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VGNKHVGRDRGERRPFVAHAVRVLAIPIVLFWVGVAVLLSVLVPKLDGVTKQHAGPMVPLDAPSQRAMLH IGEKFQESTSTSLAYILLETEGRILGDADHKYYDELIRLLDADKQHVQFIMNMWGKPITAAGSQSPDNKA AYVMLRLVGDIGEAAANESTIALRKTVQDTLQRTPPPPGLRVYVSGAAPLSADLLDAGDKSMKRVLLFTI AVIIIMLVLVYRSIACVVLILLTVAFEFTVSNGIVSFFVVHNIIGISTFATSMVESLIIAAGTDYGIFLL GRYHEARNAGEDRDRAFYTTFHGVSHVILGSGLTIAGACLCLGFARLGYFNTMGPACAIAMLVTVAAALT LGPALLAIASKFGLLDPKQTGQSRGWRRVGTIVVRWPKPVLVASSAAVLVGAVFLPSYRVSYNERAFQPV NTPANAGFMASDRHFAGGKLNSEMLLIESDHDMRNPADFISLDHVAKTIFHTPGIAQVQGITRPEGRPME RASIANILAGQGSSSGQQLPFTENQVADLDNQVAVMDHTISIMQTVIGLMDQMTQLTHEMVGTMEEMKAL ADQVEVNISAVDDFLRPIKNYYYWEPHCADIPICWMGRSMFESMDSIDGMTALTAEALASMQVMDQLLPR MLAQTRMALSDMTIMRGMMVKSRGTQALNTYTAADDANDMIDIGQDFDDSRNDDLFYAPKYIFSNTDFQV ALRFLVSPDGTAARFIINHDGEALSPEGVAHVNAIEKAAYEGLKGTSLAGAKIYLGGSASNYRDIEQYVK SDLLIAAIASFTLIFVIMLIITRSLIAACTIIGTVAFSFSGAFGLGILIWQHIIGLNLHWMVLPLTFILL VAVGSDYNLLLIARMKEELQGGIQTGIIRSVGSTGGVVTAAGLVFAFTMLSMVPNDLRAISQVGSIICVG LLLDTLIVRSFIVPAIARILGPWFWWPRVVRWRPAHASGAVLTSAPKGT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_2037 | - | - | 100% (959) | putative membrane protein MmpL |
M. abscessus ATCC 19977 | MAB_4768c | - | 0.0 | 56.55% (932) | putative membrane protein, MmpL |
M. abscessus ATCC 19977 | MAB_3562c | - | 0.0 | 55.47% (932) | MmpL family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0458c | mmpL4 | 0.0 | 50.69% (945) | transmembrane transport protein MmpL4 |
M. gilvum PYR-GCK | Mflv_4418 | - | 0.0 | 50.43% (930) | transport protein |
M. tuberculosis H37Rv | Rv0450c | mmpL4 | 0.0 | 50.79% (945) | transmembrane transport protein MmpL4 |
M. leprae Br4923 | MLBr_02378 | - | 0.0 | 48.94% (940) | hypothetical protein MLBr_02378 |
M. marinum M | MMAR_0775 | - | 0.0 | 49.31% (945) | MmpL family transport protein |
M. avium 104 | MAV_4755 | - | 0.0 | 49.84% (915) | MmpL4 protein |
M. smegmatis MC2 155 | MSMEG_0185 | - | 0.0 | 54.78% (931) | MmpL6 protein |
M. thermoresistible (build 8) | TH_3260 | - | 0.0 | 46.82% (929) | PUTATIVE MmpL4 protein |
M. ulcerans Agy99 | MUL_0757 | mmpL5 | 0.0 | 48.12% (933) | transmembrane transport protein, MmpL5 |
M. vanbaalenii PYR-1 | Mvan_1936 | - | 0.0 | 50.37% (937) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4418|M.gilvum_PYR-GCK ---------------------------------MADAGRSGIGRIIRVLA Mvan_1936|M.vanbaalenii_PYR-1 ---------------------------------MADAGRSGIGRIIHLLA TH_3260|M.thermoresistible__bu ------------MTANPGHVRTDEAPTDRLDIKVSTHGPSFISTWIRRLS MUL_0757|M.ulcerans_Agy99 ------------MTAT-----TTDTPTDVVPPAEHPPRP-FIPRMIRTFA MMAR_0775|M.marinum_M MSDDQAVSERAASNGASNGAGAENGNGNENGNGNGNGSRPSMARLIHRMA Mb0458c|M.bovis_AF2122/97 ----------------------MSTKFANDSNTNARPEKPFIARMIHAFA