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VTSLAGNLIEGARRHPNRIALRLDEIEIPYGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYY GVLRAGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAGADEAGAECILVKPGEFEELIQAAE PLEEAAVREDDDTAVILYTSGTTGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILGALPLFHAFGQTAG LNAAVAAGACLTLIPRFSPEKALQIIERDRVTVFEGVPTMFAAMLHSTERPDTGSLRLCVSGGAAMPVEV MRGFEQAFGTMVLEGYGLSETSPTASFNHPDRERKPGSIGTPIAGVQMKLLEVDTHGIGEIAIRGHNVMK GYWNRPDATAAAIDAEGWFRTGDLARIDEDGYYFIVDRSKDMIIRGGYNVYPREIEEVLYEHPEVREAAV VAVPDDMLGEEVGAAIALIPGATSDAAALSDFVKERVAAYKYPRRIWFVDELPKGPTGKILKRDITVPQA SPAQQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1606 | - | - | 100% (495) | fatty-acid-CoA ligase |
| M. marinum M | MMAR_4688 | fadD3_2 | 2e-72 | 38.18% (461) | fatty-acid-CoA ligase FadD3_2 |
| M. marinum M | MMAR_3852 | fadD35 | 3e-70 | 35.64% (477) | fatty-acid-CoA ligase FadD35 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 3e-76 | 35.81% (511) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4867 | - | 9e-82 | 37.11% (512) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 3e-76 | 35.81% (511) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01051 | xclC | 4e-58 | 34.83% (445) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 1e-74 | 35.07% (499) | AMP-binding domain protein |
| M. avium 104 | MAV_0971 | - | 2e-70 | 35.73% (445) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 3e-75 | 36.56% (465) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4599 | - | 3e-86 | 63.35% (251) | PUTATIVE fatty-acid-CoA ligase |
| M. ulcerans Agy99 | MUL_3431 | - | 0.0 | 87.07% (495) | fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_1563 | - | 9e-81 | 37.58% (479) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1606|M.marinum_M ------------------------MTSLAGNLIEGARRHPNR--IALRLD
MUL_3431|M.ulcerans_Agy99 ------------------------MTSLAGNLIEGARRHPNR--IALRLD
TH_4599|M.thermoresistible__bu --------------------------------------------------
Mflv_4867|M.gilvum_PYR-GCK ---------MTGSYDAGPTDVAILEETIGANFARIARTHPGRDALVDVAG
Mvan_1563|M.vanbaalenii_PYR-1 ---------MSQSYDAGPTDTAILEETIGANFERIAATYPDHEALVDVTG
MSMEG_5649|M.smegmatis_MC2_155 ----------MKSYDAGPTGAPVLEETIGANFERIAATYPEHEALVEVAT
MAB_4377c|M.abscessus_ATCC_199 ----------MKAYDAGATLSPIIEETIGENFERIARAHPDVGALVDVSG
Mb2533c|M.bovis_AF2122/97 MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVA
Rv2505c|M.tuberculosis_H37Rv MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVA
MAV_0971|M.avium_104 ------MQSAKRDEEESANLNSPRWQTIPEMVLSAADRFGDAEAVVDG--
MLBr_01051|M.leprae_Br4923 --------------------------------MLLASLNPSVVTATDIAD
MMAR_1606|M.marinum_M EIEIPYGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYGVLR
MUL_3431|M.ulcerans_Agy99 EIEIPYGALDTASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYGVLR
TH_4599|M.thermoresistible__bu --------------------------------------------------
Mflv_4867|M.gilvum_PYR-GCK GRRWTYAELDAEIDTVARGLMAIGVERGDRVGIWAPNCPEWVIVQYATAK
Mvan_1563|M.vanbaalenii_PYR-1 GRRWTYAELDREIDTVAKGLMSLGTESGDRVGIWAPNCPEWTIVQYATAK
MSMEG_5649|M.smegmatis_MC2_155 GRRWTYAELNDEIDATARGLMALGVDKGDRVGIWAPNCAEWIMTQFAAAK
MAB_4377c|M.abscessus_ATCC_199 DRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAEWVLVQYATAK
Mb2533c|M.bovis_AF2122/97 RRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQYATAE
Rv2505c|M.tuberculosis_H37Rv RRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQYATAE
MAV_0971|M.avium_104 PLRLTFQQVVERIRCAAGAFAELGVEKGDRVAVWAPNSAEWIIAAFGLLT
MLBr_01051|M.leprae_Br4923 AVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAITGCLI
MMAR_1606|M.marinum_M AGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAGADEAGAEC
MUL_3431|M.ulcerans_Agy99 AGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFVPAAQAGADEAGAEC
TH_4599|M.thermoresistible__bu --------------------------------------------------
Mflv_4867|M.gilvum_PYR-GCK IGAILVNINPAYRTHELRYVLEQSGVATLISATQFKTSDYVAMVDEVRPD
Mvan_1563|M.vanbaalenii_PYR-1 IGAILVNINPAYRTHELSYVLEQSGVSTLISATRFKTSDYVAMVDEVRPD
MSMEG_5649|M.smegmatis_MC2_155 VGAILVNINPAYRTHEVAYVLRQSGVRTLVSASSFKTSDYASMIAEVRPE
MAB_4377c|M.abscessus_ATCC_199 IGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDYVAMASQVMPD
Mb2533c|M.bovis_AF2122/97 IGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAEVGPR
Rv2505c|M.tuberculosis_H37Rv IGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAEVGPR
MAV_0971|M.avium_104 AGGVLVPVNTRFKTEEAADIIVRARVQAVLVQKGFLGQDYAAPAGIP---
MLBr_01051|M.leprae_Br4923 AGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIP---
MMAR_1606|M.marinum_M ILVKPGEFEELIQAAEPLEE-------------AAVREDDDTAVILYTSG
MUL_3431|M.ulcerans_Agy99 ILVKPGEFEELIQAAEPLEE-------------AAVREDDDTAVILYTSG
TH_4599|M.thermoresistible__bu ----------------------------------VIR---TIPVILYTSG
Mflv_4867|M.gilvum_PYR-GCK VPALQRVLFIGTADWDTLRAAGSGVDDADLRRRSGALSNRDPINIQYTSG
Mvan_1563|M.vanbaalenii_PYR-1 VPALQRVLFIGTDDWDRLRSRADVIDDALLRERSASLSHHDPVNIQYTSG
MSMEG_5649|M.smegmatis_MC2_155 CPDLLDVVFLDNDDWDRLR--ANQVDDAAFHERMATLANTDPINIQYTSG
MAB_4377c|M.abscessus_ATCC_199 APGLRDVVFIGTSDWTELVAGAERVTETALRARMSQLSNTDPINIQYTSG
Mb2533c|M.bovis_AF2122/97 CPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGSDPVNIQYTSG
Rv2505c|M.tuberculosis_H37Rv CPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGSDPVNIQYTSG
MAV_0971|M.avium_104 VIDIKSDFLSSGSPFSRPVN------------------GTDISDIIFTSG
MLBr_01051|M.leprae_Br4923 -------VQLDARSWNRYPE----------------PSPDATAMVIYTSG
: :***
MMAR_1606|M.marinum_M TTGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILGALPLFHAFGQTAG-
MUL_3431|M.ulcerans_Agy99 TTGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILGALPLFHAFGQTAG-
TH_4599|M.thermoresistible__bu TTGAPKGAQLTHSNLYRNALAFTGLFGLNRTDVVLGTLPLFHAFGQSNA-
Mflv_4867|M.gilvum_PYR-GCK TTGFPKGATLSHRNILNNGFFVTEQIRLQPGDRLCIPVPFYHCFGMVMGN
Mvan_1563|M.vanbaalenii_PYR-1 TTGFPKGATLSHRNILNNGFFVTEQIRLGPGDRLCIPVPFYHCFGMVMGN
MSMEG_5649|M.smegmatis_MC2_155 TTGFPKGATLSHRNILNNGFFVTELIALGPDDRLCIVPPFYHCFGMVMGT
MAB_4377c|M.abscessus_ATCC_199 TTGYPKGATLSHRNVLNNGFFVAESIQLQAGDRLCIPVPFYHCFGMVMGN
Mb2533c|M.bovis_AF2122/97 TTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGN
Rv2505c|M.tuberculosis_H37Rv TTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGN
MAV_0971|M.avium_104 TTGRPKGAMMNHRQTLRMYDEWATLADLREGDRYLQINPYFHTFGLKAGL
MLBr_01051|M.leprae_Br4923 TTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHGLPLFHVHGLVLGL
**. ***. :.: * * :* .* .
MMAR_1606|M.marinum_M LNAAVAAGACLTLIPRFSPEKALQIIERDRVTVFEGVPTMFAAMLHSTER
MUL_3431|M.ulcerans_Agy99 LNAAVAAGACLTLIPRFSPEKALQIIERDRVTVFEGVPTMFAAMLHSTER
TH_4599|M.thermoresistible__bu LNASIAVGACVSLVPRFDAAAVLRLIERHRVTVFAGVPTMYTAVLQAEAG
Mflv_4867|M.gilvum_PYR-GCK LGCTTHGATIVIPAPAFDPGLTLRAIETERCTAVYGVPTMFIAMQNHPDF
Mvan_1563|M.vanbaalenii_PYR-1 LGCTTHGATMVIPAPGFDPGQTLKTIETERCTAVYGVPTMFIAMQNHADF
MSMEG_5649|M.smegmatis_MC2_155 LGAVSHGTTIVIPAPGFDPGITLSAVESEKCTGLYGVPTMFIAMLGHPDF
MAB_4377c|M.abscessus_ATCC_199 LGCTTHGATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLADPGF
Mb2533c|M.bovis_AF2122/97 LAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPDF
Rv2505c|M.tuberculosis_H37Rv LAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPDF
MAV_0971|M.avium_104 ITSFLRGATMLP-VPVFDVDTVVDLIERERITMLPGPPTLYHSLLTVPDK
MLBr_01051|M.leprae_Br4923 LGSLRIGNRFVHTGKPTPTAYAQACSEAG-GSLYFGVPTVWSRLVADEAV
: . : . : * **::
MMAR_1606|M.marinum_M P--DTGSLRLCVSGGAAMPVEVMR-GFEQAFGTMVLEGYGLSETSPTASF
MUL_3431|M.ulcerans_Agy99 P--DTGSLRLCVSGGAAMPVEVMR-GFEQAFGTMVLEGYGLSETSPTASF
TH_4599|M.thermoresistible__bu PT-DTSSLRICVSGGAPLPVEVLR-EFESTFGAQILEGHGLSETSPTASF
Mflv_4867|M.gilvum_PYR-GCK AERDLSTLRTGIMAGAVCPVEVMKRCVEEMHLTEMSIAYGMTETSPVSCQ
Mvan_1563|M.vanbaalenii_PYR-1 AERDLSSLRTGIMAGAVCPVEVMKRCVEEMNMSEISIAYGMTETSPVSCQ
MSMEG_5649|M.smegmatis_MC2_155 ANFDLSSLRTGIMAGSVCPIEVMKRVVADMHMAEVAICYGMTETSPVSCQ
MAB_4377c|M.abscessus_ATCC_199 AHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETSPVSCQ
Mb2533c|M.bovis_AF2122/97 TDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQ
Rv2505c|M.tuberculosis_H37Rv TDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQ
MAV_0971|M.avium_104 SK--LATLRAGVTGAADIPVELVRRIHDELPFQTLMTGYGLTEAGNVTLS
MLBr_01051|M.leprae_Br4923 AR-ALRPARLLVSGSASLPVPVFD-RLAHLTGHRPIERYGSTESLITLST
. . * : ..: *: :. :* :*: .
MMAR_1606|M.marinum_M NHPDRERKPGSIGTPI--AGVQMKLL-------EVDTHGIGEIAIRGHNV
MUL_3431|M.ulcerans_Agy99 NHPDRERKPGSIGTPI--AGVQMKLL-------EVDTHGIGEIAIRGHNV
TH_4599|M.thermoresistible__bu NPAGR-TKPGSIGLPLD-AGIEMKVVDGD-G-IEVPTGDVGEIVIRGHNV
Mflv_4867|M.gilvum_PYR-GCK TLIDDDLERRTSTIGRVHPHVEIKIVDPETG-EIVERGTPGEFCTRGYSV
Mvan_1563|M.vanbaalenii_PYR-1 TLIDDDLERRTSSIGRVHPHVEIKIVDPDTG-HVVERGTPGEFCTRGYSV
MSMEG_5649|M.smegmatis_MC2_155 TLIDDDLDRRTATIGRAHPHVEIKIIDPDTG-ETVERGQPGEFCTRGYSV
MAB_4377c|M.abscessus_ATCC_199 TLFDDDLDRRTATVGRAHPHIEIKIVDPNSG-ETVQRGQSGELCTRGYSV
Mb2533c|M.bovis_AF2122/97 TRADDSVDRRVGTVGRVGPHLEIKVVDPATG-ETVPRGVVGEFCTRGYSV
Rv2505c|M.tuberculosis_H37Rv TRADDSVDRRVGTVGRVGPHLEIKVVDPATG-ETVPRGVVGEFCTRGYSV
MAV_0971|M.avium_104 -RPGDSFEDVATTAGVPCEGVEVRIADD------------GEVLVRGYGV
MLBr_01051|M.leprae_Br4923 LADGE---RRAGWVGLPLAGVQTRLVDESGGPVPYDGETVGRLQVRSPTM
. :: :: *.. *. :
MMAR_1606|M.marinum_M MKGYWNRPDATAAAIDAEGWFRTGDLARIDEDGYYFIVDR-SKDMIIRGG
MUL_3431|M.ulcerans_Agy99 MKGYWNRPDATAAVIDAEGWFRTGDLARIDEDGYYFIVDR-SKDMII---
TH_4599|M.thermoresistible__bu MKGYWNRPDETAAAIN-DGWFHTGDMAVRDEDGFFFIVDR-KKDVIIR--
Mflv_4867|M.gilvum_PYR-GCK MLGYWREDEKTAQAIDADGWMHTGDLAVMRPDGYCNIVGR-IKDVVIRGG
Mvan_1563|M.vanbaalenii_PYR-1 MLGYWRDEEKTAQAVDADGWMHTGDLAVMRPDGYCNIVGR-IKDVVIRGG
MSMEG_5649|M.smegmatis_MC2_155 MLGYWNDDEKTREAVDADGWMHTGDLAVMREDGYCTIVGR-IKDMVIRGG
MAB_4377c|M.abscessus_ATCC_199 MLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGYCTIIGR-LKDMVIRGG
Mb2533c|M.bovis_AF2122/97 MAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGR-IKDLVVRGG
Rv2505c|M.tuberculosis_H37Rv MAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGR-IKDLVVRGG
MAV_0971|M.avium_104 MQGYLDDPAGTAEAIDADGWLHTGDLGTFTETGRLRIVGR-KKDMFIVGG
MLBr_01051|M.leprae_Br4923 FGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGG
: ** * ..: :** :***:. * * .* *:.
MMAR_1606|M.marinum_M YNVYPREIEEVLYEHPEVREAAVVAVPDDMLGEEVGAAIALIPGATSDAA
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
TH_4599|M.thermoresistible__bu --------------------------------------------------
Mflv_4867|M.gilvum_PYR-GCK ENIYPREIEEFLYTHPDVEDAHVIGVPDDRYGEEVCAWIRMRPGRTALDA
Mvan_1563|M.vanbaalenii_PYR-1 ENIYPREVEEFLYTHPDIEDAQVVGVPDARYGEEICAWIRMRPGRRALDA
MSMEG_5649|M.smegmatis_MC2_155 ENIYPREIEEFLYTHPDIDDAQVIGVPDERYGEEICAWIRMKPGRPPLDA
MAB_4377c|M.abscessus_ATCC_199 ENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEELCAWVRMRPDRVVIDA
Mb2533c|M.bovis_AF2122/97 ENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDAPELTI
Rv2505c|M.tuberculosis_H37Rv ENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDAPELTI
MAV_0971|M.avium_104 FNAYPAEIEGFLLNHPAVAQAAVIGVPDERMGQVGKAFVVAN---AEVSE
MLBr_01051|M.leprae_Br4923 YRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAFVVG---AEALDA
MMAR_1606|M.marinum_M A-LSDFVKERVAAYKYPRRIWFVDELPKGPTGKILKRDITVPQASPAQQ-
MUL_3431|M.ulcerans_Agy99 --LSDFVKERVAAYKYPRRIWFVDELPKGPTGKILKRDITVPQASPAQQ-
TH_4599|M.thermoresistible__bu ---GGYTSIRVNSRRSS---------------------TNIPRCGRPR--
Mflv_4867|M.gilvum_PYR-GCK AAVREFATDKLAHYKIPRYVHVVDEFPMTVTGKIRKVEMREVSARLLGL-
Mvan_1563|M.vanbaalenii_PYR-1 AAVREFAAGKLAHYKIPRYVHVVDEFPMTVTGKIRKVEMREVSAGLFAD-
MSMEG_5649|M.smegmatis_MC2_155 DKVREFASGKLAHYKIPRYVHVVDEFPMTVTGKIRKVQMREETVALLGLE
MAB_4377c|M.abscessus_ATCC_199 VAIRAFASGRLAHYKIPRYVHVVESFPMTVTGKVRKIEMRQQTIQIFGLP
Mb2533c|M.bovis_AF2122/97 ERLREYCMGRIARFKIPRYLWIVDEFPMTVTGKVRKVEMRQQALEYLRGQ
Rv2505c|M.tuberculosis_H37Rv ERLREYCMGRIARFKIPRYLWIVDEFPMTVTGKVRKVEMRQQALEYLRGQ
MAV_0971|M.avium_104 SDLLAWCRDRMAGFKVPRTVEFLDALPLNATGKVMKDQLR----------
MLBr_01051|M.leprae_Br4923 DELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG-------
: :: : .
MMAR_1606|M.marinum_M --------
MUL_3431|M.ulcerans_Agy99 --------
TH_4599|M.thermoresistible__bu --------
Mflv_4867|M.gilvum_PYR-GCK --------
Mvan_1563|M.vanbaalenii_PYR-1 --------
MSMEG_5649|M.smegmatis_MC2_155 A-------
MAB_4377c|M.abscessus_ATCC_199 EPGRTDEQ
Mb2533c|M.bovis_AF2122/97 Q-------
Rv2505c|M.tuberculosis_H37Rv Q-------
MAV_0971|M.avium_104 --------
MLBr_01051|M.leprae_Br4923 --------