For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AQSNLVLLDIENHVALITVNDPDRRNAVTAEMSGRLREAVERVEADSDVHAVVITGAGKAFCAGADLSAL GAAGGGSAETGLQQLYDGFMAIGSCRLPTIAAVNGAAVGAGLNLALAADVRIAGPAALFDPRFQQLGLHP GGGATWMLQRAVGPQVARAALLFGMRFDAEAAVRHGLALSVADDPVAAALELAAGPAAAPREVVLATKAT MRATISLGSLDNEQHQHAMRTELGPQAHSIQSPEFAQRLAAAQRK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1678 | - | - | 100% (256) | enoyl-CoA hydratase |
| M. avium 104 | MAV_1590 | - | 6e-26 | 39.27% (191) | enoyl-CoA hydratase |
| M. avium 104 | MAV_3307 | - | 2e-25 | 34.09% (264) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2511 | echA14 | 1e-113 | 81.64% (256) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2557 | - | 1e-101 | 73.91% (253) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv2486 | echA14 | 1e-113 | 81.64% (256) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 2e-25 | 34.03% (238) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0834 | - | 7e-27 | 34.24% (257) | putative enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_3510 | echA8_5 | 8e-29 | 35.39% (243) | enoyl-CoA hydratase, EchA8_5 |
| M. smegmatis MC2 155 | MSMEG_4709 | - | 1e-103 | 75.50% (249) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_0952 | echA14 | 2e-95 | 71.54% (246) | PROBABLE ENOYL-CoA HYDRATASE ECHA14 (ENOYL HYDRASE) |
| M. ulcerans Agy99 | MUL_2758 | echA8_5 | 3e-28 | 34.98% (243) | enoyl-CoA hydratase, EchA8_5 |
| M. vanbaalenii PYR-1 | Mvan_4083 | - | 1e-105 | 75.49% (253) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2511|M.bovis_AF2122/97 ----------------MAQYDPVLLSVDKHVALITVNDPDRRNAVT-DEM
Rv2486|M.tuberculosis_H37Rv ----------------MAQYDPVLLSVDKHVALITVNDPDRRNAVT-DEM
MAV_1678|M.avium_104 ----------------MAQSNLVLLDIENHVALITVNDPDRRNAVT-AEM
Mflv_2557|M.gilvum_PYR-GCK ------------------MSELVLMQVTDRVALITINDPDRRNAVT-AEI
Mvan_4083|M.vanbaalenii_PYR-1 ------------------MSELVLTQVEDRVALITINDPDRRNAVT-AEI
MSMEG_4709|M.smegmatis_MC2_155 ------------------MADSVLVETSDRIAVITVNDPDRRNAVT-FEM
TH_0952|M.thermoresistible__bu ------------------------MAVEERVAVITVNDPERRNAVT-FEM
MMAR_3510|M.marinum_M ------------------MNTALDITTNGPIRTWTINLPDVGNAITGKDF
MUL_2758|M.ulcerans_Agy99 ------------------MNTALDITTNGPIRTWTINLPDVGNAITGRDF
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMA-LDL
MAB_0834|M.abscessus_ATCC_1997 --------------------MIRVEPREHGILVVTIDRPERRNALD-PQT
: *:: * *:: :
Mb2511|M.bovis_AF2122/97 SAQLRAAIQRAEGDPDVHAVVVTGAGKAFCAGADLSALG---AGVGDPAE
Rv2486|M.tuberculosis_H37Rv SAQLRAAIQRAEGDPDVHAVVVTGAGKAFCAGADLSALG---AGVGDPAE
MAV_1678|M.avium_104 SGRLREAVERVEADSDVHAVVITGAGKAFCAGADLSALG---AAGGGSAE
Mflv_2557|M.gilvum_PYR-GCK SAALRAAVSAAEADPDVHAVIVTGAGKAFCAGADLTALG---AAT----E
Mvan_4083|M.vanbaalenii_PYR-1 SAALRAAVEAAEADTGVHAVIVTGAGKAFCAGADLTALG---AAT----E
MSMEG_4709|M.smegmatis_MC2_155 SAALRSAVEAAEADPDVHAVVVTGAGKAFCAGADLAALG---TAT----E
TH_0952|M.thermoresistible__bu SEALRAAVARAEADEAVHAVVVTGAGRAFCAGADLAALR---TAT----E
MMAR_3510|M.marinum_M IAAFEAAVDDANIDTSVRAVILTGAGKIFSGGGNVKEMA---NRDGMFGL
MUL_2758|M.ulcerans_Agy99 IAAFEAAVDDANIDTSVRAVILTGAGKIFSGGGNVKEMA---NRDGMFGL
MLBr_01241|M.leprae_Br4923 MKSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQK-----FTAP-VPQV
MAB_0834|M.abscessus_ATCC_1997 VAELHAVIESIDGDPKVRVVVLTAVGASFCAGADLKSLPSDFTSAGVTST
:. .: * *:.*::*..* *..*.:
Mb2511|M.bovis_AF2122/97 PRLLR---------------LYDGFMAVSSCNLPTIAAVNGAAVGAGLNL
Rv2486|M.tuberculosis_H37Rv PRLLR---------------LYDGFMAVSSCNLPTIAAVNGAAVGAGLNL
MAV_1678|M.avium_104 TGLQQ---------------LYDGFMAIGSCRLPTIAAVNGAAVGAGLNL
Mflv_2557|M.gilvum_PYR-GCK DGLRV---------------IYDGFLAVAQCSLPTIAAVNGAAVGAGLNL
Mvan_4083|M.vanbaalenii_PYR-1 DGLRV---------------IYDGFLAVAECNLPTIAAVNGPAVGAGLNL
MSMEG_4709|M.smegmatis_MC2_155 DGLRK---------------IYDGFLAVAHCTLPTIAAVNGAAVGAGLNL
TH_0952|M.thermoresistible__bu DDLRR---------------LYDGFIAVARCTLPTVAAVNGPAVGAGLNL
MMAR_3510|M.marinum_M DALEQR--------QAYTDGIQRIPRALARLEVPLIGAINGAAIGAGCDL
MUL_2758|M.ulcerans_Agy99 DALEQR--------QAYTDGIQRIPRALARLEVPLIGAINGAAIGAGCDL
MLBr_01241|M.leprae_Br4923 EGLTQP-----VRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCL
MAB_0834|M.abscessus_ATCC_1997 AALLAATDSELVRTLAAQELMASLFERIHRMRQPVIAAVNGHAIGGGFAL
* : : * :.*:** *:*.* *
Mb2511|M.bovis_AF2122/97 ALAADVRIAGPAALFDARFQKLGLHPGG-GATWMLQRAVGPQVARAALLF
Rv2486|M.tuberculosis_H37Rv ALAADVRIAGPAALFDARFQKLGLHPGG-GATWMLQRAVGPQVARAALLF
MAV_1678|M.avium_104 ALAADVRIAGPAALFDPRFQQLGLHPGG-GATWMLQRAVGPQVARAALLF
Mflv_2557|M.gilvum_PYR-GCK ALAADVRIAGPHAMFDPRFQKLGIHPGG-GATWMLQRITGPQAARAALLF
Mvan_4083|M.vanbaalenii_PYR-1 ALAADVRIAGPAALFDPRFQKLGIHPGG-GATWMLQRAIGPQAARAALLF
MSMEG_4709|M.smegmatis_MC2_155 ALAADVRIAGPHALFDPRFQKLGIHPGG-GATWMLQRAAGPEVARAALLF
TH_0952|M.thermoresistible__bu ALAADVRIAGPTAVFDPRFQKLGIHPGG-GATWMLQRAIGPQAARASLLF
MMAR_3510|M.marinum_M AMMCDIRIASQRASFAESFVALGIIPGD-GGTWFLQRAIGYERAAEMTLT
MUL_2758|M.ulcerans_Agy99 AMMCDIRIASQRASFAESFVALGIIPGD-GGTWFLQRAIGYERAAEMTLT
MLBr_01241|M.leprae_Br4923 ALAADVRVASTRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLS
MAB_0834|M.abscessus_ATCC_1997 ALACDIRFASPAASFGAVFIRHGVSNCDMGTSYHLPRLVGAARAAELMLT
*: .*:*.*. * * *: * :: * * * * *
Mb2511|M.bovis_AF2122/97 GMCFDAESAVRHGLALMVA--DDPVTAALELAAGPAAAPREVVLASKATM
Rv2486|M.tuberculosis_H37Rv GMCFDAESAVRHGLALMVA--DDPVTAALELAAGPAAAPREVVLASKATM
MAV_1678|M.avium_104 GMRFDAEAAVRHGLALSVA--DDPVAAALELAAGPAAAPREVVLATKATM
Mflv_2557|M.gilvum_PYR-GCK GMRFDADAAVRHGLALEVA--DDPVARARELAAGPAGAPRDVVVATKASM
Mvan_4083|M.vanbaalenii_PYR-1 GMRFDAESAVRHGLALEVA--DDPVAAARELAAGPASAPRDVVVSTKASM
MSMEG_4709|M.smegmatis_MC2_155 GMRFDAEAAVRHGLALTVA--DDPLAAARELASGPASAPREVVLATKASM
TH_0952|M.thermoresistible__bu GLGFDAEAAVRSGLALKIA--EDPVAAARELAAGPAAAPRDVVVATKASM
MMAR_3510|M.marinum_M GDRIDAATALEWGMVSRVVPHDDLLPQAQELAERIVKNPAHALRMAKRLL
MUL_2758|M.ulcerans_Agy99 GDRIDAATALEWGMVSRVVPHGDLLPQAQELAERIVKNPAHALRMAKRLL
MLBr_01241|M.leprae_Br4923 GRDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRAL
MAB_0834|M.abscessus_ATCC_1997 GRVFDAQEAYRMGLVFDVVPAEELLDAALSKAREIAVHSPLAVWMTKETM
* ..* * . *:. . : . . * . . :* :
Mb2511|M.bovis_AF2122/97 RATASPGSLDLEQHELAKRLELGPQAKSVQSPEFAARLAAAQHR------
Rv2486|M.tuberculosis_H37Rv RATASPGSLDLEQHELAKRLELGPQAKSVQSPEFAARLAAAQHR------
MAV_1678|M.avium_104 RATISLGSLDNEQHQHAMRTELGPQAHSIQSPEFAQRLAAAQRK------
Mflv_2557|M.gilvum_PYR-GCK RATAHPGTDDLEQHRLAVDIEIVPQATSIESPEFAARLAAAKRR------
Mvan_4083|M.vanbaalenii_PYR-1 RATYNPGISDLHQHHMAVDIEIGPQARSIESPEFAARLAAAQRR------
MSMEG_4709|M.smegmatis_MC2_155 RATANPGVIDTDQHRAAVDIELGPQARSIESPEFAARLAARRK-------
TH_0952|M.thermoresistible__bu RATANPGVPDTEQHMRAVDTELPPQAASIAAPAFAERIAAALRR------
MMAR_3510|M.marinum_M QESR------VGSLESTLGMAAAMQPLAHRDPEHQQRIAKWRTR------
MUL_2758|M.ulcerans_Agy99 QESR------VGSLESTLGMAAAMQPLAHRDPEHQQRIAKWRTRIAKWRT
MLBr_01241|M.leprae_Br4923 WGGLDAASLDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARG
MAB_0834|M.abscessus_ATCC_1997 WQTVDAPSLRHALDLENRTQVMCTATG----ELRRSFDAFR-----EGRG
Mb2511|M.bovis_AF2122/97 ------
Rv2486|M.tuberculosis_H37Rv ------
MAV_1678|M.avium_104 ------
Mflv_2557|M.gilvum_PYR-GCK ------
Mvan_4083|M.vanbaalenii_PYR-1 ------
MSMEG_4709|M.smegmatis_MC2_155 ------
TH_0952|M.thermoresistible__bu ------
MMAR_3510|M.marinum_M ------
MUL_2758|M.ulcerans_Agy99 R-----
MLBr_01241|M.leprae_Br4923 CATSPG
MAB_0834|M.abscessus_ATCC_1997 ------