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IHNLADIIRVHGRERPGAPALVVGDRTVTYGELDDRSSRAAQAFAQAGVGVGDRVAFVDKNGAEFFEVTF GLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVVGQDFAGHLEAIEDGLDADIVVIGDHPRWPAFDDWV ASHPPVDPGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGGVAGPWQFDADAVSLAVMPLFHMAG SGWALAGLWQGATTVVLRDVEPAAILDAIARHRITNMLLVPAVIQFLLDTDGVAEVDLSTLRVIVYGASP ISDDVLVRGIERFGPIFAQVYGMTETTGSITQLDGPDHVPALLRSCGRPYPWVQIRIVDETGADAVAGTV GEVWTRSEQNMLGYWNNPDATASTLTADGWLKTGDAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENV LMTHPAVADAAVIGVPDRRWGEAVKAVVVAARGAQLTEAELIAFARDRIGGFKLPKSVDFVDVLPRNPSG KLLKRALREPYWDGADRHIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | - | 100% (511) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0970 | - | e-106 | 42.60% (500) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_3993 | - | 6e-98 | 41.02% (512) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 2e-78 | 35.04% (488) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 0.0 | 77.89% (511) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 2e-78 | 35.04% (488) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-70 | 31.35% (504) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 9e-95 | 41.43% (490) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_2597 | fadD13 | 9e-79 | 37.58% (479) | fatty-acid-CoA ligase FadD13 |
| M. avium 104 | MAV_3523 | - | 1e-112 | 44.36% (514) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 1e-101 | 42.09% (506) | feruloyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2854 | - | 9e-88 | 38.12% (501) | PUTATIVE putative AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 2e-76 | 37.16% (514) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3116|M.bovis_AF2122/97 --------------------------------------------MKNIGW
Rv3089|M.tuberculosis_H37Rv --------------------------------------------MKNIGW
MMAR_2597|M.marinum_M --------------------------------------------MKNIGA
Mvan_0943|M.vanbaalenii_PYR-1 -------------------------------------------MIHNLAD
Mflv_0027|M.gilvum_PYR-GCK -------------------------------------------MFHNLAD
MAV_3523|M.avium_104 --------------------------------------MPAAETRETLAG
MAB_4559|M.abscessus_ATCC_1997 ---------------------------------------------MQFTQ
MSMEG_4065|M.smegmatis_MC2_155 -------------------------------------------MTMYLTQ
TH_2854|M.thermoresistible__bu ----------------------------------------VSRSHLLIGD
MUL_0650|M.ulcerans_Agy99 ------------------------------------MSDDLLRNPTHNGH
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Mb3116|M.bovis_AF2122/97 MLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGDR
Rv3089|M.tuberculosis_H37Rv MLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGDR
MMAR_2597|M.marinum_M MLKQRAHISPRLQAYVEPSTNVRMDYTELNMLTNRCASVLRALGVGKGDR
Mvan_0943|M.vanbaalenii_PYR-1 IIRVHGRERPGAPALVV--GDRTVTYGELDDRSSRAAQAFAQAGVGVGDR
Mflv_0027|M.gilvum_PYR-GCK IVRSHGRNRPDAPALIV--GDRTVSYRELDERSNRTAQAFSRTGVGPGDR
MAV_3523|M.avium_104 IVERHAQRRPDAIAIRY--GERQWSWAEWSSRIRRAAGALRGDGIERGQC
MAB_4559|M.abscessus_ATCC_1997 WLHRALQQYPDRLITID--QGREHTVEQFADRVARLSAGLRANGVRPGDR
