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STTQLINPATEEVLASVDHTDANAVDDAVQRARAAQRRWARLAPAQRAAGLRAFAAAVQAHLDELAALEV ANSGHPIVSAEWEAGHVRDVLAFYAASPERLSGRQIPVAGGVDVTFNEPMGVVGVITPWNFPMVIASWAI APALAAGNAVLVKPAELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEV GKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNAGQDCCARSRILVQRSVYDRFME LLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKVAGYVPDDAPVAFRGTAPAGRGFWFPPTVLTPKRGDRT VTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESGNLSVNSHSSVRFNTPF GGFKQSGVGRELGPDAPLQFTETKNVFIAVGEEM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2858c | aldC | - | 100% (455) | PROBABLE ALDEHYDE DEHYDROGENASE ALDC |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-76 | 37.23% (470) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 5e-72 | 38.12% (467) | aldehyde dehydrogenase NAD dependent AldA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 0.0 | 100.00% (455) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4063 | - | 0.0 | 81.68% (453) | betaine-aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 6e-59 | 33.33% (453) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 7e-91 | 41.63% (454) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 7e-93 | 40.56% (461) | aldehyde dehydrogenase |
| M. avium 104 | MAV_2765 | - | 2e-88 | 38.91% (460) | P-cumic aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2597 | - | 0.0 | 80.93% (451) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4531 | - | 9e-79 | 38.26% (460) | PUTATIVE putative betaine aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 2e-91 | 40.35% (461) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2280 | - | 0.0 | 82.26% (451) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2858c|M.tuberculosis_H37Rv --------------------MS---TTQLINPATEEVLASVDHTDANAVD
Mb2883c|M.bovis_AF2122/97 --------------------MS---TTQLINPATEEVLASVDHTDANAVD
Mflv_4063|M.gilvum_PYR-GCK --------------------MT---ASDVINPATEEVLRTVEHTDEAGVD
Mvan_2280|M.vanbaalenii_PYR-1 --------------------MTGALASDVINPATEELLRTVEQTDEAGVD
MSMEG_2597|M.smegmatis_MC2_155 --------------------MT---ACQVINPATEQVLTTVELLDEAAVD
MMAR_2875|M.marinum_M ---MTTVAVPHHAMLIGGESVDSDRRLSLVDPGDESPVATVACGDASHVD
MUL_2877|M.ulcerans_Agy99 ---MTTVAVPHHAMLIGGESVDSDRRLSLVDPGDESPVATVACGDASHVD
MAV_2765|M.avium_104 -------MTVQAVLDDIRKRPGTGDVIAVIDPATEEKITEFTDCGAEAVD
TH_4531|M.thermoresistible__bu VTTTENRLVSEIHLAGRRLAEGSAGVYEHVNPATGKVQGEVPLAGPAEVD
MAB_3328|M.abscessus_ATCC_1997 -------MSVPSSWINGRPVATHGDTHRVINPATGEAVADLKLATTADVD
MLBr_02573|M.leprae_Br4923 ------------------------MSIATINPATGETVKTFTPTTQDEVE
::*. . . *:
Rv2858c|M.tuberculosis_H37Rv DAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAHLDELAALEVANSG
Mb2883c|M.bovis_AF2122/97 DAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAHLDELAALEVANSG
Mflv_4063|M.gilvum_PYR-GCK DAVARAKAAQR--SWARQAPAERAAALRAFAAVVDAHVEELAALEVANSG
