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AAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVARRRFNYSELLTDVHRLATGLV RAGIGPGDRVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYA AMLAEVGPRCPDLADVILLESDRWDALAGAEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGVTLSHR NILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTS LYGVPTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRA DDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTG DLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDA PELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTGKVRKVEMRQQALEYLRGQQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | - | 100% (547) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3561 | fadD3 | 6e-72 | 35.03% (491) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 5e-60 | 34.98% (486) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 0.0 | 100.00% (547) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4867 | - | 0.0 | 59.85% (533) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-46 | 27.91% (516) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 0.0 | 59.89% (531) | AMP-binding domain protein |
| M. marinum M | MMAR_3852 | fadD35 | 0.0 | 78.39% (546) | fatty-acid-CoA ligase FadD35 |
| M. avium 104 | MAV_5077 | - | 1e-78 | 35.54% (543) | long chain fatty acid-CoA ligase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 0.0 | 60.83% (531) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4650 | - | 3e-82 | 37.12% (528) | PUTATIVE long chain fatty acid-CoA ligase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-74 | 34.76% (515) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1563 | - | 0.0 | 59.96% (527) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2505c|M.tuberculosis_H37Rv --------MAAAEVVDPNRLSYDRGPS--APSLLESTIGANLAAT-----
Mb2533c|M.bovis_AF2122/97 --------MAAAEVVDPNRLSYDRGPS--APSLLESTIGANLAAT-----
MMAR_3852|M.marinum_M --------MATTAAADQNQLSYDRGPI--APALLEMTIGANLAAT-----
Mflv_4867|M.gilvum_PYR-GCK -----------------MTGSYDAGPT--DVAILEETIGANFARI-----
Mvan_1563|M.vanbaalenii_PYR-1 -----------------MSQSYDAGPT--DTAILEETIGANFERI-----
MSMEG_5649|M.smegmatis_MC2_155 ------------------MKSYDAGPT--GAPVLEETIGANFERI-----
MAB_4377c|M.abscessus_ATCC_199 ------------------MKAYDAGAT--LSPIIEETIGENFERI-----
MUL_4126|M.ulcerans_Agy99 ------------------------------MTSDPRTVPTALDRL-----
MAV_5077|M.avium_104 --------------MRHLTEARWDADR--SVPLTDHTVGGLLAAR-----
TH_4650|M.thermoresistible__bu --------------MTHLEQAYWPADR--SVPLLETTVSELLRDR-----
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
. :: :
Rv2505c|M.tuberculosis_H37Rv -----AARYGHREALVDMVA----RRRFNYSELLTDVHRLATGLVRAGIG
Mb2533c|M.bovis_AF2122/97 -----AARYGHREALVDMVA----RRRFNYSELLTDVHRLATGLVRAGIG
MMAR_3852|M.marinum_M -----ASQCESRDALVDVRS----GRRWSYAQLLTDVRQLATGLVRAGIG
Mflv_4867|M.gilvum_PYR-GCK -----ARTHPGRDALVDVAG----GRRWTYAELDAEIDTVARGLMAIGVE
Mvan_1563|M.vanbaalenii_PYR-1 -----AATYPDHEALVDVTG----GRRWTYAELDREIDTVAKGLMSLGTE
MSMEG_5649|M.smegmatis_MC2_155 -----AATYPEHEALVEVAT----GRRWTYAELNDEIDATARGLMALGVD
MAB_4377c|M.abscessus_ATCC_199 -----ARAHPDVGALVDVSG----DRRWTYRELDAEINRVARGLMSLGVA
MUL_4126|M.ulcerans_Agy99 -----VRRLPNHDALVTD------ERSFTVSELNDEVYRAAAALIELGVK
MAV_5077|M.avium_104 -----ALEHPHRVALVGQRHGSGDRVRLSYAELLDEACRAGDALSSLVT-
TH_4650|M.thermoresistible__bu -----ADEFGERVALIGTRHGTGETERLSYAEVYAEAARVAAGLSALAR-
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEG------TLTYKELDRAAHALANGLIAKGVR
. **: . :: . .*
Rv2505c|M.tuberculosis_H37Rv PGDRVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGV
Mb2533c|M.bovis_AF2122/97 PGDRVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGV
MMAR_3852|M.marinum_M RGDRVGIWAPNRWEWVLVQYATAEIGAVLVTINPAYQARELEYALRQSGV
Mflv_4867|M.gilvum_PYR-GCK RGDRVGIWAPNCPEWVIVQYATAKIGAILVNINPAYRTHELRYVLEQSGV
Mvan_1563|M.vanbaalenii_PYR-1 SGDRVGIWAPNCPEWTIVQYATAKIGAILVNINPAYRTHELSYVLEQSGV
MSMEG_5649|M.smegmatis_MC2_155 KGDRVGIWAPNCAEWIMTQFAAAKVGAILVNINPAYRTHEVAYVLRQSGV
MAB_4377c|M.abscessus_ATCC_199 AGDRVGIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGV
MUL_4126|M.ulcerans_Agy99 PAARVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEA
MAV_5077|M.avium_104 PGGFLALWAPNVVEWPIIQYGAALAGVVLVALNPVLREDELAYALRHCGA
TH_4650|M.thermoresistible__bu PGSLVALWAPNVIEWPIIQYGAALAGVVLVALNPVLRDDELEYALRHSRA
MLBr_02546|M.leprae_Br4923 GGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGA
. :.: : * : : . *. :: :*. : : .
Rv2505c|M.tuberculosis_H37Rv AMVIAVASFKDADYAAMLAEVGPRCPDLADVILLESDRWDALAG--AEPD
Mb2533c|M.bovis_AF2122/97 AMVIAVASFKDADYAAMLAEVGPRCPDLADVILLESDRWDALAG--AEPD
MMAR_3852|M.marinum_M AMVIAASGFKGSDYAAILAEVAPGCPELHDVAFLDGDGWAKLAG--SGAD
Mflv_4867|M.gilvum_PYR-GCK ATLISATQFKTSDYVAMVDEVRPDVPALQRVLFIGTADWDTLRAAGSGVD
Mvan_1563|M.vanbaalenii_PYR-1 STLISATRFKTSDYVAMVDEVRPDVPALQRVLFIGTDDWDRLRSRADVID
MSMEG_5649|M.smegmatis_MC2_155 RTLVSASSFKTSDYASMIAEVRPECPDLLDVVFLDNDDWDRLR--ANQVD
MAB_4377c|M.abscessus_ATCC_199 RTLICAKAFKSSDYVAMASQVMPDAPGLRDVVFIGTSDWTELVAGAERVT
MUL_4126|M.ulcerans_Agy99 PVLFAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGTD
MAV_5077|M.avium_104 DVLLHADTSRDYAMLEVAQRVCDAIPGLRRVSLSETARWRSTTP------
TH_4650|M.thermoresistible__bu EVLLHADVSRDYPMAEVAERVCARIPGLRRVSLSETTVWRAAEP------
MLBr_02546|M.leprae_Br4923 KVIIYDD-----EYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAE
:. .
Rv2505c|M.tuberculosis_H37Rv LPALQQTAARLDGSD-PVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGEL
Mb2533c|M.bovis_AF2122/97 LPALQQTAARLDGSD-PVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGEL
MMAR_3852|M.marinum_M LVALQEIATTLSADD-PINIQYTSGTTGFPKGVTLSHRNILNNGYLVGEL
Mflv_4867|M.gilvum_PYR-GCK DADLRRRSGALSNRD-PINIQYTSGTTGFPKGATLSHRNILNNGFFVTEQ
Mvan_1563|M.vanbaalenii_PYR-1 DALLRERSASLSHHD-PVNIQYTSGTTGFPKGATLSHRNILNNGFFVTEQ
MSMEG_5649|M.smegmatis_MC2_155 DAAFHERMATLANTD-PINIQYTSGTTGFPKGATLSHRNILNNGFFVTEL
MAB_4377c|M.abscessus_ATCC_199 ETALRARMSQLSNTD-PINIQYTSGTTGYPKGATLSHRNVLNNGFFVAES
MUL_4126|M.ulcerans_Agy99 TGAVTARAAAVSPDD-VSDILFTSGTTGRSKGVLCAHRQSLSASASWAAN
MAV_5077|M.avium_104 -SAGMINRAPSDPDQ-PVMLQYTSGTTGRPKGVVLTHRALVNVAKLTMEA
TH_4650|M.thermoresistible__bu -VDAAP--VPHDPDT-VAMLQYTSGTTGKPKGVVLNHRAIVNVARLTMET
MLBr_02546|M.leprae_Br4923 LIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSK
: *****. .**. :
Rv2505c|M.tuberculosis_H37Rv LGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRA
Mb2533c|M.bovis_AF2122/97 LGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRA
MMAR_3852|M.marinum_M LEYTAEDRICIPVPFYHCFGMVMGNLAATSHGACMVIPAPGFDPAATLRA
Mflv_4867|M.gilvum_PYR-GCK IRLQPGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVIPAPAFDPGLTLRA
Mvan_1563|M.vanbaalenii_PYR-1 IRLGPGDRLCIPVPFYHCFGMVMGNLGCTTHGATMVIPAPGFDPGQTLKT
MSMEG_5649|M.smegmatis_MC2_155 IALGPDDRLCIVPPFYHCFGMVMGTLGAVSHGTTIVIPAPGFDPGITLSA
MAB_4377c|M.abscessus_ATCC_199 IQLQAGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEA
MUL_4126|M.ulcerans_Agy99 GKITADDRHLCINPFFHNFGYKAGILACLQTG-ATLFPHLTFDPLRTLQA
MAV_5077|M.avium_104 VEAPPAAICVNPLPLFHTAGCVIATLGPLWVG-GTAVPCGRPAPGAVLET
TH_4650|M.thermoresistible__bu LRVPPGAVSFNPLPMFHTAGCVIATLGPLWVG-GTAILAERFTPQSALEV
MLBr_02546|M.leprae_Br4923 VPFRAHEVTLLPAPMFHALGYLHATLAMFLGS--TLVLRRRFKPATVLED
. *::* * . *. . . * .*
Rv2505c|M.tuberculosis_H37Rv VQDERCTSLYGVPTMFIAELGLPD--FTDYELGSLRTGIMAGAACPVEVM
Mb2533c|M.bovis_AF2122/97 VQDERCTSLYGVPTMFIAELGLPD--FTDYELGSLRTGIMAGAACPVEVM
MMAR_3852|M.marinum_M VQAERCTSLYGVPTMFIAELGLAD--FATYDLSSLRTGIMAGSTCPVEVM
Mflv_4867|M.gilvum_PYR-GCK IETERCTAVYGVPTMFIAMQNHPD--FAERDLSTLRTGIMAGAVCPVEVM
Mvan_1563|M.vanbaalenii_PYR-1 IETERCTAVYGVPTMFIAMQNHAD--FAERDLSSLRTGIMAGAVCPVEVM
MSMEG_5649|M.smegmatis_MC2_155 VESEKCTGLYGVPTMFIAMLGHPD--FANFDLSSLRTGIMAGSVCPIEVM
MAB_4377c|M.abscessus_ATCC_199 IERERCVGVYGVPTMFIAMLADPG--FAHRDLSTLRTGIMAGSVCPVEVM
