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MSDDQAVSERAASNGASNGAGAENGNGNENGNGNGNGSRPSMARLIHRMAVPIVVFWVGLVAVLVMFVPS LEEVGKQHTVSLSPSDAESMIAMKRVGKVFNEFDTDSAVMIVLEGDHPLGDEAHHYYDELVRKLKADKDH VQHVQDFWGDPLTAAGSQSPDGKAAYVQAYLVGNQGEAKANESVDAVRELVNDTPAPPGVKAYVTGPAAL IADQSTAGDASIQRVTFITIGVIFVMLLSVYRSLITVISVLVMVGIELMAARGVVAFLADNNVIGLSTFA VNLLVLMAIAAGTDYAIFVLGRYQEARGEGESREKAFYTMFHGTAHVVLGSGLTIAGAMYCLSFTRLPYF QTLGAPCAVGMLVAVLAALTLGPAVLVVGSFFKLFDPKRKMRTRGWRRVGTAIVRWPGPILAVSIAIALI GLLALPGYRTNYDSKKYLPASTPTNVGYTAADRHFSQARMNPELLMVETDHDMRNPADMLVIDRIAKGVF HLPGVARVQAVTRPLGKPIEHSSIPFQISMQNTVQVENMQYMKQRMADMLIQAAAMQDSIDTLDRMYDIM GKMVETTHDMDGLTHDMVEITDELRDHIADFDDFWRPIRSYFYWEKHCYDVPICWSLRSIFDALDGVDKI TEKLAALSRDMDRLDILMPQMRAQIPFQIASMKTMKTMMLTMHSSMSSLYDQMDEMSKNSTAMGKAFDAA RNDDSFYIPPEVFDNADFKRGLKMFLSPDGHAVRFIISHEGDPASTEGISHVKPIMDEAKQAIKGTPLEG AKIYLAGTASVYKDMRDGSRWDLLIAGVAAVSLILIIMLIITRSLVAAVVIVGTVLLSLGASFGLSVLVW QDIFGVELHWMVLAMSVILLLAVGSDYNLLLVSRLKEEIGAGLKTGIIRAMAGTGGVVTTAGLVFAATMA SFIFSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAALMGRWFWWPQQVRTRPASQLLRPYGPRPLVRA LLLPRNGDSADGPEDTNTERLAVSSPHY
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_0775 | - | - | 100% (1008) | MmpL family transport protein |
M. marinum M | MMAR_0840 | mmpL2 | 0.0 | 67.89% (953) | transmembrane transport protein, MmpL2 |
M. marinum M | MMAR_0771 | mmpL5_2 | 0.0 | 66.88% (945) | transmembrane transport protein MmpL5_2 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0519 | mmpL2 | 0.0 | 69.63% (945) | transmembrane transport protein MmpL2 |
M. gilvum PYR-GCK | Mflv_4418 | - | 0.0 | 66.31% (941) | transport protein |
M. tuberculosis H37Rv | Rv0507 | mmpL2 | 0.0 | 69.74% (945) | transmembrane transport protein MmpL2 |
M. leprae Br4923 | MLBr_02378 | - | 0.0 | 65.74% (937) | hypothetical protein MLBr_02378 |
M. abscessus ATCC 19977 | MAB_2301 | - | 0.0 | 64.16% (932) | putative membrane protein, mmpL |
M. avium 104 | MAV_4696 | - | 0.0 | 65.36% (944) | MmpL4 protein |
M. smegmatis MC2 155 | MSMEG_3496 | - | 0.0 | 66.42% (944) | MmpL4 protein |
M. thermoresistible (build 8) | TH_3260 | - | 0.0 | 61.18% (935) | PUTATIVE MmpL4 protein |
M. ulcerans Agy99 | MUL_0757 | mmpL5 | 0.0 | 64.96% (939) | transmembrane transport protein, MmpL5 |
M. vanbaalenii PYR-1 | Mvan_1936 | - | 0.0 | 66.70% (934) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_3496|M.smegmatis_MC2_155 -MSNP----SHDAPTDAMGVSGPKHAR------------------PGGIA TH_3260|M.thermoresistible__bu MTANPGHVRTDEAPTDRLDIKVSTHG-------------------PSFIS MUL_0757|M.ulcerans_Agy99 MTATT-----TDTPTDVVPP--AEHPP------------------RPFIP MLBr_02378|M.leprae_Br4923 -------------MTVKCANDLDTHTK------------------PPFVA MAB_2301|M.abscessus_ATCC_1997 -------------MSGSHAG--RSAAE------------------PTFLA Mflv_4418|M.gilvum_PYR-GCK ----------------------MADAG------------------RSGIG Mvan_1936|M.vanbaalenii_PYR-1 ----------------------MADAG------------------RSGIG Mb0519|M.bovis_AF2122/97 -------------MSERHAALTSLP---------------------PILP Rv0507|M.tuberculosis_H37Rv -------------MSERHAALTSLP---------------------PILP MMAR_0775|M.marinum_M -------MSDDQAVSERAASNGASNGAGAENGNGNENGNGNGNGSRPSMA MAV_4696|M.avium_104 -------------MSEPVEAAPRVDQPLIP----------------PFLP : MSMEG_3496|M.smegmatis_MC2_155 KWIRVLAVPIILVWVAIIAVLNTVVPQLDVVGEMRSVSMSPDDAPSVIAM TH_3260|M.thermoresistible__bu TWIRRLSLPIIVGWIALIALLNITVPQLEVVGEMRAVSMSPDEAPSMVAM MUL_0757|M.ulcerans_Agy99 RMIRTFAVPLILGWVLLIAVLNSVVPQLEVVGQMQAVSMSPDAAPSMISM MLBr_02378|M.leprae_Br4923 RMIHRFAVPIILVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAM MAB_2301|M.abscessus_ATCC_1997 KWIRRLSIPIVIGWLAIVFALNTFVPQLEQVGKEHTVSLSPQSAPSMQAM Mflv_4418|M.gilvum_PYR-GCK RIIRVLAVPIVLGWVLLTVLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSM Mvan_1936|M.vanbaalenii_PYR-1 RIIHLLAVPIVLGWIALTVLTNVAVPSLEKVGEEHTVGMSANDAPSMMSM Mb0519|M.bovis_AF2122/97 RLIRRFAVVIVLLWLGFTAFVNLAVPQLEVVGKAHSVSMSPSDAASIQAI Rv0507|M.tuberculosis_H37Rv RLIRRFAVVIVLLWLGFTAFVNLAVPQLEVVGKAHSVSMSPSDAASIQAI MMAR_0775|M.marinum_M RLIHRMAVPIVVFWVGLVAVLVMFVPSLEEVGKQHTVSLSPSDAESMIAM MAV_4696|M.avium_104 RMIHRLALPIVLVWLGIVFITNTVAPQLEVVAKTHSVSMSPTDAASFQSM *: ::: ::: *: : *.*: *.: ::*.:*. * * :: MSMEG_3496|M.smegmatis_MC2_155 KRVGEVFEEFKSNSSVMIVLEGEQPLGDEAHKYYDEIVDKLEADPAHVEH TH_3260|M.thermoresistible__bu KRVGELFDEGSSDSQVMIVLEGEEPLGADARAFYDELVKRLEADDAHVEN MUL_0757|M.ulcerans_Agy99 KHIGKVFREGDSDSAAMIVLEGQEPLGAAAHKFYDKMITKLRADTKHVQS MLBr_02378|M.leprae_Br4923 QKMGQVFNEGNSDSVIMIVLEGDKPLGDDAHRFYDGLIRKLRAD-KHVQS MAB_2301|M.abscessus_ATCC_1997 KHMGKMFKESDSDSVVMIVLEGQERLGPGSHKFYDEMVARLRADTKHVQH Mflv_4418|M.gilvum_PYR-GCK KRVGANFEEFDSDSSAMVVLEGEQPLGDAAHRYYDQLIDELEADTANVQH Mvan_1936|M.vanbaalenii_PYR-1 ERVGANFDEFDSDSSAMVVLEGEQPLGDAAHRYYDELIGKLEADTANVQH Mb0519|M.bovis_AF2122/97 KRVGQVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSDLMRKLSADTRHVAH Rv0507|M.tuberculosis_H37Rv KRVGQVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSDLMRKLSADTRHVAH MMAR_0775|M.marinum_M KRVGKVFNEFDTDSAVMIVLEGDHPLGDEAHHYYDELVRKLKADKDHVQH MAV_4696|M.avium_104 MKVGATFKEFNSDNSAMILLEGDKPLGAEAHRYYDEIVRRVEQDKKHVQH ::* * * .::. ::***:. ** :: :*. :: .: * :* MSMEG_3496|M.smegmatis_MC2_155 VQDFWGDPLTASGAQSPDGLASYVQVYTRGNQGEALANESVEAVQDIVES TH_3260|M.thermoresistible__bu VQDLWSDPLTATGVQSPDGKSAYVQVKLAGNQGEALANESVETVREMIAT MUL_0757|M.ulcerans_Agy99 VQDFWGDPLTATGAQSGDGKAAYVQVKLAGNQGESLANESVEAVKTIVDS MLBr_02378|M.leprae_Br4923 VQDFWGDPLTAPGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQ MAB_2301|M.abscessus_ATCC_1997 VQDFWGDPLTEAGAQSTDGKATYVQVNLAGNMGETLSNESTEAARNIVKQ Mflv_4418|M.gilvum_PYR-GCK IADFWGDPLTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDR Mvan_1936|M.vanbaalenii_PYR-1 VADFWGDPLTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDQ Mb0519|M.bovis_AF2122/97 IQHFWGDPLTAAGSQSADDRAAYVVVYLVGNN-ETEAYDSVHAVRHMVDT Rv0507|M.tuberculosis_H37Rv IQDFWGDPLTAAGSQSADDRAAYVVVYLVGNN-ETEAYDSVHAVRHMVDT MMAR_0775|M.marinum_M VQDFWGDPLTAAGSQSPDGKAAYVQAYLVGNQGEAKANESVDAVRELVND MAV_4696|M.avium_104 VQDFWSDPLTAAGSQSHDQKAAYVQVYLAGNMGGGLANESALAVRKIVDS : .:*.**** .* ** * ::** ** : :: :.: :: MSMEG_3496|M.smegmatis_MC2_155 VP---------APPGVKAYVTGPAALSADQHVASDRSVRVIEALTFAVII TH_3260|M.thermoresistible__bu VSEE------MAPEGVQAFVTGGAAMSADQQEAGDSSLRVIEALTFLVIT MUL_0757|M.ulcerans_Agy99 LQ---------APPGVKVYVTGSAALVADQQLAGDRSLQLIEMVTFTVII MLBr_02378|M.leprae_Br4923 TPA---------PPGITAWVTGASALIADMHHSGDKSMIRITATSVIVIL MAB_2301|M.abscessus_ATCC_1997 LEADWTKDGNKLPDGLTVYVTGPGALQTDMNHAGDGSLQLITGLTFLVIV Mflv_4418|M.gilvum_PYR-GCK TP---------APPGIKAYVTGGAPLVADQHSAGDTSVLRVTLITIGVIA Mvan_1936|M.vanbaalenii_PYR-1 TP---------APPGLKAYVTGGAPLVADQHNAGDKSVFRVTLITIGVIA Mb0519|M.bovis_AF2122/97 TP---------PPHGVKAYVTGPAALNADQAEAGDKSIAKVTAITSMVIA Rv0507|M.tuberculosis_H37Rv TP---------PPHGVKAYVTGPAALNADQAEAGDKSIAKVTAITSMVIA MMAR_0775|M.marinum_M TP---------APPGVKAYVTGPAALIADQSTAGDASIQRVTFITIGVIF MAV_4696|M.avium_104 VP---------APPGIKAYVTGAGPLFADQSHAGEKGVAVVTLITFVVII * *: .:*** ..: :* :.: .: : : ** MSMEG_3496|M.smegmatis_MC2_155 TMLLLVYRSIVTVILTLVMVVLSLSAARGMIAFLGYHEIIGLSVFATNLL TH_3260|M.thermoresistible__bu TMLLFVYRSVITVLIALFMVLIGLLTTRGVVAFLGYHNIIGLSTFATSLL MUL_0757|M.ulcerans_Agy99 VMLLLVYRSIITAAIMLTMVVLGLLATRGGVAFLGYHRIIGLSTFATNLL MLBr_02378|M.leprae_Br4923 VTLLLVYRSFITVILLLFTVGIESAVARGVVALLGHTGLIGLSTFAVNLL MAB_2301|M.abscessus_ATCC_1997 VMLLFFYRSIFTVIMVFMLVGIQLSAARGVIAFLGNTEIIGLSTFAVNLL Mflv_4418|M.gilvum_PYR-GCK VMLLIVFRSVATMVLILFMVFAELGAARGIVAFLADAEIIGLSTFATSLL Mvan_1936|M.vanbaalenii_PYR-1 VMLLLVFRSVATMVLILFMVFAELGAARGIVAFLANAEIIGLSTFATSLL Mb0519|M.bovis_AF2122/97 AMLLVIYRSVITAVLVLIMVGIDLGAIRGFIALLADHNIFSLSTFATNLL Rv0507|M.tuberculosis_H37Rv AMLLVIYRSVITAVLVLIMVGIDLGAIRGFIALLADHNIFSLSTFATNLL MMAR_0775|M.marinum_M VMLLSVYRSLITVISVLVMVGIELMAARGVVAFLADNNVIGLSTFAVNLL MAV_4696|M.avium_104 VMLLVVYRSIITVAVMLGMVFIELAAARGVVATLGNYGVMGLSTFANNML . ** .:**. * : * . ** :* *. ::.**.** .:* MSMEG_3496|M.smegmatis_MC2_155 TTLAIAAATDYAIFLIGRYQEARSVGEDREQSYYTMFHSTAHVVLGSGMT TH_3260|M.thermoresistible__bu VTLAIAIAVDYAIFLIGRYQEARSVGADRATAYHTMFGGTAHVILASGLT MUL_0757|M.ulcerans_Agy99 VVLAIAAATDYAIFLIGRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLT MLBr_02378|M.leprae_Br4923 TSLAIAAGTDYGIFITGRYQEARQANENKEAAFYTMYRGTFHVILGSGLT MAB_2301|M.abscessus_ATCC_1997 VMLSIAAGTDYAIFLIGRYQEARAMGADKEAAYYEMFHGTAHVILGSGMT Mflv_4418|M.gilvum_PYR-GCK TLMVIAAGTDYAIFAIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLT Mvan_1936|M.vanbaalenii_PYR-1 TLMVIAAGTDYAIFAIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLT Mb0519|M.bovis_AF2122/97 VLMAIAASTDYAIFMLGRYHESRYAGEDRETAFYTMFHGTAHVILGSGLT Rv0507|M.tuberculosis_H37Rv VLMAIAASTDYAIFMLGRYHESRYAGEDRETAFYTMFHGTAHVILGSGLT MMAR_0775|M.marinum_M VLMAIAAGTDYAIFVLGRYQEARGEGESREKAFYTMFHGTAHVVLGSGLT MAV_4696|M.avium_104 VLMAIAAGTDYAIFVVGRYHEARGLGETREQAFYTMFHSTAHVVLGSGLT . : ** ..**.** ***:*:* . : ::: *: .* **:*.**:* MSMEG_3496|M.smegmatis_MC2_155 IAGATLCLHFTRMPYFQSLGIPLAIGMSVVVLASLTMGAAIISVASRFGK TH_3260|M.thermoresistible__bu IAGATFCLSFTRLPYFQSLGPPLAIGMIVLIVTSLTMGPAIITVATRFG- MUL_0757|M.ulcerans_Agy99 IAGATFCLSFTRLPYFQTLGVPLAIGMVIVVATALTLGPALIAVMSRFGK MLBr_02378|M.leprae_Br4923 ISGATFCLSFARMPYFQTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFG- MAB_2301|M.abscessus_ATCC_1997 IAGAMYCLSFTRMPYFQTLGVPCSVGLLVGVLVSLTLGPALITIGSRFG- Mflv_4418|M.gilvum_PYR-GCK IAGAMLCLSFTRLPYFQTMGVPCAVGTFVAVIAALTLGPAVIVIGSRFG- Mvan_1936|M.vanbaalenii_PYR-1 IAGAMLCLSFTRLPYFQTMGVPCAVGTFVAVMAALTLGPAVVAIGSRFG- Mb0519|M.bovis_AF2122/97 IAGAMYCLSFARLPYFETLGAPIAIGMLVAVLAALTLGPAVLTVGSFFK- Rv0507|M.tuberculosis_H37Rv IAGAMYCLSFARLPYFETLGAPIAIGMLVAVLAALTLGPAVLTVGSFFK- MMAR_0775|M.marinum_M IAGAMYCLSFTRLPYFQTLGAPCAVGMLVAVLAALTLGPAVLVVGSFFK- MAV_4696|M.avium_104 IAGAMYCLSFCRLPYFQSLGVPCAVGMLVAVLAALTLAPAMLTVASFFK- *:** ** * *:***:::* * ::* : : .:**:..*:: : : * MSMEG_3496|M.smegmatis_MC2_155 TFEPKRAMRTRGWRKLGAAVVRWPAPILVTTIALSVVGLLALPGYQTNYN TH_3260|M.thermoresistible__bu LLEPKRAARVRFWRKVGASVVRWPGPIMVTTVAVTLVGLLALPGYRTNYN MUL_0757|M.ulcerans_Agy99 LLEPKRMARVRGWRKIGAAIVRWPGPILIGAVALALVGLLTLPGYKTNYN MLBr_02378|M.leprae_Br4923 LFEPKRLIKVRGWRRIGTVVVRWPLPILITTCAIAMVGLLALPGYRTNYK MAB_2301|M.abscessus_ATCC_1997 LFEPKRAMRIRSWRKIGTTIVRWPGPVLAAAMAIAIIGLAALPGYRTSYD Mflv_4418|M.gilvum_PYR-GCK LFDPKRAISSRGWRRIGVSVVRWPGPVLAATLALALVGLVTLPGYKTNYD Mvan_1936|M.vanbaalenii_PYR-1 LFDPKRAISSRGWRRIGVSVVRWPGPVLAATLALALVGLVALPGYKTNYD Mb0519|M.bovis_AF2122/97 LFDPKRRMNTRRWRRVGTAIVRWPGPVLAATCLVASIGLLALPSYRTTYD Rv0507|M.tuberculosis_H37Rv LFDPKRRMNTRRWRRVGTAIVRWPGPVLAATCLVASIGLLALPSYRTTYD MMAR_0775|M.marinum_M LFDPKRKMRTRGWRRVGTAIVRWPGPILAVSIAIALIGLLALPGYRTNYD MAV_4696|M.avium_104 LMDPKRTLQTRGWRRMGTAVVRWPAPVLAVTIAVALVGLLALPGYKTDYD ::*** * **::*. :**** *:: : :: :** :**.*:* *. MSMEG_3496|M.smegmatis_MC2_155 DRRYLPQDLPANTGYAAADRHFSQARMNPELLMIESDHDLRNSADFLVVD TH_3260|M.thermoresistible__bu DRNYLPASFPSNAGYEAAERHFDPARLNPELLLIESDHDLRNPADFLVIE MUL_0757|M.ulcerans_Agy99 DRNYLPADLPANEGYSAAERHFSQARMNPEVLMVESDHDMRNSSDFLVIN MLBr_02378|M.leprae_Br4923 DRAYLPASIPANQGFAAADRHFPQARMKPEILMIESDHDMRNPADFLILD MAB_2301|M.abscessus_ATCC_1997 DKKYIPKDIPANAGFQAADRHFSQARMNPEMLLIESDHDMRNSADFLVID Mflv_4418|M.gilvum_PYR-GCK ARDYLPEDIPANVGYAVADQHFGSARMNPELLMVESDHDLRNPADFLVID Mvan_1936|M.vanbaalenii_PYR-1 SRDYLPEDVPANVGYAVADRHFGSARMNPELLMVESDHDLRNPADFLVID Mb0519|M.bovis_AF2122/97 LRKFMPASMPSNVGDAAAGRHFSRARLNPEVLLIETDHDMRNPVDMLVLD Rv0507|M.tuberculosis_H37Rv LRKFMPASMPSNVGDAAAGRRFSRARLNPEVLLIETDHDMRNPVDMLVLD MMAR_0775|M.marinum_M SKKYLPASTPTNVGYTAADRHFSQARMNPELLMVETDHDMRNPADMLVID MAV_4696|M.avium_104 NRHFLPADTPANVGYAAADRHFDQARLNPELLMIETDHDLRNPADFIVLD : ::* . *:* * .* ::* **::**:*::*:***:**. *::::: MSMEG_3496|M.smegmatis_MC2_155 RIAKRVFQVPGISRVQAITRPQGTPIEHTSIPFQISMSGTTQMMNMKYMQ TH_3260|M.thermoresistible__bu KIAKAVFQVEGISRVQGITRPEGTPIEHSSIPFMISQQGTLQILNQQYMQ MUL_0757|M.ulcerans_Agy99 KIAKAIFGVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQ MLBr_02378|M.leprae_Br4923 KLARGIFRVPGISRVQAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQK MAB_2301|M.abscessus_ATCC_1997 KIAKAVFRVPGIARVQAITRPQGTPIEHSSIPFLISMQSVGQRQNMKLMK Mflv_4418|M.gilvum_PYR-GCK KIAKSVFRVPGVARVQTITRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQ Mvan_1936|M.vanbaalenii_PYR-1 KIAKAIFRVPGVARVQTITRPDGKPIKHTTIPFQMSMRSTTSRLNEKYMQ Mb0519|M.bovis_AF2122/97 KVAKNIYHSPGIEQVKAITRPLGTTIKHTSIPFIISMQGVNSSEQMEFMK Rv0507|M.tuberculosis_H37Rv KVAKNIYHSPGIEQVKAITRPLGTTIKHTSIPFIISMQGVNSSEQMEFMK MMAR_0775|M.marinum_M RIAKGVFHLPGVARVQAVTRPLGKPIEHSSIPFQISMQNTVQVENMQYMK MAV_4696|M.avium_104 KVAKAVFHIPGIGRVQTITRPLGTPLDHSTLGFQMGAQAAGRLQTQHYQE ::*: :: *: :*: :*** *..:.*::: * :. . . : MSMEG_3496|M.smegmatis_MC2_155 DRMADMLVMADEMQKSVDTMEEMLKITREMSDTTHSMVGKMHGMVEDIKE TH_3260|M.thermoresistible__bu DRMADMLVQADEMQLMIDTMDKMIALMEEMVETTDNMVRDMDEMAAHVAE MUL_0757|M.ulcerans_Agy99 DLTTSMLQQVNDIQTNIDQMERMHDLTQQMADVTHQMVIQMKGMVVDVEE MLBr_02378|M.leprae_Br4923 DRMNDLLRQAENMAETIASMRRMHQLMALLTENTHHILNDTVEMQKTTSK MAB_2301|M.abscessus_ATCC_1997 DRMADMKVQADKMGENVVIMKRTLANMTTMAGITHSLVGDMHTLQGTIHE Mflv_4418|M.gilvum_PYR-GCK DRMADMLVQADAMQTNVDTMTRMQSLMGQMSATTHEMVLKTKKTEIDIIE Mvan_1936|M.vanbaalenii_PYR-1 DRMADMLVQADAMQTNVDTMTKMQSLMTQMSAATHDMVTKTKKTAVDIVE Mb0519|M.bovis_AF2122/97 DRIYDILVQVAAMNTSIETMHRMYALMGEVIDNTVDMDHLTHDMSDITAT Rv0507|M.tuberculosis_H37Rv DRIDDILVQVAAMNTSIETMHRMYALMGEVIDNTVDMDHLTHDMSDITAT MMAR_0775|M.marinum_M QRMADMLIQAAAMQDSIDTLDRMYDIMGKMVETTHDMDGLTHDMVEITDE MAV_4696|M.avium_104 EQANNLLKQADELRKTMATLHEQMQVTQDLSNTTHETTRLTKETVQITER : .: . : : : . : * MSMEG_3496|M.smegmatis_MC2_155 LRDHIADFDDFLRPIRNYFYWEPHCDSIPVCQSIRSIFDTLDGIDVMTDD TH_3260|M.thermoresistible__bu MRDSISEFDDFFRPIRNYFYWEPHCYNIPVCWAMRSVFDTLDGINTMTDD MUL_0757|M.ulcerans_Agy99 LRNHIADFDDFFRPIRSYFYWEKHCFDIPVCWSLRSVFDTLDGVDLMTED MLBr_02378|M.leprae_Br4923 LRDEIANFDDFWRPIRSYFYWERHCFNIPICWSFRSIFDALDGVDQIDER MAB_2301|M.abscessus_ATCC_1997 MRDSISNFDDWFRPIRNYLYWEKHCFDIPMCWAMRSIFDTLDKIDEMTET Mflv_4418|M.gilvum_PYR-GCK VRDNLADFDDFFRPVRNYFYWEPHCYDIPVCWTMRSVFDTLDGINPLTDD Mvan_1936|M.vanbaalenii_PYR-1 VRDYLANLDDFVRPVRNYFYWEPHCYNIPVCATMRSVFDTLDGINPLTDD Mb0519|M.bovis_AF2122/97 LRDHLADFEDFFRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEK Rv0507|M.tuberculosis_H37Rv LRDHLADFEDFFRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEK MMAR_0775|M.marinum_M LRDHIADFDDFWRPIRSYFYWEKHCYDVPICWSLRSIFDALDGVDKITEK MAV_4696|M.avium_104 LRDDIANFDDFLRPIRSYFYWEKHCYDIPVCWALRSVFNALDGIDQVAEN :*: :::::*: **:*.*:*** ** .:*:* ::**:*: :* :: : : MSMEG_3496|M.smegmatis_MC2_155 IQRLMPDMDRLDELMPQMLTIMPPMIESMKTMKTMMLTTQATMGGLQDQM TH_3260|M.thermoresistible__bu IQNMLPHMHRLNDLMPQMLTLLPTTVATMKTMRSMLLTMQATNAGLQDQM MUL_0757|M.ulcerans_Agy99 INNLLPLMERLDTLMPQMTAMMPEMIQTMKSMKAQMLSMHSTQQGLQDQM MLBr_02378|M.leprae_Br4923 LNSIVGDIKNMDLLMPQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQM MAB_2301|M.abscessus_ATCC_1997 MDGMVVNMERMDTLMPKMVSDMSAMIPIMEDMQRMMLTQHSTMSGFYNQM Mflv_4418|M.gilvum_PYR-GCK ISELIPDLERLDELMPQLIALLPSQIETMRSMQAMMLRQYQTQKGQLDQN Mvan_1936|M.vanbaalenii_PYR-1 IQELIPDLERLDALMPQLIALLPSQIESMRNMQSMMLTMYQSQKGLQDQM Mb0519|M.bovis_AF2122/97 LEYLVKDMDILITLLPQMRAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQ Rv0507|M.tuberculosis_H37Rv LEYLVKDMDILITLLPQMRAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQ MMAR_0775|M.marinum_M LAALSRDMDRLDILMPQMRAQIPFQIASMKTMKTMMLTMHSSMSSLYDQM MAV_4696|M.avium_104 IVNLSANLDKLDRIQPKLVALIPPQIESQQRNLDTIMSNYAITQGLNDQA : : :. : : *:: :. : :: . .* MSMEG_3496|M.smegmatis_MC2_155 EAAMENQTAMGQAFDASKNDDSFYLPPETFENPDFKRGMKMFLSPDGHAV TH_3260|M.thermoresistible__bu AEMQENANAMGEAFDQARNDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAV MUL_0757|M.ulcerans_Agy99 AAMQEDSSAMGEAFDSSRNDDSFYLPPEVFNNPDFKRGLEQFLSPDGHAV MLBr_02378|M.leprae_Br4923 NELSDNANTMGKAFDTAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAA MAB_2301|M.abscessus_ATCC_1997 DEMSQNSTAMGKAFDAAKNDDSFYLPPEIFDNADFKRGMKSFLSPDGKAV Mflv_4418|M.gilvum_PYR-GCK AAMSEDADAMGEAFDDSMNDDSFYLPPEAFDNDDFKRGMENFISPDGRSV Mvan_1936|M.vanbaalenii_PYR-1 ASQSEDADAMGEAFDDSMNDDSFYLPPEAFDNDDFKRGIENFISPDGKSV Mb0519|M.bovis_AF2122/97 ERNNKDPGAMGRVFDAAQIDDSFYLPQSAFENPDFKRGLKMFLSPDGKAA Rv0507|M.tuberculosis_H37Rv ERNNKDPGAMGRVFDAAQIDDSFYLPQSAFENPDFKRGLKMFLSPDGKAA MMAR_0775|M.marinum_M DEMSKNSTAMGKAFDAARNDDSFYIPPEVFDNADFKRGLKMFLSPDGHAV MAV_4696|M.avium_104 KAQADNATAQGDAFDKAKNDDTFYLPPEAFKSPDFARGLKNFISPDGRAV .: : * .** : **:**:* . *.. ** *.:: *:*.