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SYLSRAAARWPDRTWCITPREEISRADALRDGSRIAAGLIAKGVRKGDRVVLVAGNGLDFVRAWLGLILC GAVTVSINPKAVASELPAVIDEVRPALVLVEAGLEVGHVEHTPPGGQPVPVMFIDEAHAASDEAVVSLDR PPAGPDDPVSFIQSSGSTGKPKFVIETNRMYTMAGEGFAHWLGLDDEDVLLTTLPLSHLNAQAYSVLGSW GCGAKLVLLPRFSASSFWSDVAKYGATVFNAIGAMLEALMAQPPSVSQERARVRLCYSAPAPAPARHREI ENRFGFRLVVGYALSETPYGLIVPVDEPTVYGSMGVPRQHPTLGAVNEVRVVDADGHEVADGTTGELELR NPAITPGYFGKTTESAAMRPGGWLRTGDLAVRRPDGHFFFGGRAKEVIRYKGENLSPAEVENAIGSHPAV RAVAVIGVPSALSEEDVKAFVQLRPGETASPTELAQWSATKLPPYKRPRYIELVTEFPLTDTQKIAKARL PRDRSTSEVDFAPRRDPRQDDRDT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4036 | - | - | 100% (515) | crotonobetaine/carnitine-CoA ligase |
| M. smegmatis MC2 155 | MSMEG_3694 | - | 1e-44 | 30.49% (469) | feruloyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5908 | - | 1e-41 | 29.07% (485) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 2e-39 | 27.58% (475) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 6e-47 | 29.74% (501) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 2e-39 | 27.58% (475) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02661 | - | 3e-36 | 27.87% (531) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4055c | - | 2e-39 | 28.78% (476) | putative acyl-CoA synthetase |
| M. marinum M | MMAR_1606 | - | 2e-45 | 30.16% (494) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_1639 | - | 3e-52 | 31.84% (512) | AMP-binding enzyme, putative |
| M. thermoresistible (build 8) | TH_4217 | - | 2e-59 | 33.62% (470) | PUTATIVE putative AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4803 | fadD7 | 2e-42 | 28.99% (507) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0898 | - | 3e-51 | 30.42% (526) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3116|M.bovis_AF2122/97 -------------------------MKNIGWMLRQRATVSPRLQAYVEPS
Rv3089|M.tuberculosis_H37Rv -------------------------MKNIGWMLRQRATVSPRLQAYVEPS
Mflv_4616|M.gilvum_PYR-GCK ------------------------MDRGIGQWVTKRAFLNGQRTALVQG-
MAB_4055c|M.abscessus_ATCC_199 ------------MTFRSPLPDVSIPDCSVYEYVFGDTGAEDSRIALIDGL
MMAR_1606|M.marinum_M -------------------------MTSLAGNLIEGARRHPNRIALR--L
MAV_1639|M.avium_104 -----------------MRAPADFGVDRFTVPAVLDRRAEQHPDRVMMSI
Mvan_0898|M.vanbaalenii_PYR-1 -------------------MKDNTIKTETTVVGLLRKCVDEHPDTLFLDL
MLBr_02661|M.leprae_Br4923 MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTD
MUL_4803|M.ulcerans_Agy99 MASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELAAAQLSEATAVIFTA
TH_4217|M.thermoresistible__bu -------------MTMTTLPVSGGHTVWSMLTYWAESTPHAPFLIFDETS
MSMEG_4036|M.smegmatis_MC2_155 -------------------------------MSYLSRAAARWPDRTWCIT
Mb3116|M.bovis_AF2122/97 TDVRMTYAQMNALANRCADVLTALGIAKGDRVALLMPNSVEFCCLFYGAA
Rv3089|M.tuberculosis_H37Rv TDVRMTYAQMNALANRCADVLTALGIAKGDRVALLMPNSVEFCCLFYGAA
Mflv_4616|M.gilvum_PYR-GCK -DTSFTYSDFDRRTNQVASSLLRLGVRKGDRVAILLVNSVEFLEVLLGCA
MAB_4055c|M.abscessus_ATCC_199 TGAQTTLGELRSQIDATAAGLAERGFGIGDVAAVFLPNCSAFAVVLHGIL
MMAR_1606|M.marinum_M DEIEIPYGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYGVL
MAV_1639|M.avium_104 AGVDVTFAQMRQRSCAAANMLSDLGVGRGDRVALFSGTCPEWVYFWLGAA
Mvan_0898|M.vanbaalenii_PYR-1 AGDTYSYADVWQRSCDLAGMLHAGGVGAGQTVVSLQDTQIDAIASWFGAN
MLBr_02661|M.leprae_Br4923 NRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIEFVVGLLAAS
MUL_4803|M.ulcerans_Agy99 DRVAVSYRDLVRLVDDLAGQLTRAGLRQGERVALRSGSNLEFVVALLAAS
TH_4217|M.thermoresistible__bu GGTTLTFSDAVELGTAGAALLSGLGVSRGDRFAVVLGNRVEFFACWFAAA
MSMEG_4036|M.smegmatis_MC2_155 PREEISRADALRDGSRIAAGLIAKGVRKGDRVVLVAGNGLDFVRAWLGLI
. : * *. *: . .
Mb3116|M.bovis_AF2122/97 KLGAVAVPINTRLAAPEVSFILSDSGSKVVIYGAPSAPVIDAIRAQADPP
Rv3089|M.tuberculosis_H37Rv KLGAVAVPINTRLAAPEVSFILSDSGSKVVIYGAPSAPVIDAIRAQADPP
Mflv_4616|M.gilvum_PYR-GCK KIGAITIPINVRLAGPEIGYILADSGADVFVFHAPLA--AAAVSALTEPG
MAB_4055c|M.abscessus_ATCC_199 RAGGTASTVNVLYTAEELAKQLIDSKAQLIFTVSPLLSRALEAAEIAGID
MMAR_1606|M.marinum_M RAGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAGADEAG--
MAV_1639|M.avium_104 RIGAVSAAINAAHKGDFLLHALRLCRPAVIFTDPEHRSRAERAAAALEGP
Mvan_0898|M.vanbaalenii_PYR-1 MLGAIWVGTNTALRGEFLRHVITDTGARVVVAEADLVDRIRAIGQHLPDV
MLBr_02661|M.leprae_Br4923 RAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVSDQRAATMRY
MUL_4803|M.ulcerans_Agy99 RANLIVVPLDPALPVAYQRARAGAAGARVVLIDG---TGPGDRDEPAVRW
TH_4217|M.thermoresistible__bu RIGAVMVPINPHSTGEELSYCLRHARCVAAVCDHDRHQLVHEVWPYDPSL
MSMEG_4036|M.smegmatis_MC2_155 LCGAVTVSINPKAVASELPAVIDEVRPALVLVEAGLEVGHVEHTPPGGQP
. : .
Mb3116|M.bovis_AF2122/97 GTVTDWIGAD---------SLAERLRSAAADEPAVECGGDDNLFIMYTSG
Rv3089|M.tuberculosis_H37Rv GTVTDWIGAD---------SLAERLRSAAADEPAVECGGDDNLFIMYTSG
Mflv_4616|M.gilvum_PYR-GCK VRVRHTLRAGGAPA-DGEIPYTDLLSDGAPAPLDSDVEGRDPAFIMYTSG
MAB_4055c|M.abscessus_ATCC_199 AAGVITVDPVEG-----RLSLADIARPDLAPPQVTFDPATHLAVLPYSSG
MMAR_1606|M.marinum_M -AECILVKPGE---------FEELIQAAEPLEEAAVREDDDTAVILYTSG
MAV_1639|M.avium_104 ARIVVQGDSLTAT------LSRAADR--APAEDRGD--AGELGCLFYTSG
Mvan_0898|M.vanbaalenii_PYR-1 DLVLQRGDERPAAD-PHLRIERLVDLGGHTVNEPGDGAVDDLTCLTYTGG
MLBr_02661|M.leprae_Br4923 WPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGLRHDDAMIMFTGG
MUL_4803|M.ulcerans_Agy99 WPIAVSVARDT----GILSVHLDAAGEPTAVASAPQGLRADDAMIMFTGG
TH_4217|M.thermoresistible__bu IAVCDRGFEG---------------IAGGPVPGHPPVRPHDPLAVLYTSG
MSMEG_4036|M.smegmatis_MC2_155 VPVMFIDEAHAAS------------DEAVVSLDRPPAGPDDPVSFIQSSG
. . :.*
Mb3116|M.bovis_AF2122/97 TTGHPKGVVHTHESVHS-AASSWASTIDVRYRDRLLLPLPMFHVAALTTV
Rv3089|M.tuberculosis_H37Rv TTGHPKGVVHTHESVHS-AASSWASTIDVRYRDRLLLPLPMFHVAALTTV
Mflv_4616|M.gilvum_PYR-GCK TTGRPKGAILTHDNLRWNAINVLGAEQGLTGSDVTVAVAPMFHIGGLGVH
MAB_4055c|M.abscessus_ATCC_199 TTGKAKGVMLTHHNLVA-NIAQAKHLYGVQRGDRVLAVLPFFHIYGLVVL
MMAR_1606|M.marinum_M TTGKPKGAELTHANLRR-NVEVIVQMLQVGPDDVILGALPLFHAFGQTAG
MAV_1639|M.avium_104 TTGPSKAVATTWHYLFS-VAATVAAAWEFRQGEVLWTAMPLFHLS-AAPS
Mvan_0898|M.vanbaalenii_PYR-1 TTGPSKGCMISNGYAIN-IARRGLAQTQRQTDELNWSPLPMFHLNVLAMT
MLBr_02661|M.leprae_Br4923 TTGLPKMVPWTDGNIAG-SVHAIITAYQLGPQDATVVVMPLYHGHGLIAA
MUL_4803|M.ulcerans_Agy99 TTGLPKMVPWTRANIAT-SIRSIIAGYRLSPQDATVAVMPLYHGHGLMAA
TH_4217|M.thermoresistible__bu TTSRPKGVVVTHANYLA-AGHVVAGQLRIRPDDRWMLVLPLFHANAQYYG
MSMEG_4036|M.smegmatis_MC2_155 STGKPKFVIETNR-MYTMAGEGFAHWLGLDDEDVLLTTLPLSHLNAQAYS
:*. .* : : *: *
Mb3116|M.bovis_AF2122/97 IFSAMR-GVTLISMP--QFDATKVWSLIVEERVCIGGAVPAILNFMRQVP
Rv3089|M.tuberculosis_H37Rv IFSAMR-GVTLISMP--QFDATKVWSLIVEERVCIGGAVPAILNFMRQVP
Mflv_4616|M.gilvum_PYR-GCK TLPLLYVGGTSVILP--SFDPVGTLKAMAESRATVQFMVPAMWSALTQVP
MAB_4055c|M.abscessus_ATCC_199 LNVQLKLGAELVILP--RFELDTFLGSIANYRVDHVFVAPPVAVVLAKHP
MMAR_1606|M.marinum_M LNAAVAAGACLTLIP--RFSPEKALQIIERDRVTVFEGVPTMFAAMLHS-
MAV_1639|M.avium_104 VLAPMLVGATTVLAA--AFHPREVWDDIRAHGAVGFAGAGAMVSMLQNLP
Mvan_0898|M.vanbaalenii_PYR-1 LIGTMLVGGSAALAQ--RFSASRFWPEIERTGARVVNLIGGLPAILAQQP
MLBr_02661|M.leprae_Br4923 LLSTLASGGVVLLPARARFSARTFWDDIDAVAATWYTAAPAIHRILLELA
MUL_4803|M.ulcerans_Agy99 LLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHATWYTAVPTIHQILLERA
TH_4217|M.thermoresistible__bu VMSALVSGASVVVAP--RFSASMWPAQVRRYQATLASLFAAPVRMILAHE
MSMEG_4036|M.smegmatis_MC2_155 VLGSWGCGAKLVLLP--RFSASSFWSDVAKYGATVFNAIGAMLEALMAQP
* * : . :
Mb3116|M.bovis_AF2122/97 EFAELD------APDFRYFITGGAPMPEALIKIYAAKN-IEVVQG--YAL
Rv3089|M.tuberculosis_H37Rv EFAELD------APDFRYFITGGAPMPEALIKIYAAKN-IEVVQG--YAL
Mflv_4616|M.gilvum_PYR-GCK DFDSYD------LSALRLAMGGGAPMPLTVIDFMHQRG-VPFTEG--FGM
MAB_4055c|M.abscessus_ATCC_199 DVDKYD------VSCLRSVFSGAAPLDEQLGNAVAARLNCRVSQG--YGM
MMAR_1606|M.marinum_M -TERPD------TGSLRLCVSGGAAMPVEVMRGFEQAFGTMVLEG--YGL
MAV_1639|M.avium_104 ADPGDA------RLP--LRFISAAPIDARSYRDIEKRYGCRIVT--MYGM
Mvan_0898|M.vanbaalenii_PYR-1 DTLEMA------RCFGQIRMVHAVPFPPALQEIWRNRFGVKVPGSKGYGM
MLBr_02661|M.leprae_Br4923 STQ----SFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVICA--FGM
MUL_4803|M.ulcerans_Agy99 KTEREADSSGRTRAALRFIRSCSGPLTPETAQALHDEFSAPVLCA--FGM
TH_4217|M.thermoresistible__bu GCDADR-------DNRLRVTLFAQNLTAEQLRRFEERFDCPLLQL--YGM