MUL_4126|M.ulcerans_Agy99 IERHRITVLPGPPTIYQTLLDHPA--RDDYDLSSLRFAVTGAATVPVVLV
MAV_5077|M.avium_104 LREQHAAVLFYVPAVLRALVEYQR--ESTETAPKLDIIMGGASEVSAELI
TH_4650|M.thermoresistible__bu MRAEGVQVLFYVPTVLAALLDQQR--SSTQPAPRLGIIMGGASNVDPALI
MLBr_02546|M.leprae_Br4923 IEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELA
:. . : *.: * . ..: :
Rv2505c|M.tuberculosis_H37Rv RKVISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEI
Mb2533c|M.bovis_AF2122/97 RKVISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEI
MMAR_3852|M.marinum_M RKVIDQMHMAGISICYGMTETSPVATQTRSNDSLQRRVTTVGRVGPHLEI
Mflv_4867|M.gilvum_PYR-GCK KRCVEEMHLTEMSIAYGMTETSPVSCQTLIDDDLERRTSTIGRVHPHVEI
Mvan_1563|M.vanbaalenii_PYR-1 KRCVEEMNMSEISIAYGMTETSPVSCQTLIDDDLERRTSSIGRVHPHVEI
MSMEG_5649|M.smegmatis_MC2_155 KRVVADMHMAEVAICYGMTETSPVSCQTLIDDDLDRRTATIGRAHPHVEI
MAB_4377c|M.abscessus_ATCC_199 KRCIDEMHMAGVAIAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEI
MUL_4126|M.ulcerans_Agy99 ERMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFEL
MAV_5077|M.avium_104 DSATATFNAR-VFNLYGQTELAPVLTVTRPGDSRRDRLYTVGRPLPQVDC
TH_4650|M.thermoresistible__bu TGAADIFGAP-VFNLYGQTELAPVLTLTRPDDGPQDRLSTVGRPLPQVEC
MLBr_02546|M.leprae_Br4923 TRALEELGPV-IYNMYGSTEIAFATIAG--PKDLQINSATVGPVVKGVKV
: : ** ** .. : * ..
Rv2505c|M.tuberculosis_H37Rv KVVDPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTG
Mb2533c|M.bovis_AF2122/97 KVVDPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTG
MMAR_3852|M.marinum_M KVVDPATGRIVPRGTAGEFCTRGYSVMSGYWKAPERTAEVIDPEGWMHTG
Mflv_4867|M.gilvum_PYR-GCK KIVDPETGEIVERGTPGEFCTRGYSVMLGYWREDEKTAQAIDADGWMHTG
Mvan_1563|M.vanbaalenii_PYR-1 KIVDPDTGHVVERGTPGEFCTRGYSVMLGYWRDEEKTAQAVDADGWMHTG
MSMEG_5649|M.smegmatis_MC2_155 KIIDPDTGETVERGQPGEFCTRGYSVMLGYWNDDEKTREAVDADGWMHTG
MAB_4377c|M.abscessus_ATCC_199 KIVDPNSGETVQRGQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTG
MUL_4126|M.ulcerans_Agy99 RIG-PDTGEVLLRGP---------NVMLGYLDDPRATAAAIDADGWLHTG
MAV_5077|M.avium_104 KIIDPIDGRVLPVGQVGEICARGYQQFVEYLHDPDATQSALDTEGFVRTG
TH_4650|M.thermoresistible__bu KIIDPHTQQTVPVGVEGEICARGYQQFLEYLHDPHATAQALDREGFVRTG
MLBr_02546|M.leprae_Br4923 KILDDSGK-EVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDGLLSSG
:: : * : * :* : :*
Rv2505c|M.tuberculosis_H37Rv DLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIG
Mb2533c|M.bovis_AF2122/97 DLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIG
MMAR_3852|M.marinum_M DLALMDECGYVQITGRIKDIVVRGGENISPREIEEFLHSHPDIVDAHVVG
Mflv_4867|M.gilvum_PYR-GCK DLAVMRPDGYCNIVGRIKDVVIRGGENIYPREIEEFLYTHPDVEDAHVIG
Mvan_1563|M.vanbaalenii_PYR-1 DLAVMRPDGYCNIVGRIKDVVIRGGENIYPREVEEFLYTHPDIEDAQVVG
MSMEG_5649|M.smegmatis_MC2_155 DLAVMREDGYCTIVGRIKDMVIRGGENIYPREIEEFLYTHPDIDDAQVIG
MAB_4377c|M.abscessus_ATCC_199 DLAVMRDDGYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVG
MUL_4126|M.ulcerans_Agy99 DIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIG
MAV_5077|M.avium_104 DLGAMDERGFVTVTGRRKELIIRGGENIAPAEVEESVAQHDCIDEVVAVG
TH_4650|M.thermoresistible__bu DLGRMDERGYVTVTGRLKELIIRGGENIAPAEVEAVLNALDSRVQAVVLG
MLBr_02546|M.leprae_Br4923 DVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIG
*:. : . : .* .:: : ** *: * *:* : : .:*
Rv2505c|M.tuberculosis_H37Rv VPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLWIVDE
Mb2533c|M.bovis_AF2122/97 VPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLWIVDE
MMAR_3852|M.marinum_M VPDERMGEELMAVVKLRAGAPELTTGLLREYCAGQIAKFKIPRYLRLVDE
Mflv_4867|M.gilvum_PYR-GCK VPDDRYGEEVCAWIRMRPGRTALDAAAVREFATDKLAHYKIPRYVHVVDE
Mvan_1563|M.vanbaalenii_PYR-1 VPDARYGEEICAWIRMRPGRRALDAAAVREFAAGKLAHYKIPRYVHVVDE
MSMEG_5649|M.smegmatis_MC2_155 VPDERYGEEICAWIRMKPGRPPLDADKVREFASGKLAHYKIPRYVHVVDE
MAB_4377c|M.abscessus_ATCC_199 VPDEKYGEELCAWVRMRPDRVVIDAVAIRAFASGRLAHYKIPRYVHVVES
MUL_4126|M.ulcerans_Agy99 IPDHRLGEVGRAFIVARPG-FNLDEKSVIDYTREHLANFKAPRSVRFVDT
MAV_5077|M.avium_104 LPDDHFGEIVAVVCRLATTASAGLKDSLLAHARARLAAFKVPARWFVADA
TH_4650|M.thermoresistible__bu VPDDRYGEVVAAVLRSDDKVDAAMKCRLVQQARDRLAGYKIPVRWFTVRE
MLBr_02546|M.leprae_Br4923 VDDKEWGARLRAFVVKKQD-ATIDEDAIKAYVRDHLARYKVPREVIFLEE
: * . * . : ::* :* *
Rv2505c|M.tuberculosis_H37Rv FPMTVTGKVRKVEMRQQALEYLRGQQ-------
Mb2533c|M.bovis_AF2122/97 FPMTVTGKVRKVEMRQQALEYLRGQQ-------
MMAR_3852|M.marinum_M FPMTVTGKVRKVEMRQQAIEYLRGQH-------
Mflv_4867|M.gilvum_PYR-GCK FPMTVTGKIRKVEMREVSARLLGL---------
Mvan_1563|M.vanbaalenii_PYR-1 FPMTVTGKIRKVEMREVSAGLFAD---------
MSMEG_5649|M.smegmatis_MC2_155 FPMTVTGKIRKVQMREETVALLGLEA-------
MAB_4377c|M.abscessus_ATCC_199 FPMTVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ
MUL_4126|M.ulcerans_Agy99 LPRNAGGKVVKPQLRELA---------------
MAV_5077|M.avium_104 FPVTPTGKVRRFALREAILRDELEEL-------
TH_4650|M.thermoresistible__bu FPVTPTGKVQRFALRDAILRQEISEL-------
MLBr_02546|M.leprae_Br4923 LPRNPTGKVLKRELRDFEVH-------------
:* . **: : :*: