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aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3528 | - | - | 100% (494) | cyclohex-1-ene-1-carboxylate:CoA ligase |
| M. thermoresistible (build 8) | TH_3874 | - | 1e-61 | 38.20% (356) | PUTATIVE AMP-binding enzyme, putative |
| M. thermoresistible (build 8) | TH_3067 | - | 2e-60 | 32.95% (519) | PUTATIVE AMP-binding enzyme, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 1e-45 | 32.89% (526) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_1784 | - | 3e-66 | 36.65% (513) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 1e-45 | 32.89% (526) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02661 | - | 9e-37 | 27.74% (530) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 2e-42 | 30.34% (524) | AMP-binding domain protein |
| M. marinum M | MMAR_0303 | - | 9e-63 | 34.25% (508) | acyl-CoA synthetase |
| M. avium 104 | MAV_1839 | - | 0.0 | 70.56% (496) | cyclohex-1-ene-1-carboxylate:CoA ligase |
| M. smegmatis MC2 155 | MSMEG_5631 | - | 1e-56 | 32.94% (507) | AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3641 | mbtA | 2e-39 | 28.35% (522) | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP |
| M. vanbaalenii PYR-1 | Mvan_4966 | - | 6e-66 | 37.30% (504) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3528|M.thermoresistible__bu ---------------------------------MTATIAGLLDDAAARKP
MAV_1839|M.avium_104 --------------------------------MMADTIVGVLDEAAASRP
Mb2533c|M.bovis_AF2122/97 ----------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYG
Rv2505c|M.tuberculosis_H37Rv ----------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYG
MAB_4377c|M.abscessus_ATCC_199 --------------------MKAYDAGATLSPIIEETIGENFERIARAHP
Mflv_1784|M.gilvum_PYR-GCK ---------------------------------MTGTLVEALRDAARDTP
Mvan_4966|M.vanbaalenii_PYR-1 ---------------------------------MT-TLADALRDAARDTP
MMAR_0303|M.marinum_M MGGPKVPQRRLIDGRWVRWDADRAAGAYAHRWWVRRTLADALREAAQSTP
MSMEG_5631|M.smegmatis_MC2_155 ---------------------MRAEDAYERGLWVRTTLADTLAEAARDTP
MUL_3641|M.ulcerans_Agy99 ------------MAGFIPYPPERVASYRAAGYWTGRSIGSLLRQAAARWP
MLBr_02661|M.leprae_Br4923 ---------MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNP
:: . *
TH_3528|M.thermoresistible__bu DQRMLIDVD-GGCLTVAEVARLSSAATRWLADAGVQPGMTVAWQLPAHSA
MAV_1839|M.avium_104 ARPLLRDCD-GATLTVAETAALSAAGTRWLWDAGIRPGMTIAWQLPSHVS
Mb2533c|M.bovis_AF2122/97 HREALVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWE
Rv2505c|M.tuberculosis_H37Rv HREALVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWE
MAB_4377c|M.abscessus_ATCC_199 DVGALVDVSGDRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAE
Mflv_1784|M.gilvum_PYR-GCK DRVLVRDD--AVALTCAELLSAATGLAHALTRR-MPAGSVVSFTVPNWHE
Mvan_4966|M.vanbaalenii_PYR-1 DRILLRDD--EASLSSAELLSAATNLAHALVRR-MPVGSVVSFAVPNWHE
MMAR_0303|M.marinum_M QRVALVDA--DRQLDCQELHRQAMALAQHLRSR-MPAGSVVSFMLPNWHE
MSMEG_5631|M.smegmatis_MC2_155 QRVLLIDG--DVRLTCAELHSRAKALAHEMAAR-MPAGSVVSFMLPNWHE
MUL_3641|M.ulcerans_Agy99 DRVGVVDA--GASHTFCELDKLADRVAAGFVSLGIAPGDRVLLQLPNSCR
MLBr_02661|M.leprae_Br4923 SAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIE
: : : : : * : .
