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TDKLKVDLSGAPQTMLATFYAKALDARLPTPILGDDMAAEIAERIDYDWSRTAITPSRAPAVTTRSRHFD RWARQFLAVHPEAVVLHLGCGLDGRFFRLAPGPGVEWFDVDYPEVIDLRSQLYPEHARCHLVSASVTDPA WLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGELQFDAFNTFGIRTQWTNTVVRRSGATLR WAIDRPDDILDTVPGTRLLAWMSVFEDPVFDELAWHYRLLAKVMRPLSPLRYMAQYHRYAF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6473 | - | - | 100% (272) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_5173 | - | 1e-25 | 29.66% (236) | O-methyltransferase, putative |
| M. smegmatis MC2 155 | MSMEG_6661 | - | 1e-24 | 33.52% (182) | O-methyltransferase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 1e-26 | 30.08% (266) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3385 | - | 9e-85 | 52.21% (272) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 2e-27 | 30.45% (266) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2169c | - | 1e-107 | 66.79% (271) | O-methyltransferase |
| M. marinum M | MMAR_2971 | - | 3e-51 | 47.06% (238) | O-methyltransferase |
| M. avium 104 | MAV_2991 | - | 3e-46 | 42.29% (253) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0460 | omt | 9e-30 | 30.86% (269) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_3020 | omt | 6e-20 | 26.44% (261) | O-methyltransferase Omt |
| M. vanbaalenii PYR-1 | Mvan_5704 | - | 1e-102 | 63.97% (272) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6473|M.smegmatis_MC2_155 ----MTDKLKVDLSGAPQ-----TMLATFYAKALDARLPTPILGDDMAAE
MAB_2169c|M.abscessus_ATCC_199 --MSHSEKIHVDLSGAPQ-----TMLATFYAKALDAGLPEPILGDQLARD
Mvan_5704|M.vanbaalenii_PYR-1 ----MSDRLRVDLHGSPQ-----TMLATLYAKALDAGAPDSVLNDTWARD
Mflv_3385|M.gilvum_PYR-GCK ----MTDKVSIDLTGPAQ-----TMLTTLYLKALDADFDRPVLGDRFAKE
MMAR_2971|M.marinum_M ----MTETHKVDFSDVRWGSVEWTNLCTLYLRACESRSPAPILGDTAAAE
MAV_2991|M.avium_104 ----MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAE
Mb1184c|M.bovis_AF2122/97 MSAHKPAKQRVALTGVSE-----TALLTLNARAAEARRRDTIIDDPMAVA
Rv1153c|M.tuberculosis_H37Rv MSAHKPAKQRVALTGVSE-----TALLTLNARAAEARRRDAIIDDPMAVA
TH_0460|M.thermoresistible__bu VSSGPLAKP--ELTGVSE-----TALLTLLVRATEARRPDGIIDDPMAVR
MUL_3020|M.ulcerans_Agy99 MGHSDNNVNAGMLGGVSE-----TALLTLNGRAHQAAKPNPIIDDPMAIK
: . * * *: :* :: ::.* *
MSMEG_6473|M.smegmatis_MC2_155 IAERIDYDWS---RTAITPSRAPAVTTRSRHFDRWARQFLAVHPEAVVLH
MAB_2169c|M.abscessus_ATCC_199 IAQRIDYDWS---KTTITAGRSPAVTTRSAHFDEWCRAFLSRHAEAVVLH
Mvan_5704|M.vanbaalenii_PYR-1 IVDRIDYDWS---STTITTRNAPSVTLRSAHFDFWTEQFLAAHPRAVVVH
Mflv_3385|M.gilvum_PYR-GCK AIERIDYDWA---DLGVTGRWAPIVTVRTAQYDIWAKQFIAAHGDCTVVH
MMAR_2971|M.marinum_M AVQRIEYDWGRMDRTMWPATSQYMVTMRAKQFDDWCTDFLGRHRNAVVLH
MAV_2991|M.avium_104 AVDRIRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLH
Mb1184c|M.bovis_AF2122/97 LVESIDFGFA-----KFGPTG-QGFALRARAFDMAAQHYLDQHPAATVVA
Rv1153c|M.tuberculosis_H37Rv LVESIDFDFA-----KFGPTG-QGFALRARAFDMAAQHYLDQHPAATVVA
TH_0460|M.thermoresistible__bu LVDSIDFDFA-----KFGPSRRQDMALRAKAFDTATRRYLRAHPKATVVA
MUL_3020|M.ulcerans_Agy99 LVESNDFDFE-----KFGRRG-QEMALRSLAVDRCEIAYLTKHPGATVVA
: :.: .: *: * :: * ..*:
MSMEG_6473|M.smegmatis_MC2_155 LGCGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEHARCHLVSA
MAB_2169c|M.abscessus_ATCC_199 LGCGLDGRYFRLN---PGPGIEWYDIDYPDVARLRSQLYPTRDHYHVVSA
Mvan_5704|M.vanbaalenii_PYR-1 LGCGLDSRFLRVQ---PGDGVDWYDVDYPQVAALRERFYPVRPGNHVVAA
Mflv_3385|M.gilvum_PYR-GCK LGCGLDSRVFRVD---PGPNVQWYDVDFPGVIELREKVYPSRPNYHLLPT
MMAR_2971|M.marinum_M LGCGMDTRAFRLH---PPQSAQWYDVDQPDVIALRRKLYDDCAGYRMIGS
MAV_2991|M.avium_104 LGCGLDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLYDDTENYRMIGS
Mb1184c|M.bovis_AF2122/97 LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQ
Rv1153c|M.tuberculosis_H37Rv LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQ
TH_0460|M.thermoresistible__bu LAEGLQTSFFRLNAADVGDEFRWVTVDLAPVIELRRQLLPADDRVTMLAQ
MUL_3020|M.ulcerans_Agy99 HAEGFQTGFWRVSNALPDTQFRWVSLDLEPVMELRRRLLPDSARVTNLAQ
. *:: *: * :* : ** :.
MSMEG_6473|M.smegmatis_MC2_155 SVTDPAWLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGELQ
MAB_2169c|M.abscessus_ATCC_199 SVTDPAWLANIADSRPVLAIGEGLTMYLKEDDGIALFRRIVDHFPYGELQ
Mvan_5704|M.vanbaalenii_PYR-1 SVTDPAWLADIPDDRPALVIGEGLTMYLREADGVALLRRVVDRFPSGELQ
Mflv_3385|M.gilvum_PYR-GCK PATELSWLDQIPTGKPLLFLAEGISMYLTEDEGVALLRRVVERFGSGELQ
MMAR_2971|M.marinum_M SVTDEAWLDEIPTDRPTLLVAEGLLMYLTEPEVRMLLQRVTDRFGAGELA
MAV_2991|M.avium_104 SVTELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMH
Mb1184c|M.bovis_AF2122/97 SALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQML
Rv1153c|M.tuberculosis_H37Rv SALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQML
TH_0460|M.thermoresistible__bu SALDYSWMDRIDTSEGVFITAEGLLMYLQPDEAMGLIRECARRFPGGQMM
MUL_3020|M.ulcerans_Agy99 SALDYTWMDKVDSCAAVFITAEGLLMYPQPNQAMELISQCAKRFAGGQMF
.. : *: : : .**: ** : *: . * *::
MSMEG_6473|M.smegmatis_MC2_155 FDA----FNTFGIRTQWTNTVVRRSGATLRWAIDRPDDILDTVPGTRLLA
MAB_2169c|M.abscessus_ATCC_199 FDA----FNKFGIKTQWSNAVVRRSGATLYWGIDRPEDLIRAIPKLQLLE
Mvan_5704|M.vanbaalenii_PYR-1 FDA----FNWLGIKAQWSNAVVRRSGSTLYWAINGPADILDSVPGTRLLQ
Mflv_3385|M.gilvum_PYR-GCK IDF----YNWLPIKSQKTQTLVRKTGSTLYWAVNSPEDILSKVPGTRLLA
MMAR_2971|M.marinum_M FDT----TSPLGP--RLSKAFTKG---ITKWGISDVRDLQQWNPRLRFLE
MAV_2991|M.avium_104 FDT----LSALAP--LLSKVFTRG---IITWGIRDARRIADWNPRLRFLE
Mb1184c|M.bovis_AF2122/97 FDLPPRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVR
Rv1153c|M.tuberculosis_H37Rv FDLPPRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVR
TH_0460|M.thermoresistible__bu FDLPPSFFAWLTRRGFRTSLRYKVPPMPFTLSPEQAADLVNTVPGVQAVH
MUL_3020|M.ulcerans_Agy99 FDLPPTIVKRVAPKGMRASRRYRVPPMPFSLSVNQLARLVDTVPGIRAVH
:* :. : . : * :
MSMEG_6473|M.smegmatis_MC2_155 WMSVFEDPVFDELAWHYRLLAKVMRPLSPLRYMAQYHRYAF------
MAB_2169c|M.abscessus_ATCC_199 WESPFDSETFQRTKAGYRLLARAMSLSPTLRYMAQYHRYAF------
Mvan_5704|M.vanbaalenii_PYR-1 WVPVFESDVFDRLPGVYRLLGAVMNRIPAARTMSQFHRYAF------
Mflv_3385|M.gilvum_PYR-GCK AATLFDASTAARASAPFKVLGRAVRAVPPLRNALQYHRYGFGPVS--
MMAR_2971|M.marinum_M QTHVGAL--CARIPSAPIRLLWRLVYATPVRNFDVLNRFAF------
MAV_2991|M.avium_104 QSPALAG--YQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY------
Mb1184c|M.bovis_AF2122/97 DLRVPPG--RGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv DLRVPPG--RGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
TH_0460|M.thermoresistible__bu DVPIPRG--RGVLVNTLIWAAQRTPLFDNVRGTYTLLEFGPPNSAST
MUL_3020|M.ulcerans_Agy99 DVPMPEG--RGLFFRTLYPALWRFPPIKPFRGAYVLLEFD-------
* .: