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TPTLELQDTIAVLNLGADENRFSPDWLETVDGLLDDVLTQAQALVTVGTGKFYSNGLDLDWLMSHGDRTD WYVGRVHALFRRVLTFGLPTVAAINGHAFGAGAMLAVAHDYRVMRSDRGFLCFPEVDIHIPFTPGMASLI QAKVGPQTAVTAMTTGHRYGGAAAVAAGLADSCAAEHEVLSTAIDLMKPLTGKDSGTLSAIKATMFAATA TALAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2465c | - | - | 100% (216) | enoyl-coa hydratase/isomerase family protein |
| M. abscessus ATCC 19977 | MAB_0981c | - | 8e-56 | 47.25% (218) | enoyl-CoA hydratase/isomerase |
| M. abscessus ATCC 19977 | MAB_0903 | - | 3e-14 | 27.96% (211) | putative enoyl-CoA hydratase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2511 | echA14 | 6e-12 | 33.14% (172) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2557 | - | 3e-11 | 33.93% (168) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv2486 | echA14 | 6e-12 | 33.14% (172) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02498 | - | 2e-71 | 58.53% (217) | putative enoyl-CoA hydratase |
| M. marinum M | MMAR_4691 | echA8_2 | 8e-11 | 33.72% (172) | enoyl-CoA hydratase, EchA8_2 |
| M. avium 104 | MAV_1678 | - | 1e-12 | 29.91% (214) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_6558 | - | 9e-73 | 63.26% (215) | putative enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3065 | - | 1e-12 | 28.74% (167) | PUTATIVE enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_0310 | echA8_2 | 5e-11 | 35.33% (150) | enoyl-CoA hydratase, EchA8_2 |
| M. vanbaalenii PYR-1 | Mvan_4083 | - | 4e-11 | 34.90% (149) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2511|M.bovis_AF2122/97 ------------MAQYDPVLLSVDKHVALITVNDPDRRNAVTDEMSAQLR
Rv2486|M.tuberculosis_H37Rv ------------MAQYDPVLLSVDKHVALITVNDPDRRNAVTDEMSAQLR
MAV_1678|M.avium_104 ------------MAQSNLVLLDIENHVALITVNDPDRRNAVTAEMSGRLR
Mflv_2557|M.gilvum_PYR-GCK --------------MSELVLMQVTDRVALITINDPDRRNAVTAEISAALR
Mvan_4083|M.vanbaalenii_PYR-1 --------------MSELVLTQVEDRVALITINDPDRRNAVTAEISAALR
MMAR_4691|M.marinum_M --------------MVDLEFDELDTGLAVLTIDRPHARNAIGLETMAQLQ
MUL_0310|M.ulcerans_Agy99 --------------MVDLEFDGLDTGLAVLTIDRPHARNAIGLETMAQLQ
MLBr_02498|M.leprae_Br4923 ----------------MTIAVHYDEKIAILELGDDENR--FTSVFLEEIN
MSMEG_6558|M.smegmatis_MC2_155 ----------------MTATLDYDGDIAVLDLGDDENR--FTPQFLDEVD
MAB_2465c|M.abscessus_ATCC_199 ----------------MTPTLELQDTIAVLNLGADENR--FSPDWLETVD
TH_3065|M.thermoresistible__bu MTNSKIATLPRYEEFAPWLLVEKRGGVHVVSINRPQAFNAVNEEVHHAFA
: :: :. . . .
Mb2511|M.bovis_AF2122/97 AAIQRAEGDPDVHAVVVTGAG-KAFCAGADLSALGAGVGD-PAEPRLLR-
Rv2486|M.tuberculosis_H37Rv AAIQRAEGDPDVHAVVVTGAG-KAFCAGADLSALGAGVGD-PAEPRLLR-
MAV_1678|M.avium_104 EAVERVEADSDVHAVVITGAG-KAFCAGADLSALGAAGGG-SAETGLQQ-
Mflv_2557|M.gilvum_PYR-GCK AAVSAAEADPDVHAVIVTGAG-KAFCAGADLTALGAAT-----EDGLRV-
Mvan_4083|M.vanbaalenii_PYR-1 AAVEAAEADTGVHAVIVTGAG-KAFCAGADLTALGAAT-----EDGLRV-
MMAR_4691|M.marinum_M DALDAAAG---AQALVIKGAGDRAFVSGGDLKELSALRTL-EDASAMAKR
MUL_0310|M.ulcerans_Agy99 DALDAAAG---AQALVIKGAGDRAFVSGGDLKELSALRTL-EDASAMAKR
MLBr_02498|M.leprae_Br4923 SHLDEIIASG-ANGLVTTALG-KFYSNGLDLDWLSAHR---DQTQWYVGK
MSMEG_6558|M.smegmatis_MC2_155 ALLDAVLEKG-AHGLVTTADS-KFYSNGLDLEWLGAHS---DQGAWYVGR
MAB_2465c|M.abscessus_ATCC_199 GLLDDVLTQ--AQALVTVGTG-KFYSNGLDLDWLMSHG---DRTDWYVGR
TH_3065|M.thermoresistible__bu TIWRALAADNDVRAVVTTGVG-KAFSAGGDMAMFDRLIEDPVARQHQITE
...:: . . : : * *: :
Mb2511|M.bovis_AF2122/97 LYDGFMAVSSCNLPTIAAVNGAAVGAGLNLALAADVRIAG-PAALFDARF
Rv2486|M.tuberculosis_H37Rv LYDGFMAVSSCNLPTIAAVNGAAVGAGLNLALAADVRIAG-PAALFDARF
MAV_1678|M.avium_104 LYDGFMAIGSCRLPTIAAVNGAAVGAGLNLALAADVRIAG-PAALFDPRF
Mflv_2557|M.gilvum_PYR-GCK IYDGFLAVAQCSLPTIAAVNGAAVGAGLNLALAADVRIAG-PHAMFDPRF
Mvan_4083|M.vanbaalenii_PYR-1 IYDGFLAVAECNLPTIAAVNGPAVGAGLNLALAADVRIAG-PAALFDPRF
MMAR_4691|M.marinum_M MRSICDQIAAFPAPVIAALNGHAFGGGAEVAVAADIRVAA-DDIKIAFNQ
MUL_0310|M.ulcerans_Agy99 MRSICDQIATFPAPVIAALNGHAFGGGAEVAVAADIRVAA-DDIKIAFNQ
MLBr_02498|M.leprae_Br4923 VQGLLARLLTLPIPTAAAVVGHAFGAGAMLAMAHDFRVMRADRGYFCFPE
MSMEG_6558|M.smegmatis_MC2_155 VQGLLARVLTFPLPTAAAVVGHAFGAGAMLAMAHDYRVMREDRGFFCFPE
MAB_2465c|M.abscessus_ATCC_199 VHALFRRVLTFGLPTVAAINGHAFGAGAMLAVAHDYRVMRSDRGFLCFPE
TH_3065|M.thermoresistible__bu ARTVFLELINFAKPLVSAVNGPAVGLGCSIALLSDFLVMG-QSSFLSDPH
: * :*: * *.* * :*: * : :
Mb2511|M.bovis_AF2122/97 QKLGLHPGGGATWMLQRAVGPQVARAALLFGMCFDAESAVRHGLALMVAD
Rv2486|M.tuberculosis_H37Rv QKLGLHPGGGATWMLQRAVGPQVARAALLFGMCFDAESAVRHGLALMVAD
MAV_1678|M.avium_104 QQLGLHPGGGATWMLQRAVGPQVARAALLFGMRFDAEAAVRHGLALSVAD
Mflv_2557|M.gilvum_PYR-GCK QKLGIHPGGGATWMLQRITGPQAARAALLFGMRFDADAAVRHGLALEVAD
Mvan_4083|M.vanbaalenii_PYR-1 QKLGIHPGGGATWMLQRAIGPQAARAALLFGMRFDAESAVRHGLALEVAD
MMAR_4691|M.marinum_M VLLEIMPAWGGAERLAAVVG--KSKALLLAGSGIALDAVEAERIGLVDLV
MUL_0310|M.ulcerans_Agy99 VLLEIMPAWGGAERLAAVVG--KSKALLLAGSGIALDAVEAERIGLVDLV
MLBr_02498|M.leprae_Br4923 VDIRIPFTPGMAALIQAKLAPQAATASMTTGRRFGGGEAARLGIVDNTAA
MSMEG_6558|M.smegmatis_MC2_155 VDIHIPFTPGMAALIQAKLTPQAAIASMTTGRRFGGSEAHEHGIVDATAH
MAB_2465c|M.abscessus_ATCC_199 VDIHIPFTPGMASLIQAKVGPQTAVTAMTTGHRYGGAAAVAAGLADSCAA
TH_3065|M.thermoresistible__bu VAVGLVAGDGGAAMLPLLIGLMKAKEYVLLGDRITAEAAVKLNLVTKVTS
: : * : : : : * . :
Mb2511|M.bovis_AF2122/97 DPVTAALELAAGP--AAAPREVVLASKATMRATASPGSLDLEQHELAKRL
Rv2486|M.tuberculosis_H37Rv DPVTAALELAAGP--AAAPREVVLASKATMRATASPGSLDLEQHELAKRL
MAV_1678|M.avium_104 DPVAAALELAAGP--AAAPREVVLATKATMRATISLGSLDNEQHQHAMRT
Mflv_2557|M.gilvum_PYR-GCK DPVARARELAAGP--AGAPRDVVVATKASMRATAHPGTDDLEQHRLAVDI
Mvan_4083|M.vanbaalenii_PYR-1 DPVAAARELAAGP--ASAPRDVVVSTKASMRATYNPGISDLHQHHMAVDI
MMAR_4691|M.marinum_M FPRASFDSTDGGW--RSLARSLARRPAAEVKRVINGTSPDEAIASFARLW
MUL_0310|M.ulcerans_Agy99 FPRASFDSTDGGW--RSLARSLARRPAAEVKRVINGTSPDEAIASFARLW
MLBr_02498|M.leprae_Br4923 EDAVTAVAVDLLH--PLGGKD--PGTLGVIKQTMFGHAAAALSANA----
MSMEG_6558|M.smegmatis_MC2_155 EGAVTLAATSLLR--PLGSKD--QGTLGAIKQVMFGAAAAALRNP-----
MAB_2465c|M.abscessus_ATCC_199 EHEVLSTAIDLMK--PLTGKD--SGTLSAIKATMFAATATALAA------
TH_3065|M.thermoresistible__bu DESVLDEALAIGERLVALPSQALRATKVAMNMHLSRAALGVLEYALAEEY
. . . :.
Mb2511|M.bovis_AF2122/97 ELGPQAKSVQSPE--FAARLAAAQHR-
Rv2486|M.tuberculosis_H37Rv ELGPQAKSVQSPE--FAARLAAAQHR-
MAV_1678|M.avium_104 ELGPQAHSIQSPE--FAQRLAAAQRK-
Mflv_2557|M.gilvum_PYR-GCK EIVPQATSIESPE--FAARLAAAKRR-
Mvan_4083|M.vanbaalenii_PYR-1 EIGPQARSIESPE--FAARLAAAQRR-
MMAR_4691|M.marinum_M VEDAHWQAAERVMNRTPNRGPGAEGAT
MUL_0310|M.ulcerans_Agy99 VEDAHWQAAEQVMNRTPNRGPGAEGAT
MLBr_02498|M.leprae_Br4923 ---------------------------
MSMEG_6558|M.smegmatis_MC2_155 ---------------------------
MAB_2465c|M.abscessus_ATCC_199 ---------------------------
TH_3065|M.thermoresistible__bu TSFSTPEFKERVAAFRARSQK------