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PDPGWAARTPEANDLLLTAGTGVGTHLANQTAWTTLGASHHASGVASAINTAATAASWLGVGSAASALNV TMLNATLHGLAGWVDVKPAVVSTAIAAFETANAAMRPAPECMENRDEWGVDNAINPSVLWTLTPRIVSLD VEYFGVMWPNNAAVGATYGGVLAALAESLAIPPPVATMGASPAAPAQAAAAVGQAAAEAAAGDGMRSAYQ GVQAGSTGAGQSTSAGENFGNQLSTFMQPMQAVMQAAPQALQAPSGLMQAPMSAMQPLQSMVGMFANPGA LGMGGAAPGASAASAAGGISAAATEVGAGGGGAALGGGGMPATSFTRPVSAFESGTSGRPVGLRPSGALG ADVVRAPTTTVGGTPIGGMPVGHAAGGHRGSHGKSEQAATVRVVDDRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3892c | PPE69 | - | 100% (399) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1196 | PPE18 | 2e-19 | 26.13% (375) | PPE family protein |
| M. tuberculosis H37Rv | Rv3621c | PPE65 | 1e-18 | 27.54% (403) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3921c | PPE69 | 0.0 | 99.75% (399) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 7e-15 | 25.65% (425) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-10 | 24.26% (408) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 3e-14 | 23.68% (418) | PPE family protein |
| M. marinum M | MMAR_2516 | - | 2e-21 | 28.32% (399) | PPE family protein |
| M. avium 104 | MAV_2924 | - | 3e-21 | 27.65% (405) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 7e-18 | 26.13% (398) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 2e-20 | 26.79% (418) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1701 | - | 2e-22 | 27.82% (399) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 4e-18 | 26.48% (423) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
Rv3892c|M.tuberculosis_H37Rv ------MPDPGWAARTPEANDLLLTAGTGVGTHLANQTAWTTLGASHHAS
Mb3921c|M.bovis_AF2122/97 ------MPDPGWAARTPEANDLLLKAGTGVGTHLANQTAWTTLGASHHAS
MMAR_2516|M.marinum_M ---------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASELSFT
MUL_1701|M.ulcerans_Agy99 ---------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASELSFT
MAV_2924|M.avium_104 ---------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAELNAA
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MAB_2230c|M.abscessus_ATCC_199 ------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQYTTA
: * .** : : *.* . : : * :.
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLSQ-MWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLTS-VWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
TH_4447|M.thermoresistible__bu ADELAGSLAALAG-AWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
Rv3892c|M.tuberculosis_H37Rv GVASAINTAATAA-SWLGVGSAASALNVTMLNATLHGLAGWVDVKPAVVS
Mb3921c|M.bovis_AF2122/97 GVASAINTAATAA-SWLGVGSAASALNVTMLNATLHGLAGWVDVKPAVVS
MMAR_2516|M.marinum_M ADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAEQAAKQAE
MUL_1701|M.ulcerans_Agy99 ADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAERAAKQAE
MAV_2924|M.avium_104 ALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAASQAR
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MAB_2230c|M.abscessus_ATCC_199 ATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNAVLHE
. : * .: : : .
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATN--FLGVNGIPIALNEAD
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATN--FLGVNTVPIAVNEAD
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATN--FLGINTVPIALNEMD
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATN--FLGINTVPIGINEMD
Rv3892c|M.tuberculosis_H37Rv TAIAAFETANAAMRPAPECMENRDEWGVDNAINPSVLWTLTPRIVSLDVE
Mb3921c|M.bovis_AF2122/97 TAIAAFETANAAMRPAPECMENRDEWGVDNAINPSVLWTLTPRIVSLDVE
MMAR_2516|M.marinum_M AAVAAFEAAFTGVVPPPLIASNRMQLMTLMARN--IYGQYTAEIASLEAQ
MUL_1701|M.ulcerans_Agy99 AAVAAFEAAFTGVVPPPLIASNRMQLMTLMARN--IYGQYTAEIASLEAQ
MAV_2924|M.avium_104 AAAAAYEAALAASVPPPLIAANRMQVSQLQATN--VLGQNTPLIAQLEAQ
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSN--IFGQNSTAIAEKEAE
MAB_2230c|M.abscessus_ATCC_199 TSAAAYTTALAAMPTLAELAANHMIHGVLLATN--FFGINTIPIALNEAD
. :: * : *: * . * : :
Mflv_0768|M.gilvum_PYR-GCK Y-IRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSEAAFAGAMS
Mvan_0077|M.vanbaalenii_PYR-1 Y-IRMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFGSTQAAMATAIG
MSMEG_0064|M.smegmatis_MC2_155 YFVRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVGETTAAAALA
TH_4447|M.thermoresistible__bu YFVRMWNQAAGAMDVYQAETAMNILFEPIMPMKPIVIPGVGEAAVAGALG
Rv3892c|M.tuberculosis_H37Rv YFGVMWPNNAAVGATYG--GVLAALAESLAIPPPVATMGASPAAPAQAAA
Mb3921c|M.bovis_AF2122/97 YFGVMWPNNAAVGATYG--GVLAALAESLAIPPPVATMGASPAAPAQAAA
MMAR_2516|M.marinum_M D-AEMWAQDARAMYTYAGSSASATKITAFTPPPETANPAASALQSNATST
MUL_1701|M.ulcerans_Agy99 Y-AEMWAQDARAMYTYAGSSASATKITAFTPPPETANPAASALQSNATST
MAV_2924|M.avium_104 Y-GEYWAQDAAAMYSYAGQSASASKVTPFQKAPQVTNPSGQAAQSAAVST
MLBr_01182|M.leprae_Br4923 Y-TEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEEV
MAB_2230c|M.abscessus_ATCC_199 Y-IRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPGGEMSRMSADM
* : * . *
Mflv_0768|M.gilvum_PYR-GCK GAVPGAGEAVMRNAIIS----------KVSSTAKLDTANQIAGRAEGTLR
Mvan_0077|M.vanbaalenii_PYR-1 SAAPGIASAAARNATFT----------KVSVVGKLDEVNQKAGHAEGLLQ
MSMEG_0064|M.smegmatis_MC2_155 QTAPRVAEGVMRNAVIE----------GVSAIATIESVGLAAGHAAAQAN
TH_4447|M.thermoresistible__bu KAAAMAPAAAARDLVFA----------KVSAQATVESAALQAGRAVAQGN
Rv3892c|M.tuberculosis_H37Rv AVGQAAAEAAAGDGMR-------------SAYQGVQAGSTGAGQSTSAGE
Mb3921c|M.bovis_AF2122/97 AVGQAAAEAAAGDGMR-------------SAYQGVQAGSTGAGQSTSAGE
MMAR_2516|M.marinum_M AAATAAG----------------------AAQSTLAGVISQLPNALTSLT
MUL_1701|M.ulcerans_Agy99 AAATAAG----------------------AAQSTLAGVISQLPNALTSLT
MAV_2924|M.avium_104 ATANSTSTNTTKALQSL----------AQPASSSTTATKAATTAASTTST
MLBr_01182|M.leprae_Br4923 VEEVVEEVVEAEQAISQ----------AALDQAVNEGMEATVVPQVDQQV
MAB_2230c|M.abscessus_ATCC_199 SGMAAQAQAAESGMALDDSESFFDKLMRQIQEFFSDPLGTLQKILQDFMR
