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LFHNLADIVRSHGRNRPDAPALIVGDRTVSYRELDERSNRTAQAFSRTGVGPGDRVAFVERNGIEFFDVA FGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVGQEFTGRIEAIADDLDVEVVVIGKHRHWPTFDDL LAAAPAVDPGVVTGPDDLVFLMYTSGTTGAPKGVMLSNANVVCKTAGVGGPWKFDADSVSLAVMPLFHMA GFGWALAGLWEGAVTVVLRDVDPGAILDAVARHRVTNMLLVPAVIQFLLDTTGLDDTDLSRLRIVVYGAS PITDDVLMRGIDRFGGIFAQVYGMTESTGSVTQLDGDEHLPQLLRSCGRPYPWVQIRVVDPTGRDVAPGT VGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTGDAGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVEN VLMTHPAVTDVAVIGIPDTRWGEAVKAVVVAGAPVTEAELIAFAREQLAGFKLPKSVDFVDALPRNPSGK LLKRQLREPYWTDEDRHIG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0027 | - | - | 100% (509) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_5271 | - | e-106 | 42.77% (498) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 4e-88 | 41.12% (501) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 5e-80 | 36.85% (483) | chain-fatty-acid-CoA ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 5e-80 | 36.85% (483) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 9e-66 | 30.84% (509) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 1e-92 | 41.28% (499) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_2597 | fadD13 | 5e-80 | 38.22% (484) | fatty-acid-CoA ligase FadD13 |
| M. avium 104 | MAV_3523 | - | 1e-118 | 45.51% (512) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 2e-96 | 40.95% (503) | feruloyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2854 | - | 1e-93 | 39.92% (506) | PUTATIVE putative AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 6e-74 | 37.20% (500) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 0.0 | 77.89% (511) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0027|M.gilvum_PYR-GCK -------------------------------------------MFHNLAD
Mvan_0943|M.vanbaalenii_PYR-1 -------------------------------------------MIHNLAD
MAV_3523|M.avium_104 --------------------------------------MPAAETRETLAG
MAB_4559|M.abscessus_ATCC_1997 ---------------------------------------------MQFTQ
MSMEG_4065|M.smegmatis_MC2_155 -------------------------------------------MTMYLTQ
TH_2854|M.thermoresistible__bu ----------------------------------------VSRSHLLIGD
Mb3116|M.bovis_AF2122/97 -----------------------------------------MKNIGWMLR
Rv3089|M.tuberculosis_H37Rv -----------------------------------------MKNIGWMLR
MMAR_2597|M.marinum_M -----------------------------------------MKNIGAMLK
MUL_4126|M.ulcerans_Agy99 ----------------------------------------MTSDPRTVPT
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
.
Mflv_0027|M.gilvum_PYR-GCK IVRSHGRNRPDAPALIVGDRTVSYRELDERSNRTAQAFSRTGVGPGDRVA
Mvan_0943|M.vanbaalenii_PYR-1 IIRVHGRERPGAPALVVGDRTVTYGELDDRSSRAAQAFAQAGVGVGDRVA
MAV_3523|M.avium_104 IVERHAQRRPDAIAIRYGERQWSWAEWSSRIRRAAGALRGDGIERGQCVA
MAB_4559|M.abscessus_ATCC_1997 WLHRALQQYPDRLITIDQGREHTVEQFADRVARLSAGLRANGVRPGDRVG
MSMEG_4065|M.smegmatis_MC2_155 GLHRAVQQTPGATMTVFGERRRTFLEVADRVARLAGALRALGVRAGDRVA
TH_2854|M.thermoresistible__bu LITRAARTYGAAPALVHGDRVMSFREFDDATNRLGNALLARGLRPGDHVA
Mb3116|M.bovis_AF2122/97 QRATVSPRLQAYVEPSTDVR-MTYAQMNALANRCADVLTALGIAKGDRVA
Rv3089|M.tuberculosis_H37Rv QRATVSPRLQAYVEPSTDVR-MTYAQMNALANRCADVLTALGIAKGDRVA
MMAR_2597|M.marinum_M QRAHISPRLQAYVEPSTNVR-MDYTELNMLTNRCASVLRALGVGKGDRVA
MUL_4126|M.ulcerans_Agy99 ALDRLVRRLPNHDALVTDERSFTVSELNDEVYRAAAALIELGVKPAARVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
: . : *: . :.
