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SNHEMPTGPIPVRRPLVPRMVRVLAVPIIVFWAFLAVTTNTFVPQVEKVAEELAGPMIPHYAPSQRAMLH IGEKFQESTSTSLTMVVLESQDRVLGDEDHRYYDELMQRFKDDSEHVQYVMDLWGKSITSAGAQSIDGKS TYVLLRLAGDIGQMQANESVRAVRAIVDKQTPPAGLRVYVSGPAPLAGDTLDIANSSLNNITIITIILII VMLLLVYRSFSTLLLPLAGVLIEMLVTKGVIATLGHLGYIELSSFAVNIVVSLTLGAGTDYGIFLLGRYH EARSTGQSREEAYYTAYRGVAPVVIGSGLTIAGACYCLSFARLNYFHTMGPAVAIAMVLTIAAALTLVPA VLTVGSLFGLFDPKAKAKAQLYRRIGASVVRWPVPIFVASSIIVMVGAVFVPTYQVSYDDRAYQPAGAPA NQGFAAADRHFSKSKLFTEMLMVESDHDMRNSADFISLDRVAKSLVRLPGVSMVQSITRPLGRPLEHATL PYLFTTQGSGNGQQLPFTKRQNGNTAQQAEIMGNTIVVLRDMIDLTQKLTDAMHATVVTMEDMQQVTEAM DQYVSNLDDFMRPLRNYFYWEPHCFDIPACWAFRSLFDMLDSVDKLAADIKDAVAQLEIVDKLLPQMVSQ LKVMANDMEGIRALIINTYGTSDLQSTLTTQTFDDMINVGLDFDKSRSDDFFYIPRQGFENEDVKTGMQL LMSPDGMAARFMITHEGNAMGPEGVEHVEQFPEAVGLALKETSLAGARVYVGGAGSNDKDIKEYGASDLL IVAIAAFVLIFLIMMFLTRSLMAPFVIIGTVAFSYSGAFGLSVLIWQHLIGLPLHWLVLPLTFIILVAVG SDYNLLLVARLKEETGAGLNTGLIRALGSTGAVVTSAGLVFAFTMLAMLASDLRTIGQVGSTICIGLLLD TLIVRSFIVPSLVRLFGTWFWWPTRVFARPLRRQNVGAHR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_3562c | - | - | 100% (951) | MmpL family protein |
M. abscessus ATCC 19977 | MAB_4768c | - | 0.0 | 80.24% (931) | putative membrane protein, MmpL |
M. abscessus ATCC 19977 | MAB_2037 | - | 0.0 | 55.47% (932) | putative membrane protein MmpL |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0458c | mmpL4 | 0.0 | 48.66% (933) | transmembrane transport protein MmpL4 |
M. gilvum PYR-GCK | Mflv_3435 | - | 0.0 | 47.28% (939) | transport protein |
M. tuberculosis H37Rv | Rv0450c | mmpL4 | 0.0 | 48.77% (933) | transmembrane transport protein MmpL4 |
M. leprae Br4923 | MLBr_02378 | - | 0.0 | 48.33% (927) | hypothetical protein MLBr_02378 |
M. marinum M | MMAR_3744 | mmpL4_1 | 0.0 | 48.78% (945) | transmembrane transport protein MmpL4_1 |
M. avium 104 | MAV_3863 | - | 0.0 | 47.25% (927) | MmpL4 protein |
M. smegmatis MC2 155 | MSMEG_0185 | - | 0.0 | 73.12% (930) | MmpL6 protein |
M. thermoresistible (build 8) | TH_3056 | - | 0.0 | 44.46% (929) | PUTATIVE Mmp14a protein |
M. ulcerans Agy99 | MUL_3688 | mmpL4_1 | 0.0 | 48.57% (945) | transmembrane transport protein MmpL4_1 |
M. vanbaalenii PYR-1 | Mvan_3189 | - | 0.0 | 46.96% (939) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb0458c|M.bovis_AF2122/97 ------------------MSTKFANDSNTNARPEKPFIARMIHAFAVPII Rv0450c|M.tuberculosis_H37Rv ------------------MSTKFANDSNTNARPEKPFIARMIHAFAVPII MLBr_02378|M.leprae_Br4923 ------------------MTVKCANDLDTHTKP--PFVARMIHRFAVPII Mflv_3435|M.gilvum_PYR-GCK --------------MSAPVSDARTDEFPAAHGPHRSFIPRMIRLFAVPII Mvan_3189|M.vanbaalenii_PYR-1 --------------MSAPVSDARTDEFPAARQPHRPFIPRMIRLFAVPII TH_3056|M.thermoresistible__bu ------------------MSVLDR----VGVEPRRPRVASFIRRYSVLII MAV_3863|M.avium_104 ---------------------------MTTDQATRSVVAQTIRRLSVPIL MMAR_3744|M.marinum_M MSESNSGASISTEDTGPIEIGAATGGAPNRERGHRPVIPHTIRILAVPII MUL_3688|M.ulcerans_Agy99 MSESNSGASISTEDTGPIEIGAATGGAPNRERGHRPVIPHTIRILAVPII MAB_3562c|M.abscessus_ATCC_199 --------------------MSNHEMPTGPIPVRRPLVPRMVRVLAVPII MSMEG_0185|M.smegmatis_MC2_155 --------------------MP-GQVRMSAHRAGRPFFARTVRVLAVPII . .. :: :* *: Mb0458c|M.bovis_AF2122/97 LGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGD Rv0450c|M.tuberculosis_H37Rv LGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGD MLBr_02378|M.leprae_Br4923 LVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVFNEGN Mflv_3435|M.gilvum_PYR-GCK LGWIALIVVVNVTVPQLETVGEAQAVSMSPNDAPSMISMKKVGELFEEGD Mvan_3189|M.vanbaalenii_PYR-1 LGWIALIVILNVTVPQLEAVGEARAVSMSPNEAPSLISMKKVGELFREGD TH_3056|M.thermoresistible__bu LGWVALTVLATVAVPPLEAVEREKSLSLIPYDAPAFAAMHRMGELFDEPD MAV_3863|M.avium_104 LVWVAVAAISNIAVPNLEDVAKAHNVSLNTPAAPSFQAMQHIGKVFHEYD MMAR_3744|M.marinum_M LGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAMMRLGHNFREFD MUL_3688|M.ulcerans_Agy99 LGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAMMRLGHNFREFD MAB_3562c|M.abscessus_ATCC_199 VFWAFLAVTTNTFVPQVEKVAEELAGPMIPHYAPSQRAMLHIGEKFQEST MSMEG_0185|M.smegmatis_MC2_155 VFWGLLAVTTNTFIPQVEHVADELAGPMIPNYAPSQVALLHIGEKFQESD : * : . . :* :* * .: . **: :: ::* * * Mb0458c|M.bovis_AF2122/97 SDSFAMVIIEG-NQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPLT Rv0450c|M.tuberculosis_H37Rv SDSFAMVIIEG-NQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPLT MLBr_02378|M.leprae_Br4923 SDSVIMIVLEG-DKPLGDDAHRFYDGLIRKLRADK-HVQSVQDFWGDPLT Mflv_3435|M.gilvum_PYR-GCK SDSSVMIVFEG-DQPLGDEAHAWYDELVDRLEADTAHVQSVQDFWSDPLT Mvan_3189|M.vanbaalenii_PYR-1 SDSSVMIVFEG-DQPLGDEAHAWYDELVERLRADTKHVQSVQDFWSDPLT TH_3056|M.thermoresistible__bu SESIAIIVLEG-QEPLGLEAHEYYDQLISQLREHPQYVQHIRDFWGDPLT MAV_3863|M.avium_104 SDSAAMIVLEG-DKPLGDDAHRFYDALVGKLEHDTKHVEHVQNFWGDPLT MMAR_3744|M.marinum_M SNSTVMIVLEG-QHKLGDDAHQYYDSLIRQLRQDPEHIQHIQDFWGDRLT MUL_3688|M.ulcerans_Agy99 SNSTVMIVLEG-QHKLGDDAHQYYDSLIRQLRQDPEHIQHIQDFWGDRLT MAB_3562c|M.abscessus_ATCC_199 STSLTMVVLESQDRVLGDEDHRYYDELMQRFKDDSEHVQYVMDLWGKSIT MSMEG_0185|M.smegmatis_MC2_155 STNLTMLVFEA-DRPLDDGDHRYYDDLVRRLQADTEHVQYVMDLWGKPIT * . ::::*. :. *. * :** *: ::. . ::: : ::*.. :* Mb0458c|M.bovis_AF2122/97 AAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTPAPPGIKAY Rv0450c|M.tuberculosis_H37Rv AAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTPAPPGIKAY MLBr_02378|M.leprae_Br4923 APGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQTPAPPGITAW Mflv_3435|M.gilvum_PYR-GCK ASGSQSNDGKAAYVQVKLSGNQGEALANESVKAVQQTVSSLEPPPGVRAF Mvan_3189|M.vanbaalenii_PYR-1 ASGSQSNDGKAAYVQVKLAGNQGESLANESVQAAQEIVRSLEPPPGVRAF TH_3056|M.thermoresistible__bu AGAAQSDDGKAAFVQVNLVGRFGQAKVNEAVRAVQEIVERTPAPEGVETF MAV_3863|M.avium_104 AAGSQSKDGKAAYVQVYLAGNQGDALANESVDAIRNIVEHTPPPPGVKAY MMAR_3744|M.marinum_M AAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINRTHEPAGVKAY MUL_3688|M.ulcerans_Agy99 AAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINRTHEPAGVKAY MAB_3562c|M.abscessus_ATCC_199 SAGAQSIDGKSTYVLLRLAGDIGQMQANESVRAVRAIVDKQTPPAGLRVY MSMEG_0185|M.smegmatis_MC2_155 AAGAQSVDGKASFVLLRLAGNIGQLEANESVDAVRDIIADDAPPQGLKVY : . ** ***:::* : * * * .:*:: * : : * *: .: Mb0458c|M.bovis_AF2122/97 VTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVLLLIT Rv0450c|M.tuberculosis_H37Rv VTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVLLLIT MLBr_02378|M.leprae_Br4923 VTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITVILLLFT Mflv_3435|M.gilvum_PYR-GCK VTGPAALAADQHIAGDRSMRLIEAATFTVIIVMLLLVYRSIVTVLITLVM Mvan_3189|M.vanbaalenii_PYR-1 VTGPAALAADQHIASDRSVRVIELVTFAVIIVMLLLVYRSIVTVLLTLVM TH_3056|M.thermoresistible__bu VTGPAALGADAGDSGTATVILITLVTVAVIFLMLLFFFRSFLTVIVLLLT MAV_3863|M.avium_104 VTGAAPLVTDQFEVGSKGIFKVTVITVLVILAMLLWVYRS-VTAVFVLVT MMAR_3744|M.marinum_M VTGPAALSDDMHLIGNASLAKITMFTLGAIAVMLLLVYRSIVTTVIQLFM MUL_3688|M.ulcerans_Agy99 VTGPAALSDDMHLIGNASLATITMFTLGAIAVMLLLVYRSIVTTVIQLFM MAB_3562c|M.abscessus_ATCC_199 VSGPAPLAGDTLDIANSSLNNITIITIILIIVMLLLVYRSFSTLLLPLAG MSMEG_0185|M.smegmatis_MC2_155 VSGAAPLASDTLSTANSSLNNITIFTIILIVVMLLLVYRSAACLLVPLPA *:*.:.* * . : : :. * ** .:** :. * Mb0458c|M.bovis_AF2122/97 VGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRY Rv0450c|M.tuberculosis_H37Rv VGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRY MLBr_02378|M.leprae_Br4923 VGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGIFITGRY Mflv_3435|M.gilvum_PYR-GCK VVMSLATARGVVAFLGHHEIIGLSTFATNLLVTLAIAAATDYAIFLIGRY Mvan_3189|M.vanbaalenii_PYR-1 VVLSLATARGVVAFLGWHEIIGLSLFATNLLVTLAIAAATDYAIFLIGRY TH_3056|M.thermoresistible__bu VAVELQVARGLVAYLGLQGWVGLTTYVVNLLVSVGIAAGTDYGIFFFGRY MAV_3863|M.avium_104 VIVEMAAARGIVAFLGSVGLIGLSTYATNLLTLLVIAAGTDYAIFFVGRY MMAR_3744|M.marinum_M TGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIAAGTDYGIFLVGRY MUL_3688|M.ulcerans_Agy99 TGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIAAGTDYGIFLVGRY MAB_3562c|M.abscessus_ATCC_199 VLIEMLVTKGVIATLGHLGYIELSSFAVNIVVSLTLGAGTDYGIFLLGRY MSMEG_0185|M.smegmatis_MC2_155 VLIEMLVAKGVIATLGHFGLIPLSSFAVNVVVALTLGAGTDYGIFLLGRY . : ::*::* ** . *: :...::. : :.*.***.**: *** Mb0458c|M.bovis_AF2122/97 QEARQAGEDKEAAYYTMYRGTAHVILGSGLTITGATFCLSFARMPYFQTL Rv0450c|M.tuberculosis_H37Rv QEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMPYFQTL MLBr_02378|M.leprae_Br4923 QEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARMPYFQTL Mflv_3435|M.gilvum_PYR-GCK QEARTAGEDKETAYYTMFHGTAHVVLGSGLTIAGATFCLSFTRLPYFQTM Mvan_3189|M.vanbaalenii_PYR-1 QEARTNGEDKESAYYTMFHGTAHVVLGSGLTIAGATYCLSFTRLPYFQTL TH_3056|M.thermoresistible__bu QEAREAGEDRDSAYFTTYRSVAKVVLASGLTIAGAIACLSFTRLPHFQPL MAV_3863|M.avium_104 HEARHEGQDRETAYYTMYRGTTHVVLGSGLTVAGAVLCLRFTRLNYFQSL MMAR_3744|M.marinum_M QEARQAGEDREDAYYTTFRGVAPVVLGSGLTIAGATYCLSFARLPWFNTM MUL_3688|M.ulcerans_Agy99 QEARQAGEDRQDAYYTTFRGVAPVVLGSGLTIAGATYCLSFARLPWFNTM MAB_3562c|M.abscessus_ATCC_199 HEARSTGQSREEAYYTAYRGVAPVVIGSGLTIAGACYCLSFARLNYFHTM MSMEG_0185|M.smegmatis_MC2_155 HEARQSGESREDAYFTAYRSVAPIIIGSGLTIAGACFCLSLARLDYFHTM :*** .:.:: *::* ::.. :::.****::** ** ::*: *:.: Mb0458c|M.bovis_AF2122/97 GIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLK-VRGWRRVGT Rv0450c|M.tuberculosis_H37Rv GIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLK-VRGWRRVGT MLBr_02378|M.leprae_Br4923 GVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKRLIK-VRGWRRIGT Mflv_3435|M.gilvum_PYR-GCK GVPLAIGMFVVVMAGVVLMVACISVATRFGKLLEPKRAMR-IRGWRKIGA Mvan_3189|M.vanbaalenii_PYR-1 GVPLAIGMFVVVMAGVILMVAMISVATRFGKLLEPKRAMR-IRGWRKIGA TH_3056|M.thermoresistible__bu GIPGAVGLLVAVAVALTLVPATIALGSRFG-LFEPKRRVM-THRWRRIGT MAV_3863|M.avium_104 GIPAAIGIGVALAAALSLTPAVITVGSLFG-LFDPKRQMA-TRGWRRIGT MMAR_3744|M.marinum_M GAPVAIGMLVVVLAGLTLGPAVVFVGSRFH-LFESKRAANRGRLWRRVGT MUL_3688|M.ulcerans_Agy99 GAPVAIGMLVVVLAGLTLGPAVVFVGSRFH-PFESKRAANRGRLWRRVGT MAB_3562c|M.abscessus_ATCC_199 GPAVAIAMVLTIAAALTLVPAVLTVGSLFG-LFDPKAKAK-AQLYRRIGA MSMEG_0185|M.smegmatis_MC2_155 GPAVAISMLFTIAAALTLAPALLTLGSLLA-LFDPKRPTR-GHLYRRIGT * . *:.: ..: ..: * * : :.: : ::.* : :*::*: Mb0458c|M.bovis_AF2122/97 VVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYAAA Rv0450c|M.tuberculosis_H37Rv VVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYAAA MLBr_02378|M.leprae_Br4923 VVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQGFAAA Mflv_3435|M.gilvum_PYR-GCK AIVRWPGPILVATMAITLVGLLALPGYKTNYNDRDYLPADLPANQGYAVA Mvan_3189|M.vanbaalenii_PYR-1 AVVRWPGPILVATLAITLVGLLALPGYKTNYNDRTYLPADLPANEGYAVA TH_3056|M.thermoresistible__bu AVVRWPVPILTAAVALSLVGLLTLPGYNPSYSDQEFIPDDIPASEGYKAA MAV_3863|M.avium_104 AIVRWPGPILVVATGVALVGLLALPGYRTNYDARPYMPASAPANTGYTAA MMAR_3744|M.marinum_M AVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYLPASAPSNLGEAAA MUL_3688|M.ulcerans_Agy99 AVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYLPASAPSNLGEAAA MAB_3562c|M.abscessus_ATCC_199 SVVRWPVPIFVASSIIVMVGAVFVPTYQVSYDDRAYQPAGAPANQGFAAA MSMEG_0185|M.smegmatis_MC2_155 SVVRWPKPIFVASAAVVMVGAVFVPSYRVNYDDRAYQPVDAAANLGFQAA :**** *:: : : :** : :* :. .*. : : * .:. * .* Mb0458c|M.bovis_AF2122/97 DRHFSQARMK-PEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRVQA Rv0450c|M.tuberculosis_H37Rv DRHFSQARMK-PEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRVQA MLBr_02378|M.leprae_Br4923 DRHFPQARMK-PEILMIESDHDMRNPADFLILDKLARGIFRVPGISRVQA Mflv_3435|M.gilvum_PYR-GCK DEHFDQARMN-PELLMIESDHDLRNSADFLVIDKIAKALFRVEGIARVQA Mvan_3189|M.vanbaalenii_PYR-1 DRHFDQARMN-PELLMIESDHDLRNSADFLVIDKIAKAIFKVEGIARVQA TH_3056|M.thermoresistible__bu ARHFPASAMSVPDVVLIEADRDMRNPADLLVLNKVAKKIFEVPGVANVQS MAV_3863|M.avium_104 ERHFSQARLN-PELLMIETDHDMRNPADMINLERVAKAIAHLPGIAQVQS MMAR_3744|M.marinum_M DRHFSHARMN-PDMLMVEAEHDMRNPADMLVLDKVAKNVIRTVGIAMIQD MUL_3688|M.ulcerans_Agy99 DRHFSHARMN-PDMLMVEAEHDMRNPADMLVLDKVAKNVIRTVGIAMIQD MAB_3562c|M.abscessus_ATCC_199 DRHFSKSKLF-TEMLMVESDHDMRNSADFISLDRVAKSLVRLPGVSMVQS MSMEG_0185|M.smegmatis_MC2_155 DRHFNQSKLF-SEMLMIETDHDMRNSADFISLDRVAKALIRLPGVAMVQS .** : : .:::::*:::*:**.**:: ::::*: : . *:: :* Mb0458c|M.bovis_AF2122/97 ITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMATTI Rv0450c|M.tuberculosis_H37Rv ITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMATTI MLBr_02378|M.leprae_Br4923 ITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENMAETI Mflv_3435|M.gilvum_PYR-GCK ITRPDGKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMADMLVQADEMANTI Mvan_3189|M.vanbaalenii_PYR-1 ITRPDGKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMADMLVQADEMANTI TH_3056|M.thermoresistible__bu VTRPEGRQIEHTTIPFMLSMSQASQRLALPFQRARMDDMLKQADELTETI MAV_3863|M.avium_104 MTRPLGTPIEHTSLAFQISAGSIGSIENLQYQKERAEDLLKQADNLKDTI MMAR_3744|M.marinum_M ITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMADMTKMADEMQVLI MUL_3688|M.ulcerans_Agy99 ITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMADMTKMADEMQVLI MAB_3562c|M.abscessus_ATCC_199 ITRPLGRPLEHATLPYLFTTQGSGNGQQLPFTKRQNGNTAQQAEIMGNTI MSMEG_0185|M.smegmatis_MC2_155 ITRPLGRPLEHATIPYLFTTQGSTNGQQLPFSEQANENTDRQAEIQARSV :*** * :.*:::.: : : . : *: : Mb0458c|M.bovis_AF2122/97 AVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPIRS Rv0450c|M.tuberculosis_H37Rv AVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPIRS MLBr_02378|M.leprae_Br4923 ASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWRPIRS Mflv_3435|M.gilvum_PYR-GCK KTMEKMSGLTAQMADITHSMVTKMEGMVVDIEDLRDSIANFDDFFRPIRN Mvan_3189|M.vanbaalenii_PYR-1 ATMEKMSNLTAQMADITHSMVSKMENMLTDIEDLRDSIANFDDFFRPIRN TH_3056|M.thermoresistible__bu ALMRRMQSLMEKMVATTHSMVGTTHELLDTTRDLRDHIADFDDFFRPIRN MAV_3863|M.avium_104 GILNQQYALQKQLAASTHDETQSFHDTIAIINDLRDKIANFDDFFRPVRS MMAR_3744|M.marinum_M DTTERMYAVMRDLDTTTTDMARVTAETSTITDELRDHLAEFDDFWRPMRS MUL_3688|M.ulcerans_Agy99 DTTERMYAVMRELDTTTTDMARVTAETSTITDELRDHLAEFDDFWRPMRS MAB_3562c|M.abscessus_ATCC_199 VVLRDMIDLTQKLTDAMHATVVTMEDMQQVTEAMDQYVSNLDDFMRPLRN MSMEG_0185|M.smegmatis_MC2_155 EVLQHVITITQQMSAELHSTVLTFENLKEVTDEVNEGISNLDDFLRPLKN : : : : ::::*** **::. Mb0458c|M.bovis_AF2122/97 YFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQ Rv0450c|M.tuberculosis_H37Rv YFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQ MLBr_02378|M.leprae_Br4923 YFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDLLMPQ Mflv_3435|M.gilvum_PYR-GCK YFYWEPHCYNIPVCWALRSVFDTLDGINIMTDDFKAIIPDMKRLDTLMPQ Mvan_3189|M.vanbaalenii_PYR-1 YFYWEPHCYNIPVCWALRSVFDTLDGINVMTDDFREILPDMKRLDSLMPQ TH_3056|M.thermoresistible__bu YFHWEPHCYNIPICWSIRSIFDALDGINEMTEKMEELVEDMDRLDALMPQ MAV_3863|M.avium_104 YFYWEKHCFDIPACFAFRSVFDALDGIDELSAQFEKLTASLDKLDAGQQK MMAR_3744|M.marinum_M YFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELTEDIQHTAGLTSQ MUL_3688|M.ulcerans_Agy99 YFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELTEDIQRTAGLTSQ MAB_3562c|M.abscessus_ATCC_199 YFYWEPHCFDIPACWAFRSLFDMLDSVDKLAADIKDAVAQLEIVDKLLPQ MSMEG_0185|M.smegmatis_MC2_155 YFYWEPHCFDIPVCFAMRSLFDSLDGIDSLDEQIGNAVVSFEAIDRLLPQ **:** **:.:* *:::**:** **.:: : : .: : Mb0458c|M.bovis_AF2122/97 MVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAA Rv0450c|M.tuberculosis_H37Rv MVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAA MLBr_02378|M.leprae_Br4923 MLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKAFDTA Mflv_3435|M.gilvum_PYR-GCK MVALMPEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSEDADAMGEAFDDS Mvan_3189|M.vanbaalenii_PYR-1 MVALMPEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSEDADAMGEAFDDS TH_3056|M.thermoresistible__bu MLVQFPQMIETMESSRTMILTMHATMSGIFDQMESSSENATAMGKAFDAS MAV_3863|M.avium_104 LVTLLPPQIADQEKNLALTLSNYATNLGINAQTRANTDTATALGQAYDAA MMAR_3744|M.marinum_M MLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSNTAIVMGQSFDAS MUL_3688|M.ulcerans_Agy99 MLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSNTAIVMGQSFDAS MAB_3562c|M.abscessus_ATCC_199 MVSQLKVMANDMEGIRALIINTYGTSDLQSTLTTQTFDDMINVGLDFDKS MSMEG_0185|M.smegmatis_MC2_155 MITQLERMIADSRALLGVITNNYGPAHLQSTQTDQTYYDQINVGNDFDAA :: : . : . . :* :* : Mb0458c|M.bovis_AF2122/97 KNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIK Rv0450c|M.tuberculosis_H37Rv KNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIK MLBr_02378|M.leprae_Br4923 KNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASVAGIA Mflv_3435|M.gilvum_PYR-GCK MNDDSFYLPPEIFENADFQRGLEQFLSPDGHAVRFIISHEGDPLSPEGVA Mvan_3189|M.vanbaalenii_PYR-1 MNDDSFYLPPEIFENKDFQRGLEQFLSPDGHAVRFIISHEGDPLSPEGVA TH_3056|M.thermoresistible__bu HNDDSFYLPPEALENKDFQRVMEIFLSPDGKAARMLVTQRGDPATPEGMA MAV_3863|M.avium_104 KNDDSFYLPPEAFTNPEFKRGLKLFLSPDGKAARMIISHEGDPATPEGIS MMAR_3744|M.marinum_M KNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFITHQGDPMTPEGIS MUL_3688|M.ulcerans_Agy99 KNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFITHQGDPMTPEGIS MAB_3562c|M.abscessus_ATCC_199 RSDDFFYIPRQGFENEDVKTGMQLLMSPDGMAARFMITHEGNAMGPEGVE MSMEG_0185|M.smegmatis_MC2_155 RSDDFFYIPHEAFDNDDVKTGMKLLMSPDGKAARFIITHEGNAMAPEGIE .** **:* : : * :.: :. ::*.** :.*::: :.*:. *: Mb0458c|M.bovis_AF2122/97 SIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAISS Rv0450c|M.tuberculosis_H37Rv SIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAISS MLBr_02378|M.leprae_Br4923 SINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIAGISS Mflv_3435|M.gilvum_PYR-GCK KIDKIKTAAKEAVKGTPLEGSKIYLGGTAAVFKDMQDGNNYDLLIAGIAA Mvan_3189|M.vanbaalenii_PYR-1 KIDKIKTAAKEAIKGTPLEGSKIYLGGTAATFKDMQDGNNYDLLIAGISA TH_3056|M.thermoresistible__bu LVEPIYIAAEEALKGTPLESSRIYLAGSAAGVKDLVEGAKYDLMIAAISA MAV_3863|M.avium_104 HIEPIRNAAKQAVKNTPLGDSNIYLAGTAATYKDIAEGAKYDLLIAGIAA MMAR_3744|M.marinum_M RVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADGEKYDLMIAVVSA MUL_3688|M.ulcerans_Agy99 RVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADGEKYDLMIAVVSA MAB_3562c|M.abscessus_ATCC_199 HVEQFPEAVGLALKETSLAGARVYVGGAGSNDKDIKEYGASDLLIVAIAA MSMEG_0185|M.smegmatis_MC2_155 HVEQFPDAIKMALKETSLAGAKIYIGGAASNNLDIKTYAASDLLIVAIAA :: * .:* :.* .:.:*:.*:.: *: **:*. ::: Mb0458c|M.bovis_AF2122/97 LCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHLHW Rv0450c|M.tuberculosis_H37Rv LCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHLHW MLBr_02378|M.leprae_Br4923 LCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGIELHY Mflv_3435|M.gilvum_PYR-GCK LGLIFIIMLILTRAVVAAAVIVGTVVLSLAASFGLSVLFWQHILGQPLHW Mvan_3189|M.vanbaalenii_PYR-1 LGLIFIIMLILTRAIVAAAVIVGTVVLSLAASFGLSVLFWQHILGTELHW TH_3056|M.thermoresistible__bu VCLIFMIMVFMTRSVIAALVIVGTVVLSLGASFGMSVLLWQHLLGIQLHW MAV_3863|M.avium_104 LSLILLIMVLITRSLVAAIVIVGTVALSLGASFGLSVLVWQDILGIKLYW MMAR_3744|M.marinum_M LTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVLIWQDLFGIKIHW MUL_3688|M.ulcerans_Agy99 LTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVLIWQDLFGIKIHW MAB_3562c|M.abscessus_ATCC_199 FVLIFLIMMFLTRSLMAPFVIIGTVAFSYSGAFGLSVLIWQHLIGLPLHW MSMEG_0185|M.smegmatis_MC2_155 FVLIFLIMLYLTRSLVAALVIPGTVAFSFAGAFGLSVMMWQHLIGLPLHW . **::**: :**:.:*. ** **.. * ..:**:**:.**.::. ::: Mb0458c|M.bovis_AF2122/97 LVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVVTN Rv0450c|M.tuberculosis_H37Rv LVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVVTN MLBr_02378|M.leprae_Br4923 LVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGKVVTN Mflv_3435|M.gilvum_PYR-GCK MVLAMAVIILLAVGADYNLLLVSRLKEEIHAGIGTGIIRAMGGSGSVVTA Mvan_3189|M.vanbaalenii_PYR-1 MVLAMAVIVLLAVGADYNLLLVSRLKEEIHAGIGTGIIRAMGGSGSVVTA TH_3056|M.thermoresistible__bu VVLAMSVIVLLAVGSDYNLMLVSRMKEEIGAGLNTGIIRAMGGTGRVVTM MAV_3863|M.avium_104 ICLALSVIILLAVGSDYNLLLISRFREEIHAGLNTGIIRSMAGSGAVVTS MMAR_3744|M.marinum_M IVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGIIRSMAGTGGVVTA MUL_3688|M.ulcerans_Agy99 IVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGIIRSMAGTGGVVTA MAB_3562c|M.abscessus_ATCC_199 LVLPLTFIILVAVGSDYNLLLVARLKEETGAGLNTGLIRALGSTGAVVTS MSMEG_0185|M.smegmatis_MC2_155 LILPLSFIILVAVGSDYNLLLISRVKEETGAGLNTGLIRALGSTGAVVTS : .::.*:*:***:****:*::*.::* **: **:**::..:* *** Mb0458c|M.bovis_AF2122/97 AGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAALL Rv0450c|M.tuberculosis_H37Rv AGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAALL MLBr_02378|M.leprae_Br4923 AGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSIAALL Mflv_3435|M.gilvum_PYR-GCK AGLVFALTMMSMSVSELTVIGQVGTTIGLGLLFDTLVIRAFMTPSIAALL Mvan_3189|M.vanbaalenii_PYR-1 AGLVFALTMMSMAVSELTVIGQVGTTIGLGLLFDTLVIRAFMTPSIAALL TH_3056|M.thermoresistible__bu AGLVFAATMASMIVSDLLMIGQVGTTIALGLLFDTMVVRAFMTPSVAAIL MAV_3863|M.avium_104 AGLVFAFTMASFVSASLLVLGQIGTTIALGLLFDTLIVRSFMTPSVAALL MMAR_3744|M.marinum_M AGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIVRTLLMPSIATLL MUL_3688|M.ulcerans_Agy99 AGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIVRTLLMPSIATLL MAB_3562c|M.abscessus_ATCC_199 AGLVFAFTMLAMLASDLRTIGQVGSTICIGLLLDTLIVRSFIVPSLVRLF MSMEG_0185|M.smegmatis_MC2_155 AGLVFAFTMLSMLVSDLRTIGQLGTTVCIGLLLDTMIVRSLVVPCLLRLL ****** ** :: :.* :**.*:*: :***:**:::*::: *.: :: Mb0458c|M.bovis_AF2122/97 GRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG----------- Rv0450c|M.tuberculosis_H37Rv GRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG----------- MLBr_02378|M.leprae_Br4923 GRWFWWPQQGRTRPLLTVAAPVGLPPD-RSLVYSD--------------- Mflv_3435|M.gilvum_PYR-GCK GPWFWWPQRVRTRPVPAPWPRSGGLQSDPSEGVRA--------------- Mvan_3189|M.vanbaalenii_PYR-1 GPWFWWPQRVRTRPVPAPWPRPGGLQSDPSEGVKV--------------- TH_3056|M.thermoresistible__bu GRWFWWPQRVRTRPASAMLRPVGPRPLVRSLLLRD--------------- MAV_3863|M.avium_104 GRWFWWPQRVRPRPASTMLRPYGPRPAVRQLLLWEDGDPAVAPETPSAAR MMAR_3744|M.marinum_M GRWFWWPQVVHPRGDNARPRVAAPTH------------------------ MUL_3688|M.ulcerans_Agy99 GRWFWWPQVVHPRGDNARPRVAAPTH------------------------ MAB_3562c|M.abscessus_ATCC_199 GTWFWWPTRVFARPLRRQNVGAHR-------------------------- MSMEG_0185|M.smegmatis_MC2_155 GPWFWWPTFIRQRPLRQAVRQRERADVV---------------------- * ***** * Mb0458c|M.bovis_AF2122/97 ---- Rv0450c|M.tuberculosis_H37Rv ---- MLBr_02378|M.leprae_Br4923 ---- Mflv_3435|M.gilvum_PYR-GCK ---- Mvan_3189|M.vanbaalenii_PYR-1 ---- TH_3056|M.thermoresistible__bu ---- MAV_3863|M.avium_104 HSRG MMAR_3744|M.marinum_M ---- MUL_3688|M.ulcerans_Agy99 ---- MAB_3562c|M.abscessus_ATCC_199 ---- MSMEG_0185|M.smegmatis_MC2_155 ----