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VTTTRHKDTHKDTREDTREDTRDDSRDDGGDPNGDTDHAVVVGGGGPTGMMTAAELALAGVDVAVVERRT TPEITGSRAGGLLSRTLEILDQRGVVDRFLSAGETMQVHGFAQVRLDVSDLPTRHPYGLALWQKHIERIL AEWVDELAVPVYRGREVVGVRQDGAGVDIELSDGRVLRAGYLVGCDGGRSLIRKSAGIEFPGWEPTTSYL LAEVEIAPEDGREPEWGIRRDALGVHALSRSDDGPVRIMVTEQDLRRSGVPDLAELREALVTVYGTDFGI HSPTSISRFTDTARQAVAYRSGRILLVGDAAHVHHPVGGQGLNTGMQDAVNLGWKLAQVVQGWSPDTLLD TYHDERQPVGARVLRNAVAQMALLRPDDRTTVLHGVVSDMLDMDEPRRRFAAMMSGLDIHYDLGDGHPLL GLRMPDLDLETAHGPTRVSALLRQARPVLLDLGAPDAVDLTGWEARVRMVRANAATVWELPVIGEVPAPA AVLIRPDGHVAWVAGDSAAAPAEAAARWFGAPTGRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2422 | - | - | 100% (526) | hypothetical protein Mvan_2422 |
| M. vanbaalenii PYR-1 | Mvan_0779 | - | 1e-40 | 32.93% (495) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_4245 | mhpA | 4e-29 | 32.00% (350) | 3-(3-hydroxyphenyl)propionate hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 6e-15 | 26.91% (327) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_5009 | - | 6e-45 | 31.82% (484) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1751 | - | 8e-15 | 26.91% (327) | hypothetical protein Rv1751 |
| M. leprae Br4923 | MLBr_02276 | - | 1e-06 | 24.45% (319) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3483 | - | 1e-168 | 61.51% (491) | hypothetical protein MAB_3483 |
| M. marinum M | MMAR_4271 | - | 1e-175 | 63.60% (489) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 0.0 | 65.84% (486) | hypothetical protein MAV_2736 |
| M. smegmatis MC2 155 | MSMEG_2252 | - | 4e-91 | 42.13% (489) | flavin-type hydroxylase |
| M. thermoresistible (build 8) | TH_1880 | - | 1e-100 | 44.49% (490) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_3663 | - | 4e-15 | 26.07% (326) | hypothetical protein MUL_3663 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
MUL_3663|M.ulcerans_Agy99 -------------------------------------MPQPS--------
MMAR_4271|M.marinum_M -------------------------------------------------M
MAV_2736|M.avium_104 ---------------------------------------MRGVRFSERSV
Mvan_2422|M.vanbaalenii_PYR-1 ---------------MTTTRHKDTHKDTREDTREDTRDDSRDDGGDPNGD
MAB_3483|M.abscessus_ATCC_1997 -------------------------------------------------M
MSMEG_2252|M.smegmatis_MC2_155 -------------------------------MADAESLAAHGSRVAGKGI
TH_1880|M.thermoresistible__bu --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK ----------------------------------------------MPGA
MLBr_02276|M.leprae_Br4923 ----------------------------------------------MRVE
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRD-SRGDTVHAS
MMAR_4271|M.marinum_M ADHAVVVVGAGPTGLMLAGELALAGVDVAVVERRVSQDLVGSRAGGLHSR
MAV_2736|M.avium_104 RGHAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQLIGSRAGGLHAR
Mvan_2422|M.vanbaalenii_PYR-1 TDHAVVVGGGGPTGMMTAAELALAGVDVAVVERRTTPEITGSRAGGLLSR
MAB_3483|M.abscessus_ATCC_1997 TEHAVVIAGGGPTGLMLAGELALAGADVAIVERRTTHELDGSRAAGMTSR
MSMEG_2252|M.smegmatis_MC2_155 SVKDVVIVGGGPTGAMLAGELRLYEVDVMVLDKDIEPTKV-VRSLGLHAR
TH_1880|M.thermoresistible__bu -VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAH-VRSLGLHVR
Mflv_5009|M.gilvum_PYR-GCK HRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAG-PATTSRANFLHAR
MLBr_02276|M.leprae_Br4923 TSADVVVVGAGPAGSAAATWAARAGNDVIVID-SVCFPRDKACGDGLTPR
: *.**:* . * ::: . :
Mb1780|M.bovis_AF2122/97 TMRLLDELGLWERFAALPYSEVR-TATLHSNGRAVTYIDFERLHQPYPYV
Rv1751|M.tuberculosis_H37Rv TMRLLDELGLWERFAALPYSEVR-TATLHSNGRAVTYIDFERLHQPYPYV
MUL_3663|M.ulcerans_Agy99 TLRLLDELGLGSQFAQIPHRLID-TISMKVQGQPVD-LDLKHLPGAHQHI
MMAR_4271|M.marinum_M TIEVLDQRGIADRFLAQGTATQ-----VARFAAIPLD--ISDFPTRHNYG
MAV_2736|M.avium_104 TLEILDQRGIVDRFLAEGQVAQ-----VAGFAQIRLD--ISDFPTRHPYG
Mvan_2422|M.vanbaalenii_PYR-1 TLEILDQRGVVDRFLSAGETMQ-----VHGFAQVRLD--VSDLPTRHPYG
MAB_3483|M.abscessus_ATCC_1997 TLEVLDQRGILDRFTPQGFSAP-----VAHFSALLLD--MTDQPTRHTFG
MSMEG_2252|M.smegmatis_MC2_155 SIEIMDQRGLLDRFLEVGRRHP-----VGGYFAGITKAPPRTLDTAHPYV
TH_1880|M.thermoresistible__bu SIEMLDQRGLLDRFLAHGQRHP-----VGGFFAAIAK-PPAELDTAHGYV
Mflv_5009|M.gilvum_PYR-GCK GSEVLDRMGALGTLPQESLRALRITNYLGDRPLATLEFGDPGMRTAAPP-
MLBr_02276|M.leprae_Br4923 AVAELKRLGLDDWLNTRIRHRG-----LRMSGFGGEVEVDWPGPSFPSTS
:.. * : :
Mb1780|M.bovis_AF2122/97 AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVRYQ
Rv1751|M.tuberculosis_H37Rv AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVRYQ
MUL_3663|M.ulcerans_Agy99 ALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSATYR
MMAR_4271|M.marinum_M LALWQNRIERILAEWVAELR-VRIYRGCEVTDITQ-------DDNGVDLT
MAV_2736|M.avium_104 LALWQNHIERILADWVGELG-VPIYRGHRIATCTQ-------DDTGVDVV
Mvan_2422|M.vanbaalenii_PYR-1 LALWQKHIERILAEWVDELA-VPVYRGREVVGVRQ-------DGAGVDIE
MAB_3483|M.abscessus_ATCC_1997 LALLQYRIERTLSEWVGEHG-VPIYRGREVTGFTS-------SDDAVRVE
MSMEG_2252|M.smegmatis_MC2_155 LGIPQPVTDRILVEHAVASG-AVLRRGCEAVGLAQ-------DDDGVSVT
TH_1880|M.thermoresistible__bu LGIRQPVTDRLLAEWAAERG-AVIRRGCAVVGLDQ-------DAAGITVE
Mflv_5009|M.gilvum_PYR-GCK MVVSQAKVEAALRARLADLD-VEPEWGRKVIDVRE-------DADGVVAD
MLBr_02276|M.leprae_Br4923 SAVPRLELDDRIRKVAENSG-ARMLLGTKAVSVYHD-----SSRRAASVT
: : : .
Mb1780|M.bovis_AF2122/97 GAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREG
Rv1751|M.tuberculosis_H37Rv GAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREG
MUL_3663|M.ulcerans_Agy99 AQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPRRP
MMAR_4271|M.marinum_M LSDG--PPLRADYVVGCDGGRSLVRRAVGIDFPGWDPTTSSLIAEVEVAV
MAV_2736|M.avium_104 ASDG--RTLRGQYLVGCDGGRSVIRKAAGIDFPGWEATTSYLLAEAEMDW
Mvan_2422|M.vanbaalenii_PYR-1 LSDG--RVLRAGYLVGCDGGRSLIRKSAGIEFPGWEPTTSYLLAEVEIAP
MAB_3483|M.abscessus_ATCC_1997 LSDG--STLRAQYLVGCDGGRSLTRKIAGIDFPGWDPSTSCLVADVQMT-
MSMEG_2252|M.smegmatis_MC2_155 LADG--TQVRARYVVGCDGGRSTVRKLMGVGFPGEPSRVDTLIGEMQVGV
TH_1880|M.thermoresistible__bu LADG--SVQRARYLVGCDGGRSTVRKLAGIGFPGEPARSETLLGEMSLSA
Mflv_5009|M.gilvum_PYR-GCK LADG--ARVRGQWLVGCDGTTSVVRRQTGIEFPGVRLSERFLLADIHLDW
MLBr_02276|M.leprae_Br4923 LADG--TEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTTPR
.* : .** * *
Mb1780|M.bovis_AF2122/97 D---AEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGT-DAQLRERGIEE
Rv1751|M.tuberculosis_H37Rv D---AEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGT-DAQLRERGIEE
MUL_3663|M.ulcerans_Agy99 D---DPTGLAGIFNSGHGGIAIDRGDYYQIAYIIPKGS-DAQLRAQGIEA
MMAR_4271|M.marinum_M G-SESGPNLGEVRHDALGVHGFTR---LPDGGPLRVVV-TERQLDAGGEP
MAV_2736|M.avium_104 R-TGQPPQWG-IHHDSLGVHALSE---TEPAGGVRVLV-TERQLRSAAEP
Mvan_2422|M.vanbaalenii_PYR-1 E-DGREPEWG-IRRDALGVHALSR---SDD-GPVRIMV-TEQDLRRSGVP
MAB_3483|M.abscessus_ATCC_1997 ----EEPEWGIHRQGAL--HSIFK---FEEDGPVRVLV-TEAQLGRREEP
MSMEG_2252|M.smegmatis_MC2_155 TPEQVTAVVAEVRKMQLRFGAGPL---GDGLYRVMVPA-AEVVEDRSATP
TH_1880|M.thermoresistible__bu DPATVAAVVAEVRKTQLRFGAMPL---GDGVYRVIVPA-EGVAGDR-AEP
Mflv_5009|M.gilvum_PYR-GCK AVDRAGTTGWIHPDGVVGAMPMPSTDGRDDLWRLFVYD-PSLDRKPTDSE
MLBr_02276|M.leprae_Br4923 SDDLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSKRPADL
Mb1780|M.bovis_AF2122/97 FRRDVSELLPEATASVAALAS-TDEVKHLNVKVNRLRRWHID-GLLCIGD
Rv1751|M.tuberculosis_H37Rv FRRDVSELLPEATASVAALAS-MDEVKHLNVKVNRLRRWHID-GLLCIGD
MUL_3663|M.ulcerans_Agy99 LHRALADLMPWLADRVDALKS-FDDVKLLDVQLNRLRRWYCD-GALCIGD
MMAR_4271|M.marinum_M SLGDLSAALTAVYGTDYGIHS-PTWISRFTDLTRQAATYRQG-RVLIAGD
MAV_2736|M.avium_104 NLDDLRQALIAVYRTDYGIHS-PRWISRFTDAARQAARYRDR-RVLLAGD
Mvan_2422|M.vanbaalenii_PYR-1 DLAELREALVTVYGTDFGIHS-PTSISRFTDTARQAVAYRSG-RILLVGD
MAB_3483|M.abscessus_ATCC_1997 TLRDLSEALLSARGTDYGIHS-PTWISRFTDVTRQAATYRKG-RVLLAGD
MSMEG_2252|M.smegmatis_MC2_155 TLDEFRQQLRATAGTDLGVHS-PRWLSRFGDGTRLADRYRTG-RVLLAGD
TH_1880|M.thermoresistible__bu TLDEFRRRLKAFAGTDFGAHT-PRWLSRFGDATRLAERYRAG-RVFLAGD
Mflv_5009|M.gilvum_PYR-GCK ILDRISELVPYRTGRRVKIGD-AEWLSMFTVHRRLADTYRRG-RVLIAGD
MLBr_02276|M.leprae_Br4923 ALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPNWMLIGD
. :. : **
Mb1780|M.bovis_AF2122/97 AAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAF
Rv1751|M.tuberculosis_H37Rv AAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAF
MUL_3663|M.ulcerans_Agy99 AAHAMSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWA
MMAR_4271|M.marinum_M AAHVHDPVGGQGLNTGVQDAVNLGWKLAQVVNRR--SPESLLDTYHAERH
MAV_2736|M.avium_104 AAHIHHPVGGQGLNTGVQDAVNLGWKLALVVGGA--SPPALLDTYHAERH
Mvan_2422|M.vanbaalenii_PYR-1 AAHVHHPVGGQGLNTGMQDAVNLGWKLAQVVQGW--SPDTLLDTYHDERQ
MAB_3483|M.abscessus_ATCC_1997 AAHVHFPIGGQGLNTGMQDAVNLGWKLAQVVNGT--SPENLLDTYHAERH
MSMEG_2252|M.smegmatis_MC2_155 AAHVHPPVGGQGLNLGVQDAFNLGWKLAASINGW--APDGLLDSYEAERR
TH_1880|M.thermoresistible__bu AAHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGGW--APDGLLDTYHAERH
Mflv_5009|M.gilvum_PYR-GCK AAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGL--AADDLLDTYEAERR
MLBr_02276|M.leprae_Br4923 AAACVNPLNGEGIDYGLETGRLAAELLDLRDLSY--VWPSLLQQHYGRGF
** * * *: .: . . * * .
Mb1780|M.bovis_AF2122/97 PTAVTQAVQRVLHRRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFV
Rv1751|M.tuberculosis_H37Rv PTAVTQAVQRVLHRRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFV
MUL_3663|M.ulcerans_Agy99 PTAFLQGIQRAIHAAIVAVAVTGGPPQPPPVVR-LVSRSVPVRRIMGYLV
MMAR_4271|M.marinum_M PVAARVLRTTMAQVALRRL-DYRKKALSDTIS-ELLMMDEPRKRFAAMMS
MAV_2736|M.avium_104 PVGERVLRNAIAQMALLRP-DERTRALRDLVT-ELLGMDEPRKRFAAMIS
Mvan_2422|M.vanbaalenii_PYR-1 PVGARVLRNAVAQMALLRP-DDRTTVLHGVVS-DMLDMDEPRRRFAAMMS
MAB_3483|M.abscessus_ATCC_1997 PVAARVLHNTMAQTALIRP-GERVDALRDIMS-DLLTLDMPRRRIAAMMS
MSMEG_2252|M.smegmatis_MC2_155 PVAAAVLDNTRAQMELLSP-EPGPQAVRRLLA-QLMAFEEVNRYLTEMIT
TH_1880|M.thermoresistible__bu PVAADVLNNTRAQMELMSP-EPGPRAVRWLLA-ELMDFEEVNRYLTEKIT
Mflv_5009|M.gilvum_PYR-GCK PLATQVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRWTTYTAS
MLBr_02276|M.leprae_Br4923 SVARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVTDDDADWVA
. . : .
