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LVRVTDPVKITLTGAPETMLATLYGRAQDATSPDSVLHDHYAAEAVARIDYDFSKTKIKGTQAIGVALRA RQLDDWTSEFLTAHHEATVLHLACGLDTRVFRINPSEMVRWADVDYPDVIALRRALLPCRDGDYRMIGSS VSEATWLDSIPADRPTLAVFEGLTMYLTEAEGQSLIRRITGRFPSGQLAFDCYGSIGIKLQKLVPAVRNA GATLHWGIDDPGQIEALHPGLRCVSDLRSTDVAGEEHLPLSGRIQMKVISHIPTLRDIGRIMRFSF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0963c | - | - | 100% (277) | putative polyketide synthase protein |
| M. abscessus ATCC 19977 | MAB_2169c | - | 3e-59 | 42.65% (272) | O-methyltransferase |
| M. abscessus ATCC 19977 | MAB_4610c | - | 7e-55 | 47.17% (265) | O-methyltransferase-like |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 4e-24 | 36.02% (186) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3385 | - | 1e-56 | 40.66% (273) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 7e-25 | 36.56% (186) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2971 | - | 5e-51 | 50.00% (218) | O-methyltransferase |
| M. avium 104 | MAV_2991 | - | 1e-45 | 44.68% (235) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 9e-61 | 43.96% (273) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0783 | omt | 1e-30 | 35.46% (251) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_3020 | omt | 8e-21 | 33.88% (183) | O-methyltransferase Omt |
| M. vanbaalenii PYR-1 | Mvan_5704 | - | 8e-64 | 45.05% (273) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6473|M.smegmatis_MC2_155 ----MTDKLKVDLSGAPQ-----TMLATFYAKALDARLPTPILGDDMAAE
Mvan_5704|M.vanbaalenii_PYR-1 ----MSDRLRVDLHGSPQ-----TMLATLYAKALDAGAPDSVLNDTWARD
Mflv_3385|M.gilvum_PYR-GCK ----MTDKVSIDLTGPAQ-----TMLTTLYLKALDADFDRPVLGDRFAKE
MAB_0963c|M.abscessus_ATCC_199 MLVRVTDPVKITLTGAPE-----TMLATLYGRAQDATSPDSVLHDHYAAE
MMAR_2971|M.marinum_M ----MTETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTAAAE
MAV_2991|M.avium_104 ----MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAE
Mb1184c|M.bovis_AF2122/97 ----MSAHKPAKQRV-ALTGVSETALLTLNARAAEARRRDTIIDDPMAVA
Rv1153c|M.tuberculosis_H37Rv ----MSAHKPAKQRV-ALTGVSETALLTLNARAAEARRRDAIIDDPMAVA
TH_0783|M.thermoresistible__bu ----VHESNPDKLDASTLSGVSETALMTLYGRAEQARHPQPIIDDPMAVR
MUL_3020|M.ulcerans_Agy99 ----MGHSD-NNVNAGMLGGVSETALLTLNGRAHQAAKPNPIIDDPMAIK
: * * *: :* :: .:: * *
MSMEG_6473|M.smegmatis_MC2_155 IAERIDYDWS---RTAITPSRAPAVTTRSRHFDRWARQFLAVHPEAVVLH
Mvan_5704|M.vanbaalenii_PYR-1 IVDRIDYDWS---STTITTRNAPSVTLRSAHFDFWTEQFLAAHPRAVVVH
Mflv_3385|M.gilvum_PYR-GCK AIERIDYDWA---DLGVTGRWAPIVTVRTAQYDIWAKQFIAAHGDCTVVH
MAB_0963c|M.abscessus_ATCC_199 AVARIDYDFS---KTKIKGTQAIGVALRARQLDDWTSEFLTAHHEATVLH
MMAR_2971|M.marinum_M AVQRIEYDWGRMDRTMWPATSQYMVTMRAKQFDDWCTDFLGRHRNAVVLH
MAV_2991|M.avium_104 AVDRIRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLH
Mb1184c|M.bovis_AF2122/97 LVESIDFGFA------KFGPTGQGFALRARAFDMAAQHYLDQHPAATVVA
Rv1153c|M.tuberculosis_H37Rv LVESIDFDFA------KFGPTGQGFALRARAFDMAAQHYLDQHPAATVVA
TH_0783|M.thermoresistible__bu LVDRIDFDFT------KFGRRGQEMALRSLAFDRAALRYLSDHPRATVVA
MUL_3020|M.ulcerans_Agy99 LVESNDFDFE------KFGRRGQEMALRSLAVDRCEIAYLTKHPGATVVA
:.: .: *: * :: * ..*:
MSMEG_6473|M.smegmatis_MC2_155 LGCGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEHAR-CHLVS
Mvan_5704|M.vanbaalenii_PYR-1 LGCGLDSRFLRVQ---PGDGVDWYDVDYPQVAALRERFYPVRPG-NHVVA
Mflv_3385|M.gilvum_PYR-GCK LGCGLDSRVFRVD---PGPNVQWYDVDFPGVIELREKVYPSRPN-YHLLP
MAB_0963c|M.abscessus_ATCC_199 LACGLDTRVFRIN---PSEMVRWADVDYPDVIALRRALLPCRDGDYRMIG
MMAR_2971|M.marinum_M LGCGMDTRAFRLH---PPQSAQWYDVDQPDVIALRRKLYDDCAG-YRMIG
MAV_2991|M.avium_104 LGCGLDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLYDDTEN-YRMIG
Mb1184c|M.bovis_AF2122/97 LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPR-VSVCA
Rv1153c|M.tuberculosis_H37Rv LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPR-VSVCA
TH_0783|M.thermoresistible__bu LAEGLQTTFWRVTDAIPDARFRWLTIDLPPIIELRERLLPAEPR-IVTLA
MUL_3020|M.ulcerans_Agy99 HAEGFQTGFWRVSNALPDTQFRWVSLDLEPVMELRRRLLPDSAR-VTNLA
. *:: *: * :* : ** .
MSMEG_6473|M.smegmatis_MC2_155 ASVTDPAWLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGEL
Mvan_5704|M.vanbaalenii_PYR-1 ASVTDPAWLADIPDDRPALVIGEGLTMYLREADGVALLRRVVDRFPSGEL
Mflv_3385|M.gilvum_PYR-GCK TPATELSWLDQIPTGKPLLFLAEGISMYLTEDEGVALLRRVVERFGSGEL
MAB_0963c|M.abscessus_ATCC_199 SSVSEATWLDSIPADRPTLAVFEGLTMYLTEAEGQSLIRRITGRFPSGQL
MMAR_2971|M.marinum_M SSVTDEAWLDEIPTDRPTLLVAEGLLMYLTEPEVRMLLQRVTDRFGAGEL
MAV_2991|M.avium_104 SSVTELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEM
Mb1184c|M.bovis_AF2122/97 QSALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQM
Rv1153c|M.tuberculosis_H37Rv QSALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQM
TH_0783|M.thermoresistible__bu QSALDFSWMDRVDTDHGVLITAEGLLMYLQPDEAMTLIERCAARFPGGQM
MUL_3020|M.ulcerans_Agy99 QSALDYTWMDKVDSCAAVFITAEGLLMYPQPNQAMELISQCAKRFAGGQM
.. : *: : : **: ** : *: : * *::
MSMEG_6473|M.smegmatis_MC2_155 QFDA----FNTFGIRTQWTNTVVRRSGATLRWAIDRPDDILDTVPGTRLL
Mvan_5704|M.vanbaalenii_PYR-1 QFDA----FNWLGIKAQWSNAVVRRSGSTLYWAINGPADILDSVPGTRLL
Mflv_3385|M.gilvum_PYR-GCK QIDF----YNWLPIKSQKTQTLVRKTGSTLYWAVNSPEDILSKVPGTRLL
MAB_0963c|M.abscessus_ATCC_199 AFDC----YGSIGIKLQKLVPAVRNAGATLHWGIDDPGQIEALHPGLRCV
MMAR_2971|M.marinum_M AFDT----TSPLGPRLSKAFTKG-----ITKWGISDVRDLQQWNPRLRFL
MAV_2991|M.avium_104 HFDT----LSALAPLLSKVFTRG-----IITWGIRDARRIADWNPRLRFL
Mb1184c|M.bovis_AF2122/97 LFDLPPRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAV
Rv1153c|M.tuberculosis_H37Rv LFDLPPRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAV
TH_0783|M.thermoresistible__bu LFDLPPVLLKKLAPKGLRASRRYRVPPMPFSLSPAQLARLADTVPGVRAV
MUL_3020|M.ulcerans_Agy99 FFDLPPTIVKRVAPKGMRASRRYRVPPMPFSLSVNQLARLVDTVPGIRAV
:* . : * :
MSMEG_6473|M.smegmatis_MC2_155 AWMSVFEDPVFDELAWHYRLLAKVMRPLSPLRYMAQYHRYAF----
Mvan_5704|M.vanbaalenii_PYR-1 QWVPVFESDVFDRLPGVYRLLGAVMNRIPAARTMSQFHRYAF----
Mflv_3385|M.gilvum_PYR-GCK AAATLFDASTAARASAPFKVLGRAVRAVPPLRNALQYHRYGFGPVS
MAB_0963c|M.abscessus_ATCC_199 SDLRSTDVAGEEHLPLSGRIQMKVISHIPTLRDIGRIMRFSF----
MMAR_2971|M.marinum_M EQT--HVGALCARIPSAPIRLLWRLVYATPVRNFDVLNRFAF----
MAV_2991|M.avium_104 EQS--PALAGYQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY----
Mb1184c|M.bovis_AF2122/97 RDLRVPPGRGLWVN--MALSTVYRLPVFDPLRPCLTLLEFSRPARG
Rv1153c|M.tuberculosis_H37Rv RDLRVPPGRGLWVN--MALSTVYRLPVFDPLRPCLTLLEFSRPARG
TH_0783|M.thermoresistible__bu HDLPMPEGRGFFFR--AVFPRFWQARPTRQWRGAYTLLEFG-----
MUL_3020|M.ulcerans_Agy99 HDVPMPEGRGLFFR--TLYPALWRFPPIKPFRGAYVLLEFD-----
* .: