For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_4217 | - | - | 100% (520) | putative AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3626 | - | 1e-66 | 36.79% (492) | PUTATIVE putative fatty-acid-CoA ligase |
| M. thermoresistible (build 8) | TH_3483 | - | 9e-59 | 32.55% (510) | PUTATIVE putative O-succinylbenzoate-CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 3e-54 | 33.40% (488) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_0027 | - | 2e-61 | 33.98% (518) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 3e-54 | 33.40% (488) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02661 | - | 2e-47 | 28.85% (520) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 1e-50 | 31.54% (501) | AMP-binding domain protein |
| M. marinum M | MMAR_1606 | - | 9e-52 | 32.84% (475) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_1639 | - | 4e-52 | 30.98% (510) | AMP-binding enzyme, putative |
| M. smegmatis MC2 155 | MSMEG_4036 | - | 3e-59 | 33.62% (470) | crotonobetaine/carnitine-CoA ligase |
| M. ulcerans Agy99 | MUL_4803 | fadD7 | 7e-51 | 30.37% (507) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 1e-59 | 32.94% (507) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 -MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVD--
Rv2505c|M.tuberculosis_H37Rv -MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVD--
MAB_4377c|M.abscessus_ATCC_199 -----------MKAYDAGATLSPIIEETIGENFERIARAHPDVGALVD--
MMAR_1606|M.marinum_M -------------------------MTSLAGNLIEGARRHPNRIALR---
Mflv_0027|M.gilvum_PYR-GCK ------------------------MFHNLADIVRSHGRNRPDAPALI---
Mvan_0943|M.vanbaalenii_PYR-1 ------------------------MIHNLADIIRVHGRERPGAPALV---
TH_4217|M.thermoresistible__bu ---------------MTMTTLPVSGGHTVWSMLTYWAESTPHAPFLIFDE
MLBr_02661|M.leprae_Br4923 MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVT-
MUL_4803|M.ulcerans_Agy99 MASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELAAAQLSEATAVIFT-
MSMEG_4036|M.smegmatis_MC2_155 -----------------------------MSYLSRAAARWPDRTWCITP-
MAV_1639|M.avium_104 ---------------MRAPADFGVDRFTVPAVLDRRAEQHPDRVMMS---
. .
Mb2533c|M.bovis_AF2122/97 MVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQYA
Rv2505c|M.tuberculosis_H37Rv MVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQYA
MAB_4377c|M.abscessus_ATCC_199 VSGDRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAEWVLVQYA
MMAR_1606|M.marinum_M -LDEIEIPYGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYG
Mflv_0027|M.gilvum_PYR-GCK -VGDRTVSYRELDERSNRTAQAFSRTGVGPGDRVAFVERNGIEFFDVAFG
Mvan_0943|M.vanbaalenii_PYR-1 -VGDRTVTYGELDDRSSRAAQAFAQAGVGVGDRVAFVDKNGAEFFEVTFG
TH_4217|M.thermoresistible__bu TSGGTTLTFSDAVELGTAGAALLSGLGVSRGDRFAVVLGNRVEFFACWFA
MLBr_02661|M.leprae_Br4923 -DNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIEFVVGLLA
MUL_4803|M.ulcerans_Agy99 -ADRVAVSYRDLVRLVDDLAGQLTRAGLRQGERVALRSGSNLEFVVALLA
MSMEG_4036|M.smegmatis_MC2_155 ---REEISRADALRDGSRIAAGLIAKGVRKGDRVVLVAGNGLDFVRAWLG
MAV_1639|M.avium_104 -IAGVDVTFAQMRQRSCAAANMLSDLGVGRGDRVALFSGTCPEWVYFWLG
: : *: *:*. . . : .
Mb2533c|M.bovis_AF2122/97 TAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAEV
Rv2505c|M.tuberculosis_H37Rv TAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAEV
MAB_4377c|M.abscessus_ATCC_199 TAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDYVAMASQV
MMAR_1606|M.marinum_M VLRAGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAGADEAG
Mflv_0027|M.gilvum_PYR-GCK SAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVGQEFTGRIEAIADDLD
Mvan_0943|M.vanbaalenii_PYR-1 LAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVVGQDFAGHLEAIEDGLD
TH_4217|M.thermoresistible__bu AARIGAVMVPINPHSTGEELSYCLRHARCVAAVCDHDRHQLVHEVWPYDP
MLBr_02661|M.leprae_Br4923 ASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVSDQRAATM
MUL_4803|M.ulcerans_Agy99 ASRANLIVVPLDPALPVAYQRARAGAAGARVVLIDG---TGPGDRDEPAV
MSMEG_4036|M.smegmatis_MC2_155 LILCGAVTVSINPKAVASELPAVIDEVRPALVLVEAGLEVGHVEHTPPGG
MAV_1639|M.avium_104 AARIGAVSAAINAAHKGDFLLHALRLCRPAVIFTDPEHRSRAERAAAALE
. : . :: .
Mb2533c|M.bovis_AF2122/97 GPRCPDLADVILLESD----RWDALAG--AEPDLPALQQTAARLDGSDPV
Rv2505c|M.tuberculosis_H37Rv GPRCPDLADVILLESD----RWDALAG--AEPDLPALQQTAARLDGSDPV
MAB_4377c|M.abscessus_ATCC_199 MPDAPGLRDVVFIGTS----DWTELVAGAERVTETALRARMSQLSNTDPI
MMAR_1606|M.marinum_M -------AECILVKPG----EFEELIQAAEPLEEAAVRE------DDDTA
Mflv_0027|M.gilvum_PYR-GCK -------VEVVVIGKHRHWPTFDDLLAAAPAVDPGVVTG------PDDLV
Mvan_0943|M.vanbaalenii_PYR-1 -------ADIVVIGDHPRWPAFDDWVASHPPVDPGVVTG------PDDVV
TH_4217|M.thermoresistible__bu --------SLIAVCDR----GFEGIAGGPVPGHPPVRPH--------DPL
MLBr_02661|M.leprae_Br4923 R-----YWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGLRHDDA
MUL_4803|M.ulcerans_Agy99 R-----WWPIAVSVARDT----GILSVHLDAAGEPTAVASAPQGLRADDA
MSMEG_4036|M.smegmatis_MC2_155 QP-----VPVMFIDEAHAASDEAVVSLDRPPAGP------------DDPV
MAV_1639|M.avium_104 G-------PARIVVQGDSLTATLSRAADRAPAEDRGDAG--------ELG
:
Mb2533c|M.bovis_AF2122/97 NIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHC
Rv2505c|M.tuberculosis_H37Rv NIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHC
MAB_4377c|M.abscessus_ATCC_199 NIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQLQAGDRLCIPVPFYHC
MMAR_1606|M.marinum_M VILYTSGTTGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILGALPLFHA
Mflv_0027|M.gilvum_PYR-GCK FLMYTSGTTGAPKGVMLSNANVVCKTAGVGGPWKFDADSVSLAVMPLFHM
Mvan_0943|M.vanbaalenii_PYR-1 LLMYTSGTTGAPKGVMLSNTNYVYKTGGVAGPWQFDADAVSLAVMPLFHM
TH_4217|M.thermoresistible__bu AVLYTSGTTSRPKGVVVTHANYLAAGHVVAGQLRIRPDDRWMLVLPLFHA
MLBr_02661|M.leprae_Br4923 MIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQLGPQDATVVVMPLYHG
MUL_4803|M.ulcerans_Agy99 MIMFTGGTTGLPKMVPWTRANIATSIRSIIAGYRLSPQDATVAVMPLYHG
MSMEG_4036|M.smegmatis_MC2_155 SFIQSSGSTGKPKFVIETNRMYTMAGEGFAHWLGLDDEDVLLTTLPLSHL
MAV_1639|M.avium_104 CLFYTSGTTGPSKAVATTWHYLFSVAATVAAAWEFRQGEVLWTAMPLFHL
. :.*:*. .* . : . :*: *
Mb2533c|M.bovis_AF2122/97 FGMVMGNLAATSHGAAMVIPAP-GFDPAATLRAVQDERCTSLYGVPTMFI
Rv2505c|M.tuberculosis_H37Rv FGMVMGNLAATSHGAAMVIPAP-GFDPAATLRAVQDERCTSLYGVPTMFI
MAB_4377c|M.abscessus_ATCC_199 FGMVMGNLGCTTHGATIVMPAP-GFDPGRTLEAIERERCVGVYGVPTMFI
MMAR_1606|M.marinum_M FGQTAG-LNAAVAAGACLTLIP-RFSPEKALQIIERDRVTVFEGVPTMFA
Mflv_0027|M.gilvum_PYR-GCK AG--FGWALAGLWEGAVTVVLR-DVDPGAILDAVARHRVTNMLLVPAVIQ
Mvan_0943|M.vanbaalenii_PYR-1 AG--SGWALAGLWQGATTVVLR-DVEPAAILDAIARHRITNMLLVPAVIQ
TH_4217|M.thermoresistible__bu NAQYYG-VMSALVSGASVVVAP-RFSASMWPAQVRRYQATLASLFAAPVR
MLBr_02661|M.leprae_Br4923 HGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAVAATWYTAAPAIHR
MUL_4803|M.ulcerans_Agy99 HGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHATWYTAVPTIHQ
MSMEG_4036|M.smegmatis_MC2_155 NAQAYSVLGSWGCGAKLVLLPR--FSASSFWSDVAKYGATVFNAIGAMLE
MAV_1639|M.avium_104 SA-APSVLAPMLVGATTVLAAA--FHPREVWDDIRAHGAVGFAGAGAMVS
. . . . . : . :
Mb2533c|M.bovis_AF2122/97 AELGLPDFTDYELGSLR-----TGIMAGAACPVEVMRKVISRMHMPGVSI
Rv2505c|M.tuberculosis_H37Rv AELGLPDFTDYELGSLR-----TGIMAGAACPVEVMRKVISRMHMPGVSI
MAB_4377c|M.abscessus_ATCC_199 AMLADPGFAHRDLSTLR-----TGIMAGSVCPVEVMKRCIDEMHMAGVAI
MMAR_1606|M.marinum_M AMLHS--TERPDTGSLR-----LCVSGGAAMPVEVMR-GFEQAFGTMVLE
Mflv_0027|M.gilvum_PYR-GCK FLLDTTGLDDTDLSRLR-----IVVYGASPITDDVLMRGIDR-FGGIFAQ
Mvan_0943|M.vanbaalenii_PYR-1 FLLDTDGVAEVDLSTLR-----VIVYGASPISDDVLVRGIER-FGPIFAQ
TH_4217|M.thermoresistible__bu MILAHEGCDADRDNRLR-----VTLFAQNLTAEQLRR--FEERFDCPLLQ
MLBr_02661|M.leprae_Br4923 ILLELASTQ----SFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVIC
MUL_4803|M.ulcerans_Agy99 ILLERAKTEREADSSGRTRAALRFIRSCSGPLTPETAQALHDEFSAPVLC
MSMEG_4036|M.smegmatis_MC2_155 ALMAQPPSVSQERARVR-------LCYSAPAPAPARHREIENRFGFRLVV
MAV_1639|M.avium_104 MLQNLPADPGDARLPLR--------FISAAPIDARSYRDIEKRYGCRIVT
: . .
Mb2533c|M.bovis_AF2122/97 CYGMTETSPVSTQTRADDSVDRRVGTVGR----VGPHLEIKVVDPATGET
Rv2505c|M.tuberculosis_H37Rv CYGMTETSPVSTQTRADDSVDRRVGTVGR----VGPHLEIKVVDPATGET
MAB_4377c|M.abscessus_ATCC_199 AYGMTETSPVSCQTLFDDDLDRRTATVGR----AHPHIEIKIVDPNSGET
MMAR_1606|M.marinum_M GYGLSETSPTASFNHPDR--ERKPGSIGT----PIAGVQMKLLEVDTHG-
Mflv_0027|M.gilvum_PYR-GCK VYGMTESTGSVTQLDGDEHLPQLLRSCGR----PYPWVQIRVVD-PTGRD
Mvan_0943|M.vanbaalenii_PYR-1 VYGMTETTGSITQLDGPDHVPALLRSCGR----PYPWVQIRIVD-ETGAD
TH_4217|M.thermoresistible__bu LYGMTETIAPPLMN--PLYGPRDNMTVGL----PSEPNRVRIVD-DHGVD
MLBr_02661|M.leprae_Br4923 AFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTGVQIRIVG-SDGQP
MUL_4803|M.ulcerans_Agy99 AFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTGPEIRIVG-PDGHP
MSMEG_4036|M.smegmatis_MC2_155 GYALSETPYGLIVPVDEPTVYGSMGVPRQHP-TLGAVNEVRVVD-ADGHE
MAV_1639|M.avium_104 MYGMTEAFPIAVKALADAGIPGTSGRPNP-------DFEVRILD-AHGNS
:.::*: .::::
Mb2533c|M.bovis_AF2122/97 VPRGVVGEFCTRGY---SVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDP
Rv2505c|M.tuberculosis_H37Rv VPRGVVGEFCTRGY---SVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDP
MAB_4377c|M.abscessus_ATCC_199 VQRGQSGELCTRGY---SVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRD
MMAR_1606|M.marinum_M -----IGEIAIRGH---NVMKGYWNRPDATAAAIDAEGWFRTGDLARIDE
Mflv_0027|M.gilvum_PYR-GCK VAPGTVGEVWTRSD---QNMLGYWNNPEATAATLTPDGWLRTGDAGYLDR
Mvan_0943|M.vanbaalenii_PYR-1 AVAGTVGEVWTRSE---QNMLGYWNNPDATASTLTADGWLKTGDAGYVDD
TH_4217|M.thermoresistible__bu VPPGQTGHLLVGGEPGITLTAGYLDDPAATAAAIVDG-WLHTGDIVTRRP
MLBr_02661|M.leprae_Br4923 LPPDTVGEVWLRGS---TVVRGYLGDPAITAANFTHG-WLRTGDLGSLSV
MUL_4803|M.ulcerans_Agy99 VGPGAVGEVWLHGP---TVVRGYLGDPKITAANFTDG-WLRTGDLGTLSQ
MSMEG_4036|M.smegmatis_MC2_155 VADGTTGELELRNP---AITPGYFG-KTTESAAMRPGGWLRTGDLAVRRP
MAV_1639|M.avium_104 LPPDTVGEIACRPRHPHVMSEGYIGDDLAVRP---HPEWFRTGDLGRLDR
*.. ** . *::***
Mb2533c|M.bovis_AF2122/97 SGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYG
Rv2505c|M.tuberculosis_H37Rv SGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYG
MAB_4377c|M.abscessus_ATCC_199 DGYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYG
MMAR_1606|M.marinum_M DGYYFIVDRSKDMIIRGGYNVYPREIEEVLYEHPEVREAAVVAVPDDMLG
Mflv_0027|M.gilvum_PYR-GCK DGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIGIPDTRWG
Mvan_0943|M.vanbaalenii_PYR-1 DGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAAVIGVPDRRWG
TH_4217|M.thermoresistible__bu DGFVVFHDRAKDMIKRSGENVAAAEVERVINEHPAVYESAVVGVPDPVRD
MLBr_02661|M.leprae_Br4923 TGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVYG
MUL_4803|M.ulcerans_Agy99 AGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENAVFGVPDALYG
MSMEG_4036|M.smegmatis_MC2_155 DGHFFFGGRAKEVIRYKGENLSPAEVENAIGSHPAVRAVAVIGVPSALSE
MAV_1639|M.avium_104 DQNLTYVDRIKDALRRRGENISSVEVETVVMGHPAVAEAAAVGVPGELGE
.* *: : . :: . .:* : * : ... *.
Mb2533c|M.bovis_AF2122/97 EELMAVVKLRNDA-PELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVT
Rv2505c|M.tuberculosis_H37Rv EELMAVVKLRNDA-PELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVT
MAB_4377c|M.abscessus_ATCC_199 EELCAWVRMRPDR-VVIDAVAIRAFASGRLAHYKIPRYVHVVESFPMTVT
MMAR_1606|M.marinum_M EEVGAAIALIPG--ATSDAAALSDFVKERVAAYKYPRRIWFVDELPKGPT
Mflv_0027|M.gilvum_PYR-GCK EAVKAVVVAG----APVTEAELIAFAREQLAGFKLPKSVDFVDALPRNPS
Mvan_0943|M.vanbaalenii_PYR-1 EAVKAVVVAARG--AQLTEAELIAFARDRIGGFKLPKSVDFVDVLPRNPS
TH_4217|M.thermoresistible__bu EAITAYVVRRTPDGCGLTAQQLIDFCAERLARGKVPDHIEFVDDLPRTSV
MLBr_02661|M.leprae_Br4923 ETVTAVIVPREVI--APTPSELAVFCRDRLAAFEVPTRFQEASALPHTAK
MUL_4803|M.ulcerans_Agy99 EAVAAVIVPREP---APTAQELTEFCREKLASFEIPATFQMASELPHTAK
MSMEG_4036|M.smegmatis_MC2_155 EDVKAFVQLRPGE--TASPTELAQWSATKLPPYKRPRYIELVTEFPLTDT
MAV_1639|M.avium_104 DDVLVVVTLRPG--ATLDCAELLDFCADRMPYFCVPRYVETVPELPKNAI
: : . : : : :: * . . :*
Mb2533c|M.bovis_AF2122/97 GKVRKVEMRQQALEYLRGQQ------------
Rv2505c|M.tuberculosis_H37Rv GKVRKVEMRQQALEYLRGQQ------------
MAB_4377c|M.abscessus_ATCC_199 GKVRKIEMRQQTIQIFGLPEPGRTDEQ-----
MMAR_1606|M.marinum_M GKILKRDITVPQASPAQQ--------------
Mflv_0027|M.gilvum_PYR-GCK GKLLKRQLREPYWTDEDRHIG-----------
Mvan_0943|M.vanbaalenii_PYR-1 GKLLKRALREPYWDGADRHIG-----------
TH_4217|M.thermoresistible__bu GKIRKHLLRSNGSGGGMGEGR-----------
MLBr_02661|M.leprae_Br4923 GSLDRRAVAEQFAHRG----------------
MUL_4803|M.ulcerans_Agy99 GSLDRRAVAQQFGGQA----------------
MSMEG_4036|M.smegmatis_MC2_155 QKIAKARLPRDRSTSEVDFAPRRDPRQDDRDT
MAV_1639|M.avium_104 GRIRKDLLRARGLTTNVWDREKHGYVVRR---
: : :