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SELVLMQVTDRVALITINDPDRRNAVTAEISAALRAAVSAAEADPDVHAVIVTGAGKAFCAGADLTALGA ATEDGLRVIYDGFLAVAQCSLPTIAAVNGAAVGAGLNLALAADVRIAGPHAMFDPRFQKLGIHPGGGATW MLQRITGPQAARAALLFGMRFDADAAVRHGLALEVADDPVARARELAAGPAGAPRDVVVATKASMRATAH PGTDDLEQHRLAVDIEIVPQATSIESPEFAARLAAAKRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2557 | - | - | 100% (250) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2444 | - | 2e-27 | 38.69% (199) | enoyl-CoA hydratase/isomerase |
| M. gilvum PYR-GCK | Mflv_4817 | - | 1e-26 | 38.81% (201) | enoyl-CoA hydratase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2511 | echA14 | 1e-101 | 74.80% (250) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv2486 | echA14 | 1e-101 | 74.80% (250) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 9e-23 | 34.74% (190) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0905 | - | 2e-25 | 36.49% (222) | putative enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_3510 | echA8_5 | 6e-28 | 42.02% (188) | enoyl-CoA hydratase, EchA8_5 |
| M. avium 104 | MAV_1678 | - | 1e-101 | 73.91% (253) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_4709 | - | 1e-115 | 81.93% (249) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_0952 | echA14 | 1e-103 | 77.05% (244) | PROBABLE ENOYL-CoA HYDRATASE ECHA14 (ENOYL HYDRASE) |
| M. ulcerans Agy99 | MUL_2758 | echA8_5 | 3e-27 | 41.49% (188) | enoyl-CoA hydratase, EchA8_5 |
| M. vanbaalenii PYR-1 | Mvan_4083 | - | 1e-120 | 88.80% (250) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2511|M.bovis_AF2122/97 ---MAQYDPVLLSVDKHVALITVNDPDRRNAVT-DEMSAQLRAAIQRAEG
Rv2486|M.tuberculosis_H37Rv ---MAQYDPVLLSVDKHVALITVNDPDRRNAVT-DEMSAQLRAAIQRAEG
MAV_1678|M.avium_104 ---MAQSNLVLLDIENHVALITVNDPDRRNAVT-AEMSGRLREAVERVEA
Mflv_2557|M.gilvum_PYR-GCK -----MSELVLMQVTDRVALITINDPDRRNAVT-AEISAALRAAVSAAEA
Mvan_4083|M.vanbaalenii_PYR-1 -----MSELVLTQVEDRVALITINDPDRRNAVT-AEISAALRAAVEAAEA
MSMEG_4709|M.smegmatis_MC2_155 -----MADSVLVETSDRIAVITVNDPDRRNAVT-FEMSAALRSAVEAAEA
TH_0952|M.thermoresistible__bu -----------MAVEERVAVITVNDPERRNAVT-FEMSEALRAAVARAEA
MAB_0905|M.abscessus_ATCC_1997 MTQTAPAAVAYSVNHAGVAAIVLDRPEASNALD-RTMKTELLQALLAAGG
MMAR_3510|M.marinum_M -----MNTALDITTNGPIRTWTINLPDVGNAITGKDFIAAFEAAVDDANI
MUL_2758|M.ulcerans_Agy99 -----MNTALDITTNGPIRTWTINLPDVGNAITGRDFIAAFEAAVDDANI
MLBr_02402|M.leprae_Br4923 ----MKYDTILVDGYQRVGIITLNRPQALNALN-SQMMNEITNAAKELDI
: .:: *: **: : : *
Mb2511|M.bovis_AF2122/97 DPDVHAVVVTGAGKAFCAGADLSALGAGVGDPAEPRLLR---LYDG----
Rv2486|M.tuberculosis_H37Rv DPDVHAVVVTGAGKAFCAGADLSALGAGVGDPAEPRLLR---LYDG----
MAV_1678|M.avium_104 DSDVHAVVITGAGKAFCAGADLSALGAAGGGSAETGLQQ---LYDG----
Mflv_2557|M.gilvum_PYR-GCK DPDVHAVIVTGAGKAFCAGADLTALGAAT----EDGLRV---IYDG----
Mvan_4083|M.vanbaalenii_PYR-1 DTGVHAVIVTGAGKAFCAGADLTALGAAT----EDGLRV---IYDG----
MSMEG_4709|M.smegmatis_MC2_155 DPDVHAVVVTGAGKAFCAGADLAALGTAT----EDGLRK---IYDG----
TH_0952|M.thermoresistible__bu DEAVHAVVVTGAGRAFCAGADLAALRTAT----EDDLRR---LYDG----
MAB_0905|M.abscessus_ATCC_1997 DPAVRAVVMSAAGKNFCVGQDLAEHVEALRDDPAHAMDT---VREHYNPV
MMAR_3510|M.marinum_M DTSVRAVILTGAGKIFSGGGNVKEMANRDGMFGLDALEQRQAYTDGIQRI
MUL_2758|M.ulcerans_Agy99 DTSVRAVILTGAGKIFSGGGNVKEMANRDGMFGLDALEQRQAYTDGIQRI
MLBr_02402|M.leprae_Br4923 DPDVGAILITGSPKVFAAGADIKEMASLT---FTDAFDADFFSAWG----
* * *::::.: : *. * :: :
Mb2511|M.bovis_AF2122/97 FMAVSSCNLPTIAAVNGAAVGAGLNLALAADVRIAGPAALFDARFQKLGL
Rv2486|M.tuberculosis_H37Rv FMAVSSCNLPTIAAVNGAAVGAGLNLALAADVRIAGPAALFDARFQKLGL
MAV_1678|M.avium_104 FMAIGSCRLPTIAAVNGAAVGAGLNLALAADVRIAGPAALFDPRFQQLGL
Mflv_2557|M.gilvum_PYR-GCK FLAVAQCSLPTIAAVNGAAVGAGLNLALAADVRIAGPHAMFDPRFQKLGI
Mvan_4083|M.vanbaalenii_PYR-1 FLAVAECNLPTIAAVNGPAVGAGLNLALAADVRIAGPAALFDPRFQKLGI
MSMEG_4709|M.smegmatis_MC2_155 FLAVAHCTLPTIAAVNGAAVGAGLNLALAADVRIAGPHALFDPRFQKLGI
TH_0952|M.thermoresistible__bu FIAVARCTLPTVAAVNGPAVGAGLNLALAADVRIAGPTAVFDPRFQKLGI
MAB_0905|M.abscessus_ATCC_1997 LEALDAIKVPVVVAINGACVGAGLGLALGADIRIAGQRAKFGTAFTGIGL
MMAR_3510|M.marinum_M PRALARLEVPLIGAINGAAIGAGCDLAMMCDIRIASQRASFAESFVALGI
MUL_2758|M.ulcerans_Agy99 PRALARLEVPLIGAINGAAIGAGCDLAMMCDIRIASQRASFAESFVALGI
MLBr_02402|M.leprae_Br4923 --KLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGV
: * : *: * .:*.* **: .*: **. * * :*:
Mb2511|M.bovis_AF2122/97 HPGGGATWMLQRAVGPQVARAALLFGMCFDAESAVRHGLALMVADD--PV
Rv2486|M.tuberculosis_H37Rv HPGGGATWMLQRAVGPQVARAALLFGMCFDAESAVRHGLALMVADD--PV
MAV_1678|M.avium_104 HPGGGATWMLQRAVGPQVARAALLFGMRFDAEAAVRHGLALSVADD--PV
Mflv_2557|M.gilvum_PYR-GCK HPGGGATWMLQRITGPQAARAALLFGMRFDADAAVRHGLALEVADD--PV
Mvan_4083|M.vanbaalenii_PYR-1 HPGGGATWMLQRAIGPQAARAALLFGMRFDAESAVRHGLALEVADD--PV
MSMEG_4709|M.smegmatis_MC2_155 HPGGGATWMLQRAAGPEVARAALLFGMRFDAEAAVRHGLALTVADD--PL
TH_0952|M.thermoresistible__bu HPGGGATWMLQRAIGPQAARASLLFGLGFDAEAAVRSGLALKIAED--PV
MAB_0905|M.abscessus_ATCC_1997 AADSALSASLPRLIGASRATAMFLLGDTIDAPTAHTWGLVHEVVDEGSPA
MMAR_3510|M.marinum_M IPGDGGTWFLQRAIGYERAAEMTLTGDRIDAATALEWGMVSRVVPHDDLL
MUL_2758|M.ulcerans_Agy99 IPGDGGTWFLQRAIGYERAAEMTLTGDRIDAATALEWGMVSRVVPHGDLL
MLBr_02402|M.leprae_Br4923 LPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLL
.. . : * * * * * * :** * *:. :.
Mb2511|M.bovis_AF2122/97 TAALELAAGPAAAPREVVLASKATMRATASPGSLDLEQHELAKRLELGP-
Rv2486|M.tuberculosis_H37Rv TAALELAAGPAAAPREVVLASKATMRATASPGSLDLEQHELAKRLELGP-
MAV_1678|M.avium_104 AAALELAAGPAAAPREVVLATKATMRATISLGSLDNEQHQHAMRTELGP-
Mflv_2557|M.gilvum_PYR-GCK ARARELAAGPAGAPRDVVVATKASMRATAHPGTDDLEQHRLAVDIEIVP-
Mvan_4083|M.vanbaalenii_PYR-1 AAARELAAGPASAPRDVVVSTKASMRATYNPGISDLHQHHMAVDIEIGP-
MSMEG_4709|M.smegmatis_MC2_155 AAARELASGPASAPREVVLATKASMRATANPGVIDTDQHRAAVDIELGP-
TH_0952|M.thermoresistible__bu AAARELAAGPAAAPRDVVVATKASMRATANPGVPDTEQHMRAVDTELPP-
MAB_0905|M.abscessus_ATCC_1997 DVANSVAGRLAGGPTAAFSEVKELLRRNAVAPLGDVLEREASAQQRLGAS
MMAR_3510|M.marinum_M PQAQELAERIVKNPAHALRMAKRLLQESRVGSLESTLGMAAAMQPLAHRD
MUL_2758|M.ulcerans_Agy99 PQAQELAERIVKNPAHALRMAKRLLQESRVGSLESTLGMAAAMQPLAHRD
MLBr_02402|M.leprae_Br4923 PEAKAVATTISQMSRSATRMAKEAVNRSFESTLAEGLLHERRLFHSTFVT
* :* . . * :. . .
Mb2511|M.bovis_AF2122/97 QAKSVQSPEFAARLAAAQHR-
Rv2486|M.tuberculosis_H37Rv QAKSVQSPEFAARLAAAQHR-
MAV_1678|M.avium_104 QAHSIQSPEFAQRLAAAQRK-
Mflv_2557|M.gilvum_PYR-GCK QATSIESPEFAARLAAAKRR-
Mvan_4083|M.vanbaalenii_PYR-1 QARSIESPEFAARLAAAQRR-
MSMEG_4709|M.smegmatis_MC2_155 QARSIESPEFAARLAARRK--
TH_0952|M.thermoresistible__bu QAASIAAPAFAERIAAALRR-
MAB_0905|M.abscessus_ATCC_1997 RDHSAAVEAFLAKDKPVFVGR
MMAR_3510|M.marinum_M PEHQQRIAKWRTR--------
MUL_2758|M.ulcerans_Agy99 PEHQQRIAKWRTRIAKWRTR-
MLBr_02402|M.leprae_Br4923 DDQSEGMAAFIEKRAPQFTHR
. : :