TH_3528|M.thermoresistible__bu AALLMLALARMPVVQAPVLHLYRQREVQAALDVAGADVLIVDASTAAN--
MAV_1839|M.avium_104 AALLMLALARCSVTQAPVLHLYRQREACAALAVAGVDTLIVDESTTAN--
Mb2533c|M.bovis_AF2122/97 WVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADY
Rv2505c|M.tuberculosis_H37Rv WVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADY
MAB_4377c|M.abscessus_ATCC_199 WVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDY
Mflv_1784|M.gilvum_PYR-GCK AAIIYLGATLAGMVVNPILPSLRERELSFILDDADSRMIFVPESFGGHDY
Mvan_4966|M.vanbaalenii_PYR-1 AAVIYLGATLAGMVVNPILPSLRERELSFILADAGSRAIFIPQTFGGHDY
MMAR_0303|M.marinum_M AAVIYLASTLAAMVANPVLPSLREHELRFILEDAGSRMIFAPADFRGHDY
MSMEG_5631|M.smegmatis_MC2_155 AAIVYLASTLAGMVINPILPSLRDHELRFILDDAASRMIFIPGEFGQHDY
MUL_3641|M.ulcerans_Agy99 FAVALFGLLRAGAIPVMCLPGHRLAELHHFAEVSGAVGLIVAQHAGGFDY
MLBr_02661|M.leprae_Br4923 FVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDS-LALEGV
.: . * : :
TH_3528|M.thermoresistible__bu ----------APDDTSVITLPDDFVDVLRAMPAEP------VLVEDPRPD
MAV_1839|M.avium_104 ----------VPPGARVVKLPDGFVELLRALPTDPQP----ELAQSHRAD
Mb2533c|M.bovis_AF2122/97 AAMLAEVGPRCPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGS
Rv2505c|M.tuberculosis_H37Rv AAMLAEVGPRCPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGS
MAB_4377c|M.abscessus_ATCC_199 VAMASQVMPDAPGLRDVVFIGTSDWTELVAGAERVTETALRARMSQLSNT
Mflv_1784|M.gilvum_PYR-GCK AAMLDRVAPGLPSPPEVVVVRGE-GRVTLADLLAEPA---DGVLPAPRPT
Mvan_4966|M.vanbaalenii_PYR-1 AAMLDRVVAGLPSPPEVVVVRGEPRRPALTDLVSEPR---DGTLPDLDPA
MMAR_0303|M.marinum_M TSMLRRVAAQLPSRPEVIEVRGQCPDGVSTFQSLLVGRETAAPLPTADPD
MSMEG_5631|M.smegmatis_MC2_155 AAMLQRVCAHLPTPPQVVVVRGE-PGPHTAFTALGAP---GGDLPALDPD
MUL_3641|M.ulcerans_Agy99 RSMAERLVAAHPQLRHVIIDGESGPFLPWSSLSEG-----ATPDIDVDTT
MLBr_02661|M.leprae_Br4923 SDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGLRH
*
TH_3528|M.thermoresistible__bu DVRWIYFTSGTTGRPKGVRHTDSTLLAAARGFTAHLGLGTHPQEVSTIAF
MAV_1839|M.avium_104 DARWIYFTSGTTGRPKGVRHTDATLLAAARGYAQYLGLGEHPNEVGTIAF
Mb2533c|M.bovis_AF2122/97 DPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQ--DRICIPV
Rv2505c|M.tuberculosis_H37Rv DPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQ--DRICIPV
MAB_4377c|M.abscessus_ATCC_199 DPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQLQAG--DRLCIPV
Mflv_1784|M.gilvum_PYR-GCK DTRMILYTSGTTGRPKGVLHTHESLAALIAQLGRFWRIDRG--DTFLVPS
Mvan_4966|M.vanbaalenii_PYR-1 ATRMILYTSGTTGRPKGVLHSHKSLGALIAQLGRYWRIDPG--DTFLVPS
MMAR_0303|M.marinum_M AVRMVLYTSGTTGRPKGVLHTHNSIHALICQIRDHWMVEPG--DGFLVAS
MSMEG_5631|M.smegmatis_MC2_155 SVRMMMHTSGTTGRPKGVLHSHNSIHALICQLRENWMIDPG--DTFLVPS
MUL_3641|M.ulcerans_Agy99 SPALLLVSGGTTGTPKLIPRTHDDYVYNATASAQLCRLTAD--DVYLVSL
MLBr_02661|M.leprae_Br4923 DDAMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQLGPQ--DATVVVM
: :.***. ** :. : :
TH_3528|M.thermoresistible__bu PVAHIGGIVYLSCALL------AGFPVLLIPKVEADELLRLLAEYRVTVT
MAV_1839|M.avium_104 PIAHIGGMVYLASALI------ADFPVLMVPKVDVETLPRLLAQHDVTVT
Mb2533c|M.bovis_AF2122/97 PFYHCFGMVMGNLAAT----SHGAAMVIPAPGFDPAATLRAVQDERCTSL
Rv2505c|M.tuberculosis_H37Rv PFYHCFGMVMGNLAAT----SHGAAMVIPAPGFDPAATLRAVQDERCTSL
MAB_4377c|M.abscessus_ATCC_199 PFYHCFGMVMGNLGCT----THGATIVMPAPGFDPGRTLEAIERERCVGV
Mflv_1784|M.gilvum_PYR-GCK PIAHIGGSIYAFECP-----LLLGTEAVLMQRWDPDAAVGLMLEHRVTHM
Mvan_4966|M.vanbaalenii_PYR-1 PIAHIGGSIYAFECP-----LLLGTQAVLMQRWDPDAAVALMLRHRCTHM
MMAR_0303|M.marinum_M PIAHIGGSIYAFECP-----LLLGTTAVLLDRWDADRAVQLMTSKRCTHM
MSMEG_5631|M.smegmatis_MC2_155 PIAHIGGSIYAFECP-----LLLGTTAVLMQRWNADDGVALMSEHHCTHM
MUL_3641|M.ulcerans_Agy99 PAAHN----FPLACPGILGSMAVGATIVFSTDPSPEAAFTLIERHGVTVT
MLBr_02661|M.leprae_Br4923 PLYHGHGLIAALLSTLASG---GVVLLPARARFSARTFWDDIDAVAATWY
* * . : .
TH_3528|M.thermoresistible__bu GGSTAFYQMLLSAQLASGQNEPLVPTLRMLIGGGAPCPPEVHRKVRAHMG
MAV_1839|M.avium_104 GASTAYYQMLLSAQVASGSGEPVVPSLRMLIGGGAACPPELHKQVREQMG
Mb2533c|M.bovis_AF2122/97 YGVPTMFIAELGLPDFTD---YELGSLRTGIMAGAACPVEVMRKVISRMH
Rv2505c|M.tuberculosis_H37Rv YGVPTMFIAELGLPDFTD---YELGSLRTGIMAGAACPVEVMRKVISRMH
MAB_4377c|M.abscessus_ATCC_199 YGVPTMFIAMLADPGFAH---RDLSTLRTGIMAGSVCPVEVMKRCIDEMH
Mflv_1784|M.gilvum_PYR-GCK AGATPFLVGLLAAAQRAG---TRLPDLKVFICGGASVPPTLIRSAAAYFD
Mvan_4966|M.vanbaalenii_PYR-1 AGATPFLDGLLAAAERAG---TRLPDLKVFICGGASVPPSLIRRAADYFD
MMAR_0303|M.marinum_M AGATPFLEQLLAAAQRAG---TRLPDLKFFVCGGASVSPSLIRCATDYFD
MSMEG_5631|M.smegmatis_MC2_155 AGATPFLDQLLNAAERAG---TRLPDLKVFICGGASVPPSLIRRASTCFE
MUL_3641|M.ulcerans_Agy99 ALVPALAKLWTQACDWEP---VIPKSLRLLQVGGSRLEPEDARQAREALT
MLBr_02661|M.leprae_Br4923 TAAPAIHRILLELASTQSFR-SKRAKLRFIRSCSAPLTQETAQALREEFL
.. *: .: : :
TH_3528|M.thermoresistible__bu IP-IVHAYGMTEAPMIGVS-----EAADTEEQQSNSSGRPIPGSEIRIAA
MAV_1839|M.avium_104 VP-IVHAYGMTEAAMVCVS-----PATDTEEQQSNSSGRPIPGSDVRISE
Mb2533c|M.bovis_AF2122/97 MPGVSICYGMTETSPVSTQT----RADDSVDRRVGTVGRVGPHLEIKVVD
Rv2505c|M.tuberculosis_H37Rv MPGVSICYGMTETSPVSTQT----RADDSVDRRVGTVGRVGPHLEIKVVD
MAB_4377c|M.abscessus_ATCC_199 MAGVAIAYGMTETSPVSCQT----LFDDDLDRRTATVGRAHPHIEIKIVD
Mflv_1784|M.gilvum_PYR-GCK KAAVSRVYGSTEVPVTTVG------ALDDIDRAADTDGRPG-IAEVRIVD
Mvan_4966|M.vanbaalenii_PYR-1 KAAVSRVYGSTEVPVTTVG------SLDDVDRAADTDGRPG-IADVTLVD
MMAR_0303|M.marinum_M KAVVTRVYGSTEVPVTTIG------APDSSAHAAATDGRVG-AADVKLVA
MSMEG_5631|M.smegmatis_MC2_155 KAVVSRVYGSTEVPVTTVGS----IEPGDVEHAACTDGRPG-LAEIRLVD
MUL_3641|M.ulcerans_Agy99 PG-LQQVFGMAEGLLNFTRL----EDPPDLLEHTQGRPLCS-ADELRIVD
MLBr_02661|M.leprae_Br4923 AP-VICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTGVQIRIVG
: :* :* :: :
TH_3528|M.thermoresistible__bu N-----------GEIXLRGSNVTTGYVX-DQWSG-STTADGWFRTGDSGH
MAV_1839|M.avium_104 T-----------GEVELRGANLTPGYVDAEQWKS-VLTSDGWFRTGDRGY
Mb2533c|M.bovis_AF2122/97 PATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAE
Rv2505c|M.tuberculosis_H37Rv PATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAE
MAB_4377c|M.abscessus_ATCC_199 PNSGETVQRGQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAV
Mflv_1784|M.gilvum_PYR-GCK ------------GEIRARGPQMFTGYLHPE-DDRESFDDAGYFRTGDLGR
Mvan_4966|M.vanbaalenii_PYR-1 ------------GEIRARGPQMLTGYLHPE-DNSESFDAEGFFRTGDLGH
MMAR_0303|M.marinum_M ------------GEIRVRGPQMLVGYRHPE-DEAGSFDAQGYFRTGDLGH
MSMEG_5631|M.smegmatis_MC2_155 ------------GEIRARGPQMLLGYLHAE-DNA--FDEQGFFRTGDLGR
MUL_3641|M.ulcerans_Agy99 GA-GAPVAPGAEGELLVRGPYTINGYFCADRDNERCFDPAGFYRSGDLVR
MLBr_02661|M.leprae_Br4923 SD-GQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFTHG-WLRTGDLGS
**. ** ** : ::**
TH_3528|M.thermoresistible__bu LRPDGRIVITGRVKDLIIRKGENISPEEIENELLAHPLIDQVAVIGHPDE
MAV_1839|M.avium_104 LRPDGRIVITGRTKDLIIRKGENIAPDEIENELLAHPLVDEVAVVGQPDD
Mb2533c|M.bovis_AF2122/97 MDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDA
Rv2505c|M.tuberculosis_H37Rv MDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDA
MAB_4377c|M.abscessus_ATCC_199 MRDDGYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDE
Mflv_1784|M.gilvum_PYR-GCK FTEDNHLVVTGRAKDIIIRNGENISPKEVEDILVTHPRIAEIAVVGIPDP
Mvan_4966|M.vanbaalenii_PYR-1 LTDDGYLVVTGRAKDLIIRNGENISPKEVEDILVTHPQIAEIAIVGIPDL
MMAR_0303|M.marinum_M WVDDEYLVVTGRAKDIIIRNGENISPKEIEDILITHPGIADVAIVGLPDD
MSMEG_5631|M.smegmatis_MC2_155 WVDGDYLTVTGRAKDLIIRNGENISPKEIEDILVGELGINEIAVVGLPDE
MUL_3641|M.ulcerans_Agy99 LRDDGYLQVTGRVKDVICRCGETISAQDLEEQLLSHPAIRSAAAVPLPDP
MLBr_02661|M.leprae_Br4923 LSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDK
: ** *::: * **.* . :* * . : . . **
TH_3528|M.thermoresistible__bu ERGELVCAVVRRSPGR-RDLTLGEVCAFLDERGLMKQKWPERLVVVDEFP
MAV_1839|M.avium_104 LRGEMVCAVVRRSPRH-RDVTLDELCAFLDQRGMMKQKWPERLFFVDEFP
Mb2533c|M.bovis_AF2122/97 KYGEELMAVVKLRNDA-PELTIERLREYCMGR-IARFKIPRYLWIVDEFP
Rv2505c|M.tuberculosis_H37Rv KYGEELMAVVKLRNDA-PELTIERLREYCMGR-IARFKIPRYLWIVDEFP
MAB_4377c|M.abscessus_ATCC_199 KYGEELCAWVRMRPDR-VVIDAVAIRAFASGR-LAHYKIPRYVHVVESFP
Mflv_1784|M.gilvum_PYR-GCK RTGERACAALVTTEDP--PPDIAELKDFLTDRGVARFKVPEQIHVVGALP
Mvan_4966|M.vanbaalenii_PYR-1 RTGERACAVIVAADSA--APDVAEIRDFLVARGVAKFKAPERVVVVDALP
MMAR_0303|M.marinum_M RTGERACAVIVAAADP--PPGLPGVRAFLEGAGVARFKIPEQVVIWDHLP
MSMEG_5631|M.smegmatis_MC2_155 RTGERACAVVVTEDGA--RPDVSALAEVLTKAGVAKFKIPEQVEIWDALP
MUL_3641|M.ulcerans_Agy99 DMGELICAAIVFAGPPQTPQTLSGLNDYLEQRGVAAHIRIDRLVAMPSLP
MLBr_02661|M.leprae_Br4923 VYGETVTAVIVPREVI--APTPSELAVFCRDR-LAAFEVPTRFQEASALP
** * : : : . :*
TH_3528|M.thermoresistible__bu MTGLGKIAKRELVQQLTGGIR----------
MAV_1839|M.avium_104 LTGLGKVAKAELVQQISGGRR----------
Mb2533c|M.bovis_AF2122/97 MTVTGKVRKVEMRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv MTVTGKVRKVEMRQQALEYLRGQQ-------
MAB_4377c|M.abscessus_ATCC_199 MTVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ
Mflv_1784|M.gilvum_PYR-GCK KNDAGKVLKHVLKAELTKES-----------
Mvan_4966|M.vanbaalenii_PYR-1 KNDAGKVLKHAIRAVLLEKPREGEP------
MMAR_0303|M.marinum_M KNHAGKIVKHRIKAALMKAEQ----------
MSMEG_5631|M.smegmatis_MC2_155 KNDAGKVLKHQIRTQLSKVE-----------
MUL_3641|M.ulcerans_Agy99 TTPVGKIDKKAIASQILTTTAT---------
MLBr_02661|M.leprae_Br4923 HTAKGSLDRRAVAEQFAHRG-----------
. *.: : :