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KSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQL ALGGLLPGDRVALCAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVS DQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGLRHDDAMIMFTGGTTGLPKMVPWT DGNIAGSVHAIITAYQLGPQDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAVA ATWYTAAPAIHRILLELASTQSFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVICAFGMTEATHQVT TTNIKWFGQGENPTVTNGLVGQSTGVQIRIVGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFTH GWLRTGDLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVYGETVTAVI VPREVIAPTPSELAVFCRDRLAAFEVPTRFQEASALPHTAKGSLDRRAVAEQFAHRG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. leprae Br4923 | MLBr_02661 | - | - | 100% (548) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_02546 | fadD2 | 7e-32 | 24.42% (520) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_01051 | xclC | 9e-30 | 30.46% (348) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0123 | fadD7 | 0.0 | 71.35% (520) | acyl-CoA synthetase |
M. gilvum PYR-GCK | Mflv_0027 | - | 2e-50 | 30.28% (535) | AMP-dependent synthetase and ligase |
M. tuberculosis H37Rv | Rv0119 | fadD7 | 0.0 | 71.35% (520) | acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_2539c | - | 1e-39 | 27.69% (520) | fatty-acid-CoA ligase FadD |
M. marinum M | MMAR_0319 | fadD7 | 0.0 | 65.51% (548) | fatty-acid-CoA ligase FadD7 |
M. avium 104 | MAV_5190 | - | 0.0 | 67.57% (518) | acyl-CoA synthetase |
M. smegmatis MC2 155 | MSMEG_5295 | - | 1e-115 | 47.54% (509) | acyl-CoA synthetase |
M. thermoresistible (build 8) | TH_3626 | - | 4e-59 | 31.59% (516) | PUTATIVE putative fatty-acid-CoA ligase |
M. ulcerans Agy99 | MUL_4803 | fadD7 | 0.0 | 64.78% (548) | acyl-CoA synthetase |
M. vanbaalenii PYR-1 | Mvan_0943 | - | 3e-45 | 28.95% (532) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0027|M.gilvum_PYR-GCK ------------------------------------------MFHNLADI Mvan_0943|M.vanbaalenii_PYR-1 ------------------------------------------MIHNLADI MMAR_0319|M.marinum_M ------------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADL MUL_4803|M.ulcerans_Agy99 ------------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADL Mb0123|M.bovis_AF2122/97 ------------------MASD--------------------FGPRIADL Rv0119|M.tuberculosis_H37Rv ------------------MASD--------------------FGPRIADL MLBr_02661|M.leprae_Br4923 ------------------MKSESITSSRAPVEQIDARLTGQFESPSIASL MAV_5190|M.avium_104 ------MDRYWTQRNAARHGGSDDTTGKDVAMTSEATPSATAAGPRLADL MSMEG_5295|M.smegmatis_MC2_155 ---------------MRFMGTAATPP--------------ATLLSGLFDV TH_3626|M.thermoresistible__bu ---------------------------------------MLSQSVHLVSL MAB_2539c|M.abscessus_ATCC_199 MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAML : Mflv_0027|M.gilvum_PYR-GCK VRSHGRNRPDAPALIVGDR--TVSYRELDERSNRTAQAFSRTGVGPGDRV Mvan_0943|M.vanbaalenii_PYR-1 IRVHGRERPGAPALVVGDR--TVTYGELDDRSSRAAQAFAQAGVGVGDRV MMAR_0319|M.marinum_M VELAAARLPEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRPGERV MUL_4803|M.ulcerans_Agy99 VELAAAQLSEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRQGERV Mb0123|M.bovis_AF2122/97 VEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRV Rv0119|M.tuberculosis_H37Rv VEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRV MLBr_02661|M.leprae_Br4923 VEAAAIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRV MAV_5190|M.avium_104 VEAAAQRAPRAPALLVASERTPIAYADLVRLVDDLAARLRAAGLAPGDRV MSMEG_5295|M.smegmatis_MC2_155 LDHHVRTRPDAPALVVTQQRIAVTYATLGRWADDVAAGLTADGLRRGEVI TH_3626|M.thermoresistible__bu PDQRAASAPAAP--CLADDTVALSNAEFRHAVDSAAAVLRGHGVGAGDVV MAB_2539c|M.abscessus_ATCC_199 LAASAIRFPDRAALIDDSG--QLTYRDLQRRAEAVAAAVYARTPSAPRSV . . :: : . : . : Mflv_0027|M.gilvum_PYR-GCK AFVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVV Mvan_0943|M.vanbaalenii_PYR-1 AFVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVV MMAR_0319|M.marinum_M ALRSGSNLEFVVALLAASRANLIVVPLDPALPVADQRARAGAAGARVVLI MUL_4803|M.ulcerans_Agy99 ALRSGSNLEFVVALLAASRANLIVVPLDPALPVAYQRARAGAAGARVVLI Mb0123|M.bovis_AF2122/97 ALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLI Rv0119|M.tuberculosis_H37Rv ALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLI MLBr_02661|M.leprae_Br4923 ALCAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLV MAV_5190|M.avium_104 GLRAGSNPEFVVALLAASRADLVVAPLDPALPAADQLSRSRAVGARAVLV MSMEG_5295|M.smegmatis_MC2_155 AVVDVNTAEFVVALLAAARIGAVVAPLDPALADAEMTDRLARLGARAVLT TH_3626|M.thermoresistible__bu AVMLPNTVDLVVTLFAAWRLGAAVTPLNPALSVDESAYQIADAGAKVLVA MAB_2539c|M.abscessus_ATCC_199 GIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDVLVY .. . : :. : . . :: *. : Mflv_0027|M.gilvum_PYR-GCK GQ---EFTGRIEAIADDLDVEVVVIGKHRH-----WPTFDDLLAAAPAVD Mvan_0943|M.vanbaalenii_PYR-1 GQ---DFAGHLEAIEDGLDADIVVIGDHPR-----WPAFDDWVASHPPVD MMAR_0319|M.marinum_M DG---TGPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVA MUL_4803|M.ulcerans_Agy99 DG---TGPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVA Mb0123|M.bovis_AF2122/97 DA---DGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPAT Rv0119|M.tuberculosis_H37Rv DA---DGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPAT MLBr_02661|M.leprae_Br4923 DSLALEGVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVT MAV_5190|M.avium_104 DR---LGEGQTAPESAPCWPVTVTVGPDDS----APTVDLTVTAAPTHDV MSMEG_5295|M.smegmatis_MC2_155 GP----CEHALGTHRVRVTASRATVEPTRG-----------ATVEPTVRQ TH_3626|M.thermoresistible__bu GG----------NLPAPATPVVRPADLKTG----------------HGPV MAB_2539c|M.abscessus_ATCC_199 DD-----EYSQAVEESQYQGLRVLAWRENP-----QENRLTLDSLADQHH . Mflv_0027|M.gilvum_PYR-GCK PGVVTGPDDLVFLMYTSGTTGAPKGVMLSNAN--VVCKTAGVGGPWKFDA Mvan_0943|M.vanbaalenii_PYR-1 PGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTN--YVYKTGGVAGPWQFDA MMAR_0319|M.marinum_M SAPQGLRADDAMIMFTGGTTGLPKMVPWTRAN--IATSIRSIIAGYRLSP MUL_4803|M.ulcerans_Agy99 SAPQGLRADDAMIMFTGGTTGLPKMVPWTRAN--IATSIRSIIAGYRLSP Mb0123|M.bovis_AF2122/97 STPEGLRPDDAMIMFTGGTTGLPKMVPWTHAN--IASSVRAIITGYRLSP Rv0119|M.tuberculosis_H37Rv STPEGLRPDDAMIMFTGGTTGLPKMVPWTHAN--IASSVRAIITGYRLSP MLBr_02661|M.leprae_Br4923 STPDGLRHDDAMIMFTGGTTGLPKMVPWTDGN--IAGSVHAIITAYQLGP MAV_5190|M.avium_104 TAPQGLRDDDAMIMFTGGTTGAPKMVPWTRHN--IAASIRSIVAGYGLGP MSMEG_5295|M.smegmatis_MC2_155 AVDLGLGPDDALILFTSGTTGRAKMVPWTHAN--IAASVHGICAAYELGD TH_3626|M.thermoresistible__bu EVAPPADDRLALLIYTSGTTGRPKGVMLDHAN--IAAMCASIIEANELTS MAB_2539c|M.abscessus_ATCC_199 PKPPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRS : : *.**** .* * . : Mflv_0027|M.gilvum_PYR-GCK DSVSLAVMPLFHMAGFGWALAGLWEGAVTVVLRD---VDPGAILDAVARH Mvan_0943|M.vanbaalenii_PYR-1 DAVSLAVMPLFHMAGSGWALAGLWQGATTVVLRD---VEPAAILDAIARH MMAR_0319|M.marinum_M QDATVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVA MUL_4803|M.ulcerans_Agy99 QDATVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVA Mb0123|M.bovis_AF2122/97 RDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAV Rv0119|M.tuberculosis_H37Rv RDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAV MLBr_02661|M.leprae_Br4923 QDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAV MAV_5190|M.avium_104 RDATVAVMPLYHGHGLLAALLATLASGGAVLLPARGKFSAHTFWDDIAAV MSMEG_5295|M.smegmatis_MC2_155 GDATVAVMPFFHGHGLVAVLLSTLAGGGKVLLPAHGRFSAHTFWADMRDA TH_3626|M.thermoresistible__bu ADSSLLILPLFHVNGIVVGTLSPLIAGGHVTIAG--RFDPRTFFDRVRRS MAB_2539c|M.abscessus_ATCC_199 RDRVLVAPPFFHGFG-LAALLGPLALGGTVMCRR--RFDAQQAMTDIRRQ : *::* * . . * ... : Mflv_0027|M.gilvum_PYR-GCK RVTNMLLVPAVIQFLLDTTGLD------DTDLSRLRIVVYGASPITDDVL Mvan_0943|M.vanbaalenii_PYR-1 RITNMLLVPAVIQFLLDTDGVA------EVDLSTLRVIVYGASPISDDVL MMAR_0319|M.marinum_M HATWYTAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSAPLTPETA MUL_4803|M.ulcerans_Agy99 HATWYTAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSGPLTPETA Mb0123|M.bovis_AF2122/97 GATWYTAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAA Rv0119|M.tuberculosis_H37Rv GATWYTAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAA MLBr_02661|M.leprae_Br4923 AATWYTAAPAIHRILLELASTQ----SFRSKRAKLRFIRSCSAPLTQETA MAV_5190|M.avium_104 GATWYTAVPTIHQILLERARTE-----APRGTHALRFIRSCSAPLTAETA MSMEG_5295|M.smegmatis_MC2_155 DATWFTAVPTIHQILLQRPDEE---------HPPLRFVRSCSAPLDPATA TH_3626|M.thermoresistible__bu RPTYFSAVPTIYTKLLELPEDP------TVDTSSLRFAACGAAPASAELL MAB_2539c|M.abscessus_ATCC_199 RVTVLMAVPVMLQRILALADLD----RRDARQLSLRMIVTGAAPISSSTV * .*.: :* **. :.* Mflv_0027|M.gilvum_PYR-GCK MRGIDRFGGIFAQVYGMTESTGSVTQLDGDE----HLPQLLRSCGRPYPW Mvan_0943|M.vanbaalenii_PYR-1 VRGIERFGPIFAQVYGMTETTGSITQLDGPD----HVPALLRSCGRPYPW MMAR_0319|M.marinum_M QALHDEFSAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTG MUL_4803|M.ulcerans_Agy99 QALHDEFSAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTG Mb0123|M.bovis_AF2122/97 LALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTG Rv0119|M.tuberculosis_H37Rv LALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTG MLBr_02661|M.leprae_Br4923 QALREEFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTG MAV_5190|M.avium_104 QALQDTFGAPVVCAFGMTEATHQVSTTAIDGAGHSENPGATPGLVGRSTG MSMEG_5295|M.smegmatis_MC2_155 EAAERRFGAPMLEAYGMTETTHQAASRRVR----THDPRMSVGPA--SGA TH_3626|M.thermoresistible__bu QRFEQRYGVPIIEGYGLSEGTCVSTANPLRG------PRKPGTVGLPLPG MAB_2539c|M.abscessus_ATCC_199 SGVLEAFGPILVNGYGSTEAGVVAIASPKD------LVASPNTIGRTALG : . :* :* Mflv_0027|M.gilvum_PYR-GCK VQIRVVDPTGRDVAPGTVGEVWTRSDQNMLGYWNNPEA-TAATLTPDGWL Mvan_0943|M.vanbaalenii_PYR-1 VQIRIVDETGADAVAGTVGEVWTRSEQNMLGYWNNPDA-TASTLTADGWL MMAR_0319|M.marinum_M PEIRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKI-TAANFT-DGWL MUL_4803|M.ulcerans_Agy99 PEIRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKI-TAANFT-DGWL Mb0123|M.bovis_AF2122/97 AQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTI-TAANFT-DGWL Rv0119|M.tuberculosis_H37Rv AQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTI-TAANFT-DGWL MLBr_02661|M.leprae_Br4923 VQIRIVGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAI-TAANFT-HGWL MAV_5190|M.avium_104 PDIRIAGPDGQSLPADTVGEVWLRGATVVRGYLGDPAI-TAANFT-DGWL MSMEG_5295|M.smegmatis_MC2_155 ARFQVVRSDGGECTPAETGEVWVSGPAVVRGYLADPEN-TAQAFT-DGWF TH_3626|M.thermoresistible__bu QQVRIVDAEGRTLGANEIGEVLIAGPTVMRGYLNRPEE-TAKTLV-DGWL MAB_2539c|M.abscessus_ATCC_199 VSVRILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIVDGHV .:: . * : . ** .: .* . Mflv_0027|M.gilvum_PYR-GCK RTGDAGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVA Mvan_0943|M.vanbaalenii_PYR-1 KTGDAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAA MMAR_0319|M.marinum_M RTGDLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVLENA MUL_4803|M.ulcerans_Agy99 RTGDLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENA Mb0123|M.bovis_AF2122/97 RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAA Rv0119|M.tuberculosis_H37Rv RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAA MLBr_02661|M.leprae_Br4923 RTGDLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVA MAV_5190|M.avium_104 HTGDLGTLSAAGDLVVRGRIKELINRGGEKISPERVEGVLAGHPDVLEAA MSMEG_5295|M.smegmatis_MC2_155 RTGDLGALDADGNLQLTGRIKNIINRGGEKISPEHVEGVLTGCDGVFEAV TH_3626|M.thermoresistible__bu RTGDIGYLDDDGYLVLVDRAKDMIIRGGENIYPKEIEAVAHRLPEISEVA MAB_2539c|M.abscessus_ATCC_199 NTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAV .*** * .. * * : .* .::* ..*:: * .:* : : . Mflv_0027|M.gilvum_PYR-GCK VIGIPDTRWGEAVKAVVVAG--APV-TEAELIAFAREQLAGFKLPKSVDF Mvan_0943|M.vanbaalenii_PYR-1 VIGVPDRRWGEAVKAVVVAARGAQL-TEAELIAFARDRIGGFKLPKSVDF MMAR_0319|M.marinum_M VFGVPDALYGEAVAAVIVPREPAP--TAQELTEFCREKLASFEIPATFQM MUL_4803|M.ulcerans_Agy99 VFGVPDALYGEAVAAVIVPREPAP--TAQELTEFCREKLASFEIPATFQM Mb0123|M.bovis_AF2122/97 VFGVPHQLYGEAVAAVIVPRESAPP-TREELVQFCRERLAAFEIPASFQE Rv0119|M.tuberculosis_H37Rv VFGVPHQLYGEAVAAVIVPRESAPP-TREELVQFCRERLAAFEIPASFQE MLBr_02661|M.leprae_Br4923 VFGDPDKVYGETVTAVIVPREVIAP-TPSELAVFCRDRLAAFEVPTRFQE MAV_5190|M.avium_104 VFGRPDQLYGETVAAVIVTRGSAAP-TADELASFCRERLAPFEVPAEFRR MSMEG_5295|M.smegmatis_MC2_155 VFAIPDATYGEQVGAAVVP-AAAHV-SADDILAQCRTGLAPYEVPARLDI TH_3626|M.thermoresistible__bu VVGRPHPLYGEVPVMYVAAAPGAVV-DTDAVRRHLAVSLAKYKQPVAIRV MAB_2539c|M.abscessus_ATCC_199 VIGVPDDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIV *.. *. :*: :.. : : :: * . Mflv_0027|M.gilvum_PYR-GCK VDALPRNPSGKLLKRQLREPYWTDEDRHIG Mvan_0943|M.vanbaalenii_PYR-1 VDVLPRNPSGKLLKRALREPYWDGADRHIG MMAR_0319|M.marinum_M ASELPHTAKGSLDRRAVAQQFGGQA----- MUL_4803|M.ulcerans_Agy99 ASELPHTAKGSLDRRAVAQQFGGQA----- Mb0123|M.bovis_AF2122/97 ASGLPHTAKGSLDRRAVAERFGHSV----- Rv0119|M.tuberculosis_H37Rv ASGLPHTAKGSLDRRAVAERFGHSV----- MLBr_02661|M.leprae_Br4923 ASALPHTAKGSLDRRAVAEQFAHRG----- MAV_5190|M.avium_104 AAELPHTAKGSLDRRAVAEQFGESA----- MSMEG_5295|M.smegmatis_MC2_155 VESLPHTAKGAIDRQAVKLLFAH------- TH_3626|M.thermoresistible__bu LDVLPKNAVGKIDKPAIRTLDATATQTA-- MAB_2539c|M.abscessus_ATCC_199 LDEIPRNASGKVLRAKLNSPGAC------- :*:.. * : : :