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ASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELAAAQLSEATAVIFTADRVAVSYRDLVRLVDDLAGQL TRAGLRQGERVALRSGSNLEFVVALLAASRANLIVVPLDPALPVAYQRARAGAAGARVVLIDGTGPGDRD EPAVRWWPIAVSVARDTGILSVHLDAAGEPTAVASAPQGLRADDAMIMFTGGTTGLPKMVPWTRANIATS IRSIIAGYRLSPQDATVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHATWYTAV PTIHQILLERAKTEREADSSGRTRAALRFIRSCSGPLTPETAQALHDEFSAPVLCAFGMTEATHQVASTG VEGSGCDENPAESTGLVGRSTGPEIRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKITAANFTDGWL RTGDLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENAVFGVPDALYGEAVAAVIVPR EPAPTAQELTEFCREKLASFEIPATFQMASELPHTAKGSLDRRAVAQQFGGQA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4803 | fadD7 | - | 100% (544) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_0362 | - | 4e-41 | 30.83% (506) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4827 | fadD12_2 | 4e-40 | 28.27% (520) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0123 | fadD7 | 0.0 | 75.05% (521) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 8e-55 | 31.64% (531) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0119 | fadD7 | 0.0 | 75.05% (521) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 0.0 | 64.78% (548) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2539c | - | 2e-40 | 31.13% (363) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0319 | fadD7 | 0.0 | 98.90% (544) | fatty-acid-CoA ligase FadD7 |
| M. avium 104 | MAV_5190 | - | 0.0 | 68.32% (543) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5295 | - | 1e-128 | 49.90% (523) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3626 | - | 3e-63 | 33.53% (513) | PUTATIVE putative fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 7e-45 | 29.23% (520) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0027|M.gilvum_PYR-GCK ------------------------------------------MFHNLADI
Mvan_0943|M.vanbaalenii_PYR-1 ------------------------------------------MIHNLADI
MUL_4803|M.ulcerans_Agy99 ------------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADL
MMAR_0319|M.marinum_M ------------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADL
Mb0123|M.bovis_AF2122/97 ------------------MASD--------------------FGPRIADL
Rv0119|M.tuberculosis_H37Rv ------------------MASD--------------------FGPRIADL
MLBr_02661|M.leprae_Br4923 ------------------MKSESITSSRAPVEQIDARLTGQFESPSIASL
MAV_5190|M.avium_104 ------MDRYWTQRNAARHGGSDDTTGKDVAMTSEATPSATAAGPRLADL
MSMEG_5295|M.smegmatis_MC2_155 ---------------MRFMGTAATPP--------------ATLLSGLFDV
TH_3626|M.thermoresistible__bu ---------------------------------------MLSQSVHLVSL
MAB_2539c|M.abscessus_ATCC_199 MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAML
:
Mflv_0027|M.gilvum_PYR-GCK VRSHGRNRPDAPALIVGDR--TVSYRELDERSNRTAQAFSRTGVGPGDRV
Mvan_0943|M.vanbaalenii_PYR-1 IRVHGRERPGAPALVVGDR--TVTYGELDDRSSRAAQAFAQAGVGVGDRV
MUL_4803|M.ulcerans_Agy99 VELAAAQLSEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRQGERV
MMAR_0319|M.marinum_M VELAAARLPEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRPGERV
Mb0123|M.bovis_AF2122/97 VEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRV
Rv0119|M.tuberculosis_H37Rv VEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRV
MLBr_02661|M.leprae_Br4923 VEAAAIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRV
MAV_5190|M.avium_104 VEAAAQRAPRAPALLVASERTPIAYADLVRLVDDLAARLRAAGLAPGDRV
MSMEG_5295|M.smegmatis_MC2_155 LDHHVRTRPDAPALVVTQQRIAVTYATLGRWADDVAAGLTADGLRRGEVI
TH_3626|M.thermoresistible__bu PDQRAASAPAAP--CLADDTVALSNAEFRHAVDSAAAVLRGHGVGAGDVV
MAB_2539c|M.abscessus_ATCC_199 LAASAIRFPDRAALIDDSG--QLTYRDLQRRAEAVAAAVYARTPSAPRSV
. . :: : . : . :
Mflv_0027|M.gilvum_PYR-GCK AFVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVV
Mvan_0943|M.vanbaalenii_PYR-1 AFVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVV
MUL_4803|M.ulcerans_Agy99 ALRSGSNLEFVVALLAASRANLIVVPLDPALPVAYQRARAGAAGARVVLI
MMAR_0319|M.marinum_M ALRSGSNLEFVVALLAASRANLIVVPLDPALPVADQRARAGAAGARVVLI
Mb0123|M.bovis_AF2122/97 ALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLI
Rv0119|M.tuberculosis_H37Rv ALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLI
MLBr_02661|M.leprae_Br4923 ALCAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLV
MAV_5190|M.avium_104 GLRAGSNPEFVVALLAASRADLVVAPLDPALPAADQLSRSRAVGARAVLV
MSMEG_5295|M.smegmatis_MC2_155 AVVDVNTAEFVVALLAAARIGAVVAPLDPALADAEMTDRLARLGARAVLT
TH_3626|M.thermoresistible__bu AVMLPNTVDLVVTLFAAWRLGAAVTPLNPALSVDESAYQIADAGAKVLVA
MAB_2539c|M.abscessus_ATCC_199 GIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDVLVY
.. . : :. : . . :: *. :
Mflv_0027|M.gilvum_PYR-GCK GQ---EFTGRIEAIADDLDVEVVVIGKHRH-----WPTFDDLLAAAPAVD
Mvan_0943|M.vanbaalenii_PYR-1 GQ---DFAGHLEAIEDGLDADIVVIGDHPR-----WPAFDDWVASHPPVD
MUL_4803|M.ulcerans_Agy99 DG---TGPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVA
MMAR_0319|M.marinum_M DG---TGPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVA
Mb0123|M.bovis_AF2122/97 DA---DGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPAT
Rv0119|M.tuberculosis_H37Rv DA---DGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPAT
MLBr_02661|M.leprae_Br4923 DSLALEGVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVT
MAV_5190|M.avium_104 DR---LGEGQTAPESAPCWPVTVTVGPDDS----APTVDLTVTAAPTHDV
MSMEG_5295|M.smegmatis_MC2_155 GP----CEHALGTHRVRVTASRATVEPTRG-----------ATVEPTVRQ
TH_3626|M.thermoresistible__bu GG----------NLPAPATPVVRPADLKTG----------------HGPV
MAB_2539c|M.abscessus_ATCC_199 DD-----EYSQAVEESQYQGLRVLAWRENP-----QENRLTLDSLADQHH
.
Mflv_0027|M.gilvum_PYR-GCK PGVVTGPDDLVFLMYTSGTTGAPKGVMLSNAN--VVCKTAGVGGPWKFDA
Mvan_0943|M.vanbaalenii_PYR-1 PGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTN--YVYKTGGVAGPWQFDA
MUL_4803|M.ulcerans_Agy99 SAPQGLRADDAMIMFTGGTTGLPKMVPWTRAN--IATSIRSIIAGYRLSP
MMAR_0319|M.marinum_M SAPQGLRADDAMIMFTGGTTGLPKMVPWTRAN--IATSIRSIIAGYRLSP
Mb0123|M.bovis_AF2122/97 STPEGLRPDDAMIMFTGGTTGLPKMVPWTHAN--IASSVRAIITGYRLSP
Rv0119|M.tuberculosis_H37Rv STPEGLRPDDAMIMFTGGTTGLPKMVPWTHAN--IASSVRAIITGYRLSP
MLBr_02661|M.leprae_Br4923 STPDGLRHDDAMIMFTGGTTGLPKMVPWTDGN--IAGSVHAIITAYQLGP
MAV_5190|M.avium_104 TAPQGLRDDDAMIMFTGGTTGAPKMVPWTRHN--IAASIRSIVAGYGLGP
MSMEG_5295|M.smegmatis_MC2_155 AVDLGLGPDDALILFTSGTTGRAKMVPWTHAN--IAASVHGICAAYELGD
TH_3626|M.thermoresistible__bu EVAPPADDRLALLIYTSGTTGRPKGVMLDHAN--IAAMCASIIEANELTS
MAB_2539c|M.abscessus_ATCC_199 PKPPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRS
: : *.**** .* * . :
Mflv_0027|M.gilvum_PYR-GCK DSVSLAVMPLFHMAGFGWALAGLWEGAVTVVLRD---VDPGAILDAVARH
Mvan_0943|M.vanbaalenii_PYR-1 DAVSLAVMPLFHMAGSGWALAGLWQGATTVVLRD---VEPAAILDAIARH
MUL_4803|M.ulcerans_Agy99 QDATVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVA
MMAR_0319|M.marinum_M QDATVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVA
Mb0123|M.bovis_AF2122/97 RDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAV
Rv0119|M.tuberculosis_H37Rv RDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAV
MLBr_02661|M.leprae_Br4923 QDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAV
MAV_5190|M.avium_104 RDATVAVMPLYHGHGLLAALLATLASGGAVLLPARGKFSAHTFWDDIAAV
MSMEG_5295|M.smegmatis_MC2_155 GDATVAVMPFFHGHGLVAVLLSTLAGGGKVLLPAHGRFSAHTFWADMRDA
TH_3626|M.thermoresistible__bu ADSSLLILPLFHVNGIVVGTLSPLIAGGHVTIAG--RFDPRTFFDRVRRS
MAB_2539c|M.abscessus_ATCC_199 RDRVLVAPPFFHGFG-LAALLGPLALGGTVMCRR--RFDAQQAMTDIRRQ
: *::* * . . * ... :
Mflv_0027|M.gilvum_PYR-GCK RVTNMLLVPAVIQFLLDTTGLD------DTDLSRLRIVVYGASPITDDVL
Mvan_0943|M.vanbaalenii_PYR-1 RITNMLLVPAVIQFLLDTDGVA------EVDLSTLRVIVYGASPISDDVL
MUL_4803|M.ulcerans_Agy99 HATWYTAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSGPLTPETA
MMAR_0319|M.marinum_M HATWYTAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSAPLTPETA
Mb0123|M.bovis_AF2122/97 GATWYTAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAA
Rv0119|M.tuberculosis_H37Rv GATWYTAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAA
MLBr_02661|M.leprae_Br4923 AATWYTAAPAIHRILLELASTQ----SFRSKRAKLRFIRSCSAPLTQETA
MAV_5190|M.avium_104 GATWYTAVPTIHQILLERARTE-----APRGTHALRFIRSCSAPLTAETA
MSMEG_5295|M.smegmatis_MC2_155 DATWFTAVPTIHQILLQRPDEE---------HPPLRFVRSCSAPLDPATA
TH_3626|M.thermoresistible__bu RPTYFSAVPTIYTKLLELPEDP------TVDTSSLRFAACGAAPASAELL
MAB_2539c|M.abscessus_ATCC_199 RVTVLMAVPVMLQRILALADLD----RRDARQLSLRMIVTGAAPISSSTV
* .*.: :* **. :.*
Mflv_0027|M.gilvum_PYR-GCK MRGIDRFGGIFAQVYGMTESTGSVTQLDGDE----HLPQLLRSCGRPYPW
Mvan_0943|M.vanbaalenii_PYR-1 VRGIERFGPIFAQVYGMTETTGSITQLDGPD----HVPALLRSCGRPYPW
MUL_4803|M.ulcerans_Agy99 QALHDEFSAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTG
MMAR_0319|M.marinum_M QALHDEFSAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTG
Mb0123|M.bovis_AF2122/97 LALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTG
Rv0119|M.tuberculosis_H37Rv LALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTG
MLBr_02661|M.leprae_Br4923 QALREEFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTG
MAV_5190|M.avium_104 QALQDTFGAPVVCAFGMTEATHQVSTTAIDGAGHSENPGATPGLVGRSTG
MSMEG_5295|M.smegmatis_MC2_155 EAAERRFGAPMLEAYGMTETTHQAASRRVR----THDPRMSVGPA--SGA
TH_3626|M.thermoresistible__bu QRFEQRYGVPIIEGYGLSEGTCVSTANPLRG------PRKPGTVGLPLPG
MAB_2539c|M.abscessus_ATCC_199 SGVLEAFGPILVNGYGSTEAGVVAIASPKD------LVASPNTIGRTALG
: . :* :*
Mflv_0027|M.gilvum_PYR-GCK VQIRVVDPTGRDVAPGTVGEVWTRSDQNMLGYWNNPEA-TAATLTPDGWL
Mvan_0943|M.vanbaalenii_PYR-1 VQIRIVDETGADAVAGTVGEVWTRSEQNMLGYWNNPDA-TASTLTADGWL
MUL_4803|M.ulcerans_Agy99 PEIRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKI-TAANFT-DGWL
MMAR_0319|M.marinum_M PEIRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKI-TAANFT-DGWL
Mb0123|M.bovis_AF2122/97 AQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTI-TAANFT-DGWL
Rv0119|M.tuberculosis_H37Rv AQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTI-TAANFT-DGWL
MLBr_02661|M.leprae_Br4923 VQIRIVGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAI-TAANFT-HGWL
MAV_5190|M.avium_104 PDIRIAGPDGQSLPADTVGEVWLRGATVVRGYLGDPAI-TAANFT-DGWL
MSMEG_5295|M.smegmatis_MC2_155 ARFQVVRSDGGECTPAETGEVWVSGPAVVRGYLADPEN-TAQAFT-DGWF
TH_3626|M.thermoresistible__bu QQVRIVDAEGRTLGANEIGEVLIAGPTVMRGYLNRPEE-TAKTLV-DGWL
MAB_2539c|M.abscessus_ATCC_199 VSVRILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIVDGHV
.:: . * : . ** .: .* .
Mflv_0027|M.gilvum_PYR-GCK RTGDAGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVA
Mvan_0943|M.vanbaalenii_PYR-1 KTGDAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAA
MUL_4803|M.ulcerans_Agy99 RTGDLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENA
MMAR_0319|M.marinum_M RTGDLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVLENA
Mb0123|M.bovis_AF2122/97 RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAA
Rv0119|M.tuberculosis_H37Rv RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAA
MLBr_02661|M.leprae_Br4923 RTGDLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVA
MAV_5190|M.avium_104 HTGDLGTLSAAGDLVVRGRIKELINRGGEKISPERVEGVLAGHPDVLEAA
MSMEG_5295|M.smegmatis_MC2_155 RTGDLGALDADGNLQLTGRIKNIINRGGEKISPEHVEGVLTGCDGVFEAV
TH_3626|M.thermoresistible__bu RTGDIGYLDDDGYLVLVDRAKDMIIRGGENIYPKEIEAVAHRLPEISEVA
MAB_2539c|M.abscessus_ATCC_199 NTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAV
.*** * .. * * : .* .::* ..*:: * .:* : : .
Mflv_0027|M.gilvum_PYR-GCK VIGIPDTRWGEAVKAVVVAG--APV-TEAELIAFAREQLAGFKLPKSVDF
Mvan_0943|M.vanbaalenii_PYR-1 VIGVPDRRWGEAVKAVVVAARGAQL-TEAELIAFARDRIGGFKLPKSVDF
MUL_4803|M.ulcerans_Agy99 VFGVPDALYGEAVAAVIVPREPAP--TAQELTEFCREKLASFEIPATFQM
MMAR_0319|M.marinum_M VFGVPDALYGEAVAAVIVPREPAP--TAQELTEFCREKLASFEIPATFQM
Mb0123|M.bovis_AF2122/97 VFGVPHQLYGEAVAAVIVPRESAPP-TREELVQFCRERLAAFEIPASFQE
Rv0119|M.tuberculosis_H37Rv VFGVPHQLYGEAVAAVIVPRESAPP-TREELVQFCRERLAAFEIPASFQE
MLBr_02661|M.leprae_Br4923 VFGDPDKVYGETVTAVIVPREVIAP-TPSELAVFCRDRLAAFEVPTRFQE
MAV_5190|M.avium_104 VFGRPDQLYGETVAAVIVTRGSAAP-TADELASFCRERLAPFEVPAEFRR
MSMEG_5295|M.smegmatis_MC2_155 VFAIPDATYGEQVGAAVVP-AAAHV-SADDILAQCRTGLAPYEVPARLDI
TH_3626|M.thermoresistible__bu VVGRPHPLYGEVPVMYVAAAPGAVV-DTDAVRRHLAVSLAKYKQPVAIRV
MAB_2539c|M.abscessus_ATCC_199 VIGVPDDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIV
*.. *. :*: :.. : : :: * .
Mflv_0027|M.gilvum_PYR-GCK VDALPRNPSGKLLKRQLREPYWTDEDRHIG
Mvan_0943|M.vanbaalenii_PYR-1 VDVLPRNPSGKLLKRALREPYWDGADRHIG
MUL_4803|M.ulcerans_Agy99 ASELPHTAKGSLDRRAVAQQFGGQA-----
MMAR_0319|M.marinum_M ASELPHTAKGSLDRRAVAQQFGGQA-----
Mb0123|M.bovis_AF2122/97 ASGLPHTAKGSLDRRAVAERFGHSV-----
Rv0119|M.tuberculosis_H37Rv ASGLPHTAKGSLDRRAVAERFGHSV-----
MLBr_02661|M.leprae_Br4923 ASALPHTAKGSLDRRAVAEQFAHRG-----
MAV_5190|M.avium_104 AAELPHTAKGSLDRRAVAEQFGESA-----
MSMEG_5295|M.smegmatis_MC2_155 VESLPHTAKGAIDRQAVKLLFAH-------
TH_3626|M.thermoresistible__bu LDVLPKNAVGKIDKPAIRTLDATATQTA--
MAB_2539c|M.abscessus_ATCC_199 LDEIPRNASGKVLRAKLNSPGAC-------
:*:.. * : : :