MSMEG_4036|M.smegmatis_MC2_155 PSVSQE------RARVRLCYSAPAPAPAR-HREIENRFGFRLVVG--YAL
. :.:
Mb3116|M.bovis_AF2122/97 TESCGGGTLLLS-----EDALRKAGSAGRATMFTDVAVR-GDDGV-----
Rv3089|M.tuberculosis_H37Rv TESCGGGTLLLS-----EDALRKAGSAGRATMFTDVAVR-GDDGV-----
Mflv_4616|M.gilvum_PYR-GCK TETAPMVSVLDA-----ANITTRAGSIGRVAMHVDARIVDADDRD-----
MAB_4055c|M.abscessus_ATCC_199 TELSPVSHLIPP-----DRPDIPLNSVGIPVPNSENKIIDTETGDEIEIP
MMAR_1606|M.marinum_M SETSPTASFNHP-----DRERKPG-SIGTPIAGVQMKLLEVDT-------
MAV_1639|M.avium_104 TEAFPIAVKALA-----DAG-IPGTSGRPN-PDFEVRILDAHGNS-----
Mvan_0898|M.vanbaalenii_PYR-1 TEVFPITYQTPD-----EQS-PAESAGRINHEDLEVRIVDERDDD-----
MLBr_02661|M.leprae_Br4923 TEATHQVTTTNIKWFGQGENPTVTNGLVGQSTGVQIRIVGSDGQP-----
MUL_4803|M.ulcerans_Agy99 TEATHQVASTGVEGSGCDENPAESTGLVGRSTGPEIRIVGPDGHP-----
TH_4217|M.thermoresistible__bu TETIAPPLMNPL------YGPRDNMTVGLPSEPNRVRIVDDHGVD-----
MSMEG_4036|M.smegmatis_MC2_155 SETPYGLIVPVDEP-TVYGSMGVPRQHPTLGAVNEVRVVDADGHE-----
:* :
Mb3116|M.bovis_AF2122/97 -IREHGEGEVVIK---SDILLKEYWNRPEATRDAFDN-GWFRTGDIGEID
Rv3089|M.tuberculosis_H37Rv -IREHGEGEVVIK---SDILLKEYWNRPEATRDAFDN-GWFRTGDIGEID
Mflv_4616|M.gilvum_PYR-GCK -VPADTVGELLVR---GPNVFVGYWMKPATTAEAFRG-GWFHTGDLGRID
MAB_4055c|M.abscessus_ATCC_199 AEGESAPGELLVR---GPNVMAGYLGNEEATAATIEPDGFLHTGDIAVVR
MMAR_1606|M.marinum_M ----HGIGEIAIR---GHNVMKGYWNRPDATAAAIDAEGWFRTGDLARID
MAV_1639|M.avium_104 -LPPDTVGEIACRPRHPHVMSEGYIG--DDLAVRPHP-EWFRTGDLGRLD
Mvan_0898|M.vanbaalenii_PYR-1 -VKPGEVGEVICRPRRSHVMFQGYWRRPDAMVDSCRN-LWFHTGDLGRID
MLBr_02661|M.leprae_Br4923 -LPPDTVGEVWLR---GSTVVRGYLGDPAITAANFTH-GWLRTGDLGSLS
MUL_4803|M.ulcerans_Agy99 -VGPGAVGEVWLH---GPTVVRGYLGDPKITAANFTD-GWLRTGDLGTLS
TH_4217|M.thermoresistible__bu -VPPGQTGHLLVGGEPGITLTAGYLDDPAATAAAIVD-GWLHTGDIVTRR
MSMEG_4036|M.smegmatis_MC2_155 -VADGTTGELELR---NPAITPGYFGKTTESAAMRPG-GWLRTGDLAVRR
*.: : * :::***:
Mb3116|M.bovis_AF2122/97 DEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKW
Rv3089|M.tuberculosis_H37Rv DEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKW
Mflv_4616|M.gilvum_PYR-GCK ADGYITLVDRKKDMIISGGENVYPIEVEQVLFRHPGVLDAAVVGGPDDKW
MAB_4055c|M.abscessus_ATCC_199 ADGVVTIVDRLKELIKYKGYQVPPAELEALLLTHPGIGDAAVIGVPDPSS
