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VTTLADALRDAARDTPDRILLRDDEASLSSAELLSAATNLAHALVRRMPVGSVVSFAVPNWHEAAVIYLG ATLAGMVVNPILPSLRERELSFILADAGSRAIFIPQTFGGHDYAAMLDRVVAGLPSPPEVVVVRGEPRRP ALTDLVSEPRDGTLPDLDPAATRMILYTSGTTGRPKGVLHSHKSLGALIAQLGRYWRIDPGDTFLVPSPI AHIGGSIYAFECPLLLGTQAVLMQRWDPDAAVALMLRHRCTHMAGATPFLDGLLAAAERAGTRLPDLKVF ICGGASVPPSLIRRAADYFDKAAVSRVYGSTEVPVTTVGSLDDVDRAADTDGRPGIADVTLVDGEIRARG PQMLTGYLHPEDNSESFDAEGFFRTGDLGHLTDDGYLVVTGRAKDLIIRNGENISPKEVEDILVTHPQIA EIAIVGIPDLRTGERACAVIVAADSAAPDVAEIRDFLVARGVAKFKAPERVVVVDALPKNDAGKVLKHAI RAVLLEKPREGEP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4966 | - | - | 100% (503) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_4135 | - | 2e-63 | 37.44% (454) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 8e-61 | 32.16% (513) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 6e-55 | 32.32% (495) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_1784 | - | 0.0 | 80.61% (495) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 6e-55 | 32.32% (495) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01051 | xclC | 6e-44 | 30.44% (496) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 1e-53 | 30.98% (523) | AMP-binding domain protein |
| M. marinum M | MMAR_0303 | - | 0.0 | 67.61% (497) | acyl-CoA synthetase |
| M. avium 104 | MAV_5212 | - | 0.0 | 68.16% (512) | AMP-binding enzyme, putative |
| M. smegmatis MC2 155 | MSMEG_5631 | - | 0.0 | 71.52% (495) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3067 | - | 0.0 | 72.33% (506) | PUTATIVE AMP-binding enzyme, putative |
| M. ulcerans Agy99 | MUL_3641 | mbtA | 6e-52 | 32.24% (518) | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 ----------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYG
Rv2505c|M.tuberculosis_H37Rv ----------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYG
MAB_4377c|M.abscessus_ATCC_199 --------------------MKAYDAGATLSPIIEETIGENFERIARAHP
Mvan_4966|M.vanbaalenii_PYR-1 ---------------------------------MT-TLADALRDAARDTP
Mflv_1784|M.gilvum_PYR-GCK ---------------------------------MTGTLVEALRDAARDTP
TH_3067|M.thermoresistible__bu ----MTETPGAGYRTDRPGHAERAAQAYARGLWVPTTLAEALAEAARTTP
MSMEG_5631|M.smegmatis_MC2_155 ---------------------MRAEDAYERGLWVRTTLADTLAEAARDTP
MAV_5212|M.avium_104 ------------MTARAAPDTAQTSLAYRRGWWVRSTLADAARAAAQRTP
MMAR_0303|M.marinum_M MGGPKVPQRRLIDGRWVRWDADRAAGAYAHRWWVRRTLADALREAAQSTP
MUL_3641|M.ulcerans_Agy99 ------------MAGFIPYPPERVASYRAAGYWTGRSIGSLLRQAAARWP
MLBr_01051|M.leprae_Br4923 ------------------------------------------MLLASLNP
*
Mb2533c|M.bovis_AF2122/97 HREALVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWE
Rv2505c|M.tuberculosis_H37Rv HREALVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWE
MAB_4377c|M.abscessus_ATCC_199 DVGALVDVSGDRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAE
Mvan_4966|M.vanbaalenii_PYR-1 DRILLRDD--EASLSSAELLSAATNLAHALVRR-MPVGSVVSFAVPNWHE
Mflv_1784|M.gilvum_PYR-GCK DRVLVRDD--AVALTCAELLSAATGLAHALTRR-MPAGSVVSFTVPNWHE
TH_3067|M.thermoresistible__bu DRTVLVDG--AVRLDCRSLHARATALAGALLRR-IPAGAVVSFMLPNWHE
MSMEG_5631|M.smegmatis_MC2_155 QRVLLIDG--DVRLTCAELHSRAKALAHEMAAR-MPAGSVVSFMLPNWHE
MAV_5212|M.avium_104 ERIALVDN--EVRLNCATLYAQAGELAAALLAR-IPAGSVVSFMLPNWHE
MMAR_0303|M.marinum_M QRVALVDA--DRQLDCQELHRQAMALAQHLRSR-MPAGSVVSFMLPNWHE
MUL_3641|M.ulcerans_Agy99 DRVGVVDAG--ASHTFCELDKLADRVAAGFVSLGIAPGDRVLLQLPNSCR
MLBr_01051|M.leprae_Br4923 SVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTAS
* * * : . * . .
