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SDRLRVDLHGSPQTMLATLYAKALDAGAPDSVLNDTWARDIVDRIDYDWSSTTITTRNAPSVTLRSAHFD FWTEQFLAAHPRAVVVHLGCGLDSRFLRVQPGDGVDWYDVDYPQVAALRERFYPVRPGNHVVAASVTDPA WLADIPDDRPALVIGEGLTMYLREADGVALLRRVVDRFPSGELQFDAFNWLGIKAQWSNAVVRRSGSTLY WAINGPADILDSVPGTRLLQWVPVFESDVFDRLPGVYRLLGAVMNRIPAARTMSQFHRYAF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5704 | - | - | 100% (272) | O-methyltransferase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3118 | - | 5e-79 | 51.65% (273) | O-methyltransferase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3107 | - | 5e-37 | 36.57% (268) | O-methyltransferase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 9e-24 | 30.47% (279) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3385 | - | 7e-82 | 51.47% (272) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 1e-24 | 30.82% (279) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2169c | - | 1e-101 | 62.36% (271) | O-methyltransferase |
| M. marinum M | MMAR_2971 | - | 2e-44 | 40.46% (262) | O-methyltransferase |
| M. avium 104 | MAV_2991 | - | 2e-41 | 39.34% (244) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 1e-102 | 63.97% (272) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0460 | omt | 1e-27 | 29.70% (266) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 2e-23 | 30.71% (267) | O-methyltransferase Omt_1 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2169c|M.abscessus_ATCC_199 --MSHSEKIHVDLSGAPQ-----TMLATFYAKALDAGLPEPILGDQLARD
MSMEG_6473|M.smegmatis_MC2_155 ----MTDKLKVDLSGAPQ-----TMLATFYAKALDARLPTPILGDDMAAE
Mvan_5704|M.vanbaalenii_PYR-1 ----MSDRLRVDLHGSPQ-----TMLATLYAKALDAGAPDSVLNDTWARD
Mflv_3385|M.gilvum_PYR-GCK ----MTDKVSIDLTGPAQ-----TMLTTLYLKALDADFDRPVLGDRFAKE
MMAR_2971|M.marinum_M ----MTETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTAAAE
MAV_2991|M.avium_104 ----MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAE
Mb1184c|M.bovis_AF2122/97 MSAHKPAKQRVALTGVSE-----TALLTLNARAAEARRRDTIIDDPMAVA
Rv1153c|M.tuberculosis_H37Rv MSAHKPAKQRVALTGVSE-----TALLTLNARAAEARRRDAIIDDPMAVA
TH_0460|M.thermoresistible__bu VSSGPLAKP--ELTGVSE-----TALLTLLVRATEARRPDGIIDDPMAVR
MUL_4852|M.ulcerans_Agy99 ----MPVIDARHLDDISE-----TALLTLHQRATEAARPDAIIDDPMAIA
: . * * *: :* :: ::.* *
MAB_2169c|M.abscessus_ATCC_199 IAQRIDYDWS---KTTITAGRSPAVTTRSAHFDEWCRAFLSRHAEAVVLH
MSMEG_6473|M.smegmatis_MC2_155 IAERIDYDWS---RTAITPSRAPAVTTRSRHFDRWARQFLAVHPEAVVLH
Mvan_5704|M.vanbaalenii_PYR-1 IVDRIDYDWS---STTITTRNAPSVTLRSAHFDFWTEQFLAAHPRAVVVH
Mflv_3385|M.gilvum_PYR-GCK AIERIDYDWA---DLGVTGRWAPIVTVRTAQYDIWAKQFIAAHGDCTVVH
MMAR_2971|M.marinum_M AVQRIEYDWGRMDRTMWPATSQYMVTMRAKQFDDWCTDFLGRHRNAVVLH
MAV_2991|M.avium_104 AVDRIRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLH
Mb1184c|M.bovis_AF2122/97 LVESIDFGFA-----KFGPTG-QGFALRARAFDMAAQHYLDQHPAATVVA
Rv1153c|M.tuberculosis_H37Rv LVESIDFDFA-----KFGPTG-QGFALRARAFDMAAQHYLDQHPAATVVA
TH_0460|M.thermoresistible__bu LVDSIDFDFA-----KFGPSRRQDMALRAKAFDTATRRYLRAHPKATVVA
MUL_4852|M.ulcerans_Agy99 LRNDIDYPYH-----HFGRTH-QATALRALAFDNSTRDFLQTRPGATVVA
: * : : : *: :* :: : ..*:
MAB_2169c|M.abscessus_ATCC_199 LGCGLDGRYFRLN---PGPGIEWYDIDYPDVARLRSQLYPTRDHYHVVSA
MSMEG_6473|M.smegmatis_MC2_155 LGCGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEHARCHLVSA
Mvan_5704|M.vanbaalenii_PYR-1 LGCGLDSRFLRVQ---PGDGVDWYDVDYPQVAALRERFYPVRPGNHVVAA
Mflv_3385|M.gilvum_PYR-GCK LGCGLDSRVFRVD---PGPNVQWYDVDFPGVIELREKVYPSRPNYHLLPT
MMAR_2971|M.marinum_M LGCGMDTRAFRLH---PPQSAQWYDVDQPDVIALRRKLYDDCAGYRMIGS
MAV_2991|M.avium_104 LGCGLDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLYDDTENYRMIGS
Mb1184c|M.bovis_AF2122/97 LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQ
Rv1153c|M.tuberculosis_H37Rv LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQ
TH_0460|M.thermoresistible__bu LAEGLQTSFFRLNAADVGDEFRWVTVDLAPVIELRRQLLPADDRVTMLAQ
MUL_4852|M.ulcerans_Agy99 LAEGLQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQ
*. *:: *: * :* . : ** :.
