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KAYDAGATLSPIIEETIGENFERIARAHPDVGALVDVSGDRRWTYRELDAEINRVARGLMSLGVAAGDRV GIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDYVAMASQVMPDA PGLRDVVFIGTSDWTELVAGAERVTETALRARMSQLSNTDPINIQYTSGTTGYPKGATLSHRNVLNNGFF VAESIQLQAGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMF IAMLADPGFAHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETSPVSCQTLFDDDLDRRT ATVGRAHPHIEIKIVDPNSGETVQRGQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDD GYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEELCAWVRMRPDRVVIDAVAI RAFASGRLAHYKIPRYVHVVESFPMTVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4377c | - | - | 100% (546) | AMP-binding domain protein |
| M. abscessus ATCC 19977 | MAB_4559 | - | 2e-69 | 33.98% (512) | putative long-chain-fatty-acid CoA ligase |
| M. abscessus ATCC 19977 | MAB_0596c | - | 2e-69 | 33.00% (494) | fatty-acid-CoA ligase FadD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 0.0 | 59.89% (531) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4867 | - | 0.0 | 73.83% (535) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 0.0 | 59.89% (531) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-51 | 29.51% (515) | acyl-CoA synthetase |
| M. marinum M | MMAR_3852 | fadD35 | 0.0 | 59.40% (532) | fatty-acid-CoA ligase FadD35 |
| M. avium 104 | MAV_5077 | - | 3e-77 | 35.28% (530) | long chain fatty acid-CoA ligase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 0.0 | 71.51% (537) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 3e-78 | 35.81% (525) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 5e-76 | 36.42% (519) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1563 | - | 0.0 | 72.28% (534) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 ------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
Rv2505c|M.tuberculosis_H37Rv ------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
MMAR_3852|M.marinum_M ------MATTAAADQNQLSYDRGPIAPALLEMTIGANLAATASQCESRDA
Mflv_4867|M.gilvum_PYR-GCK ---------------MTGSYDAGPTDVAILEETIGANFARIARTHPGRDA
Mvan_1563|M.vanbaalenii_PYR-1 ---------------MSQSYDAGPTDTAILEETIGANFERIAATYPDHEA
MSMEG_5649|M.smegmatis_MC2_155 ----------------MKSYDAGPTGAPVLEETIGANFERIAATYPEHEA
MAB_4377c|M.abscessus_ATCC_199 ----------------MKAYDAGATLSPIIEETIGENFERIARAHPDVGA
MAV_5077|M.avium_104 ------------MRHLTEARWDADRSVPLTDHTVGGLLAARALEHPHRVA
TH_2068|M.thermoresistible__bu ------------------------------MRTIPAVLDRAAERLPDHDA
MUL_4126|M.ulcerans_Agy99 --------------------------MTSDPRTVPTALDRLVRRLPNHDA
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:
Mb2533c|M.bovis_AF2122/97 LVDMVARR------------RFNYSELLTDVHRLATGLVRAGIGPGDRVG
Rv2505c|M.tuberculosis_H37Rv LVDMVARR------------RFNYSELLTDVHRLATGLVRAGIGPGDRVG
MMAR_3852|M.marinum_M LVDVRSGR------------RWSYAQLLTDVRQLATGLVRAGIGRGDRVG
Mflv_4867|M.gilvum_PYR-GCK LVDVAGGR------------RWTYAELDAEIDTVARGLMAIGVERGDRVG
Mvan_1563|M.vanbaalenii_PYR-1 LVDVTGGR------------RWTYAELDREIDTVAKGLMSLGTESGDRVG
MSMEG_5649|M.smegmatis_MC2_155 LVEVATGR------------RWTYAELNDEIDATARGLMALGVDKGDRVG
MAB_4377c|M.abscessus_ATCC_199 LVDVSGDR------------RWTYRELDAEINRVARGLMSLGVAAGDRVG
MAV_5077|M.avium_104 LVGQRHGSG--------DRVRLSYAELLDEACRAGDALSSL-VTPGGFLA
TH_2068|M.thermoresistible__bu LVTAATGGA--------EARRFSYAELRAEVRRAAAAMIAAGIAPGDRVA
MUL_4126|M.ulcerans_Agy99 LVTDE--------------RSFTVSELNDEVYRAAAALIELGVKPAARVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
* . :* . .: . :.