Mflv_0027|M.gilvum_PYR-GCK FVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVG
Mvan_0943|M.vanbaalenii_PYR-1 FVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVVG
MAV_3523|M.avium_104 FLDKNHPACLEVLIGGASVGAVTTVVNWRVIGDELVHVLADSGARVLVVG
MAB_4559|M.abscessus_ATCC_1997 MLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVLLVD
MSMEG_4065|M.smegmatis_MC2_155 MLAQNSDRYHEYLLAVPWANGVLNPVNIRWTPAEIAYSLEDSGTKVMFVD
TH_2854|M.thermoresistible__bu VLAPNGIDGVVTYYALAKAGLVRVPLNSRETDFELAYKIDDSQARALVTD
Mb3116|M.bovis_AF2122/97 LLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYG
Rv3089|M.tuberculosis_H37Rv LLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYG
MMAR_2597|M.marinum_M LLMPNSVAFCCLFYGAAKLGAVAVPLNTRLAAPELGFILADSGSTVLIYH
MUL_4126|M.ulcerans_Agy99 IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
. * . . :* . : : :.
Mflv_0027|M.gilvum_PYR-GCK QEFTGRIEAIADDLDVEVVVIGKHRH-------WPTFDDLLAA----APA
Mvan_0943|M.vanbaalenii_PYR-1 QDFAGHLEAIEDGLDADIVVIGDHPR-------WPAFDDWVAS----HPP
MAV_3523|M.avium_104 AELRPAAEAAARRVPSLERIIEVG----------DEYESLLAA----AEP
MAB_4559|M.abscessus_ATCC_1997 DTFKAAAAPLRAACACLETVIYCGAGPAP--QDMIGYEDLLAS----HEP
MSMEG_4065|M.smegmatis_MC2_155 DSFARMLPAIKDAWAELSTVIYAGEASPP--AGTLAYEELIDK----SDP
TH_2854|M.thermoresistible__bu GRIPAETELVIHT---------------------EELAGMIAG----ADP
Mb3116|M.bovis_AF2122/97 --APSAPVIDAIRAQADPPGTVTDWI------GADSLAERLRS----AAA
Rv3089|M.tuberculosis_H37Rv --APSAPVIDAIRAQADPPGTVTDWI------GADSLAERLRS----AAA
MMAR_2597|M.marinum_M --QSLEPVVTAIKTATERSHNVISWVPLS--DGEGALAQRLET----ADA
MUL_4126|M.ulcerans_Agy99 GHFLGSDRVAGLDRKALPALRHIVRIPIE--EPDGTWDEFIETGTDTGAV
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIAR------S
:
Mflv_0027|M.gilvum_PYR-GCK VDPGVVTGPDDLVFLMYTSGTTGAPKGVMLSNANVVCKTAG-VGGPWK-F
Mvan_0943|M.vanbaalenii_PYR-1 VDPGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGG-VAGPWQ-F
MAV_3523|M.avium_104 APSDAGVDTDETALVIYSSGTTGRPKGVLLSQRALVNHAAN-LAPAFP-F
MAB_4559|M.abscessus_ATCC_1997 ID-DTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNF-L
MSMEG_4065|M.smegmatis_MC2_155 VD-DARRGGDELAGLFYTGGTTGFPKGVMLSHANLLTSTYGLLTPGFA-F
TH_2854|M.thermoresistible__bu GPCRIERDPEDPLRLAYTGGTTGKPKAVVLTTRSELAEIANFLVDLLPDL
Mb3116|M.bovis_AF2122/97 DEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASS--WASTIDV
Rv3089|M.tuberculosis_H37Rv DEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASS--WASTIDV
MMAR_2597|M.marinum_M GEPICDSGGSDNLFIMYTSGTTGNPKGVVHTHDSVHTAASS--WSLTVDV
MUL_4126|M.ulcerans_Agy99 TARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASAS--WAANGKI
MLBr_02546|M.leprae_Br4923 SSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGG--ILSKVPF
. : :.**** .*.. . .
Mflv_0027|M.gilvum_PYR-GCK DADSVSLAVMPLFHMAGFGWALAGLWE-GAVTVVLRDVDPGAILDAVARH
Mvan_0943|M.vanbaalenii_PYR-1 DADAVSLAVMPLFHMAGSGWALAGLWQ-GATTVVLRDVEPAAILDAIARH
MAV_3523|M.avium_104 GDGDANLVAMPLFHVGGIGYALFGIRA-GAPTIMTREPDAAALIGAVRAG
MAB_4559|M.abscessus_ATCC_1997 TRGGRLLHSAPMFHMADFSAVLAGNLS-GSTHVIVPSFSPQGVLDAIVAH
MSMEG_4065|M.smegmatis_MC2_155 RPGGICLHAAPMFHLADLMSWSAGLLQ-GGRHVFIPSFEPVTVMQAIAQH
TH_2854|M.thermoresistible__bu TPDSVMLHAAPITHGSG-AFFLPHLVK-GARNVILPRFTPQGFVDAAVEH
Mb3116|M.bovis_AF2122/97 RYRDRLLLPLPMFHVAALTTVIFSAMR-GVTLISMPQFDATKVWSLIVEE
Rv3089|M.tuberculosis_H37Rv RYRDRLLLPLPMFHVAALTTVIFSAMR-GVTLISMPQFDATKVWSLIVEE
MMAR_2597|M.marinum_M RYQDRLLLPLPMFHVAALTTVIMCAMR-GVTLVSMPQFDPAKAWSLIVDE
MUL_4126|M.ulcerans_Agy99 TADDRHLCINPFFHNFGYKAGILACLQTGATLFPHLTFDPLRTLQAIERH
MLBr_02546|M.leprae_Br4923 RAHEVTLLPAPMFHALGYLHATLAMFL-GSTLVLRRRFKPATVLEDIEKH
* *: * * . .
