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M. gilvum PYR-GCK Mflv_3385 (-)

annotation: O-methyltransferase domain-containing protein
coordinates: 3577354 - 3578184
length: 276

MTDKVSIDLTGPAQTMLTTLYLKALDADFDRPVLGDRFAKEAIERIDYDWADLGVTGRWAPIVTVRTAQY
DIWAKQFIAAHGDCTVVHLGCGLDSRVFRVDPGPNVQWYDVDFPGVIELREKVYPSRPNYHLLPTPATEL
SWLDQIPTGKPLLFLAEGISMYLTEDEGVALLRRVVERFGSGELQIDFYNWLPIKSQKTQTLVRKTGSTL
YWAVNSPEDILSKVPGTRLLAAATLFDASTAARASAPFKVLGRAVRAVPPLRNALQYHRYGFGPVS

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_3385 - - 100% (276) O-methyltransferase domain-containing protein
M. gilvum PYR-GCK Mflv_3375 - 1e-34 33.45% (281) O-methyltransferase domain-containing protein
M. gilvum PYR-GCK Mflv_2136 - 8e-28 30.08% (236) O-methyltransferase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1184c omt 3e-24 28.14% (231) O-methyltransferase
M. tuberculosis H37Rv Rv1153c omt 5e-25 28.57% (231) O-methyltransferase
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_2169c - 7e-77 45.02% (271) O-methyltransferase
M. marinum M MMAR_2971 - 2e-47 41.22% (262) O-methyltransferase
M. avium 104 MAV_2991 - 8e-43 40.45% (220) tetracenomycin polyketide synthesis O-methyltransferase TcmP
M. smegmatis MC2 155 MSMEG_6473 - 1e-84 52.21% (272) tetracenomycin polyketide synthesis O-methyltransferase TcmP
M. thermoresistible (build 8) TH_0460 omt 2e-27 30.26% (228) PROBABLE O-METHYLTRANSFERASE OMT
M. ulcerans Agy99 MUL_4852 omt_1 6e-16 26.11% (226) O-methyltransferase Omt_1
M. vanbaalenii PYR-1 Mvan_3118 - 1e-118 70.44% (274) O-methyltransferase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3385|M.gilvum_PYR-GCK          --MTDKVSIDLT-----GPAQTMLTTLYLKALDADFDRPVLGDRFAKEAI
Mvan_3118|M.vanbaalenii_PYR-1       --MSNKVPVDLS-----GPAKTMLSTLYLKALDADFDRPVLGDRFAKAAI
MAB_2169c|M.abscessus_ATCC_199      MSHSEKIHVDLS-----GAPQTMLATFYAKALDAGLPEPILGDQLARDIA
MSMEG_6473|M.smegmatis_MC2_155      --MTDKLKVDLS-----GAPQTMLATFYAKALDARLPTPILGDDMAAEIA
MMAR_2971|M.marinum_M               --MTETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTAAAEAV
MAV_2991|M.avium_104                --MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAV
Mb1184c|M.bovis_AF2122/97           ---MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPMAVALV
Rv1153c|M.tuberculosis_H37Rv        ---MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALV
TH_0460|M.thermoresistible__bu      ---VSSGPLAKP--ELTGVSETALLTLLVRATEARRPDGIIDDPMAVRLV
MUL_4852|M.ulcerans_Agy99           -------MPVIDARHLDDISETALLTLHQRATEAARPDAIIDDPMAIALR
                                                     .   * * *:  :* ::     ::.*  *    

Mflv_3385|M.gilvum_PYR-GCK          ERIDYDWADLGVTGRWAP---IVTVRTAQYDIWAKQFIAAHGDCTVVHLG
Mvan_3118|M.vanbaalenii_PYR-1       DKLDFDWRELEITPKWAP---LFTVRTALYDGWVREFIAAHPECTVVHLG
MAB_2169c|M.abscessus_ATCC_199      QRIDYDWSKTTITAGRSP---AVTTRSAHFDEWCRAFLSRHAEAVVLHLG
MSMEG_6473|M.smegmatis_MC2_155      ERIDYDWSRTAITPSRAP---AVTTRSRHFDRWARQFLAVHPEAVVLHLG
MMAR_2971|M.marinum_M               QRIEYDWGRMDRTMWPATSQYMVTMRAKQFDDWCTDFLGRHRNAVVLHLG
MAV_2991|M.avium_104                DRIRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLHLG
Mb1184c|M.bovis_AF2122/97           ESIDFGFAKFGPTG------QGFALRARAFDMAAQHYLDQHPAATVVALA
Rv1153c|M.tuberculosis_H37Rv        ESIDFDFAKFGPTG------QGFALRARAFDMAAQHYLDQHPAATVVALA
TH_0460|M.thermoresistible__bu      DSIDFDFAKFGPSRR-----QDMALRAKAFDTATRRYLRAHPKATVVALA
MUL_4852|M.ulcerans_Agy99           NDIDYPYHHFGRTH------QATALRALAFDNSTRDFLQTRPGATVVALA
                                    : : : :                : *:  :*     ::  :  ..*: *.

Mflv_3385|M.gilvum_PYR-GCK          CGLDSRVFRVD---PGPNVQWYDVDFPGVIELREKVYPSRPNYHLLPTPA
Mvan_3118|M.vanbaalenii_PYR-1       CGLDCRVFRVD---PGPDVRWYDVDFPQVIALREQIYPTRPNYQLIATPA
MAB_2169c|M.abscessus_ATCC_199      CGLDGRYFRLN---PGPGIEWYDIDYPDVARLRSQLYPTRDHYHVVSASV
MSMEG_6473|M.smegmatis_MC2_155      CGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEHARCHLVSASV
MMAR_2971|M.marinum_M               CGMDTRAFRLH---PPQSAQWYDVDQPDVIALRRKLYDDCAGYRMIGSSV
MAV_2991|M.avium_104                CGLDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLYDDTENYRMIGSSV
Mb1184c|M.bovis_AF2122/97           EGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA
Rv1153c|M.tuberculosis_H37Rv        EGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA
TH_0460|M.thermoresistible__bu      EGLQTSFFRLNAADVGDEFRWVTVDLAPVIELRRQLLPADDRVTMLAQSA
MUL_4852|M.ulcerans_Agy99           EGLQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSA
                                     *::   :*:          *  :* . :  ** ::            ..

Mflv_3385|M.gilvum_PYR-GCK          TELSWLDQIPTGKPLLFLAEGISMYLTEDEGVALLRRVVERFGSGELQID
Mvan_3118|M.vanbaalenii_PYR-1       TEPNWLDEIPADRPTLLIAEGISMYLTEDEGIALLRRFIDRFGAGELQID
MAB_2169c|M.abscessus_ATCC_199      TDPAWLANIADSRPVLAIGEGLTMYLKEDDGIALFRRIVDHFPYGELQFD
MSMEG_6473|M.smegmatis_MC2_155      TDPAWLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGELQFD
MMAR_2971|M.marinum_M               TDEAWLDEIPTDRPTLLVAEGLLMYLTEPEVRMLLQRVTDRFGAGELAFD
MAV_2991|M.avium_104                TELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFD
Mb1184c|M.bovis_AF2122/97           LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFD
Rv1153c|M.tuberculosis_H37Rv        LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFD
TH_0460|M.thermoresistible__bu      LDYSWMDRIDTSEGVFITAEGLLMYLQPDEAMGLIRECARRFPGGQMMFD
MUL_4852|M.ulcerans_Agy99           FDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRVPHGQLVFD
                                     :  *:  :      :  .**:  **       *:      .  *:: :*

Mflv_3385|M.gilvum_PYR-GCK          FYNWLPIKSQK-----TQTLVRKTGSTLYWAVNSPEDILSKVPGTRLLAA
Mvan_3118|M.vanbaalenii_PYR-1       FFNWLAIKSQK-----SQSLVRTSGSVLYWAVNSPQDILSKLPDIRLLAA
MAB_2169c|M.abscessus_ATCC_199      AFNKFGIKTQW-----SNAVVRRSGATLYWGIDRPEDLIRAIPKLQLLEW
MSMEG_6473|M.smegmatis_MC2_155      AFNTFGIRTQW-----TNTVVRRSGATLRWAIDRPDDILDTVPGTRLLAW
MMAR_2971|M.marinum_M               TTSPLGPRLSK-----AFTKG-----ITKWGISDVRDLQQWNPRLRFLEQ
MAV_2991|M.avium_104                TLSALAPLLSK-----VFTRG-----IITWGIRDARRIADWNPRLRFLEQ
Mb1184c|M.bovis_AF2122/97           LPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRD
Rv1153c|M.tuberculosis_H37Rv        LPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRD
TH_0460|M.thermoresistible__bu      LPPSFFAWLTR-RGFRTSLRYKVPPMPFTLSPEQAADLVNTVPGVQAVHD
MUL_4852|M.ulcerans_Agy99           SIPWLLSVYSRRRGFKLSEHYTAPPMPFWFTADHYDELR-AIPGVRAVRE
                                                                         :    *    :  

Mflv_3385|M.gilvum_PYR-GCK          ATLFDASTAARASAPFKVLGRAVRAVPPLRNALQYHRYGFGPVS--
Mvan_3118|M.vanbaalenii_PYR-1       TTFFDASTYSRTGPGLQAAKRAVRLLPPLRNALQYHRYAYGPR---
MAB_2169c|M.abscessus_ATCC_199      ESPFDSETFQRTKAGYRLLARAMSLSPTLRYMAQYHRYAF------
MSMEG_6473|M.smegmatis_MC2_155      MSVFEDPVFDELAWHYRLLAKVMRPLSPLRYMAQYHRYAF------
MMAR_2971|M.marinum_M               T--HVGALCARIPSAPIRLLWRLVYATPVRNFDVLNRFAF------
MAV_2991|M.avium_104                S--PALAGYQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY------
Mb1184c|M.bovis_AF2122/97           LR--VPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv        LR--VPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
TH_0460|M.thermoresistible__bu      VP--IPRGRGVLVNTLIWAAQRTPLFDNVRGTYTLLEFGPPNSAST
MUL_4852|M.ulcerans_Agy99           LP--APAGRGRFLRWALPVAYRLPGLGRLRAPVTLVEFG-------
                                                                 *      .:

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_3385	-	-	100% (276)	O-methyltransferase domain-containing protein
M. gilvum PYR-GCK	Mflv_3375	-	1e-34	33.45% (281)	O-methyltransferase domain-containing protein
M. gilvum PYR-GCK	Mflv_2136	-	8e-28	30.08% (236)	O-methyltransferase domain-containing protein