MSMEG_4065|M.smegmatis_MC2_155 GLHRAVQQTPGATMTVF--GERRRTFLEVADRVARLAGALRALGVRAGDR
TH_2854|M.thermoresistible__bu LITRAARTYGAAPALVH--GDRVMSFREFDDATNRLGNALLARGLRPGDH
MUL_0650|M.ulcerans_Agy99 LLVGALERHKNRPVLFL--GDTTLTGGQLAERISQYIQAFEALGAGTGVT
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALID--EEGTLTYKELDRAAHALANGLIAKGVRGGDG
: : * *
Mb3116|M.bovis_AF2122/97 VALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVI
Rv3089|M.tuberculosis_H37Rv VALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVI
MMAR_2597|M.marinum_M VALLMPNSVAFCCLFYGAAKLGAVAVPLNTRLAAPELGFILADSGSTVLI
Mvan_0943|M.vanbaalenii_PYR-1 VAFVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVV
Mflv_0027|M.gilvum_PYR-GCK VAFVERNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVV
MAV_3523|M.avium_104 VAFLDKNHPACLEVLIGGASVGAVTTVVNWRVIGDELVHVLADSGARVLV
MAB_4559|M.abscessus_ATCC_1997 VGMLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVLL
MSMEG_4065|M.smegmatis_MC2_155 VAMLAQNSDRYHEYLLAVPWANGVLNPVNIRWTPAEIAYSLEDSGTKVMF
TH_2854|M.thermoresistible__bu VAVLAPNGIDGVVTYYALAKAGLVRVPLNSRETDFELAYKIDDSQARALV
MUL_0650|M.ulcerans_Agy99 VGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALI
MLBr_02546|M.leprae_Br4923 IAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVII
:..: * . . :: : : :.
Mb3116|M.bovis_AF2122/97 YGAPSAPVIDAIRA------QADPPGTVTDWI----GADSLAERLRSAAA
Rv3089|M.tuberculosis_H37Rv YGAPSAPVIDAIRA------QADPPGTVTDWI----GADSLAERLRSAAA
MMAR_2597|M.marinum_M YHQSLEPVVTAIKT------ATERSHNVISWVPLSDGEGALAQRLETADA
Mvan_0943|M.vanbaalenii_PYR-1 VGQDFAGHLEAIED----GLDADIVVIGDHPR-----WPAFDDWVASHPP
Mflv_0027|M.gilvum_PYR-GCK VGQEFTGRIEAIAD----DLDVEVVVIGKHRH-----WPTFDDLLAAAPA
MAV_3523|M.avium_104 VGAELRPAAEAAAR----RVPSLERIIEVG--------DEYESLLAAAEP
MAB_4559|M.abscessus_ATCC_1997 VDDTFKAAAAPLRA----ACACLETVIYCGAGPAPQDMIGYEDLLASHEP
MSMEG_4065|M.smegmatis_MC2_155 VDDSFARMLPAIKD----AWAELSTVIYAGEASPPAGTLAYEELIDKSDP
TH_2854|M.thermoresistible__bu TDGR-----------------------IPAETELVIHTEELAGMIAGADP
MUL_0650|M.ulcerans_Agy99 IDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDRAVDLSAEAAKYQP
MLBr_02546|M.leprae_Br4923 YDDEYTKVVSKAEP-----ALGKLRALGVNPDEEEPPGSTDETLAELIAR
Mb3116|M.bovis_AF2122/97 DEPAVECGG-DDNLFIMYTSGTTGHPKGVVHTHESVHSAASS-WASTIDV
Rv3089|M.tuberculosis_H37Rv DEPAVECGG-DDNLFIMYTSGTTGHPKGVVHTHESVHSAASS-WASTIDV
MMAR_2597|M.marinum_M GEPICDSGG-SDNLFIMYTSGTTGNPKGVVHTHDSVHTAASS-WSLTVDV
Mvan_0943|M.vanbaalenii_PYR-1 VDPGVVTGP-DDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGG-VAGPWQF
Mflv_0027|M.gilvum_PYR-GCK VDPGVVTGP-DDLVFLMYTSGTTGAPKGVMLSNANVVCKTAG-VGGPWKF
MAV_3523|M.avium_104 APSDAGVDT-DETALVIYSSGTTGRPKGVLLSQRALVNHAAN-LAPAFPF
MAB_4559|M.abscessus_ATCC_1997 ID-DTRTGG-DSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNFL
MSMEG_4065|M.smegmatis_MC2_155 VD-DARRGG-DELAGLFYTGGTTGFPKGVMLSHANLLTSTYGLLTPGFAF
TH_2854|M.thermoresistible__bu GPCRIERDPEDPLR-LAYTGGTTGKPKAVVLTTRSELAEIANFLVDLLPD
MUL_0650|M.ulcerans_Agy99 KPLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEWEWP
MLBr_02546|M.leprae_Br4923 SSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGG-ILSKVPF
. : :.**** **.. .
Mb3116|M.bovis_AF2122/97 RYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEER
Rv3089|M.tuberculosis_H37Rv RYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEER
MMAR_2597|M.marinum_M RYQDRLLLPLPMFHVAALTTVIMCAMRGVTLVSMPQFDPAKAWSLIVDER
Mvan_0943|M.vanbaalenii_PYR-1 DADAVSLAVMPLFHMAGSGWALAGLWQGATTVVLRDVEPAAILDAIARHR
Mflv_0027|M.gilvum_PYR-GCK DADSVSLAVMPLFHMAGFGWALAGLWEGAVTVVLRDVDPGAILDAVARHR
MAV_3523|M.avium_104 GDGDANLVAMPLFHVGGIGYALFGIRAGAPTIMTREPDAAALIGAVRAG-
MAB_4559|M.abscessus_ATCC_1997 TRGGRLLHSAPMFHMADFSAVLAGNLSGSTHVIVPSFSPQGVLDAIVAHD
MSMEG_4065|M.smegmatis_MC2_155 RPGGICLHAAPMFHLADLMSWSAGLLQGGRHVFIPSFEPVTVMQAIAQHQ
TH_2854|M.thermoresistible__bu LTPDSVMLHAAPITHGSGAFFLPHLVKGARNVILPRFTPQGFVDAAVEHG
MUL_0650|M.ulcerans_Agy99 EHPR--FLMCTPLSHAGAAFFTPTLVKGGEMIVLAKFDPGEVLRVIEEQR
MLBr_02546|M.leprae_Br4923 RAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEKHQ
: . : * : .
Mb3116|M.bovis_AF2122/97 VCIGGAVPAILNFMRQVPEFAE--LDAPDFRYFITGGAPMPEALIKIYAA
Rv3089|M.tuberculosis_H37Rv VCIGGAVPAILNFMRQVPEFAE--LDAPDFRYFITGGAPMPEALIKIYAA
MMAR_2597|M.marinum_M VSLAGAVPAILNFMRLVPEFTE--LDAPEFRCFITGGAPMPEALIRMYAA
Mvan_0943|M.vanbaalenii_PYR-1 ITNMLLVPAVIQFLLDTDGVAE--VDLSTLRVIVYGASPISDDVLVRGIE
Mflv_0027|M.gilvum_PYR-GCK VTNMLLVPAVIQFLLDTTGLDD--TDLSRLRIVVYGASPITDDVLMRGID
MAV_3523|M.avium_104 ATHAFFVPPVIARFLDAGEAAR--ASIAGLRYIVYGAAPMPLPLLHRALS
MAB_4559|M.abscessus_ATCC_1997 VQDMLLVPTMIQMLVDHPGAAQ--LDLSGIRSITYGASVISEAVLQRATR
MSMEG_4065|M.smegmatis_MC2_155 VTDALLVPTMIQKLIDHPDINR--YDLTSFRALFYAASAIPQALLERAMK
TH_2854|M.thermoresistible__bu ATATFMVPTMIAMMLEDAEID---RDRLKLRRLCYGGAPIAPTLLARGLE
MUL_0650|M.ulcerans_Agy99 ITATMLVPSMLYALMDHPDPHT--RDLSSLETVYYGASAINPVRLAEAID
MLBr_02546|M.leprae_Br4923 ATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALE
** :: : . :. . ..: :
Mb3116|M.bovis_AF2122/97 KN--IEVVQGYALTESCGGGTLLLSEDAL-----RKAGSAGRATMFTDVA
Rv3089|M.tuberculosis_H37Rv KN--IEVVQGYALTESCGGGTLLLSEDAL-----RKAGSAGRATMFTDVA
MMAR_2597|M.marinum_M KN--MQVVQGYALTESCGGGTLLLGEDAL-----AKVGSAGRATMFADVR
Mvan_0943|M.vanbaalenii_PYR-1 RF-GPIFAQVYGMTETTGSITQLDGPDH----VPALLRSCGRPYPWVQIR
Mflv_0027|M.gilvum_PYR-GCK RF-GGIFAQVYGMTESTGSVTQLDGDEH----LPQLLRSCGRPYPWVQIR
MAV_3523|M.avium_104 TWPGTKFVQVYGQTELCGAVTALSDDDHRDAARPQLQLSAGKAVQGCEIR
MAB_4559|M.abscessus_ATCC_1997 VFPNARFTQAYGMTEVSPVATLLLPDDHD---DPALLRSAGRAAPHCEVR
MSMEG_4065|M.smegmatis_MC2_155 VFPNAEFVQGYGMTELSPLATLLSPDDHQ---KPRLLRSAGRAAPSAEVR
TH_2854|M.thermoresistible__bu TL-GPVFVQLYGQAEAPLAITCLQPWEHT----PERLTSAGKPYTFVEMD
MUL_0650|M.ulcerans_Agy99 RF-GPIFAQYYGQSEAPMVITYLPKADHD----EKRLTSCGRPTLFARVA
MLBr_02546|M.leprae_Br4923 EL-GPVIYNMYGSTEIAFATIAGPKDLQIN------SATVGPVVKGVKVK
. : *. :* : * :
Mb3116|M.bovis_AF2122/97 VRGDDG--VIREHGEGEVVIKSDILLKEYWNRPEATRDAFD-NGWFRTGD
Rv3089|M.tuberculosis_H37Rv VRGDDG--VIREHGEGEVVIKSDILLKEYWNRPEATRDAFD-NGWFRTGD
MMAR_2597|M.marinum_M VRTDDG--MIAERGQGEVVIKSDFLLKEYWNRPDATRDAFH-GDWFRTGD
Mvan_0943|M.vanbaalenii_PYR-1 IVDETG-ADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADGWLKTGD
Mflv_0027|M.gilvum_PYR-GCK VVDPTG-RDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTGD
MAV_3523|M.avium_104 IVDPNNCAELPAGRSGEVWVRSNQNMSGYLNRAEATAETITADGWVRTGD
MAB_4559|M.abscessus_ATCC_1997 IVDPDD-NEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIR-DGWMHTGD
MSMEG_4065|M.smegmatis_MC2_155 IVDPDG-NEVPRRTVGEVAVRGGNVMLGYWNKPQETAAAIR-DGWMHTGD
TH_2854|M.thermoresistible__bu IRDEED-NSVPPGTPGEVVTRGPHTMSGYWRRPEATAETLGEDGWLRTGD
MUL_0650|M.ulcerans_Agy99 LLGEDG-KPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFR-DGWLHTGD
MLBr_02546|M.leprae_Br4923 ILDDSG-KEVPRGQVGRIFVGNAFPFEGYTG----GGGKQIIDGLLSSGD
: . *.: . * .. . :**
Mb3116|M.bovis_AF2122/97 IGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGL
Rv3089|M.tuberculosis_H37Rv IGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGL
MMAR_2597|M.marinum_M IGEIDSDGYLYIKDRIKDMIISGGENIYPAEIENVITGIPGVAEVAVIGL
Mvan_0943|M.vanbaalenii_PYR-1 AGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAAVIGV
Mflv_0027|M.gilvum_PYR-GCK AGYLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIGI
MAV_3523|M.avium_104 VGRLDADGYVYIEDRLKDMIITGGENVYGPEVESVLIEHPAVVDAAVIGV
MAB_4559|M.abscessus_ATCC_1997 AGRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAACAVIGI
MSMEG_4065|M.smegmatis_MC2_155 AAYMDDDGYIYVVDRIKDMIITGGENVYSAEVENAVVQHPSVAACAVIGV
TH_2854|M.thermoresistible__bu IGQVDEEGYLYLLDRRNDVIISGGFNVYPREVEDALLTHPAVREAVVVGV
MUL_0650|M.ulcerans_Agy99 MAREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGA
MLBr_02546|M.leprae_Br4923 VGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGV
. * . :: .* .:::::*. *:: *:*. : . * .:*
Mb3116|M.bovis_AF2122/97 PDEKWGEIAAAIVVADQNEVSEQQ--------IVEYCGTRLARYKLPKKV
Rv3089|M.tuberculosis_H37Rv PDEKWGEIAAAIVVADQNEVSEQQ--------IVEYCGTRLARYKLPKKV
MMAR_2597|M.marinum_M PDQKWGEIACAIVVSDQGAVSEAG--------IVEFCAARLARYKLPKRL
Mvan_0943|M.vanbaalenii_PYR-1 PDRRWGEAVKAVVVAARGAQLTEA-------ELIAFARDRIGGFKLPKSV
Mflv_0027|M.gilvum_PYR-GCK PDTRWGEAVKAVVVAG--APVTEA-------ELIAFAREQLAGFKLPKSV
MAV_3523|M.avium_104 PDDFWGESVKAIVVAD--GDVDAA-------DVIEFCRRHLAGFKCPRTV
MAB_4559|M.abscessus_ATCC_1997 PDEQWGERVHAVVVKQAQSECCDG-------DLQEHCREHIANYKVPRSF
MSMEG_4065|M.smegmatis_MC2_155 PDADWGERVHAVVVLQPGAELAAC-------QIREHAKRLIAGYKCPRSI
TH_2854|M.thermoresistible__bu DDERWGQRVSAAVVLREEVD---------TQALIDHCAERLAGFKRPRHI
MUL_0650|M.ulcerans_Agy99 PDEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQV
MLBr_02546|M.leprae_Br4923 DDKEWGARLRAFVVKKQDATIDED-------AIKAYVRDHLARYKVPREV
* ** * ** : . : *: .
Mb3116|M.bovis_AF2122/97 IFAEAIPRNPTGKILKTVLREQYSATVPK------
Rv3089|M.tuberculosis_H37Rv IFAEAIPRNPTGKILKTVLREQYSATVPK------
MMAR_2597|M.marinum_M IFTATLPRNPAGKVLKRELRELYR-----------
Mvan_0943|M.vanbaalenii_PYR-1 DFVDVLPRNPSGKLLKRALREPYWDGADRHIG---
Mflv_0027|M.gilvum_PYR-GCK DFVDALPRNPSGKLLKRQLREPYWTDEDRHIG---
MAV_3523|M.avium_104 DFVAELPRNASGKILKTQLREPFWRDRDRRV----
MAB_4559|M.abscessus_ATCC_1997 EFVDELPLSGAGKILKRVLRQKYWESRDAGVS---
MSMEG_4065|M.smegmatis_MC2_155 EFVNALPLSGAGKVLKRELRERHLGARERDRGSLP
TH_2854|M.thermoresistible__bu EVWDELPKSPVGKSLRRTVRETMRANEEVTAHA--
MUL_0650|M.ulcerans_Agy99 VVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG---
MLBr_02546|M.leprae_Br4923 IFLEELPRNPTGKVLKRELRDFEVH----------
. :* . ** : :*