Mvan_2280|M.vanbaalenii_PYR-1 DAVARARAAQR--RWAALAPAERAAGLRAFAAVVDAHVEELAALEVANSG
MSMEG_2597|M.smegmatis_MC2_155 DAVARATVAQR--RWAALAPAERAAALRAFAAAVDAHIDELAALEVSNSG
MMAR_2875|M.marinum_M AAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIELEMACNG
MUL_2877|M.ulcerans_Agy99 AAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIELEMACNG
MAV_2765|M.avium_104 EAAARAKASFESGVWSQLPGRERAKILWRIGDLIDEHAEEFAQLDSLNTG
TH_4531|M.thermoresistible__bu EAVAAAQEAFK--EWRKWRPEDRRRLLTRIAERIRAHEDELAVLQARENG
MAB_3328|M.abscessus_ATCC_1997 AAVAAARAAGP--AWASSTPVDRSSVLAKLAAVLSANADTLVADEVAQTG
MLBr_02573|M.leprae_Br4923 DAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLEMG
* * : :* : *
Rv2858c|M.tuberculosis_H37Rv HPIVSAE-WEAGHVRDVLAFYAASPERLSGRQ------IPVAGG----VD
Mb2883c|M.bovis_AF2122/97 HPIVSAE-WEAGHVRDVLAFYAASPERLSGRQ------IPVAGG----VD
Mflv_4063|M.gilvum_PYR-GCK HPIGNAR-WEAGHVRDVLQYYSASPERLSGKQ------IPVAGG----LD
Mvan_2280|M.vanbaalenii_PYR-1 HPIGNAR-WEAGHVRDVLHYYSASPERLSGKQ------IPVAGG----LD
MSMEG_2597|M.smegmatis_MC2_155 HPIGQAE-WEAGHVRDVLNFYAATPERLSGKQ------IPVAGG----LD
MMAR_2875|M.marinum_M ATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETFPVLS-----QS
MUL_2877|M.ulcerans_Agy99 ATIRLATGFHIGHALSHFSYFADLAESYAYQRPAPIETFPVLS-----QS
MAV_2765|M.avium_104 MPLLQAQLQMS-TCSEFFRYYAGWCSKINGTAYDVKTDGIATDTFVNMHA
TH_4531|M.thermoresistible__bu LPVSQGKAVLVPHGAGWFEAAAGWADKLEG-AVVPTTPGETVD-------
MAB_3328|M.abscessus_ATCC_1997 KPVRLASEFDVPGSIDNVEFFAGAARHLEGKAT----AEYSADH----TS
MLBr_02573|M.leprae_Br4923 KTLQSAK-DEAMKCAKGFRYYAEKAETLLADEP---AEAAAVGAS---KA
.: . . : .
Rv2858c|M.tuberculosis_H37Rv VTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTTM
Mb2883c|M.bovis_AF2122/97 VTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTTM
Mflv_4063|M.gilvum_PYR-GCK VTFNEPLGVVGVITPWNFPMTIASWGFAPALAAGNAVLVKPAEWTPLTTI
Mvan_2280|M.vanbaalenii_PYR-1 VTFNEPLGVVGVITPWNFPMTIAAWGFAPALAAGNAVLVKPAEWTPLTTM
MSMEG_2597|M.smegmatis_MC2_155 VTFNEPLGVVGVITPWNFPMTIAAWGFAPALAAGCAVLLKPAEWTPLTTI
MMAR_2875|M.marinum_M VVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLSIL
MUL_2877|M.ulcerans_Agy99 VVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLSIL
MAV_2765|M.avium_104 YTLKEPYSVVGLIFPWNGPIFNASAKLAPALAAGCSLLVKPAEETPLSAL
TH_4531|M.thermoresistible__bu LTLLEPIGVVAVILTWNAPIGGWGMCVAPPLAAGCCVILKPSELAPFTSS
MAB_3328|M.abscessus_ATCC_1997 SIRREAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPSELTPLTTL
MLBr_02573|M.leprae_Br4923 LARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCAL
:. .** : .** *: *.: ** ::* . .*
Rv2858c|M.tuberculosis_H37Rv RLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKR
Mb2883c|M.bovis_AF2122/97 RLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKR
Mflv_4063|M.gilvum_PYR-GCK RLGELAVEAGLPADLFQVLPGRGSVVGERFVTHPDVRKIVFTGSTEVGTR
Mvan_2280|M.vanbaalenii_PYR-1 RLGELAVESGLPADLFQVLPGRGSVVGERFVSHPDVRKIVFTGSTEVGTR
MSMEG_2597|M.smegmatis_MC2_155 RIGEIARESGLPEGLFQVLPGKGSVVGERFVSHPGIRKVVFTGSTEVGRR