MAB_2169c|M.abscessus_ATCC_199 SVTDPAWLANIADSRPVLAIGEGLTMYLKEDDGIALFRRIVDHFPYGELQ
MSMEG_6473|M.smegmatis_MC2_155 SVTDPAWLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGELQ
Mvan_5704|M.vanbaalenii_PYR-1 SVTDPAWLADIPDDRPALVIGEGLTMYLREADGVALLRRVVDRFPSGELQ
Mflv_3385|M.gilvum_PYR-GCK PATELSWLDQIPTGKPLLFLAEGISMYLTEDEGVALLRRVVERFGSGELQ
MMAR_2971|M.marinum_M SVTDEAWLDEIPTDRPTLLVAEGLLMYLTEPEVRMLLQRVTDRFGAGELA
MAV_2991|M.avium_104 SVTELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMH
Mb1184c|M.bovis_AF2122/97 SALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQML
Rv1153c|M.tuberculosis_H37Rv SALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQML
TH_0460|M.thermoresistible__bu SALDYSWMDRIDTSEGVFITAEGLLMYLQPDEAMGLIRECARRFPGGQMM
MUL_4852|M.ulcerans_Agy99 SAFDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRVPHGQLV
.. : *: : : .**: ** *: . *::
MAB_2169c|M.abscessus_ATCC_199 FDAFN-----KFGIKTQWSNAVVRRSGATLYWGIDRPEDLIRAIPKLQLL
MSMEG_6473|M.smegmatis_MC2_155 FDAFN-----TFGIRTQWTNTVVRRSGATLRWAIDRPDDILDTVPGTRLL
Mvan_5704|M.vanbaalenii_PYR-1 FDAFN-----WLGIKAQWSNAVVRRSGSTLYWAINGPADILDSVPGTRLL
Mflv_3385|M.gilvum_PYR-GCK IDFYN-----WLPIKSQKTQTLVRKTGSTLYWAVNSPEDILSKVPGTRLL
MMAR_2971|M.marinum_M FDTTS-----PLGP--RLSKAFTKG---ITKWGISDVRDLQQWNPRLRFL
MAV_2991|M.avium_104 FDTLS-----ALAP--LLSKVFTRG---IITWGIRDARRIADWNPRLRFL
Mb1184c|M.bovis_AF2122/97 FDLPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAV
Rv1153c|M.tuberculosis_H37Rv FDLPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAV
TH_0460|M.thermoresistible__bu FDLPPSFFAWLTR-RGFRTSLRYKVPPMPFTLSPEQAADLVNTVPGVQAV
MUL_4852|M.ulcerans_Agy99 FDSIPWLLSVYSRRRGFKLSEHYTAPPMPFWFTADHYDELR-AIPGVRAV
:* . : * :
MAB_2169c|M.abscessus_ATCC_199 EWESPFDSETFQRTKAGYRLLARAMSLSPTLRYMAQYHRYAF------
MSMEG_6473|M.smegmatis_MC2_155 AWMSVFEDPVFDELAWHYRLLAKVMRPLSPLRYMAQYHRYAF------
Mvan_5704|M.vanbaalenii_PYR-1 QWVPVFESDVFDRLPGVYRLLGAVMNRIPAARTMSQFHRYAF------
Mflv_3385|M.gilvum_PYR-GCK AAATLFDASTAARASAPFKVLGRAVRAVPPLRNALQYHRYGFGPVS--
MMAR_2971|M.marinum_M EQTHVGAL--CARIPSAPIRLLWRLVYATPVRNFDVLNRFAF------
MAV_2991|M.avium_104 EQSPALAG--YQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY------
Mb1184c|M.bovis_AF2122/97 RDLRVPPG--RGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv RDLRVPPG--RGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
TH_0460|M.thermoresistible__bu HDVPIPRG--RGVLVNTLIWAAQRTPLFDNVRGTYTLLEFGPPNSAST
MUL_4852|M.ulcerans_Agy99 RELPAPAG--RGRFLRWALPVAYRLPGLGRLRAPVTLVEFG-------
* .: