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M. leprae Br4923 MLBr_02661 (-)

annotation: acyl-CoA synthetase
coordinates: 3185729 - 3187375
length: 548

KSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQL
ALGGLLPGDRVALCAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVS
DQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGLRHDDAMIMFTGGTTGLPKMVPWT
DGNIAGSVHAIITAYQLGPQDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAVA
ATWYTAAPAIHRILLELASTQSFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVICAFGMTEATHQVT
TTNIKWFGQGENPTVTNGLVGQSTGVQIRIVGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFTH
GWLRTGDLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVYGETVTAVI
VPREVIAPTPSELAVFCRDRLAAFEVPTRFQEASALPHTAKGSLDRRAVAEQFAHRG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_02661--100% (548)acyl-CoA synthetase
M. leprae Br4923MLBr_02546fadD27e-3224.42% (520) acyl-CoA synthetase
M. leprae Br4923MLBr_01051xclC9e-3030.46% (348) acyl-CoA synthetase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0123fadD70.071.35% (520) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_0027-2e-5030.28% (535) AMP-dependent synthetase and ligase
M. tuberculosis H37RvRv0119fadD70.071.35% (520) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_2539c-1e-3927.69% (520) fatty-acid-CoA ligase FadD
M. marinum MMMAR_0319fadD70.065.51% (548) fatty-acid-CoA ligase FadD7
M. avium 104MAV_5190-0.067.57% (518) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_5295-1e-11547.54% (509) acyl-CoA synthetase
M. thermoresistible (build 8)TH_3626-4e-5931.59% (516) PUTATIVE putative fatty-acid-CoA ligase
M. ulcerans Agy99MUL_4803fadD70.064.78% (548) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_0943-3e-4528.95% (532) AMP-dependent synthetase and ligase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0027|M.gilvum_PYR-GCK          ------------------------------------------MFHNLADI
Mvan_0943|M.vanbaalenii_PYR-1       ------------------------------------------MIHNLADI
MMAR_0319|M.marinum_M               ------------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADL
MUL_4803|M.ulcerans_Agy99           ------------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADL
Mb0123|M.bovis_AF2122/97            ------------------MASD--------------------FGPRIADL
Rv0119|M.tuberculosis_H37Rv         ------------------MASD--------------------FGPRIADL
MLBr_02661|M.leprae_Br4923          ------------------MKSESITSSRAPVEQIDARLTGQFESPSIASL
MAV_5190|M.avium_104                ------MDRYWTQRNAARHGGSDDTTGKDVAMTSEATPSATAAGPRLADL
MSMEG_5295|M.smegmatis_MC2_155      ---------------MRFMGTAATPP--------------ATLLSGLFDV
TH_3626|M.thermoresistible__bu      ---------------------------------------MLSQSVHLVSL
MAB_2539c|M.abscessus_ATCC_199      MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAML
                                                                                     :

Mflv_0027|M.gilvum_PYR-GCK          VRSHGRNRPDAPALIVGDR--TVSYRELDERSNRTAQAFSRTGVGPGDRV
Mvan_0943|M.vanbaalenii_PYR-1       IRVHGRERPGAPALVVGDR--TVTYGELDDRSSRAAQAFAQAGVGVGDRV
MMAR_0319|M.marinum_M               VELAAARLPEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRPGERV
MUL_4803|M.ulcerans_Agy99           VELAAAQLSEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRQGERV
Mb0123|M.bovis_AF2122/97            VEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRV
Rv0119|M.tuberculosis_H37Rv         VEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRV
MLBr_02661|M.leprae_Br4923          VEAAAIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRV
MAV_5190|M.avium_104                VEAAAQRAPRAPALLVASERTPIAYADLVRLVDDLAARLRAAGLAPGDRV
MSMEG_5295|M.smegmatis_MC2_155      LDHHVRTRPDAPALVVTQQRIAVTYATLGRWADDVAAGLTADGLRRGEVI
TH_3626|M.thermoresistible__bu      PDQRAASAPAAP--CLADDTVALSNAEFRHAVDSAAAVLRGHGVGAGDVV
MAB_2539c|M.abscessus_ATCC_199      LAASAIRFPDRAALIDDSG--QLTYRDLQRRAEAVAAAVYARTPSAPRSV
                                            .  .          ::   :    .  :  .          :

Mflv_0027|M.gilvum_PYR-GCK          AFVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVV
Mvan_0943|M.vanbaalenii_PYR-1       AFVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVV
MMAR_0319|M.marinum_M               ALRSGSNLEFVVALLAASRANLIVVPLDPALPVADQRARAGAAGARVVLI
MUL_4803|M.ulcerans_Agy99           ALRSGSNLEFVVALLAASRANLIVVPLDPALPVAYQRARAGAAGARVVLI
Mb0123|M.bovis_AF2122/97            ALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLI
Rv0119|M.tuberculosis_H37Rv         ALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLI
MLBr_02661|M.leprae_Br4923          ALCAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLV
MAV_5190|M.avium_104                GLRAGSNPEFVVALLAASRADLVVAPLDPALPAADQLSRSRAVGARAVLV
MSMEG_5295|M.smegmatis_MC2_155      AVVDVNTAEFVVALLAAARIGAVVAPLDPALADAEMTDRLARLGARAVLT
TH_3626|M.thermoresistible__bu      AVMLPNTVDLVVTLFAAWRLGAAVTPLNPALSVDESAYQIADAGAKVLVA
MAB_2539c|M.abscessus_ATCC_199      GIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDVLVY
                                    ..   .   :    :.  : .   . ::  *.                : 

Mflv_0027|M.gilvum_PYR-GCK          GQ---EFTGRIEAIADDLDVEVVVIGKHRH-----WPTFDDLLAAAPAVD
Mvan_0943|M.vanbaalenii_PYR-1       GQ---DFAGHLEAIEDGLDADIVVIGDHPR-----WPAFDDWVASHPPVD
MMAR_0319|M.marinum_M               DG---TGPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVA
MUL_4803|M.ulcerans_Agy99           DG---TGPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVA
Mb0123|M.bovis_AF2122/97            DA---DGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPAT
Rv0119|M.tuberculosis_H37Rv         DA---DGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPAT
MLBr_02661|M.leprae_Br4923          DSLALEGVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVT
MAV_5190|M.avium_104                DR---LGEGQTAPESAPCWPVTVTVGPDDS----APTVDLTVTAAPTHDV
MSMEG_5295|M.smegmatis_MC2_155      GP----CEHALGTHRVRVTASRATVEPTRG-----------ATVEPTVRQ
TH_3626|M.thermoresistible__bu      GG----------NLPAPATPVVRPADLKTG----------------HGPV
MAB_2539c|M.abscessus_ATCC_199      DD-----EYSQAVEESQYQGLRVLAWRENP-----QENRLTLDSLADQHH
                                    .                                                 

Mflv_0027|M.gilvum_PYR-GCK          PGVVTGPDDLVFLMYTSGTTGAPKGVMLSNAN--VVCKTAGVGGPWKFDA
Mvan_0943|M.vanbaalenii_PYR-1       PGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTN--YVYKTGGVAGPWQFDA
MMAR_0319|M.marinum_M               SAPQGLRADDAMIMFTGGTTGLPKMVPWTRAN--IATSIRSIIAGYRLSP
MUL_4803|M.ulcerans_Agy99           SAPQGLRADDAMIMFTGGTTGLPKMVPWTRAN--IATSIRSIIAGYRLSP
Mb0123|M.bovis_AF2122/97            STPEGLRPDDAMIMFTGGTTGLPKMVPWTHAN--IASSVRAIITGYRLSP
Rv0119|M.tuberculosis_H37Rv         STPEGLRPDDAMIMFTGGTTGLPKMVPWTHAN--IASSVRAIITGYRLSP
MLBr_02661|M.leprae_Br4923          STPDGLRHDDAMIMFTGGTTGLPKMVPWTDGN--IAGSVHAIITAYQLGP
MAV_5190|M.avium_104                TAPQGLRDDDAMIMFTGGTTGAPKMVPWTRHN--IAASIRSIVAGYGLGP
MSMEG_5295|M.smegmatis_MC2_155      AVDLGLGPDDALILFTSGTTGRAKMVPWTHAN--IAASVHGICAAYELGD
TH_3626|M.thermoresistible__bu      EVAPPADDRLALLIYTSGTTGRPKGVMLDHAN--IAAMCASIIEANELTS
MAB_2539c|M.abscessus_ATCC_199      PKPPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRS
                                               : : *.**** .* *         .           :  

Mflv_0027|M.gilvum_PYR-GCK          DSVSLAVMPLFHMAGFGWALAGLWEGAVTVVLRD---VDPGAILDAVARH
Mvan_0943|M.vanbaalenii_PYR-1       DAVSLAVMPLFHMAGSGWALAGLWQGATTVVLRD---VEPAAILDAIARH
MMAR_0319|M.marinum_M               QDATVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVA
MUL_4803|M.ulcerans_Agy99           QDATVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVA
Mb0123|M.bovis_AF2122/97            RDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAV
Rv0119|M.tuberculosis_H37Rv         RDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAV
MLBr_02661|M.leprae_Br4923          QDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAV
MAV_5190|M.avium_104                RDATVAVMPLYHGHGLLAALLATLASGGAVLLPARGKFSAHTFWDDIAAV
MSMEG_5295|M.smegmatis_MC2_155      GDATVAVMPFFHGHGLVAVLLSTLAGGGKVLLPAHGRFSAHTFWADMRDA
TH_3626|M.thermoresistible__bu      ADSSLLILPLFHVNGIVVGTLSPLIAGGHVTIAG--RFDPRTFFDRVRRS
MAB_2539c|M.abscessus_ATCC_199      RDRVLVAPPFFHGFG-LAALLGPLALGGTVMCRR--RFDAQQAMTDIRRQ
                                        :   *::*  *      .    .  *       ...      :   

Mflv_0027|M.gilvum_PYR-GCK          RVTNMLLVPAVIQFLLDTTGLD------DTDLSRLRIVVYGASPITDDVL
Mvan_0943|M.vanbaalenii_PYR-1       RITNMLLVPAVIQFLLDTDGVA------EVDLSTLRVIVYGASPISDDVL
MMAR_0319|M.marinum_M               HATWYTAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSAPLTPETA
MUL_4803|M.ulcerans_Agy99           HATWYTAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSGPLTPETA
Mb0123|M.bovis_AF2122/97            GATWYTAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAA
Rv0119|M.tuberculosis_H37Rv         GATWYTAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAA
MLBr_02661|M.leprae_Br4923          AATWYTAAPAIHRILLELASTQ----SFRSKRAKLRFIRSCSAPLTQETA
MAV_5190|M.avium_104                GATWYTAVPTIHQILLERARTE-----APRGTHALRFIRSCSAPLTAETA
MSMEG_5295|M.smegmatis_MC2_155      DATWFTAVPTIHQILLQRPDEE---------HPPLRFVRSCSAPLDPATA
TH_3626|M.thermoresistible__bu      RPTYFSAVPTIYTKLLELPEDP------TVDTSSLRFAACGAAPASAELL
MAB_2539c|M.abscessus_ATCC_199      RVTVLMAVPVMLQRILALADLD----RRDARQLSLRMIVTGAAPISSSTV
                                      *    .*.:   :*                  **.    :.*      

Mflv_0027|M.gilvum_PYR-GCK          MRGIDRFGGIFAQVYGMTESTGSVTQLDGDE----HLPQLLRSCGRPYPW
Mvan_0943|M.vanbaalenii_PYR-1       VRGIERFGPIFAQVYGMTETTGSITQLDGPD----HVPALLRSCGRPYPW
MMAR_0319|M.marinum_M               QALHDEFSAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTG
MUL_4803|M.ulcerans_Agy99           QALHDEFSAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTG
Mb0123|M.bovis_AF2122/97            LALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTG
Rv0119|M.tuberculosis_H37Rv         LALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTG
MLBr_02661|M.leprae_Br4923          QALREEFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTG
MAV_5190|M.avium_104                QALQDTFGAPVVCAFGMTEATHQVSTTAIDGAGHSENPGATPGLVGRSTG
MSMEG_5295|M.smegmatis_MC2_155      EAAERRFGAPMLEAYGMTETTHQAASRRVR----THDPRMSVGPA--SGA
TH_3626|M.thermoresistible__bu      QRFEQRYGVPIIEGYGLSEGTCVSTANPLRG------PRKPGTVGLPLPG
MAB_2539c|M.abscessus_ATCC_199      SGVLEAFGPILVNGYGSTEAGVVAIASPKD------LVASPNTIGRTALG
                                          :   .   :* :*                               

Mflv_0027|M.gilvum_PYR-GCK          VQIRVVDPTGRDVAPGTVGEVWTRSDQNMLGYWNNPEA-TAATLTPDGWL
Mvan_0943|M.vanbaalenii_PYR-1       VQIRIVDETGADAVAGTVGEVWTRSEQNMLGYWNNPDA-TASTLTADGWL
MMAR_0319|M.marinum_M               PEIRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKI-TAANFT-DGWL
MUL_4803|M.ulcerans_Agy99           PEIRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKI-TAANFT-DGWL
Mb0123|M.bovis_AF2122/97            AQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTI-TAANFT-DGWL
Rv0119|M.tuberculosis_H37Rv         AQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTI-TAANFT-DGWL
MLBr_02661|M.leprae_Br4923          VQIRIVGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAI-TAANFT-HGWL
MAV_5190|M.avium_104                PDIRIAGPDGQSLPADTVGEVWLRGATVVRGYLGDPAI-TAANFT-DGWL
MSMEG_5295|M.smegmatis_MC2_155      ARFQVVRSDGGECTPAETGEVWVSGPAVVRGYLADPEN-TAQAFT-DGWF
TH_3626|M.thermoresistible__bu      QQVRIVDAEGRTLGANEIGEVLIAGPTVMRGYLNRPEE-TAKTLV-DGWL
MAB_2539c|M.abscessus_ATCC_199      VSVRILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIVDGHV
                                      .::         .   * :   .     **       .:     .* .

Mflv_0027|M.gilvum_PYR-GCK          RTGDAGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVA
Mvan_0943|M.vanbaalenii_PYR-1       KTGDAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAA
MMAR_0319|M.marinum_M               RTGDLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVLENA
MUL_4803|M.ulcerans_Agy99           RTGDLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENA
Mb0123|M.bovis_AF2122/97            RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAA
Rv0119|M.tuberculosis_H37Rv         RTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAA
MLBr_02661|M.leprae_Br4923          RTGDLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVA
MAV_5190|M.avium_104                HTGDLGTLSAAGDLVVRGRIKELINRGGEKISPERVEGVLAGHPDVLEAA
MSMEG_5295|M.smegmatis_MC2_155      RTGDLGALDADGNLQLTGRIKNIINRGGEKISPEHVEGVLTGCDGVFEAV
TH_3626|M.thermoresistible__bu      RTGDIGYLDDDGYLVLVDRAKDMIIRGGENIYPKEIEAVAHRLPEISEVA
MAB_2539c|M.abscessus_ATCC_199      NTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAV
                                    .*** * ..  * * : .* .::*  ..*:: * .:*        : : .

Mflv_0027|M.gilvum_PYR-GCK          VIGIPDTRWGEAVKAVVVAG--APV-TEAELIAFAREQLAGFKLPKSVDF
Mvan_0943|M.vanbaalenii_PYR-1       VIGVPDRRWGEAVKAVVVAARGAQL-TEAELIAFARDRIGGFKLPKSVDF
MMAR_0319|M.marinum_M               VFGVPDALYGEAVAAVIVPREPAP--TAQELTEFCREKLASFEIPATFQM
MUL_4803|M.ulcerans_Agy99           VFGVPDALYGEAVAAVIVPREPAP--TAQELTEFCREKLASFEIPATFQM
Mb0123|M.bovis_AF2122/97            VFGVPHQLYGEAVAAVIVPRESAPP-TREELVQFCRERLAAFEIPASFQE
Rv0119|M.tuberculosis_H37Rv         VFGVPHQLYGEAVAAVIVPRESAPP-TREELVQFCRERLAAFEIPASFQE
MLBr_02661|M.leprae_Br4923          VFGDPDKVYGETVTAVIVPREVIAP-TPSELAVFCRDRLAAFEVPTRFQE
MAV_5190|M.avium_104                VFGRPDQLYGETVAAVIVTRGSAAP-TADELASFCRERLAPFEVPAEFRR
MSMEG_5295|M.smegmatis_MC2_155      VFAIPDATYGEQVGAAVVP-AAAHV-SADDILAQCRTGLAPYEVPARLDI
TH_3626|M.thermoresistible__bu      VVGRPHPLYGEVPVMYVAAAPGAVV-DTDAVRRHLAVSLAKYKQPVAIRV
MAB_2539c|M.abscessus_ATCC_199      VIGVPDDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIV
                                    *.. *.  :*:     :..           :       :  :: *  .  

Mflv_0027|M.gilvum_PYR-GCK          VDALPRNPSGKLLKRQLREPYWTDEDRHIG
Mvan_0943|M.vanbaalenii_PYR-1       VDVLPRNPSGKLLKRALREPYWDGADRHIG
MMAR_0319|M.marinum_M               ASELPHTAKGSLDRRAVAQQFGGQA-----
MUL_4803|M.ulcerans_Agy99           ASELPHTAKGSLDRRAVAQQFGGQA-----
Mb0123|M.bovis_AF2122/97            ASGLPHTAKGSLDRRAVAERFGHSV-----
Rv0119|M.tuberculosis_H37Rv         ASGLPHTAKGSLDRRAVAERFGHSV-----
MLBr_02661|M.leprae_Br4923          ASALPHTAKGSLDRRAVAEQFAHRG-----
MAV_5190|M.avium_104                AAELPHTAKGSLDRRAVAEQFGESA-----
MSMEG_5295|M.smegmatis_MC2_155      VESLPHTAKGAIDRQAVKLLFAH-------
TH_3626|M.thermoresistible__bu      LDVLPKNAVGKIDKPAIRTLDATATQTA--
MAB_2539c|M.abscessus_ATCC_199      LDEIPRNASGKVLRAKLNSPGAC-------
                                       :*:.. * : :  :