Mb2533c|M.bovis_AF2122/97 IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
Rv2505c|M.tuberculosis_H37Rv IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
MMAR_3852|M.marinum_M IWAPNRWEWVLVQYATAEIGAVLVTINPAYQARELEYALRQSGVAMVIAA
Mflv_4867|M.gilvum_PYR-GCK IWAPNCPEWVIVQYATAKIGAILVNINPAYRTHELRYVLEQSGVATLISA
Mvan_1563|M.vanbaalenii_PYR-1 IWAPNCPEWTIVQYATAKIGAILVNINPAYRTHELSYVLEQSGVSTLISA
MSMEG_5649|M.smegmatis_MC2_155 IWAPNCAEWIMTQFAAAKVGAILVNINPAYRTHEVAYVLRQSGVRTLVSA
MAB_4377c|M.abscessus_ATCC_199 IWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICA
MAV_5077|M.avium_104 LWAPNVVEWPIIQYGAALAGVVLVALNPVLREDELAYALRHCGADVLLHA
TH_2068|M.thermoresistible__bu LWAPNTWHWVVACLATHYAGAVMVPLNTRYTASEAADVLARTGAPLLVAA
MUL_4126|M.ulcerans_Agy99 IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: : * : : . *. :: :*. : : . :.
Mb2533c|M.bovis_AF2122/97 ASFKDAD-YAAMLAEVGPRCPDLADVILLESD-RWDALAG----AEPDLP
Rv2505c|M.tuberculosis_H37Rv ASFKDAD-YAAMLAEVGPRCPDLADVILLESD-RWDALAG----AEPDLP
MMAR_3852|M.marinum_M SGFKGSD-YAAILAEVAPGCPELHDVAFLDGD-GWAKLAG----SGADLV
Mflv_4867|M.gilvum_PYR-GCK TQFKTSD-YVAMVDEVRPDVPALQRVLFIGTA-DWDTLRAA--GSGVDDA
Mvan_1563|M.vanbaalenii_PYR-1 TRFKTSD-YVAMVDEVRPDVPALQRVLFIGTD-DWDRLRSR--ADVIDDA
MSMEG_5649|M.smegmatis_MC2_155 SSFKTSD-YASMIAEVRPECPDLLDVVFLDND-DWDRLR----ANQVDDA
MAB_4377c|M.abscessus_ATCC_199 KAFKSSD-YVAMASQVMPDAPGLRDVVFIGTS-DWTELVAG--AERVTET
MAV_5077|M.avium_104 DTSRDYA-MLEVAQRVCDAIPGLRRVSLSETA-RWRSTTP---------S
TH_2068|M.thermoresistible__bu GEFLGADKTADLDRDALPALRRIVRIPVDKPDGTWDEFIAGGSMSGAALA
MUL_4126|M.ulcerans_Agy99 GHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGTDTGA---
MLBr_02546|M.leprae_Br4923 DEY------TKVVSKAEPALGKLRALGVNPDE--EEPPGSTDETLAELIA
: . : : .
Mb2533c|M.bovis_AF2122/97 ALQQTAARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGY
Rv2505c|M.tuberculosis_H37Rv ALQQTAARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGY
MMAR_3852|M.marinum_M ALQEIATTLSADDPINIQYTSGTTGFPKGVTLSHRNILNNGYLVGELLEY
Mflv_4867|M.gilvum_PYR-GCK DLRRRSGALSNRDPINIQYTSGTTGFPKGATLSHRNILNNGFFVTEQIRL
Mvan_1563|M.vanbaalenii_PYR-1 LLRERSASLSHHDPVNIQYTSGTTGFPKGATLSHRNILNNGFFVTEQIRL
MSMEG_5649|M.smegmatis_MC2_155 AFHERMATLANTDPINIQYTSGTTGFPKGATLSHRNILNNGFFVTELIAL
MAB_4377c|M.abscessus_ATCC_199 ALRARMSQLSNTDPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQL
MAV_5077|M.avium_104 AGMINRAPSDPDQPVMLQYTSGTTGRPKGVVLTHRALVNVAKLTMEAVEA
TH_2068|M.thermoresistible__bu EVDARAAAVRPDDVSDILFTSGTTGRSKGALCAHRQSLDASAAWAECGRL
MUL_4126|M.ulcerans_Agy99 -VTARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKI
MLBr_02546|M.leprae_Br4923 RSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPF
: *****. .**. :
Mb2533c|M.bovis_AF2122/97 TAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQD
Rv2505c|M.tuberculosis_H37Rv TAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQD
MMAR_3852|M.marinum_M TAEDRICIPVPFYHCFGMVMGNLAATSHGACMVIPAPGFDPAATLRAVQA
Mflv_4867|M.gilvum_PYR-GCK QPGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVIPAPAFDPGLTLRAIET
Mvan_1563|M.vanbaalenii_PYR-1 GPGDRLCIPVPFYHCFGMVMGNLGCTTHGATMVIPAPGFDPGQTLKTIET
MSMEG_5649|M.smegmatis_MC2_155 GPDDRLCIVPPFYHCFGMVMGTLGAVSHGTTIVIPAPGFDPGITLSAVES
MAB_4377c|M.abscessus_ATCC_199 QAGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAIER
MAV_5077|M.avium_104 PPAAICVNPLPLFHTAGCVIATLGPLWVGG-TAVPCGRPAPGAVLETLRE
TH_2068|M.thermoresistible__bu SSDDRYLCINPFFHNFGYKAGILACIQTGATLYPQLT-FDPEQAMRAVAE
MUL_4126|M.ulcerans_Agy99 TADDRHLCINPFFHNFGYKAGILACLQTGATLFPHLT-FDPLRTLQAIER
MLBr_02546|M.leprae_Br4923 RAHEVTLLPAPMFHALGYLHATLAMFLGST--LVLRRRFKPATVLEDIEK
. *::* * . *. . * .: :
Mb2533c|M.bovis_AF2122/97 ERCTSLYGVPTMFIAELGLPD--FTDYELGSLRTGIMAGAACPVEVMRKV
Rv2505c|M.tuberculosis_H37Rv ERCTSLYGVPTMFIAELGLPD--FTDYELGSLRTGIMAGAACPVEVMRKV
MMAR_3852|M.marinum_M ERCTSLYGVPTMFIAELGLAD--FATYDLSSLRTGIMAGSTCPVEVMRKV
Mflv_4867|M.gilvum_PYR-GCK ERCTAVYGVPTMFIAMQNHPD--FAERDLSTLRTGIMAGAVCPVEVMKRC
Mvan_1563|M.vanbaalenii_PYR-1 ERCTAVYGVPTMFIAMQNHAD--FAERDLSSLRTGIMAGAVCPVEVMKRC
MSMEG_5649|M.smegmatis_MC2_155 EKCTGLYGVPTMFIAMLGHPD--FANFDLSSLRTGIMAGSVCPIEVMKRV
MAB_4377c|M.abscessus_ATCC_199 ERCVGVYGVPTMFIAMLADPG--FAHRDLSTLRTGIMAGSVCPVEVMKRC
MAV_5077|M.avium_104 QHAAVLFYVPAVLRALVEYQR--ESTETAPKLDIIMGGASEVSAELIDSA
TH_2068|M.thermoresistible__bu HRITVLPGPPTIYQTILDHPK--RGEYDLSSLRFAVTGAAVVPVVLIERM
MUL_4126|M.ulcerans_Agy99 HRITVLPGPPTIYQTLLDHPA--RDDYDLSSLRFAVTGAATVPVVLVERM
MLBr_02546|M.leprae_Br4923 HQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRA
.: . : *.: .* . ..: :
Mb2533c|M.bovis_AF2122/97 ISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVV
Rv2505c|M.tuberculosis_H37Rv ISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVV
MMAR_3852|M.marinum_M IDQMHMAGISICYGMTETSPVATQTRSNDSLQRRVTTVGRVGPHLEIKVV
Mflv_4867|M.gilvum_PYR-GCK VEEMHLTEMSIAYGMTETSPVSCQTLIDDDLERRTSTIGRVHPHVEIKIV
Mvan_1563|M.vanbaalenii_PYR-1 VEEMNMSEISIAYGMTETSPVSCQTLIDDDLERRTSSIGRVHPHVEIKIV
MSMEG_5649|M.smegmatis_MC2_155 VADMHMAEVAICYGMTETSPVSCQTLIDDDLDRRTATIGRAHPHVEIKII
MAB_4377c|M.abscessus_ATCC_199 IDEMHMAGVAIAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEIKIV
MAV_5077|M.avium_104 TATFNAR-VFNLYGQTELAPVLTVTRPGDSRRDRLYTVGRPLPQVDCKII
TH_2068|M.thermoresistible__bu QSELDIDIVLTAYGLTEASGFGTMCRPEDDAVTVATTCGRPIAGFELRID
MUL_4126|M.ulcerans_Agy99 QSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELRIG
MLBr_02546|M.leprae_Br4923 LEELGPV-IYNMYGSTEIAFATIAG--PKDLQINSATVGPVVKGVKVKIL
: : ** ** .. : * .. ::
Mb2533c|M.bovis_AF2122/97 DPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLA
Rv2505c|M.tuberculosis_H37Rv DPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLA
MMAR_3852|M.marinum_M DPATGRIVPRGTAGEFCTRGYSVMSGYWKAPERTAEVIDPEGWMHTGDLA
Mflv_4867|M.gilvum_PYR-GCK DPETGEIVERGTPGEFCTRGYSVMLGYWREDEKTAQAIDADGWMHTGDLA
Mvan_1563|M.vanbaalenii_PYR-1 DPDTGHVVERGTPGEFCTRGYSVMLGYWRDEEKTAQAVDADGWMHTGDLA
MSMEG_5649|M.smegmatis_MC2_155 DPDTGETVERGQPGEFCTRGYSVMLGYWNDDEKTREAVDADGWMHTGDLA
MAB_4377c|M.abscessus_ATCC_199 DPNSGETVQRGQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLA
MAV_5077|M.avium_104 DPIDGRVLPVGQVGEICARGYQQFVEYLHDPDATQSALDTEGFVRTGDLG
TH_2068|M.thermoresistible__bu NPAE------DGTGEVLLRGPNVMLGYLDDPEATAAAIDADGWLHTGDVG
MUL_4126|M.ulcerans_Agy99 ----------PDTGEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIG
MLBr_02546|M.leprae_Br4923 D-DSGKEVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDGLLSSGDVG
*.. . : * :* : :**:.
Mb2533c|M.bovis_AF2122/97 EMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPD
Rv2505c|M.tuberculosis_H37Rv EMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPD
MMAR_3852|M.marinum_M LMDECGYVQITGRIKDIVVRGGENISPREIEEFLHSHPDIVDAHVVGVPD
Mflv_4867|M.gilvum_PYR-GCK VMRPDGYCNIVGRIKDVVIRGGENIYPREIEEFLYTHPDVEDAHVIGVPD
Mvan_1563|M.vanbaalenii_PYR-1 VMRPDGYCNIVGRIKDVVIRGGENIYPREVEEFLYTHPDIEDAQVVGVPD
MSMEG_5649|M.smegmatis_MC2_155 VMREDGYCTIVGRIKDMVIRGGENIYPREIEEFLYTHPDIDDAQVIGVPD
MAB_4377c|M.abscessus_ATCC_199 VMRDDGYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPD
MAV_5077|M.avium_104 AMDERGFVTVTGRRKELIIRGGENIAPAEVEESVAQHDCIDEVVAVGLPD
TH_2068|M.thermoresistible__bu KVDERGNLTITDRLKDMYICGGFNVYPAEVEQVLARLDGVAEAAVIGVPD
MUL_4126|M.ulcerans_Agy99 VLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPD
MLBr_02546|M.leprae_Br4923 YFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDD
. . : .* .:: : ** *: * *:*: : : : .:*: *
Mb2533c|M.bovis_AF2122/97 AKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLWIVDEFPM
Rv2505c|M.tuberculosis_H37Rv AKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLWIVDEFPM
MMAR_3852|M.marinum_M ERMGEELMAVVKLRAGAPELTTGLLREYCAGQIAKFKIPRYLRLVDEFPM
Mflv_4867|M.gilvum_PYR-GCK DRYGEEVCAWIRMRPGRTALDAAAVREFATDKLAHYKIPRYVHVVDEFPM
Mvan_1563|M.vanbaalenii_PYR-1 ARYGEEICAWIRMRPGRRALDAAAVREFAAGKLAHYKIPRYVHVVDEFPM
MSMEG_5649|M.smegmatis_MC2_155 ERYGEEICAWIRMKPGRPPLDADKVREFASGKLAHYKIPRYVHVVDEFPM
MAB_4377c|M.abscessus_ATCC_199 EKYGEELCAWVRMRPDRVVIDAVAIRAFASGRLAHYKIPRYVHVVESFPM
MAV_5077|M.avium_104 DHFGEIVAVVCRLATTASAGLKDSLLAHARARLAAFKVPARWFVADAFPV
TH_2068|M.thermoresistible__bu QRLGEVGKAFVVRRPGAT-LDEQAVIAYCKQHLANFKVPRSVEFLDALPR
MUL_4126|M.ulcerans_Agy99 HRLGEVGRAFIVARPGFN-LDEKSVIDYTREHLANFKAPRSVRFVDTLPR
MLBr_02546|M.leprae_Br4923 KEWGARLRAFVVKKQDAT-IDEDAIKAYVRDHLARYKVPREVIFLEELPR
. * . : . ::* :* * . : :*
Mb2533c|M.bovis_AF2122/97 TVTGKVRKVEMRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv TVTGKVRKVEMRQQALEYLRGQQ-------
MMAR_3852|M.marinum_M TVTGKVRKVEMRQQAIEYLRGQH-------
Mflv_4867|M.gilvum_PYR-GCK TVTGKIRKVEMREVSARLLGL---------
Mvan_1563|M.vanbaalenii_PYR-1 TVTGKIRKVEMREVSAGLFAD---------
MSMEG_5649|M.smegmatis_MC2_155 TVTGKIRKVQMREETVALLGLEA-------
MAB_4377c|M.abscessus_ATCC_199 TVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ
MAV_5077|M.avium_104 TPTGKVRRFALREAILRDELEEL-------
TH_2068|M.thermoresistible__bu NPGGKVVKPLLRERA---------------
MUL_4126|M.ulcerans_Agy99 NAGGKVVKPQLRELA---------------
MLBr_02546|M.leprae_Br4923 NPTGKVLKRELRDFEVH-------------
. **: : :*: