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TETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTAAAEAVQRIEYDWGRMDRTMWPATSQYMV TMRAKQFDDWCTDFLGRHRNAVVLHLGCGMDTRAFRLHPPQSAQWYDVDQPDVIALRRKLYDDCAGYRMI GSSVTDEAWLDEIPTDRPTLLVAEGLLMYLTEPEVRMLLQRVTDRFGAGELAFDTTSPLGPRLSKAFTKG ITKWGISDVRDLQQWNPRLRFLEQTHVGALCARIPSAPIRLLWRLVYATPVRNFDVLNRFAF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2971 | - | - | 100% (273) | O-methyltransferase |
| M. marinum M | MMAR_2317 | - | 2e-37 | 35.66% (244) | O-methyltransferase |
| M. marinum M | MMAR_4300 | omt_2 | 9e-21 | 30.05% (213) | O-methyltransferase Omt_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 2e-16 | 28.87% (194) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3385 | - | 2e-47 | 41.22% (262) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 3e-17 | 29.38% (194) | O-methyltransferase |
| M. leprae Br4923 | MLBr_02640 | - | 9e-05 | 28.93% (121) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_4610c | - | 2e-78 | 53.87% (271) | O-methyltransferase-like |
| M. avium 104 | MAV_2991 | - | 1e-101 | 65.20% (273) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 3e-51 | 47.06% (238) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0783 | omt | 8e-23 | 33.81% (210) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 3e-16 | 30.51% (177) | O-methyltransferase Omt_1 |
| M. vanbaalenii PYR-1 | Mvan_3118 | - | 8e-45 | 40.36% (223) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2971|M.marinum_M MTETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTAAAEAVQR
MAV_2991|M.avium_104 MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAVDR
MAB_4610c|M.abscessus_ATCC_199 --MTAKVDFSDVEWRSVTWTMLVTLFLRAYESRSPRSILNDRAAAELVDR
Mflv_3385|M.gilvum_PYR-GCK MTDKVSIDLTGPAQ-----TMLTTLYLKALDADFDRPVLGDRFAKEAIER
Mvan_3118|M.vanbaalenii_PYR-1 MSNKVPVDLSGPAK-----TMLSTLYLKALDADFDRPVLGDRFAKAAIDK
MSMEG_6473|M.smegmatis_MC2_155 MTDKLKVDLSGAPQ-----TMLATFYAKALDARLPTPILGDDMAAEIAER
Mb1184c|M.bovis_AF2122/97 MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
Rv1153c|M.tuberculosis_H37Rv MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
TH_0783|M.thermoresistible__bu VHESNPDKLDASTLSGVSETALMTLYGRAEQARHPQPIIDDPMAVRLVDR
MUL_4852|M.ulcerans_Agy99 ----MP-VIDARHLDDISETALLTLHQRATEAARPDAIIDDPMAIALRND
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
* : . :* :: .:: * *
MMAR_2971|M.marinum_M IEY--------DWGRMDRTMWPATSQYMVTMRAKQFDDWCTDFLGRHRNA
MAV_2991|M.avium_104 IRY--------DFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDA
MAB_4610c|M.abscessus_ATCC_199 IDY--------DWPRIERTTAPRSNQYTVTLRARALDDWTGEFLTAHPDA
Mflv_3385|M.gilvum_PYR-GCK IDY--------DWADLGVTGRWAP---IVTVRTAQYDIWAKQFIAAHGDC
Mvan_3118|M.vanbaalenii_PYR-1 LDF--------DWRELEITPKWAP---LFTVRTALYDGWVREFIAAHPEC
MSMEG_6473|M.smegmatis_MC2_155 IDY--------DWSRTAITPSRAP---AVTTRSRHFDRWARQFLAVHPEA
Mb1184c|M.bovis_AF2122/97 IDF--------GFAKFGPTGQGFA------LRARAFDMAAQHYLDQHPAA
Rv1153c|M.tuberculosis_H37Rv IDF--------DFAKFGPTGQGFA------LRARAFDMAAQHYLDQHPAA
TH_0783|M.thermoresistible__bu IDF--------DFTKFGRRGQEMA------LRSLAFDRAALRYLSDHPRA
MUL_4852|M.ulcerans_Agy99 IDY--------PYHHFGRTHQATA------LRALAFDNSTRDFLQTRPGA
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNN
. : : ::
MMAR_2971|M.marinum_M VVLH-------LGCGMDTRAFRLH---PPQSAQWYDVDQPDVIALRRKLY
MAV_2991|M.avium_104 VVLH-------LGCGLDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLY
MAB_4610c|M.abscessus_ATCC_199 TVLH-------LGCGLDSRAFRLN---LPADVRWFDVDMPEVIAMRRRVI
Mflv_3385|M.gilvum_PYR-GCK TVVH-------LGCGLDSRVFRVD---PGPNVQWYDVDFPGVIELREKVY
Mvan_3118|M.vanbaalenii_PYR-1 TVVH-------LGCGLDCRVFRVD---PGPDVRWYDVDFPQVIALREQIY
MSMEG_6473|M.smegmatis_MC2_155 VVLH-------LGCGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLY
Mb1184c|M.bovis_AF2122/97 TVVA-------LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLL
Rv1153c|M.tuberculosis_H37Rv TVVA-------LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLL
TH_0783|M.thermoresistible__bu TVVA-------LAEGLQTTFWRVTDAIPDARFRWLTIDLPPIIELRERLL
MUL_4852|M.ulcerans_Agy99 TVVA-------LAEGLQTSFWRLD----NGELNWLSVDLAPIVRLREQLL
MLBr_02640|M.leprae_Br4923 AVIDGIRQFVILASGLDSRAYRLD---WPTGTTVYEIDQPKVLAYKSTTL
.*: *. *:: :*: :* . :: :
MMAR_2971|M.marinum_M DDCAGYRMIGSSVTDEAWLDEIP---------TDRPTLLVAEGLLMYLTE
MAV_2991|M.avium_104 DDTENYRMIGSSVTELQWLDEVP---------AGRPTLMVAEGLLMYLRE
MAB_4610c|M.abscessus_ATCC_199 EERTGYRMIASSVTGAAWFDDIP---------TDRPTLVVAEGLVMYLTE
Mflv_3385|M.gilvum_PYR-GCK PSRPNYHLLPTPATELSWLDQIP---------TGKPLLFLAEGISMYLTE
Mvan_3118|M.vanbaalenii_PYR-1 PTRPNYQLIATPATEPNWLDEIP---------ADRPTLLIAEGISMYLTE
MSMEG_6473|M.smegmatis_MC2_155 PEHARCHLVSASVTDPAWLDEVP---------TGRPALMLGEGLTMYLTE
Mb1184c|M.bovis_AF2122/97 PSSPRVSVCAQSALDYSWMDSVD---------PAGGVFITAEGLLMYLQP
Rv1153c|M.tuberculosis_H37Rv PSSPRVSVCAQSALDYSWMDSVD---------PAGGVFITAEGLLMYLQP
TH_0783|M.thermoresistible__bu PAEPRIVTLAQSALDFSWMDRVD---------TDHGVLITAEGLLMYLQP
MUL_4852|M.ulcerans_Agy99 PACDRLRYCAQSAFDYSWMEQVD---------DTNGVLITAEGLFQYLRR
MLBr_02640|M.leprae_Br4923 AEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPA
: .**: **
MMAR_2971|M.marinum_M PEVRMLLQRVTDRFGAG-ELAFDTTSPLGPRLSK----------AFTKGI
MAV_2991|M.avium_104 DEVRRLLQRLIDRFPGG-EMHFDTLSALAPLLSK----------VFTRGI
MAB_4610c|M.abscessus_ATCC_199 DEIRELLQRITDRFPSG-QIVFDAMPPSIVRAQK----------LFKS--
Mflv_3385|M.gilvum_PYR-GCK DEGVALLRRVVERFGSG-ELQIDFYNWLPIKSQKTQTLV-----RKTGST
Mvan_3118|M.vanbaalenii_PYR-1 DEGIALLRRFIDRFGAG-ELQIDFFNWLAIKSQKSQSLV-----RTSGSV
MSMEG_6473|M.smegmatis_MC2_155 TEGLALLRRVVDRFGTG-ELQFDAFNTFGIRTQWTNTVV-----RRSGAT
Mb1184c|M.bovis_AF2122/97 EQALGLIAQCAQTFPGG-QMLFDLPPRWFAGWSR-LGLRTSLRYKVPRMP
Rv1153c|M.tuberculosis_H37Rv EQALGLIAQCAQTFPGG-QMLFDLPPRWFAGWSR-LGLRTSLRYKVPRMP
TH_0783|M.thermoresistible__bu DEAMTLIERCAARFPGG-QMLFDLPPVLLKKLAP-KGLRASRRYRVPPMP
MUL_4852|M.ulcerans_Agy99 DVVFELIAACAKRVPHG-QLVFDSIPWLLSVYSRRRGFKLSEHYTAPPMP
MLBr_02640|M.leprae_Br4923 TAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLR--FRRVSDALG
*: * .: .:
MMAR_2971|M.marinum_M TKWGISDVRDLQQWNPRLRFLEQTHVGALCARIPS--APIR-LLWRLVYA
MAV_2991|M.avium_104 ITWGIRDARRIADWNPRLRFLEQSPALAGYQRIPS--TVVR-SIYRLTWL
MAB_4610c|M.abscessus_ATCC_199 ---SIRSAAQVQGWNRRLRCVEETTPWRLYPLVPS--RFLRGIYWAMASL
Mflv_3385|M.gilvum_PYR-GCK LYWAVNSPEDILSKVPGTRLLAAATLFDASTAARAS-APFKVLGRAVRAV
Mvan_3118|M.vanbaalenii_PYR-1 LYWAVNSPQDILSKLPDIRLLAATTFFDASTYSRTG-PGLQAAKRAVRLL
MSMEG_6473|M.smegmatis_MC2_155 LRWAIDRPDDILDTVPGTRLLAWMSVFEDPVFDELA-WHYRLLAKVMRPL
Mb1184c|M.bovis_AF2122/97 FSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVN---MALSTVYRLPVF
Rv1153c|M.tuberculosis_H37Rv FSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVN---MALSTVYRLPVF
TH_0783|M.thermoresistible__bu FSLSPAQLARLADTVPGVRAVHDLPMPEGRGFFFR---AVFPRFWQARPT
MUL_4852|M.ulcerans_Agy99 FWFTADHYDELR-AIPGVRAVRELPAPAGRGRFLR---WALPVAYRLPGL
MLBr_02640|M.leprae_Br4923 FEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGV
:
MMAR_2971|M.marinum_M TPVRNFDVLNRFAF----
MAV_2991|M.avium_104 TGGRGYDVLNRFEY----
MAB_4610c|M.abscessus_ATCC_199 PWLRSFERLYRFSF----
Mflv_3385|M.gilvum_PYR-GCK PPLRNALQYHRYGFGPVS
Mvan_3118|M.vanbaalenii_PYR-1 PPLRNALQYHRYAYGPR-
MSMEG_6473|M.smegmatis_MC2_155 SPLRYMAQYHRYAF----
Mb1184c|M.bovis_AF2122/97 DPLRPCLTLLEFSRPARG
Rv1153c|M.tuberculosis_H37Rv DPLRPCLTLLEFSRPARG
TH_0783|M.thermoresistible__bu RQWRGAYTLLEFG-----
MUL_4852|M.ulcerans_Agy99 GRLRAPVTLVEFG-----
MLBr_02640|M.leprae_Br4923 PMADDKDAFAEFVTAHRL
.: