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TATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAVDRIRYDFKRIHRMSLPASNQYLV ALRAVQFDDWCAEFLARHPDAVVLHLGCGLDGRAFRVSVPPSLSWFDVDQPSVIGLRRRLYDDTENYRMI GSSVTELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFDTLSALAPLLSKVFTRG IITWGIRDARRIADWNPRLRFLEQSPALAGYQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2991 | - | - | 100% (273) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. avium 104 | MAV_4048 | - | 8e-30 | 31.88% (229) | Omt protein |
| M. avium 104 | MAV_2762 | - | 7e-10 | 29.89% (174) | methyltransferase, putative, family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 3e-21 | 33.69% (187) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3385 | - | 9e-43 | 40.45% (220) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 5e-22 | 34.22% (187) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4610c | - | 7e-76 | 52.92% (274) | O-methyltransferase-like |
| M. marinum M | MMAR_2971 | - | 1e-101 | 65.20% (273) | O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 4e-46 | 42.29% (253) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0783 | omt | 7e-29 | 34.21% (266) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_3020 | omt | 5e-20 | 27.37% (274) | O-methyltransferase Omt |
| M. vanbaalenii PYR-1 | Mvan_3118 | - | 1e-44 | 42.47% (219) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2991|M.avium_104 MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAVDR
MMAR_2971|M.marinum_M MTETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTAAAEAVQR
MAB_4610c|M.abscessus_ATCC_199 --MTAKVDFSDVEWRSVTWTMLVTLFLRAYESRSPRSILNDRAAAELVDR
Mflv_3385|M.gilvum_PYR-GCK MTDKVSIDLTGPAQ-----TMLTTLYLKALDADFDRPVLGDRFAKEAIER
Mvan_3118|M.vanbaalenii_PYR-1 MSNKVPVDLSGPAK-----TMLSTLYLKALDADFDRPVLGDRFAKAAIDK
MSMEG_6473|M.smegmatis_MC2_155 MTDKLKVDLSGAPQ-----TMLATFYAKALDARLPTPILGDDMAAEIAER
Mb1184c|M.bovis_AF2122/97 MSAHKPAKQRV-ALTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
Rv1153c|M.tuberculosis_H37Rv MSAHKPAKQRV-ALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
TH_0783|M.thermoresistible__bu VHESNPDKLDASTLSGVSETALMTLYGRAEQARHPQPIIDDPMAVRLVDR
MUL_3020|M.ulcerans_Agy99 MGHSD-NNVNAGMLGGVSETALLTLNGRAHQAAKPNPIIDDPMAIKLVES
. * * *: :* :: .::.* * :
MAV_2991|M.avium_104 IRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLHLGCG
MMAR_2971|M.marinum_M IEYDWGRMDRTMWPATSQYMVTMRAKQFDDWCTDFLGRHRNAVVLHLGCG
MAB_4610c|M.abscessus_ATCC_199 IDYDWPRIERTTAPRSNQYTVTLRARALDDWTGEFLTAHPDATVLHLGCG
Mflv_3385|M.gilvum_PYR-GCK IDYDWADLGVTGRWAP---IVTVRTAQYDIWAKQFIAAHGDCTVVHLGCG
Mvan_3118|M.vanbaalenii_PYR-1 LDFDWRELEITPKWAP---LFTVRTALYDGWVREFIAAHPECTVVHLGCG
MSMEG_6473|M.smegmatis_MC2_155 IDYDWSRTAITPSRAP---AVTTRSRHFDRWARQFLAVHPEAVVLHLGCG
Mb1184c|M.bovis_AF2122/97 IDFGFAKFGPTGQGFA------LRARAFDMAAQHYLDQHPAATVVALAEG
Rv1153c|M.tuberculosis_H37Rv IDFDFAKFGPTGQGFA------LRARAFDMAAQHYLDQHPAATVVALAEG
TH_0783|M.thermoresistible__bu IDFDFTKFGRRGQEMA------LRSLAFDRAALRYLSDHPRATVVALAEG
MUL_3020|M.ulcerans_Agy99 NDFDFEKFGRRGQEMA------LRSLAVDRCEIAYLTKHPGATVVAHAEG
:.: . *: * :: * ..*: . *
MAV_2991|M.avium_104 LDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLYDDTENYRMIGSSVTE
MMAR_2971|M.marinum_M MDTRAFRLH---PPQSAQWYDVDQPDVIALRRKLYDDCAGYRMIGSSVTD
MAB_4610c|M.abscessus_ATCC_199 LDSRAFRLN---LPADVRWFDVDMPEVIAMRRRVIEERTGYRMIASSVTG
Mflv_3385|M.gilvum_PYR-GCK LDSRVFRVD---PGPNVQWYDVDFPGVIELREKVYPSRPNYHLLPTPATE
Mvan_3118|M.vanbaalenii_PYR-1 LDCRVFRVD---PGPDVRWYDVDFPQVIALREQIYPTRPNYQLIATPATE
MSMEG_6473|M.smegmatis_MC2_155 LDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEHARCHLVSASVTD
Mb1184c|M.bovis_AF2122/97 LQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALD
Rv1153c|M.tuberculosis_H37Rv LQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALD
TH_0783|M.thermoresistible__bu LQTTFWRVTDAIPDARFRWLTIDLPPIIELRERLLPAEPRIVTLAQSALD
MUL_3020|M.ulcerans_Agy99 FQTGFWRVSNALPDTQFRWVSLDLEPVMELRRRLLPDSARVTNLAQSALD
:: :*: * :* :: :* :: ..
MAV_2991|M.avium_104 LQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFDTL
MMAR_2971|M.marinum_M EAWLDEIPTDRPTLLVAEGLLMYLTEPEVRMLLQRVTDRFGAGELAFDTT
MAB_4610c|M.abscessus_ATCC_199 AAWFDDIPTDRPTLVVAEGLVMYLTEDEIRELLQRITDRFPSGQIVFDAM
Mflv_3385|M.gilvum_PYR-GCK LSWLDQIPTGKPLLFLAEGISMYLTEDEGVALLRRVVERFGSGELQIDFY
Mvan_3118|M.vanbaalenii_PYR-1 PNWLDEIPADRPTLLIAEGISMYLTEDEGIALLRRFIDRFGAGELQIDFF
MSMEG_6473|M.smegmatis_MC2_155 PAWLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGELQFDAF
Mb1184c|M.bovis_AF2122/97 YSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLP
Rv1153c|M.tuberculosis_H37Rv YSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLP
TH_0783|M.thermoresistible__bu FSWMDRVDTDHGVLITAEGLLMYLQPDEAMTLIERCAARFPGGQMLFDLP
MUL_3020|M.ulcerans_Agy99 YTWMDKVDSCAAVFITAEGLLMYPQPNQAMELISQCAKRFAGGQMFFDLP
*:* : . :. .**: ** : *: : * *:: :*
MAV_2991|M.avium_104 S----ALAPLLSK-----VFTRGIITWGIRDARRIADWNPRLRFLEQSPA
MMAR_2971|M.marinum_M S----PLGPRLSK-----AFTKGITKWGISDVRDLQQWNPRLRFLEQTHV
MAB_4610c|M.abscessus_ATCC_199 P----PSIVRAQK-----LFKS-----SIRSAAQVQGWNRRLRCVEETTP
Mflv_3385|M.gilvum_PYR-GCK N----WLPIKSQKTQTLVRKTGSTLYWAVNSPEDILSKVPGTRLLAAATL
Mvan_3118|M.vanbaalenii_PYR-1 N----WLAIKSQKSQSLVRTSGSVLYWAVNSPQDILSKLPDIRLLAATTF
MSMEG_6473|M.smegmatis_MC2_155 N----TFGIRTQWTNTVVRRSGATLRWAIDRPDDILDTVPGTRLLAWMSV
Mb1184c|M.bovis_AF2122/97 PRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLRV
Rv1153c|M.tuberculosis_H37Rv PRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLRV
TH_0783|M.thermoresistible__bu PVLLKKLAPKGLRASRRYRVPPMPFSLSPAQLARLADTVPGVRAVHDLPM
MUL_3020|M.ulcerans_Agy99 PTIVKRVAPKGMRASRRYRVPPMPFSLSVNQLARLVDTVPGIRAVHDVPM
. : :
MAV_2991|M.avium_104 LAGYQRIPS-TVVR-SIYRLTWLTGGRGYDVLNRFEY----
MMAR_2971|M.marinum_M GALCARIPS-APIR-LLWRLVYATPVRNFDVLNRFAF----
MAB_4610c|M.abscessus_ATCC_199 WRLYPLVPS-RFLRGIYWAMASLPWLRSFERLYRFSF----
Mflv_3385|M.gilvum_PYR-GCK FDASTAARASAPFKVLGRAVRAVPPLRNALQYHRYGFGPVS
Mvan_3118|M.vanbaalenii_PYR-1 FDASTYSRTGPGLQAAKRAVRLLPPLRNALQYHRYAYGPR-
MSMEG_6473|M.smegmatis_MC2_155 FEDPVFDELAWHYRLLAKVMRPLSPLRYMAQYHRYAF----
Mb1184c|M.bovis_AF2122/97 PPGRGLWVN--MALSTVYRLPVFDPLRPCLTLLEFSRPARG
Rv1153c|M.tuberculosis_H37Rv PPGRGLWVN--MALSTVYRLPVFDPLRPCLTLLEFSRPARG
TH_0783|M.thermoresistible__bu PEGRGFFFR--AVFPRFWQARPTRQWRGAYTLLEFG-----
MUL_3020|M.ulcerans_Agy99 PEGRGLFFR--TLYPALWRFPPIKPFRGAYVLLEFD-----
* .: