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TAKVDFSDVEWRSVTWTMLVTLFLRAYESRSPRSILNDRAAAELVDRIDYDWPRIERTTAPRSNQYTVTL RARALDDWTGEFLTAHPDATVLHLGCGLDSRAFRLNLPADVRWFDVDMPEVIAMRRRVIEERTGYRMIAS SVTGAAWFDDIPTDRPTLVVAEGLVMYLTEDEIRELLQRITDRFPSGQIVFDAMPPSIVRAQKLFKSSIR SAAQVQGWNRRLRCVEETTPWRLYPLVPSRFLRGIYWAMASLPWLRSFERLYRFSF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4610c | - | - | 100% (267) | O-methyltransferase-like |
| M. abscessus ATCC 19977 | MAB_0963c | - | 7e-55 | 47.17% (265) | putative polyketide synthase protein |
| M. abscessus ATCC 19977 | MAB_2169c | - | 5e-40 | 41.40% (186) | O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 6e-22 | 32.43% (185) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3385 | - | 7e-42 | 40.72% (221) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 1e-22 | 32.97% (185) | O-methyltransferase |
| M. leprae Br4923 | MLBr_02020 | - | 9e-08 | 24.78% (230) | hypothetical protein MLBr_02020 |
| M. marinum M | MMAR_2971 | - | 2e-78 | 53.87% (271) | O-methyltransferase |
| M. avium 104 | MAV_2991 | - | 7e-76 | 52.92% (274) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 4e-46 | 48.39% (186) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0460 | omt | 1e-31 | 39.61% (207) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 8e-23 | 32.97% (182) | O-methyltransferase Omt_1 |
| M. vanbaalenii PYR-1 | Mvan_5704 | - | 1e-47 | 41.60% (262) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2971|M.marinum_M -------MTETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTA
MAV_2991|M.avium_104 -------MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTA
MAB_4610c|M.abscessus_ATCC_199 ---------MTAKVDFSDVEWRSVTWTMLVTLFLRAYESRSPRSILNDRA
MSMEG_6473|M.smegmatis_MC2_155 -------MTDKLKVDLSGAPQ-----TMLATFYAKALDARLPTPILGDDM
Mvan_5704|M.vanbaalenii_PYR-1 -------MSDRLRVDLHGSPQ-----TMLATLYAKALDAGAPDSVLNDTW
Mflv_3385|M.gilvum_PYR-GCK -------MTDKVSIDLTGPAQ-----TMLTTLYLKALDADFDRPVLGDRF
Mb1184c|M.bovis_AF2122/97 --------MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPM
Rv1153c|M.tuberculosis_H37Rv --------MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPM
TH_0460|M.thermoresistible__bu --------VSSGPLAKP--ELTGVSETALLTLLVRATEARRPDGIIDDPM
MUL_4852|M.ulcerans_Agy99 ------------MPVIDARHLDDISETALLTLHQRATEAARPDAIIDDPM
MLBr_02020|M.leprae_Br4923 MMAATPEFGSLRSDDDHWDIVSSVGYTALLVAGWRALHAVGPQPLVRDEY
* * . :* .: :: *
MMAR_2971|M.marinum_M AAEAVQR-----IEYDWGRMDRTMWPATSQYMVTMRAKQFDDWCTDFLGR
MAV_2991|M.avium_104 AAEAVDR-----IRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLAR
MAB_4610c|M.abscessus_ATCC_199 AAELVDR-----IDYDWPRIERTTAPRSNQYTVTLRARALDDWTGEFLTA
MSMEG_6473|M.smegmatis_MC2_155 AAEIAER-----IDYDWSRTAITPSRAP---AVTTRSRHFDRWARQFLAV
Mvan_5704|M.vanbaalenii_PYR-1 ARDIVDR-----IDYDWSSTTITTRNAP---SVTLRSAHFDFWTEQFLAA
Mflv_3385|M.gilvum_PYR-GCK AKEAIER-----IDYDWADLGVTGRWAP---IVTVRTAQYDIWAKQFIAA
Mb1184c|M.bovis_AF2122/97 AVALVES-----IDFGFAKFGPTG------QGFALRARAFDMAAQHYLDQ
Rv1153c|M.tuberculosis_H37Rv AVALVES-----IDFDFAKFGPTG------QGFALRARAFDMAAQHYLDQ
TH_0460|M.thermoresistible__bu AVRLVDS-----IDFDFAKFGPSRR-----QDMALRAKAFDTATRRYLRA
MUL_4852|M.ulcerans_Agy99 AIALRND-----IDYPYHHFGRTH------QATALRALAFDNSTRDFLQT
MLBr_02020|M.leprae_Br4923 AKYFITASRDPYLMNLLANPGTSLNETAFPRLYGVQTRFFDDFFSSAGDT
* : :: *
MMAR_2971|M.marinum_M HRNAVVLHLGCGMDTRAFRLH---PPQSAQWYDVDQPDVIALRRKLYDDC
MAV_2991|M.avium_104 HPDAVVLHLGCGLDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLYDDT
MAB_4610c|M.abscessus_ATCC_199 HPDATVLHLGCGLDSRAFRLN---LPADVRWFDVDMPEVIAMRRRVIEER
MSMEG_6473|M.smegmatis_MC2_155 HPEAVVLHLGCGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEH
Mvan_5704|M.vanbaalenii_PYR-1 HPRAVVVHLGCGLDSRFLRVQ---PGDGVDWYDVDYPQVAALRERFYPVR
Mflv_3385|M.gilvum_PYR-GCK HGDCTVVHLGCGLDSRVFRVD---PGPNVQWYDVDFPGVIELREKVYPSR
Mb1184c|M.bovis_AF2122/97 HPAATVVALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSS
Rv1153c|M.tuberculosis_H37Rv HPAATVVALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSS
TH_0460|M.thermoresistible__bu HPKATVVALAEGLQTSFFRLNAADVGDEFRWVTVDLAPVIELRRQLLPAD
MUL_4852|M.ulcerans_Agy99 RPGATVVALAEGLQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPAC
MLBr_02020|M.leprae_Br4923 G-IRQAVIVAAGLDSRAYRLK---WPNGATVFEIDLPKVLEFKARVLAEQ
.: :. *:: *: :* . : :: :.
MMAR_2971|M.marinum_M AGYRMIGSSVTDEAWLDEIP---------TDRPTLLVAEGLLMYLTEPEV
MAV_2991|M.avium_104 ENYRMIGSSVTELQWLDEVP---------AGRPTLMVAEGLLMYLREDEV
MAB_4610c|M.abscessus_ATCC_199 TGYRMIASSVTGAAWFDDIP---------TDRPTLVVAEGLVMYLTEDEI
MSMEG_6473|M.smegmatis_MC2_155 ARCHLVSASVTDPAWLDEVP---------TGRPALMLGEGLTMYLTETEG
Mvan_5704|M.vanbaalenii_PYR-1 PGNHVVAASVTDPAWLADIP---------DDRPALVIGEGLTMYLREADG
Mflv_3385|M.gilvum_PYR-GCK PNYHLLPTPATELSWLDQIP---------TGKPLLFLAEGISMYLTEDEG
Mb1184c|M.bovis_AF2122/97 PRVSVCAQSALDYSWMDSVD---------PAGGVFITAEGLLMYLQPEQA
Rv1153c|M.tuberculosis_H37Rv PRVSVCAQSALDYSWMDSVD---------PAGGVFITAEGLLMYLQPEQA
TH_0460|M.thermoresistible__bu DRVTMLAQSALDYSWMDRID---------TSEGVFITAEGLLMYLQPDEA
MUL_4852|M.ulcerans_Agy99 DRLRYCAQSAFDYSWMEQVD---------DTNGVLITAEGLFQYLRRDVV
MLBr_02020|M.leprae_Br4923 GAIPNAGRSEVAADLRADWPRALKAAGFDPQRSSAWSVEGLLPYLTNDAQ
. **: **
MMAR_2971|M.marinum_M RMLLQRVTDRFGAG-ELAFDTTSPLGPRLS----------KAFTKGITKW
MAV_2991|M.avium_104 RRLLQRLIDRFPGG-EMHFDTLSALAPLLS----------KVFTRGIITW
MAB_4610c|M.abscessus_ATCC_199 RELLQRITDRFPSG-QIVFDAMPPSIVRAQ----------KLFKS-----
MSMEG_6473|M.smegmatis_MC2_155 LALLRRVVDRFGTG-ELQFDAFNTFGIRTQW-----TNTVVRRSGATLRW
Mvan_5704|M.vanbaalenii_PYR-1 VALLRRVVDRFPSG-ELQFDAFNWLGIKAQW-----SNAVVRRSGSTLYW
Mflv_3385|M.gilvum_PYR-GCK VALLRRVVERFGSG-ELQIDFYNWLPIKSQK-----TQTLVRKTGSTLYW
Mb1184c|M.bovis_AF2122/97 LGLIAQCAQTFPGG-QMLFDLPPRWFAGWSR-LGLRTSLRYKVPRMPFSM
Rv1153c|M.tuberculosis_H37Rv LGLIAQCAQTFPGG-QMLFDLPPRWFAGWSR-LGLRTSLRYKVPRMPFSM
TH_0460|M.thermoresistible__bu MGLIRECARRFPGG-QMMFDLPPSFFAWLTR-RGFRTSLRYKVPPMPFTL
MUL_4852|M.ulcerans_Agy99 FELIAACAKRVPHG-QLVFDSIPWLLSVYSRRRGFKLSEHYTAPPMPFWF
MLBr_02020|M.leprae_Br4923 SALFTRIGELCAPGSRIAVGALGSRLDRKQL-------AALEATHPGVNI
*: * .: ..
MMAR_2971|M.marinum_M GISDVRDLQQWNPRLRFLEQTHVGAL-CARIPSAPIR-LLWRLVYATPVR
MAV_2991|M.avium_104 GIRDARRIADWNPRLRFLEQSPALAG-YQRIPSTVVR-SIYRLTWLTGGR
MAB_4610c|M.abscessus_ATCC_199 SIRSAAQVQGWNRRLRCVEETTPWRL-YPLVPSRFLRGIYWAMASLPWLR
MSMEG_6473|M.smegmatis_MC2_155 AIDRPDDILDTVPGTRLLAWMSVFEDPVFDELAWHYRLLAKVMRPLSPLR
Mvan_5704|M.vanbaalenii_PYR-1 AINGPADILDSVPGTRLLQWVPVFESDVFDRLPGVYRLLGAVMNRIPAAR
Mflv_3385|M.gilvum_PYR-GCK AVNSPEDILSKVPGTRLLAAATLFDASTAARASAPFKVLGRAVRAVPPLR
Mb1184c|M.bovis_AF2122/97 SVAQAADLVNKVPGVVAVRDLRVPPG--RGLWVNMALSTVYRLPVFDPLR
Rv1153c|M.tuberculosis_H37Rv SVAQAADLVNKVPGVVAVRDLRVPPG--RGLWVNMALSTVYRLPVFDPLR
TH_0460|M.thermoresistible__bu SPEQAADLVNTVPGVQAVHDVPIPRG--RGVLVNTLIWAAQRTPLFDNVR
MUL_4852|M.ulcerans_Agy99 TADHYDELR-AIPGVRAVRELPAPAG--RGRFLRWALPVAYRLPGLGRLR
MLBr_02020|M.leprae_Br4923 SGDVDFSALTYEPKTDSAQWLAAHGWAVEPVRNTLELQTSYGMTPPDVDV
MMAR_2971|M.marinum_M NFDVLNRFAF------
MAV_2991|M.avium_104 GYDVLNRFEY------
MAB_4610c|M.abscessus_ATCC_199 SFERLYRFSF------
MSMEG_6473|M.smegmatis_MC2_155 YMAQYHRYAF------
Mvan_5704|M.vanbaalenii_PYR-1 TMSQFHRYAF------
Mflv_3385|M.gilvum_PYR-GCK NALQYHRYGFGPVS--
Mb1184c|M.bovis_AF2122/97 PCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv PCLTLLEFSRPARG--
TH_0460|M.thermoresistible__bu GTYTLLEFGPPNSAST
MUL_4852|M.ulcerans_Agy99 APVTLVEFG-------
MLBr_02020|M.leprae_Br4923 QMDSFMHSQYITATR-
.