Mb1780|M.bovis_AF2122/97 GVGVRPEH--------APAFARRGPGNRKGP-------------------
Rv1751|M.tuberculosis_H37Rv GVGVRPEH--------APAFARRGPGNRKGP-------------------
MUL_3663|M.ulcerans_Agy99 AIGPLPEH--------APKYPRRAR-------------------------
MMAR_4271|M.marinum_M GLDIRYH-----LGGGHPLLGRRMPDLDLTTADGPRRVFTHLHAARPVLL
MAV_2736|M.avium_104 GLDVRYD-----LGPGHPLLGRRMPDLDLVTADGASRVFALLRNARPVLL
Mvan_2422|M.vanbaalenii_PYR-1 GLDIHYD-----LGDGHPLLGLRMPDLDLETAHGPTRVSALLRQARPVLL
MAB_3483|M.abscessus_ATCC_1997 GLDIHYD-----LGPGHPLLGRRMPDLEVRTAQGPRCVFTLLREGRGVLL
MSMEG_2252|M.smegmatis_MC2_155 ATGIRYD-----FGAEDDLVGRRLRDIRLRRG----RLYELTRTGRGLLL
TH_1880|M.thermoresistible__bu AIGVRYHT----MGDGHGLLGRRMRDIPLTGG----RLYARMHAGRGVLL
Mflv_5009|M.gilvum_PYR-GCK QLWVSYRNGPLGGRGSKPRPGDRIDDAPCSRPDGTATRLHGELGGRWALL
MLBr_02276|M.leprae_Br4923 RVWRSGG--------WASWLVDRRPPFS----------------------
*
Mb1780|M.bovis_AF2122/97 --------------------------------------------------
Rv1751|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3663|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4271|M.marinum_M NLAEPGRFDIAGWRHRVLLIDAK---YVGVWELPVLGAIAAPAAALIRPD
MAV_2736|M.avium_104 NFAGAGRRSVAGWADRVRVVDAK---CVADWELPVLGRVSAPPAVLIRPD
Mvan_2422|M.vanbaalenii_PYR-1 DLGAPDAVDLTGWEARVRMVRAN---AATVWELPVIGEVPAPAAVLIRPD
MAB_3483|M.abscessus_ATCC_1997 NLGTP-ITGASGWSHRVDVVEAEYLDAEGTFELPVIGMVEAPHAVLIRPD
MSMEG_2252|M.smegmatis_MC2_155 DQTGQ--LSAAGWSDRVDHVVDV-------------SDELDVPAVLLRPD
TH_1880|M.thermoresistible__bu DRTGT--LSVSGWADRVDHIVDP-------------GAALDVPAVLLRPD
Mflv_5009|M.gilvum_PYR-GCK LPRGVPAVGAAAVRGPAGYLADH----------VVTLHHDRDDVMLVRPD
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mb1780|M.bovis_AF2122/97 ---------------------------------------
Rv1751|M.tuberculosis_H37Rv ---------------------------------------
MUL_3663|M.ulcerans_Agy99 ---------------------------------------
MMAR_4271|M.marinum_M GYVAWVGDD-LTDRGLFDALTAWFGRPAVPSPRLRASAP
MAV_2736|M.avium_104 GHVAWAGD--PNDPGLHDALTTWCGPPAAGG--------
Mvan_2422|M.vanbaalenii_PYR-1 GHVAWVAG--DSAAAPAEAAARWFGAPTGRR--------
MAB_3483|M.abscessus_ATCC_1997 GYVAWVGN--GTTAGLNGALQRWFGPPRYSGGGS-----
MSMEG_2252|M.smegmatis_MC2_155 GHIAWVGDE---QGDLEGCLVRWFGVPA-----------
TH_1880|M.thermoresistible__bu GHVAWVGADHPGQQDLTARLSRWFGAPA-----------
Mflv_5009|M.gilvum_PYR-GCK AHLAWRGAH-----DDPTGLDRWLATALHPGGTQ-----
MLBr_02276|M.leprae_Br4923 ---------------------------------------