For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSRLIVIGGGIGGLAVALSVAASGNEVVVLERAREFAEIGAGIQLAPNGLHALKLLGVGDRVAGIGVQVD SLRLFDATVDRLINTMSLGVDYQHRFNSPYLVVHRAELHRILVDACAADERIELRSRSEVIGYQQDALGA RAQLADGSSLGGDGLVGADGINSTIRRTLLADGQPRVSGITVYRTTVPIEQVDASLRSNSVTWWTGPGCH LVTYPIAGGSLLNLAASRTDGATEAFSGVSVSEARVLSELAPLRGTARALLELGRDWRSWALVDRDPVRQ WSDGRVVLLGDAAHPMLHYAAQGASQALEDAVVFGAIIGTDPDRVPGRFSRFVEARCDRTGDVTLAARAS IGLWHAAGEAAVERNEKLGAMRDSDLHQALAWMHGDTDFGLASVTSAVGVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0288 | - | - | 100% (401) | putative monooxygenase (salicylate/ hydroxybenzoate hydroxylase |
| M. abscessus ATCC 19977 | MAB_3330 | - | 9e-49 | 34.75% (377) | putative salicylate hydroxylase |
| M. abscessus ATCC 19977 | MAB_2237c | - | 5e-41 | 34.16% (363) | hypothetical protein MAB_2237c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 5e-11 | 25.94% (320) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_2621 | - | 9e-32 | 33.82% (343) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1751 | - | 5e-11 | 25.94% (320) | hypothetical protein Rv1751 |
| M. leprae Br4923 | MLBr_02276 | - | 1e-06 | 27.37% (179) | putative FAD-linked oxidoreductase |
| M. marinum M | MMAR_4944 | - | 6e-29 | 28.72% (376) | oxidoreductase |
| M. avium 104 | MAV_4429 | - | 7e-18 | 28.35% (321) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3841 | - | 2e-33 | 35.20% (358) | hypothetical protein MSMEG_3841 |
| M. thermoresistible (build 8) | TH_4641 | - | 8e-12 | 28.08% (317) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_0460 | - | 3e-16 | 29.17% (216) | hypothetical protein MUL_0460 |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 5e-33 | 33.73% (332) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3841|M.smegmatis_MC2_155 ------------------------------------------------MS
MAB_0288|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4429|M.avium_104 ---------------------------------------------MVGDA
TH_4641|M.thermoresistible__bu ----------------------------------------------MARE
MLBr_02276|M.leprae_Br4923 ----------------------------------------------MRVE
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Mflv_2621|M.gilvum_PYR-GCK MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG-AGSGISLWPNA
Mvan_3960|M.vanbaalenii_PYR-1 MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLT-SGAGISIWPNA
MMAR_4944|M.marinum_M --MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAISVWSNG
MUL_0460|M.ulcerans_Agy99 --MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAISVWSNG
MSMEG_3841|M.smegmatis_MC2_155 ITTTVAIAGAGIGGLTAALALQQRGFEVVVLESAHELRPLGVGINLLPHA
MAB_0288|M.abscessus_ATCC_1997 -MSRLIVIGGGIGGLAVALSVAASGNEVVVLERAREFAEIGAGIQLAPNG
MAV_4429|M.avium_104 RPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVTVWSNG
TH_4641|M.thermoresistible__bu TTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPATTSRANFLHARG
MLBr_02276|M.leprae_Br4923 TSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKACGDGLTPRA
: *.* * . * .. : : . : .
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALP-YSEVRTATLHSNGRAVTYIDF-ERLHQPYP-Y
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALP-YSEVRTATLHSNGRAVTYIDF-ERLHQPYP-Y
Mflv_2621|M.gilvum_PYR-GCK LAALDQIGLGDSVRDAGGRVTAG-AIRWRDGTWVRRPSV-RRIVDALGEP
Mvan_3960|M.vanbaalenii_PYR-1 LAALDQIGLGDNVRQAGGRVTAG-AIRWRDGTWLRRPSA-QRIVHALGEP
MMAR_4944|M.marinum_M VKCLNYLGLEQQTARLGGIVETMSYAEAHSGETMCRISM-QPLIEQVGQR
MUL_0460|M.ulcerans_Agy99 VKCLNYLGLDQQTARLGGIVETMSYAEAHSGETMCRISM-QPLIEQVGQR
MSMEG_3841|M.smegmatis_MC2_155 VRELDHLGLGDAVGDAS--VAPTAIRFYSADGTLLFTEP-RGLAAGDTHP
MAB_0288|M.abscessus_ATCC_1997 LHALKLLGVGDRVAGIGVQVDSLRLFDATVDRLINTMSLGVDYQHRFNSP
MAV_4429|M.avium_104 ETVLRQLGVEMDG---AGRQLSSVGAVTSTGRPLATLDV-TAMARRLGAP
TH_4641|M.thermoresistible__bu SEVLDRLGALGGLPERS--VRAMQITTHLGGEPVMRMQF-GDPGMRTAAP
MLBr_02276|M.leprae_Br4923 VAELKRLGLDDWLN---TRIRHRGLRMSGFGGEVEVDWP----GPSFPST
* :* . :
Mb1780|M.bovis_AF2122/97 VAMVPQWDLLNLLAEAAQAEP-SFTLRMKTEVTGLLREGGKVTGVRYQGA
Rv1751|M.tuberculosis_H37Rv VAMVPQWDLLNLLAEAAQAEP-SFTLRMKTEVTGLLREGGKVTGVRYQGA
Mflv_2621|M.gilvum_PYR-GCK LVVVRRSRLTDILREALPAG----TVRTGLAATRVSVGASSVRITLSDGE
Mvan_3960|M.vanbaalenii_PYR-1 LVVVRRSALTEILLDALPPD----TVQTGLSATALSIAAATARVTLSDGR
MMAR_4944|M.marinum_M PYPIARAELQQMLMEAYGID----EIHFGMKMVEVANRDGAATATFADGT
MUL_0460|M.ulcerans_Agy99 PYPIARAELQQMLMEAYGID----DIHFGMKMVEVANQDGAATATFTDGT
MSMEG_3841|M.smegmatis_MC2_155 QLSIHRGRLQMLLLAAVRERLGADAVRTGARVSGFHDDGSRVVVRTDAGD
MAB_0288|M.abscessus_ATCC_1997 YLVVHRAELHRILVDACAADER-IELRSRSEVIGYQQDALGARAQLADGS
MAV_4429|M.avium_104 VRMVPRRVLLERLLDGFPTG----RIHCDRRAVALATSRDGVSVEFTDGT
TH_4641|M.thermoresistible__bu PMVISQAEVEAALRNRLAELG--GRVELDCPLTGLRQDASTVTAGIGGGG
MLBr_02276|M.leprae_Br4923 SSAVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRRAASVTLADGT
: : : : : . *
Mb1780|M.bovis_AF2122/97 EGPGELRAELTVACDGRWSIARH-EAGLKAREFPVNFDVWWF---KLPRE
Rv1751|M.tuberculosis_H37Rv EGPGELRAELTVACDGRWSIARH-EAGLKAREFPVNFDVWWF---KLPRE
Mflv_2621|M.gilvum_PYR-GCK VR----ESDAVVGADGVNSVLAR-TLNGPLRTRYVGYTAWRG---IAAHP
Mvan_3960|M.vanbaalenii_PYR-1 TR----EADAVVGADGVNSMVAR-ALNGPLPSRYVGYTAWRG---VAAYR
MMAR_4944|M.marinum_M IA----SADILIGADGANSITREYVLGGPVTRRYAGYVNYNG---LVEVD
MUL_0460|M.ulcerans_Agy99 IA----SADILIGADGANSITREYVLGGPVTRRYAGYVNYNG---LVEVD
MSMEG_3841|M.smegmatis_MC2_155 VR-----ADVLVGADGIGSVVRAALHPGPDPLRFSGITMFRGAGRMAAFL
MAB_0288|M.abscessus_ATCC_1997 SLG----GDGLVGADGINSTIRR-TLLADGQPRVSGITVYRTT-VPIEQV
MAV_4429|M.avium_104 VA----EGDVLIGADGLHSMVRE--WVGARHAKATGWCSWQG----LVSL
TH_4641|M.thermoresistible__bu ELR----GRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLAD-----VYL
MLBr_02276|M.leprae_Br4923 EVG----CRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGY--LTTPRS
: .** *
Mb1780|M.bovis_AF2122/97 GDAEFSFLPR--FSPGKGLG----VIPR---EGYFQIAYLG--PKGTDAQ
Rv1751|M.tuberculosis_H37Rv GDAEFSFLPR--FSPGKGLG----VIPR---EGYFQIAYLG--PKGTDAQ
Mflv_2621|M.gilvum_PYR-GCK LDPELGGET---LGPGTQVG----HVPLGPDHTYWFATERT--AEGGS--
Mvan_3960|M.vanbaalenii_PYR-1 LDPALAGET---MSAGTEVG----HVPLGPDHTYWFATERT--REGSR--
MMAR_4944|M.marinum_M EAISPANEWTMYVGDGKRVS----AMPVADDR-FYFFFDVV--EPEGLPF
MUL_0460|M.ulcerans_Agy99 EAISPANEWTMYVGDGKRVS----AMPPTTPRPASGRADAR--RWKTRWH
MSMEG_3841|M.smegmatis_MC2_155 DGHTMAIVKGDRGDQGVDLV----TYPIAPDLVNWVVQVPQSAPTSAGWN
MAB_0288|M.abscessus_ATCC_1997 DASLRSNSVTWWTGPGCHLV----TYPIAGGSLLNLAASRT---DGATEA
MAV_4429|M.avium_104 PEIAESDAALMMIGGSGNLG----LWPAGGAEVQWWFDLPW----STGFV
TH_4641|M.thermoresistible__bu DWRLDRSGTTGWIHPDGMVG----AMPMPDGLWRIIAYDPG---------
MLBr_02276|M.leprae_Br4923 DDLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALS--------T
. : *
Mb1780|M.bovis_AF2122/97 LRERGIEEFRRDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHID-
Rv1751|M.tuberculosis_H37Rv LRERGIEEFRRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHID-
Mflv_2621|M.gilvum_PYR-GCK APGGEHAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDRARAARWSDG-
Mvan_3960|M.vanbaalenii_PYR-1 SAGGEHAYLTAKLAGWADPIPALLASTDPADVLRNDLYDRAQPRDWSRG-
MMAR_4944|M.marinum_M EKGTAREVLREQFAGWAPGVQALIDKLDPTTTNRVEILDLDPFHTWVKG-
MUL_0460|M.ulcerans_Agy99 CNGRSRTTPPTLRPRWPP--------IRPAAPNGPAIWYCGPVS------
MSMEG_3841|M.smegmatis_MC2_155 TPASAADVLPHVAGWRLDWLDVDSLIGSTPQIFTYPMVDKDPVRQWGRGG
MAB_0288|M.abscessus_ATCC_1997 FSGVSVSEARVLSELAPLRGTARALLELGRDWRSWALVDRDPVRQWSDG-
MAV_4429|M.avium_104 RPQHPIETIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPIPPPGRG
TH_4641|M.thermoresistible__bu ----PGDLDQGALERLLYERTGHRVKVTGTVWQSEFRVHRRLADTYRRG-
MLBr_02276|M.leprae_Br4923 SKRPADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGP
Mb1780|M.bovis_AF2122/97 GLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLR-------EHRV
Rv1751|M.tuberculosis_H37Rv GLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLR-------EHRV
Mflv_2621|M.gilvum_PYR-GCK RAVLIGDAAHPMRPHLGQGGCQGIEDAAILARFLELAD--------DVPT
Mvan_3960|M.vanbaalenii_PYR-1 PAVIVGDAAHPMRPHLGQGGCQGLEDAAILARFVGLSP--------DLPA
MMAR_4944|M.marinum_M RVAVLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNPT-------DVAA
MUL_0460|M.ulcerans_Agy99 -------AATSSTPRTPIPPQPGMR-----SCETNTAPT-------SFAG
MSMEG_3841|M.smegmatis_MC2_155 RVTLLGDAAHPMYPVGANGGSQAVVDARVLADHLAEAG----------VR
MAB_0288|M.abscessus_ATCC_1997 RVVLLGDAAHPMLHYAAQGASQALEDAVVFGAIIGTDPD-------RVPG
MAV_4429|M.avium_104 RVTLLGDAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTPGGQADVAN
TH_4641|M.thermoresistible__bu RVFIAGDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIRG-----YAGPA
MLBr_02276|M.leprae_Br4923 NWMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLS-----YVWPS
** .:
Mb1780|M.bovis_AF2122/97 SSRHLAAVRRRRAFPTAV--TQAVQRVLHRRLLGPLLQGRDPTPPAALLG
Rv1751|M.tuberculosis_H37Rv SSRHLAAVRRRRAFPTAV--TQAVQRVLHRRLLGPLLQGRDPTPPAALLG
Mflv_2621|M.gilvum_PYR-GCK AFERFEAFRKPRVG----------MLVREAQTLGRIVNVRPAVLSGLAGR
Mvan_3960|M.vanbaalenii_PYR-1 AFDRFGAFRRRRVR----------PLVRESAAIGRIVNLRPAFLSGVASR
MMAR_4944|M.marinum_M ALAAYQASRTERAG----------DLVLRARKRCDVIHAKDPDTTAAWYE
MUL_0460|M.ulcerans_Agy99 SSPTSWVGRSLR--------------------------------------
MSMEG_3841|M.smegmatis_MC2_155 GLRTYEAERADETA----------AVIVANREMHRAANTRSATELDRVTR
MAB_0288|M.abscessus_ATCC_1997 RFSRFVEARCDRTG----------DVTLAARASIGLWHAAGEAAVERNE-
MAV_4429|M.avium_104 ALRWYEKTRRRRVRAVSW--VASLPVSHGEAVLRPAALVSDRLQAAALTM
TH_4641|M.thermoresistible__bu LLDTYEAERRPLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPS
MLBr_02276|M.leprae_Br4923 LLQQHYGRGFSVARR--------LALLLTFKRCLPAIGPSAMRSTSLITI
Mb1780|M.bovis_AF2122/97 LVERLPWLSAVPAYFVGVGVRPEHAPAFARRGPGNRKGP-----------
Rv1751|M.tuberculosis_H37Rv LVERLPWLSAVPAYFVGVGVRPEHAPAFARRGPGNRKGP-----------
Mflv_2621|M.gilvum_PYR-GCK ATALIPERMVTAHLAWIAAGSAFVLPTAADLAR-----------------
Mvan_3960|M.vanbaalenii_PYR-1 ASALIPEWAVASHLASIAAGSAFILPTAGDVGG-----------------
MMAR_4944|M.marinum_M ELRNEDGTNIIRGLVANIMGGPLTPLS-----------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3841|M.smegmatis_MC2_155 KYRTDTARSTRA--------------------------------------
MAB_0288|M.abscessus_ATCC_1997 KLGAMRDSDLHQALAWMHGDTDFGLASVTSAVGVR---------------
MAV_4429|M.avium_104 FLRWTSHRRMSDHINRSVGEAINRSLGEAPKIPSRR--------------
TH_4641|M.thermoresistible__bu VQRRLTYQTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHIS
MLBr_02276|M.leprae_Br4923 AVRVMANLVTDDDADWVARVWRSGGWASWLVDRRPPFS------------
Mb1780|M.bovis_AF2122/97 --------------------------------------------------
Rv1751|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3841|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0288|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_4641|M.thermoresistible__bu RLYEQLGGRWAVLEPGSGRHHREGPGLLGTAHTFLGEYVVGLRGAEMRGC
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mb1780|M.bovis_AF2122/97 -----------------------------------
Rv1751|M.tuberculosis_H37Rv -----------------------------------
Mflv_2621|M.gilvum_PYR-GCK -----------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 -----------------------------------
MMAR_4944|M.marinum_M -----------------------------------
MUL_0460|M.ulcerans_Agy99 -----------------------------------
MSMEG_3841|M.smegmatis_MC2_155 -----------------------------------
MAB_0288|M.abscessus_ATCC_1997 -----------------------------------
MAV_4429|M.avium_104 -----------------------------------
TH_4641|M.thermoresistible__bu DAFLVRPDGHLAWRGRDATDLADWLKSALTVGRVR
MLBr_02276|M.leprae_Br4923 -----------------------------------