MMAR_2875|M.marinum_M EFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVGRE
MUL_2877|M.ulcerans_Agy99 EFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVGRE
MAV_2765|M.avium_104 LLDRLVHEAGVPEGVVNLLTGYGHTAGAAITAHPDVEKVAFTGSTEVGKE
TH_4531|M.thermoresistible__bu FIARICEEEGMPPGVVTVLPG-GPDAGEALVRHPGVAKVSFTGGGPTGRK
MAB_3328|M.abscessus_ATCC_1997 TLARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLVTFTGSTAVGRK
MLBr_02573|M.leprae_Br4923 YLADVIARGGFPEDCFQTLLISANGV-EAILRDPRVAAATLTGSEPAGQA
: : . *. . . : . . : .* : :**. .*
Rv2858c|M.tuberculosis_H37Rv VMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNAGQDCC
Mb2883c|M.bovis_AF2122/97 VMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNAGQDCC
Mflv_4063|M.gilvum_PYR-GCK VMAQAATQVKRVTLELGGKSANIVFDDCDLERAAATAPYGVFDNSGQDCC
Mvan_2280|M.vanbaalenii_PYR-1 VMAGAAAQVKRVTLELGGKSANIVFDDCDLERAAATAPYGVFDNSGQDCC
MSMEG_2597|M.smegmatis_MC2_155 VMAGAAAQIKRVTLELGGKSANIVFEDCDLEKAAATAPYGVFDNAGQDCC
MMAR_2875|M.marinum_M IMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCFAYSGQVCE
MUL_2877|M.ulcerans_Agy99 IMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCFAYSGQVCE
MAV_2765|M.avium_104 IVRASAGNLKKVTLELGGKSPVLIFDDADLDKAILMASLGIFVHSGQGCV
TH_4531|M.thermoresistible__bu IAAACGEQLKPVLLELGGKSANIVFPDADLAKAAETAASVIFS-AGQACT
MAB_3328|M.abscessus_ATCC_1997 VMAAAAVHGHRTQLELGGKAPFVVFDDADMDAAIAGAVAGAIINSGQDCT
MLBr_02573|M.leprae_Br4923 VGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCI
: .. : . *****. . ::: ..*: * . . ** *
Rv2858c|M.tuberculosis_H37Rv ARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKV
Mb2883c|M.bovis_AF2122/97 ARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKV
Mflv_4063|M.gilvum_PYR-GCK ARSRILVQRSVFDRFMELLEPAVKGVVVGDPGAEGTEMGPLVSKAHWNSV
Mvan_2280|M.vanbaalenii_PYR-1 ARSRILVQRNVFDRFMDLMEPAVKGVVVGDPAAEDTEMGPLVSRAHWNSV
MSMEG_2597|M.smegmatis_MC2_155 ARSRILVQRSVYDRFMEMLEPAVKGVVVGDPSVRDTEMGPLVSRPHWESV
MMAR_2875|M.marinum_M SGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRTRI
MUL_2877|M.ulcerans_Agy99 SGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVIDAAQRTRI
MAV_2765|M.avium_104 CGSRIFVQRGVYDRVVEGIAMMANTFKLGAPSEEGCVSGPLISQKQLNRV
TH_4531|M.thermoresistible__bu LPTRILVHESIYDEFTAMVAGALGQIPLGDPLDPATMMGPVISEAAVERI
MAB_3328|M.abscessus_ATCC_1997 AATRALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPLISAAHRAKV
MLBr_02573|M.leprae_Br4923 AAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQV
.* :. ::: . . . :* . **: :
Rv2858c|M.tuberculosis_H37Rv AGYVP----DDAPVAFRGTAPAG----RGFWFPPTVLTPKRGDRTVT-DE
Mb2883c|M.bovis_AF2122/97 AGYVP----DDAPVAFRGTAPAG----RGFWFPPTVLTPKRGDRTVT-DE
Mflv_4063|M.gilvum_PYR-GCK SSYVP----DDAPVAFRGSAPQG----PGFWFPPTVLTPARDDRTVV-EE
Mvan_2280|M.vanbaalenii_PYR-1 ASYVP----DDAPVAFRGDAPSG----PGFWFPPTVLTPQRDDRTVV-EE
MSMEG_2597|M.smegmatis_MC2_155 HSYVP----DDAPVAFRGSAPDG----PGFWFPPTVLTPSRDDRTVS-EE