Mflv_0027|M.gilvum_PYR-GCK RVTNMLLVPAVIQFLLDTTG--LDDTDLSRLRIVVYGASPITDDVLMRGI
Mvan_0943|M.vanbaalenii_PYR-1 RITNMLLVPAVIQFLLDTDG--VAEVDLSTLRVIVYGASPISDDVLVRGI
MAV_3523|M.avium_104 -ATHAFFVPPVIARFLDAGE--AARASIAGLRYIVYGAAPMPLPLLHRAL
MAB_4559|M.abscessus_ATCC_1997 DVQDMLLVPTMIQMLVDHPG--AAQLDLSGIRSITYGASVISEAVLQRAT
MSMEG_4065|M.smegmatis_MC2_155 QVTDALLVPTMIQKLIDHPD--INRYDLTSFRALFYAASAIPQALLERAM
TH_2854|M.thermoresistible__bu GATATFMVPTMIAMMLEDAE--IDRDRLK-LRRLCYGGAPIAPTLLARGL
Mb3116|M.bovis_AF2122/97 RVCIGGAVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEALIKIYA
Rv3089|M.tuberculosis_H37Rv RVCIGGAVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEALIKIYA
MMAR_2597|M.marinum_M RVSLAGAVPAILNFMRLVPE--FTELDAPEFRCFITGGAPMPEALIRMYA
MUL_4126|M.ulcerans_Agy99 RITVLPGPPTIYQTLLDHPA--RDDYDLSSLRFAVTGAATVPVVLVERMQ
MLBr_02546|M.leprae_Br4923 QATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRAL
* : : :* ..: : :
Mflv_0027|M.gilvum_PYR-GCK DRF-GGIFAQVYGMTESTGSVTQLDGDEH----LPQLLRSCGRPYPWVQI
Mvan_0943|M.vanbaalenii_PYR-1 ERF-GPIFAQVYGMTETTGSITQLDGPDH----VPALLRSCGRPYPWVQI
MAV_3523|M.avium_104 STWPGTKFVQVYGQTELCGAVTALSDDDHRDAARPQLQLSAGKAVQGCEI
MAB_4559|M.abscessus_ATCC_1997 RVFPNARFTQAYGMTEVSPVATLLLPDDHD---DPALLRSAGRAAPHCEV
MSMEG_4065|M.smegmatis_MC2_155 KVFPNAEFVQGYGMTELSPLATLLSPDDHQ---KPRLLRSAGRAAPSAEV
TH_2854|M.thermoresistible__bu ETL-GPVFVQLYGQAEAPLAITCLQPWEHT----PERLTSAGKPYTFVEM
Mb3116|M.bovis_AF2122/97 AKN--IEVVQGYALTESCGGGTLLLS-EDALR----KAGSAGRATMFTDV
Rv3089|M.tuberculosis_H37Rv AKN--IEVVQGYALTESCGGGTLLLS-EDALR----KAGSAGRATMFTDV
MMAR_2597|M.marinum_M AKN--MQVVQGYALTESCGGGTLLLG-EDALA----KVGSAGRATMFADV
MUL_4126|M.ulcerans_Agy99 SELDIDIVLTAYGLTEANGMGTMCRADDDALT----VATTCGRP--FADF
MLBr_02546|M.leprae_Br4923 EELG-PVIYNMYGSTEIAFATIAGPKDLQINS------ATVGPVVKGVKV
. *. :* . : * ..
Mflv_0027|M.gilvum_PYR-GCK RVVDPTG-RDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTG
Mvan_0943|M.vanbaalenii_PYR-1 RIVDETG-ADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADGWLKTG
MAV_3523|M.avium_104 RIVDPNNCAELPAGRSGEVWVRSNQNMSGYLNRAEATAETITADGWVRTG
MAB_4559|M.abscessus_ATCC_1997 RIVDPDD-NEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIR-DGWMHTG
MSMEG_4065|M.smegmatis_MC2_155 RIVDPDG-NEVPRRTVGEVAVRGGNVMLGYWNKPQETAAAIR-DGWMHTG
TH_2854|M.thermoresistible__bu DIRDEED-NSVPPGTPGEVVTRGPHTMSGYWRRPEATAETLGEDGWLRTG
Mb3116|M.bovis_AF2122/97 AVRGDDG--VIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNG-WFRTG
Rv3089|M.tuberculosis_H37Rv AVRGDDG--VIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNG-WFRTG
MMAR_2597|M.marinum_M RVRTDDG--MIAERGQGEVVIKSDFLLKEYWNRPDATRDAFHGD-WFRTG
MUL_4126|M.ulcerans_Agy99 ELRIG--------PDTGEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTG
MLBr_02546|M.leprae_Br4923 KILDDSG-KEVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDGLLSSG
: *.: . : * . . :*
Mflv_0027|M.gilvum_PYR-GCK DAGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIG
Mvan_0943|M.vanbaalenii_PYR-1 DAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAAVIG
MAV_3523|M.avium_104 DVGRLDADGYVYIEDRLKDMIITGGENVYGPEVESVLIEHPAVVDAAVIG
MAB_4559|M.abscessus_ATCC_1997 DAGRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAACAVIG
MSMEG_4065|M.smegmatis_MC2_155 DAAYMDDDGYIYVVDRIKDMIITGGENVYSAEVENAVVQHPSVAACAVIG
TH_2854|M.thermoresistible__bu DIGQVDEEGYLYLLDRRNDVIISGGFNVYPREVEDALLTHPAVREAVVVG
Mb3116|M.bovis_AF2122/97 DIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIG
Rv3089|M.tuberculosis_H37Rv DIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIG
MMAR_2597|M.marinum_M DIGEIDSDGYLYIKDRIKDMIISGGENIYPAEIENVITGIPGVAEVAVIG
MUL_4126|M.ulcerans_Agy99 DIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIG
MLBr_02546|M.leprae_Br4923 DVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIG
* . .* . : : .* .:: : *. *:: *:*. : * ..:*
Mflv_0027|M.gilvum_PYR-GCK IPDTRWGEAVKAVVVAG--APVTEAELIAFAREQLAGFKLPKSVDFVDAL
Mvan_0943|M.vanbaalenii_PYR-1 VPDRRWGEAVKAVVVAARGAQLTEAELIAFARDRIGGFKLPKSVDFVDVL
MAV_3523|M.avium_104 VPDDFWGESVKAIVVAD--GDVDAADVIEFCRRHLAGFKCPRTVDFVAEL
MAB_4559|M.abscessus_ATCC_1997 IPDEQWGERVHAVVVKQAQSECCDGDLQEHCREHIANYKVPRSFEFVDEL
MSMEG_4065|M.smegmatis_MC2_155 VPDADWGERVHAVVVLQPGAELAACQIREHAKRLIAGYKCPRSIEFVNAL
TH_2854|M.thermoresistible__bu VDDERWGQRVSAAVVLR--EEVDTQALIDHCAERLAGFKRPRHIEVWDEL
Mb3116|M.bovis_AF2122/97 LPDEKWGEIAAAIVVADQNE-VSEQQIVEYCGTRLARYKLPKKVIFAEAI
Rv3089|M.tuberculosis_H37Rv LPDEKWGEIAAAIVVADQNE-VSEQQIVEYCGTRLARYKLPKKVIFAEAI
MMAR_2597|M.marinum_M LPDQKWGEIACAIVVSDQGA-VSEAGIVEFCAARLARYKLPKRLIFTATL
MUL_4126|M.ulcerans_Agy99 IPDHRLGEVGRAFIVARPGFNLDEKSVIDYTREHLANFKAPRSVRFVDTL
MLBr_02546|M.leprae_Br4923 VDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEEL
: * * * :* : . :. :* *: . . :
Mflv_0027|M.gilvum_PYR-GCK PRNPSGKLLKRQLREPYWTDEDRHIG---
Mvan_0943|M.vanbaalenii_PYR-1 PRNPSGKLLKRALREPYWDGADRHIG---
MAV_3523|M.avium_104 PRNASGKILKTQLREPFWRDRDRRV----
MAB_4559|M.abscessus_ATCC_1997 PLSGAGKILKRVLRQKYWESRDAGVS---
MSMEG_4065|M.smegmatis_MC2_155 PLSGAGKVLKRELRERHLGARERDRGSLP
TH_2854|M.thermoresistible__bu PKSPVGKSLRRTVRETMRANEEVTAHA--
Mb3116|M.bovis_AF2122/97 PRNPTGKILKTVLREQYSATVPK------
Rv3089|M.tuberculosis_H37Rv PRNPTGKILKTVLREQYSATVPK------
MMAR_2597|M.marinum_M PRNPAGKVLKRELRELYR-----------
MUL_4126|M.ulcerans_Agy99 PRNAGGKVVKPQLRELA------------
MLBr_02546|M.leprae_Br4923 PRNPTGKVLKRELRDFEVH----------
* . ** :: :*: