997      KHCFDIPMCWAMRSIFDTLDKIDEMTETMDGMVVNMERMDTLMPKMVSDM
TH_3056|M.thermoresistible__bu      PHCYNIPICWSIRSIFDALDGINEMTEKMEELVEDMDRLDALMPQMLVQF
                                     ** .**:* ::**:**:** :: : : :  ::  : .:* ***:*   :

Mb0458c|M.bovis_AF2122/97           PPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAAKNDDS
Rv0450c|M.tuberculosis_H37Rv        PPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAAKNDDS
MMAR_0771|M.marinum_M               PPMIETMESMRLMMLTMHSTMSGLYDQMSEMSENANAMGKAFDAAKNDDS
MLBr_02378|M.leprae_Br4923          PPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKAFDTAKNDDS
Mflv_3435|M.gilvum_PYR-GCK          PEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSEDADAMGEAFDDSMNDDS
Mvan_3189|M.vanbaalenii_PYR-1       PEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSEDADAMGEAFDDSMNDDS
MUL_0757|M.ulcerans_Agy99           PEMIQTMKSMKAQMLSMHSTQQGLQDQMAAMQEDSSAMGEAFDSSRNDDS
MAV_2510|M.avium_104                PSMIENMKAMKTTMLTMYSTQKGLQDQQNEAQKNSNAMGKAFDASKNDDS
MSMEG_3496|M.smegmatis_MC2_155      PPMIESMKTMKTMMLTTQATMGGLQDQMEAAMENQTAMGQAFDASKNDDS
MAB_2301|M.abscessus_ATCC_1997      SAMIPIMEDMQRMMLTQHSTMSGFYNQMDEMSQNSTAMGKAFDAAKNDDS
TH_3056|M.thermoresistible__bu      PQMIETMESSRTMILTMHATMSGIFDQMESSSENATAMGKAFDASHNDDS
                                    .  *  *:  :  :*:   :  *  :*     .:  :**:*** : ****

Mb0458c|M.bovis_AF2122/97           FYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIKSIDAI
Rv0450c|M.tuberculosis_H37Rv        FYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIKSIDAI
MMAR_0771|M.marinum_M               FYLPPEVFKNEDFKRAMKSFLSPDGHAARFIILHRGDPQSAQGIASIDQI
MLBr_02378|M.leprae_Br4923          FYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASVAGIASINAI
Mflv_3435|M.gilvum_PYR-GCK          FYLPPEIFENADFQRGLEQFLSPDGHAVRFIISHEGDPLSPEGVAKIDKI
Mvan_3189|M.vanbaalenii_PYR-1       FYLPPEIFENKDFQRGLEQFLSPDGHAVRFIISHEGDPLSPEGVAKIDKI
MUL_0757|M.ulcerans_Agy99           FYLPPEVFNNPDFKRGLEQFLSPDGHAVRFIISHEGDPMSQAGINHIDKI
MAV_2510|M.avium_104                FYLPPETFNNKEFKKGMKNFISPDGHAVRFIISHDGDPMTQEGISHIGAI
MSMEG_3496|M.smegmatis_MC2_155      FYLPPETFENPDFKRGMKMFLSPDGHAVRFIISHEGDPMSPEGIKHIDAI
MAB_2301|M.abscessus_ATCC_1997      FYLPPEIFDNADFKRGMKSFLSPDGKAVRMIISHRGDPATPEGLSHVEPI
TH_3056|M.thermoresistible__bu      FYLPPEALENKDFQRVMEIFLSPDGKAARMLVTQRGDPATPEGMALVEPI
                                    ****** :.* :*:: :: *:*.**:*.*::: : *** :  *:  :  *

Mb0458c|M.bovis_AF2122/97           RTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAISSLCLIF
Rv0450c|M.tuberculosis_H37Rv        RTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAISSLCLIF
MMAR_0771|M.marinum_M               RTAAEESLKGTPLEDAKIYVAGTASVFKDISEGADWDLLIAGISSLCLIF
MLBr_02378|M.leprae_Br4923          RTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIAGISSLCLIF
Mflv_3435|M.gilvum_PYR-GCK          KTAAKEAVKGTPLEGSKIYLGGTAAVFKDMQDGNNYDLLIAGIAALGLIF
Mvan_3189|M.vanbaalenii_PYR-1       KTAAKEAIKGTPLEGSKIYLGGTAATFKDMQDGNNYDLLIAGISALGLIF
MUL_0757|M.ulcerans_Agy99           KTAAKEAIKGTPLEGSTIYLGGTVAMFKDLSDGNTFDLMIAGISALCLIF
MAV_2510|M.avium_104                KKAAYEALKGTPLEGSKIYLAGTASIYKDLSDGNNYDLLIAGISSLCLIF
MSMEG_3496|M.smegmatis_MC2_155      KQAAKEAIKGTPLEGSKIYLGGTAATFKDLQEGANYDLIIAGIAALCLIF
MAB_2301|M.abscessus_ATCC_1997      KQAAIEAVKGTPLEDAKIELGGTAAVFKDMSDGAKYDLMIAGISALCLIF
TH_3056|M.thermoresistible__bu      YIAAEEALKGTPLESSRIYLAGSAAGVKDLVEGAKYDLMIAAISAVCLIF
                                      ** *::******.: * :.*:.:  :*: :*  :**:**.*::: ***

Mb0458c|M.bovis_AF2122/97           IIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHLHWLVLAM
Rv0450c|M.tuberculosis_H37Rv        IIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHLHWLVLAM
MMAR_0771|M.marinum_M               IIMLILTRAFVAAAVIVGTVALSLGASFGMSVLLWQHILNIDLHYMVLAM
MLBr_02378|M.leprae_Br4923          IIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGIELHYLVLAM
Mflv_3435|M.gilvum_PYR-GCK          IIMLILTRAVVAAAVIVGTVVLSLAASFGLSVLFWQHILGQPLHWMVLAM
Mvan_3189|M.vanbaalenii_PYR-1       IIMLILTRAIVAAAVIVGTVVLSLAASFGLSVLFWQHILGTELHWMVLAM
MUL_0757|M.ulcerans_Agy99           IIMLIITRSVVAAAVIVGTVVLSLGASFGLSVLIWQHVLGIELHWLVLAM
MAV_2510|M.avium_104                IIMLIITRGVVASAVIVGTVLLSLGASFGLSVLIWQHLIGIELHWMVLAM
MSMEG_3496|M.smegmatis_MC2_155      IIMLIITRAVVASAVIVGTVVISLGASFGLSVLIWQHIIGLELHWMVLAM
MAB_2301|M.abscessus_ATCC_1997      LIMLLITRSFVASLVIVGTVALSLGASFGLSVIIWQYILGIELHWLVMQM
TH_3056|M.thermoresistible__bu      MIMVFMTRSVIAALVIVGTVVLSLGASFGMSVLLWQHLLGIQLHWVVLAM
                                    :**:::**..:*: ****** :**.****:**::**:::   **::*: *

Mb0458c|M.bovis_AF2122/97           SVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVVTNAGLVF
Rv0450c|M.tuberculosis_H37Rv        SVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVVTNAGLVF
MMAR_0771|M.marinum_M               SVIVLLAVGSDYNLLLVSRFKEEIPAGLKTGIIRAMGGTGKVVTNAGLVF
MLBr_02378|M.leprae_Br4923          SVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGKVVTNAGLVF
Mflv_3435|M.gilvum_PYR-GCK          AVIILLAVGADYNLLLVSRLKEEIHAGIGTGIIRAMGGSGSVVTAAGLVF
Mvan_3189|M.vanbaalenii_PYR-1       AVIVLLAVGADYNLLLVSRLKEEIHAGIGTGIIRAMGGSGSVVTAAGLVF
MUL_0757|M.ulcerans_Agy99           AVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGSGSVVTAAGLVF
MAV_2510|M.avium_104                SVIILLAVGADYNLLLVARFKEEIHAGLNTGIIRSMGGTGSVVTSAGLVF
MSMEG_3496|M.smegmatis_MC2_155      AVIVLLAVGADYNLLLVSRIKEEIHAGLNTGIIRSMGGTGSVVTSAGLVF
MAB_2301|M.abscessus_ATCC_1997      AIIVLLAVGSDYNLLLVSRLKEELHGGLKTGIIRSMGGTGSVVTSAGLVF
TH_3056|M.thermoresistible__bu      SVIVLLAVGSDYNLMLVSRMKEEIGAGLNTGIIRAMGGTGRVVTMAGLVF
                                    ::*:*****:****:**:*:*:*: .*: *****:***:* *** *****

Mb0458c|M.bovis_AF2122/97           AVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAALLGRWFW
Rv0450c|M.tuberculosis_H37Rv        AVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAALLGRWFW
MMAR_0771|M.marinum_M               AFTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRAFMTPSIAALLGRWFW
MLBr_02378|M.leprae_Br4923          AFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSIAALLGRWFW
Mflv_3435|M.gilvum_PYR-GCK          ALTMMSMSVSELTVIGQVGTTIGLGLLFDTLVIRAFMTPSIAALLGPWFW
Mvan_3189|M.vanbaalenii_PYR-1       ALTMMSMAVSELTVIGQVGTTIGLGLLFDTLVIRAFMTPSIAALLGPWFW
MUL_0757|M.ulcerans_Agy99           AFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSIAALLGKWFW
MAV_2510|M.avium_104                AFTMMTMAVSELTVIGQVGTTIGLGLLFDTLIVRSLMTPSIAALLGKWFW
MSMEG_3496|M.smegmatis_MC2_155      AFTMMSMAVSELAVIAQVGTTIGLGLLFDTLVIRSFMTPSIAALMGKWFW
MAB_2301|M.abscessus_ATCC_1997      AFTMAVMVVSDLRIIGQVGTTIALGLLFDTLIVRSFMTPAVATLLGRWFW
TH_3056|M.thermoresistible__bu      AATMASMIVSDLLMIGQVGTTIALGLLFDTMVVRAFMTPSVAAILGRWFW
                                    * **  : **:* ::.******.:******:::*::* *::*:::* ***

Mb0458c|M.bovis_AF2122/97           WPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG------------
Rv0450c|M.tuberculosis_H37Rv        WPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG------------
MMAR_0771|M.marinum_M               WPMRVRTRPARTPSSPTADPEPDRALAMSGER--------------
MLBr_02378|M.leprae_Br4923          WPQQGRTRPLLTVAAPVG-LPPDRSLVYSD----------------
Mflv_3435|M.gilvum_PYR-GCK          WPQRVRTRPVPAPWPRSGGLQSDPSEGVRA----------------
Mvan_3189|M.vanbaalenii_PYR-1       WPQRVRTRPVPAPWPRPGGLQSDPSEGVKV----------------
MUL_0757|M.ulcerans_Agy99           WPQVVRQRPAPQPWPTPAPTPPPATTSV------------------
MAV_2510|M.avium_104                WPQRVRQRPVPSPWPKPAAQEREVLADA------------------
MSMEG_3496|M.smegmatis_MC2_155      WPQRVRQRPLPAPWPQPVQRDPEDALNRV-----------------
MAB_2301|M.abscessus_ATCC_1997      WPLNVRTRPLPPPRTTVAADPTPPPVPVGPGHGDDPITTEFPRPSV
TH_3056|M.thermoresistible__bu      WPQRVRTRPASAMLRPVGPRPLVRSLLLRD----------------
                                    **   * **