Rv0450c|M.tuberculosis_H37Rv ----------------------MSTKFANDSNTNARPEKPFIARMIHAFA MLBr_02378|M.leprae_Br4923 ----------------------MTVKCANDLDTHTKP--PFVARMIHRFA MAV_4755|M.avium_104 -----------------------------------------------MLS MAB_2037|M.abscessus_ATCC_1997 -------------------------MGNKHVGRDRGERRPFVAHAVRVLA MSMEG_0185|M.smegmatis_MC2_155 -------------------------MPGQVRMSAHRAGRPFFARTVRVLA :: Mflv_4418|M.gilvum_PYR-GCK VPIVLGWVLLTVLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSMKRVGANF Mvan_1936|M.vanbaalenii_PYR-1 VPIVLGWIALTVLTNVAVPSLEKVGEEHTVGMSANDAPSMMSMERVGANF TH_3260|M.thermoresistible__bu LPIIVGWIALIALLNITVPQLEVVGEMRAVSMSPDEAPSMVAMKRVGELF MUL_0757|M.ulcerans_Agy99 VPLILGWVLLIAVLNSVVPQLEVVGQMQAVSMSPDAAPSMISMKHIGKVF MMAR_0775|M.marinum_M VPIVVFWVGLVAVLVMFVPSLEEVGKQHTVSLSPSDAESMIAMKRVGKVF Mb0458c|M.bovis_AF2122/97 VPIILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVF Rv0450c|M.tuberculosis_H37Rv VPIILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVF MLBr_02378|M.leprae_Br4923 VPIILVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVF MAV_4755|M.avium_104 LPITLGWVFVAVALGVLSPSLDDVASQHSVPMTPRDAPAFKSMMHIGDKF MAB_2037|M.abscessus_ATCC_1997 IPIVLFWVGVAVLLSVLVPKLDGVTKQHAGPMVPLDAPSQRAMLHIGEKF MSMEG_0185|M.smegmatis_MC2_155 VPIIVFWGLLAVTTNTFIPQVEHVADELAGPMIPNYAPSQVALLHIGEKF :*: : * : . *.:: * . : : . * : :: ::* * Mflv_4418|M.gilvum_PYR-GCK EEFDSDSSAMVVLEGE-QPLGDAAHRYYDQLIDELEADTANVQHIADFWG Mvan_1936|M.vanbaalenii_PYR-1 DEFDSDSSAMVVLEGE-QPLGDAAHRYYDELIGKLEADTANVQHVADFWG TH_3260|M.thermoresistible__bu DEGSSDSQVMIVLEGE-EPLGADARAFYDELVKRLEADDAHVENVQDLWS MUL_0757|M.ulcerans_Agy99 REGDSDSAAMIVLEGQ-EPLGAAAHKFYDKMITKLRADTKHVQSVQDFWG MMAR_0775|M.marinum_M NEFDTDSAVMIVLEGD-HPLGDEAHHYYDELVRKLKADKDHVQHVQDFWG Mb0458c|M.bovis_AF2122/97 KEGDSDSFAMVIIEGN-QPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWG Rv0450c|M.tuberculosis_H37Rv KEGDSDSFAMVIIEGN-QPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWG MLBr_02378|M.leprae_Br4923 NEGNSDSVIMIVLEGD-KPLGDDAHRFYDGLIRKLRADK-HVQSVQDFWG MAV_4755|M.avium_104 NEFHTDSTAMVVLEGK-DKLGDSAHEFYDRIVRKLRDDHQHVQNIQDFWS MAB_2037|M.abscessus_ATCC_1997 QESTSTSLAYILLETEGRILGDADHKYYDELIRLLDADKQHVQFIMNMWG MSMEG_0185|M.smegmatis_MC2_155 QESDSTNLTMLVFEAD-RPLDDGDHRYYDDLVRRLQADTEHVQYVMDLWG * : . :::* . *. : :** :: * * :*: : ::*. Mflv_4418|M.gilvum_PYR-GCK DPLTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDRTP---- Mvan_1936|M.vanbaalenii_PYR-1 DPLTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDQTP---- TH_3260|M.thermoresistible__bu DPLTATGVQSPDGKSAYVQVKLAGNQGEALANESVETVREMIATVSE-EM MUL_0757|M.ulcerans_Agy99 DPLTATGAQSGDGKAAYVQVKLAGNQGESLANESVEAVKTIVDSL----Q MMAR_0775|M.marinum_M DPLTAAGSQSPDGKAAYVQAYLVGNQGEAKANESVDAVRELVNDTP---- Mb0458c|M.bovis_AF2122/97 DPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTP---- Rv0450c|M.tuberculosis_H37Rv DPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTP---- MLBr_02378|M.leprae_Br4923 DPLTAPGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQTP---- MAV_4755|M.avium_104 DPLTAAGSQSPDGKSAYVQVFLNGAQGTTPSYESVAAVRKIVDSTP---- MAB_2037|M.abscessus_ATCC_1997 KPITAAGSQSPDNKAAYVMLRLVGDIGEAAANESTIALRKTVQDTLQRTP MSMEG_0185|M.smegmatis_MC2_155 KPITAAGAQSVDGKASFVLLRLAGNIGQLEANESVDAVRDIIAD----DA .*:**.* ** *.*:::* * * * : *: ::: : Mflv_4418|M.gilvum_PYR-GCK APPGIKAYVTGGAPLVADQHSAGDTSVLRVTLITIGVIAVMLLIVFRSVA Mvan_1936|M.vanbaalenii_PYR-1 APPGLKAYVTGGAPLVADQHNAGDKSVFRVTLITIGVIAVMLLLVFRSVA TH_3260|M.thermoresistible__bu APEGVQAFVTGGAAMSADQQEAGDSSLRVIEALTFLVITTMLLFVYRSVI MUL_0757|M.ulcerans_Agy99 APPGVKVYVTGSAALVADQQLAGDRSLQLIEMVTFTVIIVMLLLVYRSII MMAR_0775|M.marinum_M APPGVKAYVTGPAALIADQSTAGDASIQRVTFITIGVIFVMLLSVYRSLI Mb0458c|M.bovis_AF2122/97 APPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSII Rv0450c|M.tuberculosis_H37Rv APPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSII MLBr_02378|M.leprae_Br4923 APPGITAWVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFI MAV_4755|M.avium_104 APPGVKAYVAGNTVLNADTSIVGHKSMATMALVSIVVIFVMLLVVYRSIV MAB_2037|M.abscessus_ATCC_1997 PPPGLRVYVSGAAPLSADLLDAGDKSMKRVLLFTIAVIIIMLVLVYRSIA MSMEG_0185|M.smegmatis_MC2_155 PPQGLKVYVSGAAPLASDTLSTANSSLNNITIFTIILIVVMLLLVYRSAA .* *: .:*:* : : :* .. *: : :. :* *: *:** Mflv_4418|M.gilvum_PYR-GCK TMVLILFMVFAELGAARGIVAFLADAEIIGLSTFATSLLTLMVIAAGTDY Mvan_1936|M.vanbaalenii_PYR-1 TMVLILFMVFAELGAARGIVAFLANAEIIGLSTFATSLLTLMVIAAGTDY TH_3260|M.thermoresistible__bu TVLIALFMVLIGLLTTRGVVAFLGYHNIIGLSTFATSLLVTLAIAIAVDY MUL_0757|M.ulcerans_Agy99 TAAIMLTMVVLGLLATRGGVAFLGYHRIIGLSTFATNLLVVLAIAAATDY MMAR_0775|M.marinum_M TVISVLVMVGIELMAARGVVAFLADNNVIGLSTFAVNLLVLMAIAAGTDY Mb0458c|M.bovis_AF2122/97 TVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDY Rv0450c|M.tuberculosis_H37Rv TVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDY MLBr_02378|M.leprae_Br4923 TVILLLFTVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDY MAV_4755|M.avium_104 TTVLSLVIIGIELFAAQGITATAGNLNIIGLTPYAVSMITMLSIAAGTDY MAB_2037|M.abscessus_ATCC_1997 CVVLILLTVAFEFTVSNGIVSFFVVHNIIGISTFATSMVESLIIAAGTDY MSMEG_0185|M.smegmatis_MC2_155 CLLVPLPAVLIEMLVAKGVIATLGHFGLIPLSSFAVNVVVALTLGAGTDY * : .:.* : * ::.:*..:: : :. ..