MMAR_2875|M.marinum_M LNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVHNDMAIAREE
MUL_2877|M.ulcerans_Agy99 LNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVHNDMAIAREE
MAV_2765|M.avium_104 MGFIDEGKND-GVEVVTGGYRLD---RKGYFVHPTVLTNVDPGMRLYQQE
TH_4531|M.thermoresistible__bu LRTVDEATRDNGAELLTGGSRAGGELASGYYIEPTLLGNVSPTSEVAQNE
MAB_3328|M.abscessus_ATCC_1997 SSIVDRAPAQGGRIVTGATAPDL----PGSFYRPTLIADVAETSEVYRDE
MLBr_02573|M.leprae_Br4923 EQQVDAAAAAGAVIRCGGKRPDR----PGWFYPPTVITDITKDMALYTDE
: . . * : **:: : :*
Rv2858c|M.tuberculosis_H37Rv IFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESG
Mb2883c|M.bovis_AF2122/97 IFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESG
Mflv_4063|M.gilvum_PYR-GCK IFGPVVTVLPFDDEADAIALANDTVYGLSGSIWTDNISRAMRVSRAVEAG
Mvan_2280|M.vanbaalenii_PYR-1 IFGPVVTVLPFEDEADAIALANDTVYGLSGSIWTDNLSRALRVSRAVESG
MSMEG_2597|M.smegmatis_MC2_155 IFGPVVTVLPFDDEADAIAVANDTAYGLSGSIWTDNVSRAIRVSRAIEAG
MMAR_2875|M.marinum_M VFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGLAMAERIQSG
MUL_2877|M.ulcerans_Agy99 VFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGLAMAERIRSG
MAV_2765|M.avium_104 IFGPVVAILPFDDEDEAVAMANDTTYGLAATAWTENLGRAHRIVKRLQAG
TH_4531|M.thermoresistible__bu VFGPVTAAIRFSDEEEAVAIANGTPYGLAGYVHTRDVSRVLRLASALEAG
MAB_3328|M.abscessus_ATCC_1997 IFGPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRAQRASREIRAG
MLBr_02573|M.leprae_Br4923 VFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAG
:**** . :*: ** : :**.. * : . : :*
Rv2858c|M.tuberculosis_H37Rv NLSVN-SHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEE
Mb2883c|M.bovis_AF2122/97 NLSVN-SHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEE
Mflv_4063|M.gilvum_PYR-GCK NLSVN-SHSSVRYSTPFGGFKQSGLGRELGPDAPLSFTETKNVFFAVEEN
Mvan_2280|M.vanbaalenii_PYR-1 NLSVN-SHSSVRYSTPFGGFKQSGLGRELGPDAPLSFTETKNVFFAVQEE
MSMEG_2597|M.smegmatis_MC2_155 NLSVN-SHSSVRYNTPFGGFKQSGLGRELGPDAPLSFTETKNVFIAV---
MMAR_2875|M.marinum_M SVWIN-DAHQINCRLPFGGYKQSGVGRELGPDALDAYTEVKTIHLDLSGG
MUL_2877|M.ulcerans_Agy99 SVWIN-DAHQINCRLLFGGYKQSGVGRELGPDTLDAYTEVKTIHLDLSGG
MAV_2765|M.avium_104 SVQVN-CQLVFDHDVPFGGYKQSGWGHEFGKEGLEIYLKTKSVWAQL---
TH_4531|M.thermoresistible__bu TVAFNGAGAPAGPGAPFGGYKESGYGREGGKLGVLEFVQHKTVSVALS--
MAB_3328|M.abscessus_ATCC_1997 CVWIN-DHIPIISEMPHGGFGASGFGKDMSDYSLEEYLTVKHVMSDITGT
MLBr_02573|M.leprae_Br4923 QVFIN-GMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA----
: .* .** ** *:: . : * :
Rv2858c|M.tuberculosis_H37Rv M---------------
Mb2883c|M.bovis_AF2122/97 M---------------
Mflv_4063|M.gilvum_PYR-GCK ----------------
Mvan_2280|M.vanbaalenii_PYR-1 H---------------
MSMEG_2597|M.smegmatis_MC2_155 ----------------
MMAR_2875|M.marinum_M REAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 REAKPYDVLLGHPETG
MAV_2765|M.avium_104 ----------------
TH_4531|M.thermoresistible__bu ----------------
MAB_3328|M.abscessus_ATCC_1997 ADKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 ----------------