**::. MSMEG_3496|M.smegmatis_MC2_155 RFIISHEGDPMSPEGIKHIDAIKQAAKEAIKGTPLEGSKIYLGGTAATFK TH_3260|M.thermoresistible__bu RFIISHQGDPMTPEGLAKIEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFK MUL_0757|M.ulcerans_Agy99 RFIISHEGDPMSQAGINHIDKIKTAAKEAIKGTPLEGSTIYLGGTVAMFK MLBr_02378|M.leprae_Br4923 RFIILHRGDPASVAGIASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFK MAB_2301|M.abscessus_ATCC_1997 RMIISHRGDPATPEGLSHVEPIKQAAIEAVKGTPLEDAKIELGGTAAVFK Mflv_4418|M.gilvum_PYR-GCK RFIISHEGDPATVEGISEVVPIKTAAKEAIKGTPLEGSTVYLAGTAATYK Mvan_1936|M.vanbaalenii_PYR-1 RFIIAHEGDPATVEGISRVLPIKTAAKEAIKGTPLEGSTVYLAGTAATYK Mb0519|M.bovis_AF2122/97 RFVIALEGDPATPEGICRVEPIKREAREAIKGTPLQGAAIYLGGTAATFK Rv0507|M.tuberculosis_H37Rv RFVIALEGDPATPEGISRVEPIKREAREAIKGTPLQGAAIYLGGTAATFK MMAR_0775|M.marinum_M RFIISHEGDPASTEGISHVKPIMDEAKQAIKGTPLEGAKIYLAGTASVYK MAV_4696|M.avium_104 RLIISHEGDPASPEGIRHIEPIKQAVHEAIKGTPWEGAKVYLGGTAATYK *::* .*** : *: : * . :*:**** :.: : *.**.: :* MSMEG_3496|M.smegmatis_MC2_155 DLQEGANYDLIIAGIAALCLIFIIMLIITRAVVASAVIVGTVVISLGASF TH_3260|M.thermoresistible__bu DMSDGTKYDLIIAAIAAVCLIFIIMLILTRAVVAAAVIVGTVTLSLAASF MUL_0757|M.ulcerans_Agy99 DLSDGNTFDLMIAGISALCLIFIIMLIITRSVVAAAVIVGTVVLSLGASF MLBr_02378|M.leprae_Br4923 DIDEGANWDLVIAGISSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASF MAB_2301|M.abscessus_ATCC_1997 DMSDGAKYDLMIAGISALCLIFLIMLLITRSFVASLVIVGTVALSLGASF Mflv_4418|M.gilvum_PYR-GCK DMSDGAFYDLLIAGIAAVTLIFVIMLVITRSVVAAAVIVGTVLLSLGASF Mvan_1936|M.vanbaalenii_PYR-1 DMRDGANYDLLIAGIAAVTLIFVIMLIITRSVVAAAVIVGTVLLSLGASF Mb0519|M.bovis_AF2122/97 DIREGARYDLLIAGVAAISLILIIMMIITRSVVAAVVIVGTVVLSMGASF Rv0507|M.tuberculosis_H37Rv DIREGARYDLLIAGVAAISLILIIMMIITRSVVAAVVIVGTVVLSMGASF MMAR_0775|M.marinum_M DMRDGSRWDLLIAGVAAVSLILIIMLIITRSLVAAVVIVGTVLLSLGASF MAV_4696|M.avium_104 DMHDGSNIDLLIAGIAAATLIFIIMLVITRSVVAAFVIVGTVLLSLGASF *: :* **:**.::: **::**:::**:.**: ****** :*:.*** MSMEG_3496|M.smegmatis_MC2_155 GLSVLIWQHIIGLELHWMVLAMAVIVLLAVGADYNLLLVSRIKEEIHAGL TH_3260|M.thermoresistible__bu GVSVLIWQYIVGLEMHWMVFPMALIILLAVGADYNLLVVARLREEIPAGL MUL_0757|M.ulcerans_Agy99 GLSVLIWQHVLGIELHWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGI MLBr_02378|M.leprae_Br4923 GLSVLLWQHILGIELHYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGL MAB_2301|M.abscessus_ATCC_1997 GLSVIIWQYILGIELHWLVMQMAIIVLLAVGSDYNLLLVSRLKEELHGGL Mflv_4418|M.gilvum_PYR-GCK GLSVLLWQHIIGLALHWMVLPMAVILLLAVGSDYNLLLVSRFKEELSGGL Mvan_1936|M.vanbaalenii_PYR-1 GLSVLLWQHIIGLALHWMVLPMAVILLLAVGSDYNLLLVSRFKEELAGGL Mb0519|M.bovis_AF2122/97 GLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYNLLLISRLKEEIGAGL Rv0507|M.tuberculosis_H37Rv GLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYNLLLISRLKEEIGAGL MMAR_0775|M.marinum_M GLSVLVWQDIFGVELHWMVLAMSVILLLAVGSDYNLLLVSRLKEEIGAGL MAV_4696|M.avium_104 GLSVLLWQYLLGLKLHWMVLAMAVILLLAVGSDYNLLLISRFKEEIHAGL *:**::** :.*: ::::*: *::*:*****:*****:::*:::*: .*: MSMEG_3496|M.smegmatis_MC2_155 NTGIIRSMGGTGSVVTSAGLVFAFTMMSMAVSELAVIAQVGTTIGLGLLF TH_3260|M.thermoresistible__bu NTGMIRAMGGSGSVVTAAGLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLF MUL_0757|M.ulcerans_Agy99 NTGIIRAMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLF MLBr_02378|M.leprae_Br4923 KTGIIRSMGGTGKVVTNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLF MAB_2301|M.abscessus_ATCC_1997 KTGIIRSMGGTGSVVTSAGLVFAFTMAVMVVSDLRIIGQVGTTIALGLLF Mflv_4418|M.gilvum_PYR-GCK KTGIIRAMAGTGSVVTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLF Mvan_1936|M.vanbaalenii_PYR-1 KTGIIRSMAGTGSVVTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLF Mb0519|M.bovis_AF2122/97 NTGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLF Rv0507|M.tuberculosis_H37Rv NTGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLF MMAR_0775|M.marinum_M KTGIIRAMAGTGGVVTTAGLVFAATMASFIFSDLRVIGQVGTTIGLGLLF MAV_4696|M.avium_104 KTGTIRAMAGSGSVVTSAGLVFAATMATFMFSPLLVMAQVGTTIALGLLF :** **:*.*:* *** **:**. ** : .* * ::.*:****.:**** MSMEG_3496|M.smegmatis_MC2_155 DTLVIRSFMTPSIAALMGKWFWWPQRVRQRPLPAPWPQPVQRDPEDALNR TH_3260|M.thermoresistible__bu DTFVVRSFMMPSIATLLGRWFWWPQFVRKRPVPQPWPSVPPRGP-ATTDR MUL_0757|M.ulcerans_Agy99 DTLIVRSFMTPSIAALLGKWFWWPQVVRQRPAPQPWPTPAPTPPPATTSV MLBr_02378|M.leprae_Br4923 DTLIVRSFMMPSIAALLGRWFWWPQQGRTRPLLTVAAPVGLPPDRSLVYS MAB_2301|M.abscessus_ATCC_1997 DTLIVRSFMTPAVATLLGRWFWWPLNVRTRPLPPPRTTVAADPTPPPVPV Mflv_4418|M.gilvum_PYR-GCK DTLIVRSFMTPAVAALLGRWFWWPQKFRSAASERRLARIGVQPATAGR-- Mvan_1936|M.vanbaalenii_PYR-1 DTLIVRSFMTPAVAALLGRWFWWPQKVRSHASQRRLAALNH--------- Mb0519|M.bovis_AF2122/97 DTLVVRSFMTPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLL Rv0507|M.tuberculosis_H37Rv DTLVVRSFMTPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLL MMAR_0775|M.marinum_M DTLIVRSFMTPSIAALMGRWFWWPQQVRTRPASQLLRPYGPRPLVRALLL MAV_4696|M.avium_104 DTLIVRSFMTPSLATLLGRWFWWPQHVRPRPASTMLRPYGPRRAVRELIL **:::**** *::*:*:*:***** * . MSMEG_3496|M.smegmatis_MC2_155 V------------------------ TH_3260|M.thermoresistible__bu VSV---------------------- MUL_0757|M.ulcerans_Agy99 ------------------------- MLBr_02378|M.leprae_Br4923 D------------------------ MAB_2301|M.abscessus_ATCC_1997 GPGHGDDPITTEFPRPSV------- Mflv_4418|M.gilvum_PYR-GCK ------------------------- Mvan_1936|M.vanbaalenii_PYR-1 ------------------------- Mb0519|M.bovis_AF2122/97 P----SGQHPSATGAHE-------- Rv0507|M.tuberculosis_H37Rv P----SGQHPSATGAHE-------- MMAR_0775|M.marinum_M PRNGDSADGPEDTNTERLAVSSPHY MAV_4696|M.avium_104 AD---VDEHPPGGVVQPR-------