** Mflv_4418|M.gilvum_PYR-GCK AIFAIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFT Mvan_1936|M.vanbaalenii_PYR-1 AIFAIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFT TH_3260|M.thermoresistible__bu AIFLIGRYQEARSVGADRATAYHTMFGGTAHVILASGLTIAGATFCLSFT MUL_0757|M.ulcerans_Agy99 AIFLIGRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFT MMAR_0775|M.marinum_M AIFVLGRYQEARGEGESREKAFYTMFHGTAHVVLGSGLTIAGAMYCLSFT Mb0458c|M.bovis_AF2122/97 GIFIIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTITGATFCLSFA Rv0450c|M.tuberculosis_H37Rv GIFIIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFA MLBr_02378|M.leprae_Br4923 GIFITGRYQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFA MAV_4755|M.avium_104 VIFLLGRYHEARSFGQGREEAFYTAYHGVSHVILGSGLTIAGACLCLTAA MAB_2037|M.abscessus_ATCC_1997 GIFLLGRYHEARNAGEDRDRAFYTTFHGVSHVILGSGLTIAGACLCLGFA MSMEG_0185|M.smegmatis_MC2_155 GIFLLGRYHEARQSGESREDAYFTAYRSVAPIIIGSGLTIAGACFCLSLA ** ***:*** . .: *:.* : .. :::.*****:** ** : Mflv_4418|M.gilvum_PYR-GCK RLPYFQTMGVPCAVGTFVAVIAALTLGPAVIVIGSRFG-LFDPKRAISSR Mvan_1936|M.vanbaalenii_PYR-1 RLPYFQTMGVPCAVGTFVAVMAALTLGPAVVAIGSRFG-LFDPKRAISSR TH_3260|M.thermoresistible__bu RLPYFQSLGPPLAIGMIVLIVTSLTMGPAIITVATRFG-LLEPKRAARVR MUL_0757|M.ulcerans_Agy99 RLPYFQTLGVPLAIGMVIVVATALTLGPALIAVMSRFGKLLEPKRMARVR MMAR_0775|M.marinum_M RLPYFQTLGAPCAVGMLVAVLAALTLGPAVLVVGSFFK-LFDPKRKMRTR Mb0458c|M.bovis_AF2122/97 RMPYFQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVR Rv0450c|M.tuberculosis_H37Rv RMPYFQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVR MLBr_02378|M.leprae_Br4923 RMPYFQTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKRLIKVR MAV_4755|M.avium_104 RLPYFQTMGLPCAIAMVVIVLAALTLAPAILAVGSRFG-LFDPKRAIDVR MAB_2037|M.abscessus_ATCC_1997 RLGYFNTMGPACAIAMLVTVAAALTLGPALLAIASKFG-LLDPKQTGQSR MSMEG_0185|M.smegmatis_MC2_155 RLDYFHTMGPAVAISMLFTIAAALTLAPALLTLGSLLA-LFDPKRPTRGH *: **:::* . *:. .. : .:**:.**:: : : : *::**: : Mflv_4418|M.gilvum_PYR-GCK GWRRIGVSVVRWPGPVLAATLALALVGLVTLPGYKTNYDARDYLPEDIPA Mvan_1936|M.vanbaalenii_PYR-1 GWRRIGVSVVRWPGPVLAATLALALVGLVALPGYKTNYDSRDYLPEDVPA TH_3260|M.thermoresistible__bu FWRKVGASVVRWPGPIMVTTVAVTLVGLLALPGYRTNYNDRNYLPASFPS MUL_0757|M.ulcerans_Agy99 GWRKIGAAIVRWPGPILIGAVALALVGLLTLPGYKTNYNDRNYLPADLPA MMAR_0775|M.marinum_M GWRRVGTAIVRWPGPILAVSIAIALIGLLALPGYRTNYDSKKYLPASTPT Mb0458c|M.bovis_AF2122/97 GWRRVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPA Rv0450c|M.tuberculosis_H37Rv GWRRVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPA MLBr_02378|M.leprae_Br4923 GWRRIGTVVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPA MAV_4755|M.avium_104 GWRKVGTAVVRWPKPIIVVTAAIAVIGFISLLTYVPNYDDQKFTPKDMPA MAB_2037|M.abscessus_ATCC_1997 GWRRVGTIVVRWPKPVLVASSAAVLVGAVFLPSYRVSYNERAFQPVNTPA MSMEG_0185|M.smegmatis_MC2_155 LYRRIGTSVVRWPKPIFVASAAVVMVGAVFVPSYRVNYDDRAYQPVDAAA :*::*. :**** *:: : * .::* : : * .*. : : * .: Mflv_4418|M.gilvum_PYR-GCK NVGYAVADQHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKSVFRVPG Mvan_1936|M.vanbaalenii_PYR-1 NVGYAVADRHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKAIFRVPG TH_3260|M.thermoresistible__bu NAGYEAAERHFDPARLNPELLLIESDHDLRNPADFLVIEKIAKAVFQVEG MUL_0757|M.ulcerans_Agy99 NEGYSAAERHFSQARMNPEVLMVESDHDMRNSSDFLVINKIAKAIFGVEG MMAR_0775|M.marinum_M NVGYTAADRHFSQARMNPELLMVETDHDMRNPADMLVIDRIAKGVFHLPG Mb0458c|M.bovis_AF2122/97 NQGYAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPG Rv0450c|M.tuberculosis_H37Rv NQGYAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPG MLBr_02378|M.leprae_Br4923 NQGFAAADRHFPQARMKPEILMIESDHDMRNPADFLILDKLARGIFRVPG MAV_4755|M.avium_104 NAAMTAAERHFSQARMNPELLMVEADHDLRDPADMLVVDRIAKSVFHLRG MAB_2037|M.abscessus_ATCC_1997 NAGFMASDRHFAGGKLNSEMLLIESDHDMRNPADFISLDHVAKTIFHTPG MSMEG_0185|M.smegmatis_MC2_155 NLGFQAADRHFNQSKLFSEMLMIETDHDMRNSADFISLDRVAKALIRLPG * . .:::** .:: .*:*::*:***:*:.:*:: ::::*: :: * Mflv_4418|M.gilvum_PYR-GCK VARVQTITRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQDRMADMLVQAD Mvan_1936|M.vanbaalenii_PYR-1 VARVQTITRPDGKPIKHTTIPFQMSMRSTTSRLNEKYMQDRMADMLVQAD TH_3260|M.thermoresistible__bu ISRVQGITRPEGTPIEHSSIPFMISQQGTLQILNQQYMQDRMADMLVQAD MUL_0757|M.ulcerans_Agy99 ISRVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTTSMLQQVN MMAR_0775|M.marinum_M VARVQAVTRPLGKPIEHSSIPFQISMQNTVQVENMQYMKQRMADMLIQAA Mb0458c|M.bovis_AF2122/97 ISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQAD Rv0450c|M.tuberculosis_H37Rv ISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQAD MLBr_02378|M.leprae_Br4923 ISRVQAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAE MAV_4755|M.avium_104 IERVQTITRPLGAPIEHSSIPFQIAMQNSGTLQTAKFMNDTMANMLEQAD MAB_2037|M.abscessus_ATCC_1997 IAQVQGITRPEGRPMERASIANILAGQGSSSGQQLPFTENQVADLDNQVA MSMEG_0185|M.smegmatis_MC2_155 VAMVQSITRPLGRPLEHATIPYLFTTQGSTNGQQLPFSEQANENTDRQAE : ** :*** * .:.:::*. :: :.: : .: . *. Mflv_4418|M.gilvum_PYR-GCK AMQTNVDTMTRMQSLMGQMSATTHEMVLKTKKTEIDIIEVRDNLADFDDF Mvan_1936|M.vanbaalenii_PYR-1 AMQTNVDTMTKMQSLMTQMSAATHDMVTKTKKTAVDIVEVRDYLANLDDF TH_3260|M.thermoresistible__bu EMQLMIDTMDKMIALMEEMVETTDNMVRDMDEMAAHVAEMRDSISEFDDF MUL_0757|M.ulcerans_Agy99 DIQTNIDQMERMHDLTQQMADVTHQMVIQMKGMVVDVEELRNHIADFDDF MMAR_0775|M.marinum_M AMQDSIDTLDRMYDIMGKMVETTHDMDGLTHDMVEITDELRDHIADFDDF Mb0458c|M.bovis_AF2122/97 EMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDF Rv0450c|M.tuberculosis_H37Rv EMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDF MLBr_02378|M.leprae_Br4923 NMAETIASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDF MAV_4755|M.avium_104 ELDKTIAVMEHMYGVMKELTATTHSMVGRTHEMVDTTNELRDRIADFDDF MAB_2037|M.abscessus_ATCC_1997 VMDHTISIMQTVIGLMDQMTQLTHEMVGTMEEMKALADQVEVNISAVDDF MSMEG_0185|M.smegmatis_MC2_155 IQARSVEVLQHVITITQQMSAELHSTVLTFENLKEVTDEVNEGISNLDDF : : : : : . ::. :: .*** Mflv_4418|M.gilvum_PYR-GCK FRPVRNYFYWEPHCYDIPVCWTMRSVFDTLDGINPLTDDISELIPDLERL Mvan_1936|M.vanbaalenii_PYR-1 VRPVRNYFYWEPHCYNIPVCATMRSVFDTLDGINPLTDDIQELIPDLERL TH_3260|M.thermoresistible__bu FRPIRNYFYWEPHCYNIPVCWAMRSVFDTLDGINTMTDDIQNMLPHMHRL MUL_0757|M.ulcerans_Agy99 FRPIRSYFYWEKHCFDIPVCWSLRSVFDTLDGVDLMTEDINNLLPLMERL MMAR_0775|M.marinum_M WRPIRSYFYWEKHCYDVPICWSLRSIFDALDGVDKITEKLAALSRDMDRL Mb0458c|M.bovis_AF2122/97 WRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREM Rv0450c|M.tuberculosis_H37Rv WRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREM MLBr_02378|M.leprae_Br4923 WRPIRSYFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNM MAV_4755|M.avium_104 FRPIRSYFYWEKHCFDIPVCWSMRSLFDALDGIDELSDQISGLTIDLDHM MAB_2037|M.abscessus_ATCC_1997 LRPIKNYYYWEPHCADIPICWMGRSMFESMDSIDGMTALTAEALASMQVM MSMEG_0185|M.smegmatis_MC2_155 LRPLKNYFYWEPHCFDIPVCFAMRSLFDSLDGIDSLDEQIGNAVVSFEAI **::.*:*** ** .:*:* **:*:::*.:: : : : Mflv_4418|M.gilvum_PYR-GCK DELMPQLIALLPSQIETMRSMQAMMLRQYQTQKGQLDQNAAMSEDADAMG Mvan_1936|M.vanbaalenii_PYR-1 DALMPQLIALLPSQIESMRNMQSMMLTMYQSQKGLQDQMASQSEDADAMG TH_3260|M.thermoresistible__bu NDLMPQMLTLLPTTVATMKTMRSMLLTMQATNAGLQDQMAEMQENANAMG MUL_0757|M.ulcerans_Agy99 DTLMPQMTAMMPEMIQTMKSMKAQMLSMHSTQQGLQDQMAAMQEDSSAMG MMAR_0775|M.marinum_M DILMPQMRAQIPFQIASMKTMKTMMLTMHSSMSSLYDQMDEMSKNSTAMG Mb0458c|M.bovis_AF2122/97 DRLMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMG Rv0450c|M.tuberculosis_H37Rv DRLMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMG MLBr_02378|M.leprae_Br4923 DLLMPQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMG MAV_4755|M.avium_104 DRLMPQLLADFPKTIDSMKTMRDFMLSTHSTMAGIQAHQQEAAEGSTLMG MAB_2037|M.abscessus_ATCC_1997 DQLLPRMLAQTRMALSDMTIMRGMMVKSRGTQALNTYTAADDANDMIDIG MSMEG_0185|M.smegmatis_MC2_155 DRLLPQMITQLERMIADSRALLGVITNNYGPAHLQSTQTDQTYYDQINVG : *:*:: : : : . . :* Mflv_4418|M.gilvum_PYR-GCK EAFDDSMNDDSFYLPPEAFDNDDFKRGMENFISPDGRSVRFIISHEGDPA Mvan_1936|M.vanbaalenii_PYR-1 EAFDDSMNDDSFYLPPEAFDNDDFKRGIENFISPDGKSVRFIIAHEGDPA TH_3260|M.thermoresistible__bu EAFDQARNDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAVRFIISHQGDPM MUL_0757|M.ulcerans_Agy99 EAFDSSRNDDSFYLPPEVFNNPDFKRGLEQFLSPDGHAVRFIISHEGDPM MMAR_0775|M.marinum_M KAFDAARNDDSFYIPPEVFDNADFKRGLKMFLSPDGHAVRFIISHEGDPA Mb0458c|M.bovis_AF2122/97 KAFDAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQ Rv0450c|M.tuberculosis_H37Rv KAFDAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQ MLBr_02378|M.leprae_Br4923 KAFDTAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPA MAV_4755|M.avium_104 QYFDEAKNDDSFYLPPEVFKNPDFKRGLKMFVSPDGTAVRFIITHQGDPA MAB_2037|M.abscessus_ATCC_1997 QDFDDSRNDDLFYAPKYIFSNTDFQVALRFLVSPDGTAARFIINHDGEAL MSMEG_0185|M.smegmatis_MC2_155 NDFDAARSDDFFYIPHEAFDNDDVKTGMKLLMSPDGKAARFIITHEGNAM : ** : .** ** * *.* *.: .:. ::*.** :.**** * *:. Mflv_4418|M.gilvum_PYR-GCK TVEGISEVVPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMSDGAFYDLL Mvan_1936|M.vanbaalenii_PYR-1 TVEGISRVLPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMRDGANYDLL TH_3260|M.thermoresistible__bu TPEGLAKIEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFKDMSDGTKYDLI MUL_0757|M.ulcerans_Agy99 SQAGINHIDKIKTAAKEAIKGTPLEGSTIYLGGTVAMFKDLSDGNTFDLM MMAR_0775|M.marinum_M STEGISHVKPIMDEAKQAIKGTPLEGAKIYLAGTASVYKDMRDGSRWDLL Mb0458c|M.bovis_AF2122/97 SPEGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLL Rv0450c|M.tuberculosis_H37Rv SPEGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLL MLBr_02378|M.leprae_Br4923 SVAGIASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLV MAV_4755|M.avium_104 SVEGIKHVAGVKDAVADAIKGTPLESSKVYLAGTASMYSDMQEGVIIDLL MAB_2037|M.abscessus_ATCC_1997 SPEGVAHVNAIEKAAYEGLKGTSLAGAKIYLGGSASNYRDIEQYVKSDLL MSMEG_0185|M.smegmatis_MC2_155 APEGIEHVEQFPDAIKMALKETSLAGAKIYIGGAASNNLDIKTYAASDLL : *: : . .:* *.* .: :*:.*:.: *: **: Mflv_4418|M.gilvum_PYR-GCK IAGIAAVTLIFVIMLVITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHII Mvan_1936|M.vanbaalenii_PYR-1 IAGIAAVTLIFVIMLIITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHII TH_3260|M.thermoresistible__bu IAAIAAVCLIFIIMLILTRAVVAAAVIVGTVTLSLAASFGVSVLIWQYIV MUL_0757|M.ulcerans_Agy99 IAGISALCLIFIIMLIITRSVVAAAVIVGTVVLSLGASFGLSVLIWQHVL MMAR_0775|M.marinum_M IAGVAAVSLILIIMLIITRSLVAAVVIVGTVLLSLGASFGLSVLVWQDIF Mb0458c|M.bovis_AF2122/97 IAAISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHIL Rv0450c|M.tuberculosis_H37Rv IAAISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHIL MLBr_02378|M.leprae_Br4923 IAGISSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHIL MAV_4755|M.avium_104 VAGISCLILIFTIMLIITRSVVAALVIVGTVAASLGTACGLSVLMWQDLI MAB_2037|M.abscessus_ATCC_1997 IAAIASFTLIFVIMLIITRSLIAACTIIGTVAFSFSGAFGLGILIWQHII MSMEG_0185|M.smegmatis_MC2_155 IVAIAAFVLIFLIMLYLTRSLVAALVIPGTVAFSFAGAFGLSVMMWQHLI :..::.. **: *** :**:.:** .* *** *:. : *:.:::** :. Mflv_4418|M.gilvum_PYR-GCK GLALHWMVLPMAVILLLAVGSDYNLLLVSRFKEELSGGLKTGIIRAMAGT Mvan_1936|M.vanbaalenii_PYR-1 GLALHWMVLPMAVILLLAVGSDYNLLLVSRFKEELAGGLKTGIIRSMAGT TH_3260|M.thermoresistible__bu GLEMHWMVFPMALIILLAVGADYNLLVVARLREEIPAGLNTGMIRAMGGS MUL_0757|M.ulcerans_Agy99 GIELHWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGS MMAR_0775|M.marinum_M GVELHWMVLAMSVILLLAVGSDYNLLLVSRLKEEIGAGLKTGIIRAMAGT Mb0458c|M.bovis_AF2122/97 AIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGT Rv0450c|M.tuberculosis_H37Rv AIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGT MLBr_02378|M.leprae_Br4923 GIELHYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGT MAV_4755|M.avium_104 GLGVQWIVLPLSIVILLAVGSDYNLLLVSRLKEEIPAGLNTGIIRGMGAS MAB_2037|M.abscessus_ATCC_1997 GLNLHWMVLPLTFILLVAVGSDYNLLLIARMKEELQGGIQTGIIRSVGST MSMEG_0185|M.smegmatis_MC2_155 GLPLHWLILPLSFIILVAVGSDYNLLLISRVKEETGAGLNTGLIRALGST .: ::::::.::.::*:***:*****:::*.::* .*::**:**.:..: Mflv_4418|M.gilvum_PYR-GCK GSVVTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTP Mvan_1936|M.vanbaalenii_PYR-1 GSVVTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTP TH_3260|M.thermoresistible__bu GSVVTAAGLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLFDTFVVRSFMMP MUL_0757|M.ulcerans_Agy99 GSVVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTP MMAR_0775|M.marinum_M GGVVTTAGLVFAATMASFIFSDLRVIGQVGTTIGLGLLFDTLIVRSFMTP Mb0458c|M.bovis_AF2122/97 GKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTP Rv0450c|M.tuberculosis_H37Rv GKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTP MLBr_02378|M.leprae_Br4923 GKVVTNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMP MAV_4755|M.avium_104 GRVVTAAGLVFAFTMASMIVSQLRVIGELGTTIALGLLVDTLIVRSFMTP MAB_2037|M.abscessus_ATCC_1997 GGVVTAAGLVFAFTMLSMVPNDLRAISQVGSIICVGLLLDTLIVRSFIVP MSMEG_0185|M.smegmatis_MC2_155 GAVVTSAGLVFAFTMLSMLVSDLRTIGQLGTTVCIGLLLDTMIVRSLVVP * *** *****. ** : .:* .:.::*: : :***.**::***:: * Mflv_4418|M.gilvum_PYR-GCK AVAALLGRWFWWPQKFRSAASERRLARIGVQPATAGR------------- Mvan_1936|M.vanbaalenii_PYR-1 AVAALLGRWFWWPQKVRSHASQRRLAALNH-------------------- TH_3260|M.thermoresistible__bu SIATLLGRWFWWPQFVRKRPVPQPWPSVPPRGPATTDRVSV--------- MUL_0757|M.ulcerans_Agy99 SIAALLGKWFWWPQVVRQRPAPQPWPTPAPTPPPATTSV----------- MMAR_0775|M.marinum_M SIAALMGRWFWWPQQVRTRPASQLLRPYGPRPLVRALLLPRNGDSADGPE Mb0458c|M.bovis_AF2122/97 SIAALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG----- Rv0450c|M.tuberculosis_H37Rv SIAALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG----- MLBr_02378|M.leprae_Br4923 SIAALLGRWFWWPQQGRTRPLLTVAAPVGLPPD-RSLVYSD--------- MAV_4755|M.avium_104 SIAAALGHWFWWPINTIRMTRRTHHDEEAHTAPIRQPALR---------- MAB_2037|M.abscessus_ATCC_1997 AIARILGPWFWWPRVVRWRPAHASGAVLTSAPKGT--------------- MSMEG_0185|M.smegmatis_MC2_155 CLLRLLGPWFWWPTFIRQRPLRQAVRQRERADVV---------------- .: :* ***** . Mflv_4418|M.gilvum_PYR-GCK -------------- Mvan_1936|M.vanbaalenii_PYR-1 -------------- TH_3260|M.thermoresistible__bu -------------- MUL_0757|M.ulcerans_Agy99 -------------- MMAR_0775|M.marinum_M DTNTERLAVSSPHY Mb0458c|M.bovis_AF2122/97 -------------- Rv0450c|M.tuberculosis_H37Rv -------------- MLBr_02378|M.leprae_Br4923 -------------- MAV_4755|M.avium_104 -------------- MAB_2037|M.abscessus_ATCC_1997 -------------- MSMEG_0185|M.smegmatis_MC2_155 --------------