Mb2533c|M.bovis_AF2122/97 WVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADY
Rv2505c|M.tuberculosis_H37Rv WVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADY
MAB_4377c|M.abscessus_ATCC_199 WVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDY
Mvan_4966|M.vanbaalenii_PYR-1 AAVIYLGATLAGMVVNPILPSLRERELSFILADAGSRAIFIPQTFGGHDY
Mflv_1784|M.gilvum_PYR-GCK AAIIYLGATLAGMVVNPILPSLRERELSFILDDADSRMIFVPESFGGHDY
TH_3067|M.thermoresistible__bu AAVIYLGATLAGMVVNPILPSLRDRELRFILDDADSRMIFIPETFGNHDY
MSMEG_5631|M.smegmatis_MC2_155 AAIVYLASTLAGMVINPILPSLRDHELRFILDDAASRMIFIPGEFGQHDY
MAV_5212|M.avium_104 AAVIYLAATLAGMVVNPILPSLRDHDLRFVLEDAGAAMVFVPHRYGGHDY
MMAR_0303|M.marinum_M AAVIYLASTLAAMVANPVLPSLREHELRFILEDAGSRMIFAPADFRGHDY
MUL_3641|M.ulcerans_Agy99 FAVALFGLLRAGAIPVMCLPGHRLAELHHFAEVSGAVGLIVAQHAGGFDY
MLBr_01051|M.leprae_Br4923 TVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPS-----
.: . . . : . : :
Mb2533c|M.bovis_AF2122/97 AAMLAEVGPRCPDLADVILLESDRWD---ALAG--AEPDLPALQQTAARL
Rv2505c|M.tuberculosis_H37Rv AAMLAEVGPRCPDLADVILLESDRWD---ALAG--AEPDLPALQQTAARL
MAB_4377c|M.abscessus_ATCC_199 VAMASQVMPDAPGLRDVVFIGTSDWT---ELVAGAERVTETALRARMSQL
Mvan_4966|M.vanbaalenii_PYR-1 AAMLDRVVAGLPSPPEVVVVRGEP-----RRPALTDLVSEPRDG-TLPDL
Mflv_1784|M.gilvum_PYR-GCK AAMLDRVAPGLPSPPEVVVVRGE------GRVTLADLLAEPADG-VLPAP
TH_3067|M.thermoresistible__bu AAMLDRVTAELPNPPQVVVVRGAVR---PDRVSYDALLSGPVDRPVLPAL
MSMEG_5631|M.smegmatis_MC2_155 AAMLQRVCAHLPTPPQVVVVRGEP-----GPHTAFTALGAPGGD--LPAL
MAV_5212|M.avium_104 PAMLDRVTAAMSAAPQVVVLRGPDTGRTGRHTPYRCMLGGPPGG--LPAL
MMAR_0303|M.marinum_M TSMLRRVAAQLPSRPEVIEVRGQCP---DGVSTFQSLLVGRETAAPLPTA
MUL_3641|M.ulcerans_Agy99 RSMAERLVAAHPQLRHVIIDGESG--------PFLPWSSLSEGATPDIDV
MLBr_01051|M.leprae_Br4923 ---ADSAPDGLPHIPVQLDARSWNR---------------------YPEP
. :
Mb2533c|M.bovis_AF2122/97 DGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIP
Rv2505c|M.tuberculosis_H37Rv DGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIP
MAB_4377c|M.abscessus_ATCC_199 SNTDPINIQYTSGTTGYPKGATLSHRNVLNNGFFVAESIQLQAGDRLCIP
Mvan_4966|M.vanbaalenii_PYR-1 DPAATRMILYTSGTTGRPKGVLHSHKSLGALIAQLGRYWRIDPGDTFLVP
Mflv_1784|M.gilvum_PYR-GCK RPTDTRMILYTSGTTGRPKGVLHTHESLAALIAQLGRFWRIDRGDTFLVP
TH_3067|M.thermoresistible__bu DPDAVRMILYTSGTTGRPKGVLHSHNSIHALIHQLREHWLIDPGDTFLVP
MSMEG_5631|M.smegmatis_MC2_155 DPDSVRMMMHTSGTTGRPKGVLHSHNSIHALICQLRENWMIDPGDTFLVP
MAV_5212|M.avium_104 DPDAVRMILYTSGTTSRPKGVLHTHNSIHALICQIRDHWAIDPGDTFLVP
MMAR_0303|M.marinum_M DPDAVRMVLYTSGTTGRPKGVLHTHNSIHALICQIRDHWMVEPGDGFLVA
MUL_3641|M.ulcerans_Agy99 DTTSPALLLVSGGTTGTPKLIPRTHDDYVYNATASAQLCRLTADDVYLVS
MLBr_01051|M.leprae_Br4923 SPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHG
: :.***. ** :: *
Mb2533c|M.bovis_AF2122/97 VPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGV
Rv2505c|M.tuberculosis_H37Rv VPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGV
MAB_4377c|M.abscessus_ATCC_199 VPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAIERERCVGVYGV
Mvan_4966|M.vanbaalenii_PYR-1 SPIAHIGGSIYAFECPLLLGTQAVLMQR-WDPDAAVALMLRHRCTHMAGA
Mflv_1784|M.gilvum_PYR-GCK SPIAHIGGSIYAFECPLLLGTEAVLMQR-WDPDAAVGLMLEHRVTHMAGA
TH_3067|M.thermoresistible__bu SPIAHIGGSIYAFECPLLAGTTAVLMDR-WRPDEAVRLMRAEHCTHMAGA
MSMEG_5631|M.smegmatis_MC2_155 SPIAHIGGSIYAFECPLLLGTTAVLMQR-WNADDGVALMSEHHCTHMAGA
MAV_5212|M.avium_104 SPLAHIGGSIYAFECPLLLGTTAVLMDR-WDPARAVALMTAHRCTHMAGA
MMAR_0303|M.marinum_M SPIAHIGGSIYAFECPLLLGTTAVLLDR-WDADRAVQLMTSKRCTHMAGA
MUL_3641|M.ulcerans_Agy99 LPAAHNFPLACPGILGSMAVGATIVFSTDPSPEAAFTLIERHGVTVTALV
MLBr_01051|M.leprae_Br4923 LPLFHVHGLVLGLLGSLRIGNRFVHTGK-PTPTAYAQACSEAGGSLYFGV
* * : . .
Mb2533c|M.bovis_AF2122/97 PTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSI
Rv2505c|M.tuberculosis_H37Rv PTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSI
MAB_4377c|M.abscessus_ATCC_199 PTMFIAMLADPGFAHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAI
Mvan_4966|M.vanbaalenii_PYR-1 TPFLDGLLAAAERAGTRLPDLKVFICGGASVPPSLIRRAADYFDKAAVSR
Mflv_1784|M.gilvum_PYR-GCK TPFLVGLLAAAQRAGTRLPDLKVFICGGASVPPTLIRSAAAYFDKAAVSR
TH_3067|M.thermoresistible__bu TPFLDGLLTAARQAGTRLPDLKVFICGGASVSPSLIRSAADYFERAVVTR
MSMEG_5631|M.smegmatis_MC2_155 TPFLDQLLNAAERAGTRLPDLKVFICGGASVPPSLIRRASTCFEKAVVSR
MAV_5212|M.avium_104 TPFLQQLLSAAANAGTRLPDLKVFICGGASVSPSLIRRAAAYFDRAVVTR
MMAR_0303|M.marinum_M TPFLEQLLAAAQRAGTRLPDLKFFVCGGASVSPSLIRCATDYFDKAVVTR
MUL_3641|M.ulcerans_Agy99 PALAKLWTQACDWEPVIPKSLRLLQVGGSRLEPEDARQAREALTPG-LQQ
MLBr_01051|M.leprae_Br4923 PTVWSRLVADEAVARALRPAR--LLVSGSASLPVPVFDRLAHLTGHRPIE
... .*: :
Mb2533c|M.bovis_AF2122/97 CYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPR-
Rv2505c|M.tuberculosis_H37Rv CYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPR-
MAB_4377c|M.abscessus_ATCC_199 AYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEIKIVDPNSGETVQR-
Mvan_4966|M.vanbaalenii_PYR-1 VYGSTEVPVTTVGSLD--DVDRAADTDGRPG-IADVTLVD----------
Mflv_1784|M.gilvum_PYR-GCK VYGSTEVPVTTVGALD--DIDRAADTDGRPG-IAEVRIVD----------
TH_3067|M.thermoresistible__bu VYGSTEVPVTTVGVLGPADADRAAETDGRPG-IAEVRLADHAAAPPGA--
MSMEG_5631|M.smegmatis_MC2_155 VYGSTEVPVTTVGSIEPGDVEHAACTDGRPG-LAEIRLVD----------
MAV_5212|M.avium_104 VYGCTEVPVATVGAPRPQEADYAADTDGRPG-IAEIKLVAHPAAPTGD--
MMAR_0303|M.marinum_M VYGSTEVPVTTIGAPD--SSAHAAATDGRVG-AADVKLVA----------
MUL_3641|M.ulcerans_Agy99 VFGMAEGLLNFTRLED--PPDLLEHTQGRPLCSADELRIVDGAGAPVAP-
MLBr_01051|M.leprae_Br4923 RYGSTESLITLSTLAD---GERRAGWVGLPLAGVQTRLVDESGGPVPYDG
:* :* * :
Mb2533c|M.bovis_AF2122/97 GVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSG----
Rv2505c|M.tuberculosis_H37Rv GVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSG----
MAB_4377c|M.abscessus_ATCC_199 GQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDG----
Mvan_4966|M.vanbaalenii_PYR-1 ---GEIRARGPQMLTGYLHP-EDNSESFDAEGFFRTGDLGHLTDDG----
Mflv_1784|M.gilvum_PYR-GCK ---GEIRARGPQMFTGYLHP-EDDRESFDDAGYFRTGDLGRFTEDN----
TH_3067|M.thermoresistible__bu ---GEVLARGPQMLVGYLHP-EDERDAFDADGFFRTGDLARWVDGD----
MSMEG_5631|M.smegmatis_MC2_155 ---GEIRARGPQMLLGYLHA-EDN--AFDEQGFFRTGDLGRWVDGD----
MAV_5212|M.avium_104 ---GEICVRGPQMLRGYRHP-EDDAESFDAAGFFRTGDLGRWALADSADR
MMAR_0303|M.marinum_M ---GEIRVRGPQMLVGYRHP-EDEAGSFDAQGYFRTGDLGHWVDDE----
MUL_3641|M.ulcerans_Agy99 GAEGELLVRGPYTINGYFCADRDNERCFDPAGFYRSGDLVRLRDDG----
MLBr_01051|M.leprae_Br4923 ETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGG---M
*.. .*. : ** :* *: ::**:
Mb2533c|M.bovis_AF2122/97 YVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEE
Rv2505c|M.tuberculosis_H37Rv YVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEE
MAB_4377c|M.abscessus_ATCC_199 YCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEE
Mvan_4966|M.vanbaalenii_PYR-1 YLVVTGRAKDLIIRNGENISPKEVEDILVTHPQIAEIAIVGIPDLRTGER
Mflv_1784|M.gilvum_PYR-GCK HLVVTGRAKDIIIRNGENISPKEVEDILVTHPRIAEIAVVGIPDPRTGER
TH_3067|M.thermoresistible__bu HLVITGRAKDIIIRNGENISPKEVEDLLIGHPGVAEIAVVGVPDPRTGER
MSMEG_5631|M.smegmatis_MC2_155 YLTVTGRAKDLIIRNGENISPKEIEDILVGELGINEIAVVGLPDERTGER
MAV_5212|M.avium_104 YLVVTGRAKDVIIRSGENISAKEVEDLLADHPGIAEIAVVGLPDERTGER
MMAR_0303|M.marinum_M YLVVTGRAKDIIIRNGENISPKEIEDILITHPGIADVAIVGLPDDRTGER
MUL_3641|M.ulcerans_Agy99 YLQVTGRVKDVICRCGETISAQDLEEQLLSHPAIRSAAAVPLPDPDMGEL
MLBr_01051|M.leprae_Br4923 HRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQR
: : . *:: * * . ::* * . : . : :** *:
Mb2533c|M.bovis_AF2122/97 LMAVVKLR--NDAPELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTG
Rv2505c|M.tuberculosis_H37Rv LMAVVKLR--NDAPELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTG
MAB_4377c|M.abscessus_ATCC_199 LCAWVRMR--PDRVVIDAVAIRAFASGRLAHYKIPRYVHVVESFPMTVTG
Mvan_4966|M.vanbaalenii_PYR-1 ACAVIVAA--DSAAPDVAEIRDFLVARGVAKFKAPERVVVVDALPKNDAG
Mflv_1784|M.gilvum_PYR-GCK ACAALVTT--EDPPPDIAELKDFLTDRGVARFKVPEQIHVVGALPKNDAG
TH_3067|M.thermoresistible__bu ACAAIVPT--GRPGPDVAELREFLLARGVAKFKAPEQVVFFDALPKNDAG
MSMEG_5631|M.smegmatis_MC2_155 ACAVVVTE--DGARPDVSALAEVLTKAGVAKFKIPEQVEIWDALPKNDAG
MAV_5212|M.avium_104 ACAVIVPT--PGASPDVASLLALLVSKGVAKFKAPEQVVLWDALPKNDAG
MMAR_0303|M.marinum_M ACAVIVAA--ADPPPGLPGVRAFLEGAGVARFKIPEQVVIWDHLPKNHAG
MUL_3641|M.ulcerans_Agy99 ICAAIVFAGPPQTPQTLSGLNDYLEQRGVAAHIRIDRLVAMPSLPTTPVG
MLBr_01051|M.leprae_Br4923 IVAFVVGA-----EALDADELINYVAQQLSIHKRPREVRFVDALPRNAMG
* : :: . : :* . *
Mb2533c|M.bovis_AF2122/97 KVRKVEMRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv KVRKVEMRQQALEYLRGQQ-------
MAB_4377c|M.abscessus_ATCC_199 KVRKIEMRQQTIQIFGLPEPGRTDEQ
Mvan_4966|M.vanbaalenii_PYR-1 KVLKHAIRAVLLEKPREGEP------
Mflv_1784|M.gilvum_PYR-GCK KVLKHVLKAELTKES-----------
TH_3067|M.thermoresistible__bu KVLKHQIQATLTAAEVSG--------
MSMEG_5631|M.smegmatis_MC2_155 KVLKHQIRTQLSKVE-----------
MAV_5212|M.avium_104 KVLKHRIRAALSKDG-----------
MMAR_0303|M.marinum_M KIVKHRIKAALMKAEQ----------
MUL_3641|M.ulcerans_Agy99 KIDKKAIASQILTTTAT---------
MLBr_01051|M.leprae_Br4923 KVLKKQLLFEG---------------
*: * :