Mflv_0768|M.gilvum_PYR-GCK GVVDRAGSHAEKSQG--LEQAP-------QQGMQMGMQMASQLGSTLGQM
Mvan_0077|M.vanbaalenii_PYR-1 QAADSGRSQAEQGQL--LQQAP-------QQGMQMGMQMASQLGSTLGQL
MSMEG_0064|M.smegmatis_MC2_155 FAEQRGQGAAQKGEN-AGQEAGRESGKNMQQGMQMVMQMGSQA----AQA
TH_4447|M.thermoresistible__bu MAAQRAEGTVQKTENLAHQSATRSEPQQLQQGVQMGMQMGSQLGSTLAQL
Rv3892c|M.tuberculosis_H37Rv NFGNQLST--------------------FMQPMQAVMQAAPQA-------
Mb3921c|M.bovis_AF2122/97 NFGNQLST--------------------FMQPMQAVMQAAPQA-------
MMAR_2516|M.marinum_M SPIAS----------------------ALTSAASPATWIDWLVN-----W
MUL_1701|M.ulcerans_Agy99 SPIAS----------------------ALTSAASPATWIDWLVN-----W
MAV_2924|M.avium_104 DPLSEIWF-------------------LLTGQTSLPTNLGTLVN-----G
MLBr_01182|M.leprae_Br4923 NVDVATPQTAVPDSS-------------SAAAPQLWGGFAQHLS-----P
MAB_2230c|M.abscessus_ATCC_199 NPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPLWLPLLLVGLAQL
Mflv_0768|M.gilvum_PYR-GCK PQQMMQGVTQPFQQLTQPLQQMSSLFGGM--MNGDK-GAQIGMVGATPFS
Mvan_0077|M.vanbaalenii_PYR-1 PQQMMQGVTQPFQQLTQPLQQMSSLFGQMGGLGGDR-GAQIGMLGATPFS
MSMEG_0064|M.smegmatis_MC2_155 PAQLASMFQSGVQTMTQPLQQATQMVSQFASMGGSERAMQVGLMGASPFS
TH_4447|M.thermoresistible__bu PQQAGQMISQPMQQLTAPLQQVSSVFGQMGGMGSGD-SAQIGLIGASPFS
Rv3892c|M.tuberculosis_H37Rv -LQAPSGLMQAPMSAMQPLQSMVGMFANPGALGMGG-----AAPGASAAS
Mb3921c|M.bovis_AF2122/97 -LQAPSGLMQAPMSAMQPLQSMVGMFANPGALGMGG-----AAPGASAAS
MMAR_2516|M.marinum_M YLPISQLFYNTVGLPYFAIGIGSSLITSERALGLIG------PEAEAAAA
MUL_1701|M.ulcerans_Agy99 YLPISQLFYNTVGLPYFAIGIGSSLITSERALGLIG------PEAEAAAA
MAV_2924|M.avium_104 YSPFAGLFYNTEGLPYFSTGMANTFTQIAKSVGAIG------GAAPAAAK
MLBr_01182|M.leprae_Br4923 INDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTT-----TKAAESAFK
MAB_2230c|M.abscessus_ATCC_199 VNPVPVEADAPADEPAPQQARVERSSPQQQPFAMGG-MPGGGGAPATPAN
. :.
Mflv_0768|M.gilvum_PYR-GCK NHPAIGGTGPATGSGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPT-SPV
Mvan_0077|M.vanbaalenii_PYR-1 NHPAIGGSGAATGAGLVRAASLPGAGGTAARTPLMSNLVGSGLQPTVSAV
MSMEG_0064|M.smegmatis_MC2_155 NHPMLGGSGPSTGAGLVRAMSLPGAGGTAPRTPLLSNLLG-ISG-EMKAA
TH_4447|M.thermoresistible__bu NHPLAGGSGPATGAGLVRAASLPGLGGTSPTTSLISNLLG-HQNPTAAPA
Rv3892c|M.tuberculosis_H37Rv AAGGISAAATEVGAGGGGAALG---GGGMPATSFTRPVSAFESGTSGRPV
Mb3921c|M.bovis_AF2122/97 AAGGISAAATEVGAGGGGAALG---GGGMPATSFTRPVSAFESGTSGRPV
MMAR_2516|M.marinum_M GAGAAEAAAGAAPAALGGAGPIGAGLGNASALGKLSVPPSWAGSGLDVPP
MUL_1701|M.ulcerans_Agy99 GAGAAEAAAGAAPAALGGAGPIGAGLGNASALGKLSVPPSWPGSGLDVPP
MAV_2924|M.avium_104 ALPGLGGLGGMLGGGAAAAHPVAALGGAGSIGGKLSVPVAWSG--APATP
MLBr_01182|M.leprae_Br4923 AMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTA
MAB_2230c|M.abscessus_ATCC_199 APATPANAPASPAAAAATPAYMVYAVQEDPPAARFGPTLNEGSGAKAPAA
. . .
Mflv_0768|M.gilvum_PYR-GCK AVGAGAGPGAGVGLAPVGT------------------GGGMGAG-GPMGM
Mvan_0077|M.vanbaalenii_PYR-1 AVGAGAGAGAGAGLAPVGA------------------GSGMGGG-GPMGM
MSMEG_0064|M.smegmatis_MC2_155 PAGAGS-AAAG-GLAPVGA------------------GAGGGAG-APVAH
TH_4447|M.thermoresistible__bu PTGAVA-GGAGTGPAPIG---------------------GGGMG-APMAA
Rv3892c|M.tuberculosis_H37Rv GLRPSGALGADVVRAPTTT------------------VGGTPIGGMPVGH
Mb3921c|M.bovis_AF2122/97 GLRPSGALGADVVRAPTTT------------------VGGTPIGGMPVGH
MMAR_2516|M.marinum_M SVSAGGPLASDIVNPPEAS------------------APGSLLGGMPLAG
MUL_1701|M.ulcerans_Agy99 SVSAGGPLASDIVNPPEAS------------------APGSLLGGMPLAG
MAV_2924|M.avium_104 ALGHAIPVSSISAAPEAAG------------------GPGNLLGGMPLAG
MLBr_01182|M.leprae_Br4923 ATRALSPARVAVATESESAP-----------------LLGGGLPMAPMVP
MAB_2230c|M.abscessus_ATCC_199 GISAAAAAAASARSRARRKRGARIKDPAPQFMDMNSPVDPDFSEPATRHT
.
Mflv_0768|M.gilvum_PYR-GCK FGQRGKSGGN-KPGLNAPAPLDHDLGEDEDEEW-----------------
Mvan_0077|M.vanbaalenii_PYR-1 LGQRGKSGGN-KPGLNAPAPLEHDLSEDDDDDW-----------------
MSMEG_0064|M.smegmatis_MC2_155 AGQNSKSGGK-KDGLVAPTPLTYDLSEDEDDEW-----------------
TH_4447|M.thermoresistible__bu MGQNQKSGGS-KSGLKAPAPLVQDLSEDEGDDW-----------------
Rv3892c|M.tuberculosis_H37Rv AAGGHRGSHG-KSEQAATVRVVDDRR------------------------
Mb3921c|M.bovis_AF2122/97 AAGGHRGSHG-KSEQAATVRVVDDRR------------------------
MMAR_2516|M.marinum_M GPGGAAAGAGPRYGFRVTVMARPPFAG-----------------------
MUL_1701|M.ulcerans_Agy99 GPGGAAAGAGPRYGFRVTVMARPPFAG-----------------------
MAV_2924|M.avium_104 AGAGGHGAAGPKYGFRPTVMARPPFAG-----------------------
MLBr_01182|M.leprae_Br4923 GGGSGTGGVNTALRLQPRAFVMPRNPAAG---------------------
MAB_2230c|M.abscessus_ATCC_199 AGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIEREAASEMDGTRTVPMLP
.
Mflv_0768|M.gilvum_PYR-GCK ---------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 ---------------------------------
MSMEG_0064|M.smegmatis_MC2_155 ---------------------------------
TH_4447|M.thermoresistible__bu ---------------------------------
Rv3892c|M.tuberculosis_H37Rv ---------------------------------
Mb3921c|M.bovis_AF2122/97 ---------------------------------
MMAR_2516|M.marinum_M ---------------------------------
MUL_1701|M.ulcerans_Agy99 ---------------------------------
MAV_2924|M.avium_104 ---------------------------------
MLBr_01182|M.leprae_Br4923 ---------------------------------
MAB_2230c|M.abscessus_ATCC_199 TSWGTDPEPDPDRAPSVPAPDEDWPPGERGAST