MMAR_1606|M.marinum_M EDGYYFIVDRSKDMIIRGGYNVYPREIEEVLYEHPEVREAAVVAVPDDML
MAV_1639|M.avium_104 RDQNLTYVDRIKDALRRRGENISSVEVETVVMGHPAVAEAAAVGVPGELG
Mvan_0898|M.vanbaalenii_PYR-1 DAGYFYFADRKHDYLRRRGENISSQELETTYVAHPDIVAVAVHAVPSELT
MLBr_02661|M.leprae_Br4923 VTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVY
MUL_4803|M.ulcerans_Agy99 QAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENAVFGVPDALY
TH_4217|M.thermoresistible__bu PDGFVVFHDRAKDMIKRSGENVAAAEVERVINEHPAVYESAVVGVPDPVR
MSMEG_4036|M.smegmatis_MC2_155 PDGHFFFGGRAKEVIRYKGENLSPAEVENAIGSHPAVRAVAVIGVPSALS
.* :: : * :: . .:* : *. . *.
Mb3116|M.bovis_AF2122/97 GEIAAAIVVAD---QNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNP
Rv3089|M.tuberculosis_H37Rv GEIAAAIVVAD---QNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNP
Mflv_4616|M.gilvum_PYR-GCK GERVVAVVVADPAAEQEPSADELIAWCRERLAHFKCPREVHLLPELPRNA
MAB_4055c|M.abscessus_ATCC_199 GEIPKAFVVRTD--DDLTDEAVMA-FVEQKVAPHKRIRQVEFIDAIPKSA
MMAR_1606|M.marinum_M GEEVGAAIALIP--GATSDAAALSDFVKERVAAYKYPRRIWFVDELPKGP
MAV_1639|M.avium_104 EDDVLVVVTLRP--GATLDCAELLDFCADRMPYFCVPRYVETVPELPKNA
Mvan_0898|M.vanbaalenii_PYR-1 EDDVKVTVVLRP--GSVLTPAELFEWSKERVPYFALPRYVEFRTELPTSP
MLBr_02661|M.leprae_Br4923 GETVTAVIVPRE--VIAPTPSELAVFCRDRLAAFEVPTRFQEASALPHTA
MUL_4803|M.ulcerans_Agy99 GEAVAAVIVPRE--P-APTAQELTEFCREKLASFEIPATFQMASELPHTA
TH_4217|M.thermoresistible__bu DEAITAYVVRRTPDGCGLTAQQLIDFCAERLARGKVPDHIEFVDDLPRTS
MSMEG_4036|M.smegmatis_MC2_155 EEDVKAFVQLRP--GETASPTELAQWSATKLPPYKRPRYIELVTEFPLTD
: . : : : ::. . :*
Mb3116|M.bovis_AF2122/97 TGKILKTVLREQYS----ATVPK----------
Rv3089|M.tuberculosis_H37Rv TGKILKTVLREQYS----ATVPK----------
Mflv_4616|M.gilvum_PYR-GCK TGKLLKTELRKRFTGVEGGVVQR----------
MAB_4055c|M.abscessus_ATCC_199 AGKILRKDLRARI--------------------
MMAR_1606|M.marinum_M TGKILKRDITVPQASPAQQ--------------
MAV_1639|M.avium_104 IGRIRKDLLRARGLTTNVWDREKHGYVVRR---
Mvan_0898|M.vanbaalenii_PYR-1 LGRVHKYLLREQGCTPETWDREAAGVSWDRR--
MLBr_02661|M.leprae_Br4923 KGSLDRRAVAEQFAHRG----------------
MUL_4803|M.ulcerans_Agy99 KGSLDRRAVAQQFGGQA----------------
TH_4217|M.thermoresistible__bu VGKIRKHLLRSNGSGGGMGEGR-----------
MSMEG_4036|M.smegmatis_MC2_155 TQKIAKARLPRDRSTSEVDFAPRRDPRQDDRDT
: : :