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SAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVESIDFDFAKFGPTGQGFALRARAF DMAAQHYLDQHPAATVVALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLPPRWFAGWSRLGLRTSLRY KVPRMPFSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPAR G*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1153c | omt | - | 100% (282) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. tuberculosis H37Rv | Rv0830 | - | 1e-09 | 30.14% (209) | hypothetical protein Rv0830 |
| M. tuberculosis H37Rv | Rv3787c | - | 8e-07 | 28.19% (188) | hypothetical protein Rv3787c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 1e-161 | 99.29% (282) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_2136 | - | 2e-89 | 63.24% (272) | O-methyltransferase domain-containing protein |
| M. leprae Br4923 | MLBr_02640 | - | 5e-06 | 26.10% (249) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_0668c | - | 6e-76 | 56.06% (264) | O-methyltransferase OmT |
| M. marinum M | MMAR_4300 | omt_2 | 1e-122 | 78.89% (270) | O-methyltransferase Omt_2 |
| M. avium 104 | MAV_2991 | - | 6e-22 | 34.22% (187) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_5173 | - | 1e-100 | 65.70% (277) | O-methyltransferase, putative |
| M. thermoresistible (build 8) | TH_0460 | omt | 4e-97 | 66.42% (268) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_3020 | omt | 1e-80 | 57.95% (264) | O-methyltransferase Omt |
| M. vanbaalenii PYR-1 | Mvan_0979 | - | 1e-88 | 62.03% (266) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1153c|M.tuberculosis_H37Rv MS-AHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
Mb1184c|M.bovis_AF2122/97 MS-AHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
MMAR_4300|M.marinum_M MTPADEFAQQKVALTGVSETALLTLNARAAEARRRDPIIEDPMAVRLVDS
Mflv_2136|M.gilvum_PYR-GCK ---MSPTDKHSADLTGVSETALMTLLVRATEARRPDSLIDDPMAVKLVDS
MSMEG_5173|M.smegmatis_MC2_155 MT-TDATARTRVSLTGVSETALLTLQVRANEARRPDGLIKDPMAVQLVDS
TH_0460|M.thermoresistible__bu ---VSSGPLAKPELTGVSETALLTLLVRATEARRPDGIIDDPMAVRLVDS
MUL_3020|M.ulcerans_Agy99 -MGHSDNNVNAGMLGGVSETALLTLNGRAHQAAKPNPIIDDPMAIKLVES
Mvan_0979|M.vanbaalenii_PYR-1 -MDQ-DGKIDAGALAGVSETALLTLNGRAYQARHPNAIIDDPMAIRLVDA
MAB_0668c|M.abscessus_ATCC_199 -----MSGIDVRHLDGVSETALLTLHQRATEAARTDGILDDPMAISLHAS
MAV_2991|M.avium_104 MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAVDR
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
.* * ::. ** :: : :: *. *
Rv1153c|M.tuberculosis_H37Rv I--------DFDFAKFGPTG------QGFALRARAFDMAAQHYLDQHPAA
Mb1184c|M.bovis_AF2122/97 I--------DFGFAKFGPTG------QGFALRARAFDMAAQHYLDQHPAA
MMAR_4300|M.marinum_M I--------DFDFAKFGPTR------QDIALRALAFDTRALAYLNKHPSA
Mflv_2136|M.gilvum_PYR-GCK L--------DFDRAKFGFVRR-----QDMAVRALVFDKWTRRYLVDHPRA
MSMEG_5173|M.smegmatis_MC2_155 I--------DFDFAKFGHSHR-----QDMALRSLIFDRATSDYLRDHPKA
TH_0460|M.thermoresistible__bu I--------DFDFAKFGPSRR-----QDMALRAKAFDTATRRYLRAHPKA
MUL_3020|M.ulcerans_Agy99 N--------DFDFEKFGRR-G-----QEMALRSLAVDRCEIAYLTKHPGA
Mvan_0979|M.vanbaalenii_PYR-1 I--------DFDFDKFGRRKG-----QEMALRSLAFDRAATRYLSRHPAA
MAB_0668c|M.abscessus_ATCC_199 V--------DYDFAHFGRTH------QATALRALIFDKATREYLDYHPCA
MAV_2991|M.avium_104 I--------RYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDA
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNN
. . . : : :: :
Rv1153c|M.tuberculosis_H37Rv TVVA-------LAEGLQTSFWRLD--VAIPGGQFRWLTVDLPPIVDLRTR
Mb1184c|M.bovis_AF2122/97 TVVA-------LAEGLQTSFWRLD--VAIPGGQFRWLTVDLPPIVDLRTR
MMAR_4300|M.marinum_M TVVA-------LAEGLQTSFWRLD--SALPGKKFRWLTVDLPPIIDIRKR
Mflv_2136|M.gilvum_PYR-GCK TVVA-------LAEGLQTSFYRLDSGPESVGHDFRWLTVDLPPMIDLRTK
MSMEG_5173|M.smegmatis_MC2_155 TVVA-------LAEGLQTSFYRLN--EAGVGDQFCWLTVDLPPMVEIRNK
TH_0460|M.thermoresistible__bu TVVA-------LAEGLQTSFFRLN--AADVGDEFRWVTVDLAPVIELRRQ
MUL_3020|M.ulcerans_Agy99 TVVA-------HAEGFQTGFWRVS--NALPDTQFRWVSLDLEPVMELRRR
Mvan_0979|M.vanbaalenii_PYR-1 TVVA-------LAEGLQTSFWRLD--AAIPDSRFRWVSIDLEPVIALRRR
MAB_0668c|M.abscessus_ATCC_199 TVVA-------LAEGLQTSFWRVD------NGRLTWLSVDLEPIVRLRQR
MAV_2991|M.avium_104 VVLH-------LGCGLDGRAFRVS-----VPPSLSWFDVDQPSVIGLRRR
MLBr_02640|M.leprae_Br4923 AVIDGIRQFVILASGLDSRAYRLD-----WPTGTTVYEIDQPKVLAYKST
.*: . *:: :*:. :* :: :
Rv1153c|M.tuberculosis_H37Rv LLPSSPRVSVCAQS----ALDYSWMDSVDPA-----GGVFITAEGLLMYL
Mb1184c|M.bovis_AF2122/97 LLPSSPRVSVCAQS----ALDYSWMDSVDPA-----GGVFITAEGLLMYL
MMAR_4300|M.marinum_M LLPNSPRVSVCAQS----ALDYGWMDSVDTS-----GGVFITAEGLLMYL
Mflv_2136|M.gilvum_PYR-GCK LLPPSDRVRTLAQS----ALDFSWMDQVDTS-----EGVFITAEGLLMYL
MSMEG_5173|M.smegmatis_MC2_155 LLPPSDRVRTCAQS----ALDYSWMDQVDDS-----EGVFITAEGLLMYL
TH_0460|M.thermoresistible__bu LLPADDRVTMLAQS----ALDYSWMDRIDTS-----EGVFITAEGLLMYL
MUL_3020|M.ulcerans_Agy99 LLPDSARVTNLAQS----ALDYTWMDKVDSC-----AAVFITAEGLLMYP
Mvan_0979|M.vanbaalenii_PYR-1 LLPDSPRITTLAQS----ALDYSWMDAVDTT-----DGVFITAEGLLMYL
MAB_0668c|M.abscessus_ATCC_199 LLPRSERLSHCAQS----ALDYSWMDRVDDS-----AGVLITAEGLFQYL
MAV_2991|M.avium_104 LYDDTENYRMIGSS----VTELQWLDEVPAG-----RPTLMVAEGLLMYL
MLBr_02640|M.leprae_Br4923 TLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYL
* : . ****: *
Rv1153c|M.tuberculosis_H37Rv QPEQALGLIAQCAQTFPGGQMLFDLPPRWFAGWSRLGLRTSLRYKVPRMP
Mb1184c|M.bovis_AF2122/97 QPEQALGLIAQCAQTFPGGQMLFDLPPRWFAGWSRLGLRTSLRYKVPRMP
MMAR_4300|M.marinum_M EPDQALDLIAQCAKRFPGAQMLFDLPPRWFSLFTRLGMRTSIRYKIPPMP
Mflv_2136|M.gilvum_PYR-GCK QPAEAMSLITECAARFPGGQMIFDLPPSAFAFLVGRGVRASLRYRVPPMP
MSMEG_5173|M.smegmatis_MC2_155 QPEESMGLIKECARRFPGGQMIFDLPPSWFAAWARKGMRTSRRYRVPPMP
TH_0460|M.thermoresistible__bu QPDEAMGLIRECARRFPGGQMMFDLPPSFFAWLTRRGFRTSLRYKVPPMP
MUL_3020|M.ulcerans_Agy99 QPNQAMELISQCAKRFAGGQMFFDLPPTIVKRVAPKGMRASRRYRVPPMP
Mvan_0979|M.vanbaalenii_PYR-1 QPDEAMDLITACASRFPGGQMIFDLPPTMVKKIAPKGMRSSARYRVPPMP
MAB_0668c|M.abscessus_ATCC_199 ERDLVFDLISVCAQRFPGGRLIFDSVPKFLSTHSQRGIRLSEQYVVPPMP
MAV_2991|M.avium_104 REDEVRRLLQRLIDRFPGGEMHFDTLSALAPLLSKVFTRGIITWGIR---
MLBr_02640|M.leprae_Br4923 PATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDALG
*: . . . :
Rv1153c|M.tuberculosis_H37Rv FSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTVYRLPVFDP-
Mb1184c|M.bovis_AF2122/97 FSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTVYRLPVFDP-
MMAR_4300|M.marinum_M FSLSVAQAADLVNTIPGIRAVRDVQLPAGRGLMFNAALSTVYRLPALDS-
Mflv_2136|M.gilvum_PYR-GCK FSLTIAEAADLVNTVPGVRAVHDLPAEHARGRLINALLWTAQRVPLLDP-
MSMEG_5173|M.smegmatis_MC2_155 FSLSPAEVADLVNTVPGVRVVHDLPFPPARGKFMRTVVWGVQRLPLFDP-
TH_0460|M.thermoresistible__bu FTLSPEQAADLVNTVPGVQAVHDVPIPRGRGVLVNTLIWAAQRTPLFDN-
MUL_3020|M.ulcerans_Agy99 FSLSVNQLARLVDTVPGIRAVHDVPMPEGRGLFFRTLYPALWRFPPIKP-
Mvan_0979|M.vanbaalenii_PYR-1 FSLSPAQLAELVHTVPGVTAVHDLPMPRGRGFLFERVFPAFWQFKPTRN-
MAB_0668c|M.abscessus_ATCC_199 FSFTANQYDELR-AIPGIRSVRELRMPAGRGKVLRWAAPLLYALPGLDR-
MAV_2991|M.avium_104 ------DARRIADWNPRLRFLEQSPALAGYQRIPSTVVRSIYRLTWLTG-
MLBr_02640|M.leprae_Br4923 FEQ-AVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDG
: : : : .
Rv1153c|M.tuberculosis_H37Rv ---LRPCLTLLEFSRPARG--
Mb1184c|M.bovis_AF2122/97 ---LRPCLTLLEFSRPARG--
MMAR_4300|M.marinum_M ---LRPCLTLLEFG-------
Mflv_2136|M.gilvum_PYR-GCK ---IRPMFTLLEFG-------
MSMEG_5173|M.smegmatis_MC2_155 ---IRPVMALLEFG-------
TH_0460|M.thermoresistible__bu ---VRGTYTLLEFGPPNSAST
MUL_3020|M.ulcerans_Agy99 ---FRGAYVLLEFD-------
Mvan_0979|M.vanbaalenii_PYR-1 ---YRGAYTLLEFG-------
MAB_0668c|M.abscessus_ATCC_199 ---WRAPHTVVEFG-------
MAV_2991|M.avium_104 ---GRGYDVLNRFEY------
MLBr_02640|M.leprae_Br4923 VPMADDKDAFAEFVTAHRL--
.. .*