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SHSEKIHVDLSGAPQTMLATFYAKALDAGLPEPILGDQLARDIAQRIDYDWSKTTITAGRSPAVTTRSAH FDEWCRAFLSRHAEAVVLHLGCGLDGRYFRLNPGPGIEWYDIDYPDVARLRSQLYPTRDHYHVVSASVTD PAWLANIADSRPVLAIGEGLTMYLKEDDGIALFRRIVDHFPYGELQFDAFNKFGIKTQWSNAVVRRSGAT LYWGIDRPEDLIRAIPKLQLLEWESPFDSETFQRTKAGYRLLARAMSLSPTLRYMAQYHRYAF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2169c | - | - | 100% (274) | O-methyltransferase |
| M. abscessus ATCC 19977 | MAB_0963c | - | 3e-59 | 42.65% (272) | putative polyketide synthase protein |
| M. abscessus ATCC 19977 | MAB_4610c | - | 5e-40 | 41.40% (186) | O-methyltransferase-like |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 1e-20 | 27.59% (232) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3385 | - | 7e-77 | 45.02% (271) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 2e-21 | 28.02% (232) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2971 | - | 2e-46 | 41.76% (261) | O-methyltransferase |
| M. avium 104 | MAV_2991 | - | 5e-43 | 39.29% (224) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 1e-107 | 66.79% (271) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0783 | omt | 6e-24 | 33.52% (182) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 2e-19 | 29.30% (256) | O-methyltransferase Omt_1 |
| M. vanbaalenii PYR-1 | Mvan_5704 | - | 1e-101 | 62.36% (271) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2169c|M.abscessus_ATCC_199 MSHSEKIHVDLSGAPQ-----TMLATFYAKALDAGLPEPILGDQLARDIA
MSMEG_6473|M.smegmatis_MC2_155 --MTDKLKVDLSGAPQ-----TMLATFYAKALDARLPTPILGDDMAAEIA
Mvan_5704|M.vanbaalenii_PYR-1 --MSDRLRVDLHGSPQ-----TMLATLYAKALDAGAPDSVLNDTWARDIV
Mflv_3385|M.gilvum_PYR-GCK --MTDKVSIDLTGPAQ-----TMLTTLYLKALDADFDRPVLGDRFAKEAI
MMAR_2971|M.marinum_M --MTETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTAAAEAV
MAV_2991|M.avium_104 --MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAV
Mb1184c|M.bovis_AF2122/97 --MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDTIIDDPMAVALV
Rv1153c|M.tuberculosis_H37Rv --MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDAIIDDPMAVALV
TH_0783|M.thermoresistible__bu --VHESNPDKLDASTLSGVSETALMTLYGRAEQARHPQPIIDDPMAVRLV
MUL_4852|M.ulcerans_Agy99 ------MP-VIDARHLDDISETALLTLHQRATEAARPDAIIDDPMAIALR
* * *: :* :: .::.* *
MAB_2169c|M.abscessus_ATCC_199 QRIDYDWSKTTITAGRSP---AVTTRSAHFDEWCRAFLSRHAEAVVLHLG
MSMEG_6473|M.smegmatis_MC2_155 ERIDYDWSRTAITPSRAP---AVTTRSRHFDRWARQFLAVHPEAVVLHLG
Mvan_5704|M.vanbaalenii_PYR-1 DRIDYDWSSTTITTRNAP---SVTLRSAHFDFWTEQFLAAHPRAVVVHLG
Mflv_3385|M.gilvum_PYR-GCK ERIDYDWADLGVTGRWAP---IVTVRTAQYDIWAKQFIAAHGDCTVVHLG
MMAR_2971|M.marinum_M QRIEYDWGRMDRTMWPATSQYMVTMRAKQFDDWCTDFLGRHRNAVVLHLG
MAV_2991|M.avium_104 DRIRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLHLG
Mb1184c|M.bovis_AF2122/97 ESIDFGFAKFGPTG------QGFALRARAFDMAAQHYLDQHPAATVVALA
Rv1153c|M.tuberculosis_H37Rv ESIDFDFAKFGPTG------QGFALRARAFDMAAQHYLDQHPAATVVALA
TH_0783|M.thermoresistible__bu DRIDFDFTKFGRRG------QEMALRSLAFDRAALRYLSDHPRATVVALA
MUL_4852|M.ulcerans_Agy99 NDIDYPYHHFGRTH------QATALRALAFDNSTRDFLQTRPGATVVALA
: * : : : *: :* :: : ..*: *.
MAB_2169c|M.abscessus_ATCC_199 CGLDGRYFRLN---PGPGIEWYDIDYPDVARLRSQLYPTRDHYHVVSASV
MSMEG_6473|M.smegmatis_MC2_155 CGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEHARCHLVSASV
Mvan_5704|M.vanbaalenii_PYR-1 CGLDSRFLRVQ---PGDGVDWYDVDYPQVAALRERFYPVRPGNHVVAASV
Mflv_3385|M.gilvum_PYR-GCK CGLDSRVFRVD---PGPNVQWYDVDFPGVIELREKVYPSRPNYHLLPTPA
MMAR_2971|M.marinum_M CGMDTRAFRLH---PPQSAQWYDVDQPDVIALRRKLYDDCAGYRMIGSSV
MAV_2991|M.avium_104 CGLDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLYDDTENYRMIGSSV
Mb1184c|M.bovis_AF2122/97 EGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA
Rv1153c|M.tuberculosis_H37Rv EGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA
TH_0783|M.thermoresistible__bu EGLQTTFWRVTDAIPDARFRWLTIDLPPIIELRERLLPAEPRIVTLAQSA
MUL_4852|M.ulcerans_Agy99 EGLQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSA
*:: *: * :* . : ** :. ..
MAB_2169c|M.abscessus_ATCC_199 TDPAWLANIADSRPVLAIGEGLTMYLKEDDGIALFRRIVDHFPYGELQFD
MSMEG_6473|M.smegmatis_MC2_155 TDPAWLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGELQFD
Mvan_5704|M.vanbaalenii_PYR-1 TDPAWLADIPDDRPALVIGEGLTMYLREADGVALLRRVVDRFPSGELQFD
Mflv_3385|M.gilvum_PYR-GCK TELSWLDQIPTGKPLLFLAEGISMYLTEDEGVALLRRVVERFGSGELQID
MMAR_2971|M.marinum_M TDEAWLDEIPTDRPTLLVAEGLLMYLTEPEVRMLLQRVTDRFGAGELAFD
MAV_2991|M.avium_104 TELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFD
Mb1184c|M.bovis_AF2122/97 LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFD
Rv1153c|M.tuberculosis_H37Rv LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFD
TH_0783|M.thermoresistible__bu LDFSWMDRVDTDHGVLITAEGLLMYLQPDEAMTLIERCAARFPGGQMLFD
MUL_4852|M.ulcerans_Agy99 FDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRVPHGQLVFD
: *: : : .**: ** *: . *:: :*
MAB_2169c|M.abscessus_ATCC_199 AFNKFGIKTQWSNAVVRRS-----GATLYWGIDRPEDLIRAIPKLQLLEW
MSMEG_6473|M.smegmatis_MC2_155 AFNTFGIRTQWTNTVVRRS-----GATLRWAIDRPDDILDTVPGTRLLAW
Mvan_5704|M.vanbaalenii_PYR-1 AFNWLGIKAQWSNAVVRRS-----GSTLYWAINGPADILDSVPGTRLLQW
Mflv_3385|M.gilvum_PYR-GCK FYNWLPIKSQKTQTLVRKT-----GSTLYWAVNSPEDILSKVPGTRLLAA
MMAR_2971|M.marinum_M TTSPLGP--RLSKAFTKG--------ITKWGISDVRDLQQWNPRLRFLE-
MAV_2991|M.avium_104 TLSALAP--LLSKVFTRG--------IITWGIRDARRIADWNPRLRFLE-
Mb1184c|M.bovis_AF2122/97 LPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRD
Rv1153c|M.tuberculosis_H37Rv LPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRD
TH_0783|M.thermoresistible__bu LPPVLLKKLAP-KGLRASRRYRVPPMPFSLSPAQLARLADTVPGVRAVHD
MUL_4852|M.ulcerans_Agy99 SIPWLLSVYSRRRGFKLSEHYTAPPMPFWFTADHYDELR-AIPGVRAVRE
. : * :
MAB_2169c|M.abscessus_ATCC_199 ESPFDSETFQRTKAGYRLLARAMSLSPTLRYMAQYHRYAF----
MSMEG_6473|M.smegmatis_MC2_155 MSVFEDPVFDELAWHYRLLAKVMRPLSPLRYMAQYHRYAF----
Mvan_5704|M.vanbaalenii_PYR-1 VPVFESDVFDRLPGVYRLLGAVMNRIPAARTMSQFHRYAF----
Mflv_3385|M.gilvum_PYR-GCK ATLFDASTAARASAPFKVLGRAVRAVPPLRNALQYHRYGFGPVS
MMAR_2971|M.marinum_M QTHVGALCARIPSAPIRLLWRLVYATP-VRNFDVLNRFAF----
MAV_2991|M.avium_104 QSPALAGYQRIPSTVVRSIYRLTWLTG-GRGYDVLNRFEY----
Mb1184c|M.bovis_AF2122/97 LRVPPGRGLWVNMALSTVYR--LPVFDPLRPCLTLLEFSRPARG
Rv1153c|M.tuberculosis_H37Rv LRVPPGRGLWVNMALSTVYR--LPVFDPLRPCLTLLEFSRPARG
TH_0783|M.thermoresistible__bu LPMPEGRGFFFRAVFPRFWQ--ARPTRQWRGAYTLLEFG-----
MUL_4852|M.ulcerans_Agy99 LPAPAGRGRFLRWALPVAYR--LPGLGRLRAPVTLVEFG-----
* .: