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DFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASELSFTADGYERVIKALSGEEWFGPASAMMLEAITP YVTWMRSTAVQAERAAKQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLEAQYA EMWAQDARAMYTYAGSSASATKITAFTPPPETANPAASALQSNATSTAAATAAGAAQSTLAGVISQLPNA LTSLTSPIASALTSAASPATWIDWLVNWYLPISQLFYNTVGLPYFAIGIGSSLITSERALGLIGPEAEAA AAGAGAAEAAAGAAPAALGGAGPIGAGLGNASALGKLSVPPSWPGSGLDVPPSVSAGGPLASDIVNPPEA SAPGSLLGGMPLAGGPGGAAAGAGPRYGFRVTVMARPPFAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1701 | - | - | 100% (392) | PPE family protein |
| M. ulcerans Agy99 | MUL_5078 | - | e-106 | 49.74% (392) | PPE family protein |
| M. ulcerans Agy99 | MUL_3087 | - | 3e-95 | 47.83% (414) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1731c | PPE22 | 1e-150 | 67.68% (393) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 4e-27 | 28.43% (394) | PPE protein |
| M. tuberculosis H37Rv | Rv1705c | PPE22 | 1e-149 | 67.43% (393) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-47 | 32.94% (419) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-25 | 25.75% (400) | PPE family protein |
| M. marinum M | MMAR_2516 | - | 0.0 | 99.23% (392) | PPE family protein |
| M. avium 104 | MAV_2924 | - | 3e-98 | 48.80% (416) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-30 | 29.48% (424) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 8e-30 | 29.12% (419) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-28 | 28.71% (418) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1701|M.ulcerans_Agy99 ---------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASELSFT
MMAR_2516|M.marinum_M ---------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASELSFT
Mb1731c|M.bovis_AF2122/97 ---------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVA
Rv1705c|M.tuberculosis_H37Rv ---------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVA
MAV_2924|M.avium_104 ---------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAELNAA
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MSMEG_0619|M.smegmatis_MC2_155 ------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEYAAA
Mvan_0415|M.vanbaalenii_PYR-1 ------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAEYAAA
MAB_4783|M.abscessus_ATCC_1997 ------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTEYSSA
TH_3113|M.thermoresistible__bu ------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAA
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
* .** :: : *.*. .: ** * :: .
MUL_1701|M.ulcerans_Agy99 ADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAERAAKQAE
MMAR_2516|M.marinum_M ADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAEQAAKQAE
Mb1731c|M.bovis_AF2122/97 AVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAASQAR
Rv1705c|M.tuberculosis_H37Rv AVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAASQAR
MAV_2924|M.avium_104 ALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAASQAR
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MSMEG_0619|M.smegmatis_MC2_155 AAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAAVQHE
Mvan_0415|M.vanbaalenii_PYR-1 AAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAAAQHE
MAB_4783|M.abscessus_ATCC_1997 ANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVAAQTE
TH_3113|M.thermoresistible__bu AVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLE
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQN-WQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
* : : * .: * *: : . . *
MUL_1701|M.ulcerans_Agy99 AAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLEAQYA
MMAR_2516|M.marinum_M AAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLEAQDA
Mb1731c|M.bovis_AF2122/97 AAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQYA
Rv1705c|M.tuberculosis_H37Rv AAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQYA
MAV_2924|M.avium_104 AAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLEAQYG
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYT
MSMEG_0619|M.smegmatis_MC2_155 TAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNEADYV
Mvan_0415|M.vanbaalenii_PYR-1 AAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTEADYV
MAB_4783|M.abscessus_ATCC_1997 TAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNEADYI
TH_3113|M.thermoresistible__bu AAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADYA
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADYI
. . : * : : *: * *. * ** **:
MUL_1701|M.ulcerans_Agy99 EMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPA--ASALQSNATST
MMAR_2516|M.marinum_M EMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPA--ASALQSNATST
Mb1731c|M.bovis_AF2122/97 EMWAQDAMAMYGYAGSSATAT-KVTPFAPPPNTTSPS--AAATQLSAVAK
Rv1705c|M.tuberculosis_H37Rv EMWAQDAMAMYGYAGSSATAT-KVTPFAPPPNTTSPS--AAATQLSAVAK
MAV_2924|M.avium_104 EYWAQDAAAMYSYAGQSASAS-KVTPFQKAPQVTNPS--GQAAQSAAVST
MLBr_01182|M.leprae_Br4923 EMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEEVVEE
MSMEG_0619|M.smegmatis_MC2_155 RMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASASVQQ
Mvan_0415|M.vanbaalenii_PYR-1 RMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAADVTA
MAB_4783|M.abscessus_ATCC_1997 RMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART------
TH_3113|M.thermoresistible__bu RMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAITGAH
Mflv_0768|M.gilvum_PYR-GCK RMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSEAAFAGAMSGAV
. * * * .* * *
MUL_1701|M.ulcerans_Agy99 AAATAAG---------------------------------AAQSTLAGVI
MMAR_2516|M.marinum_M AAATAAG---------------------------------AAQSTLAGVI
Mb1731c|M.bovis_AF2122/97 AAGTSAG---------------------------------AAQSAIAELI
Rv1705c|M.tuberculosis_H37Rv AAGTSAG---------------------------------AAQSAIAELI
MAV_2924|M.avium_104 ATANSTSTNTTKALQ---------------------SLAQPASSSTTATK
MLBr_01182|M.leprae_Br4923 VVEEVVEAEQAISQA---------------------ALDQAVNEGMEATV
MSMEG_0619|M.smegmatis_MC2_155 MSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPLGNLG
Mvan_0415|M.vanbaalenii_PYR-1 FAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTI
MAB_4783|M.abscessus_ATCC_1997 -AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPVGTIV
TH_3113|M.thermoresistible__bu VTAELRAAESRTLLDEINELIDRLFAP-LFPPGFADALPDGL---LGTLL
Mflv_0768|M.gilvum_PYR-GCK PGAGEAVMRNAIISKVSS------------------TAKLDTANQIAGRA
MUL_1701|M.ulcerans_Agy99 SQLPNALTSLTSPIAS---ALTSAASPAT--WIDWLVNWYLPIS---QLF
MMAR_2516|M.marinum_M SQLPNALTSLTSPIAS---ALTSAASPAT--WIDWLVNWYLPIS---QLF
Mb1731c|M.bovis_AF2122/97 AHLPNTLLGLTSPLSS---ALTAAATPG---WLEWFINWYLPIS---QLF
Rv1705c|M.tuberculosis_H37Rv AHLPNTLLGLTSPLSS---ALTAAATPG---WLEWFINWYLPIS---QLF
MAV_2924|M.avium_104 AATTAASTTSTDPLSEIWFLLTGQTSLPT--NLGTLVNGYSPFA---GLF
MLBr_01182|M.leprae_Br4923 VPQVDQQVNVDVATPQTAVPDSSSAAAPQ--LWGGFAQHLSPINDTLSMI
MSMEG_0619|M.smegmatis_MC2_155 RLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPA
Mvan_0415|M.vanbaalenii_PYR-1 KLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLLLLPL
MAB_4783|M.abscessus_ATCC_1997 RIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAIMGPA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGVVHTT
Mflv_0768|M.gilvum_PYR-GCK EGTLRGVVDRAGSHAEKSQGLEQAPQQG--MQMGMQMASQLGSTLGQMPQ
.
MUL_1701|M.ulcerans_Agy99 YNTVGLPYFAIGIGSSLITSERALG-LIGPEAEAAAAG----AGAAEAAA
MMAR_2516|M.marinum_M YNTVGLPYFAIGIGSSLITSERALG-LIGPEAEAAAAG----AGAAEAAA
Mb1731c|M.bovis_AF2122/97 YNTVGLPYFAIGIGNSLITSWRALG-WIGPEAAEAAA----------AAP
Rv1705c|M.tuberculosis_H37Rv YNTVGLPYFAIGIGNSLITSWRALG-WIGPEAAEAAA----------AAP
MAV_2924|M.avium_104 YNTEGLPYFSTGMANTFTQIAKSVG-AIGGAAPAAAKA----LPGLGGLG
MLBr_01182|M.leprae_Br4923 NNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKA----MGSAVQST
MSMEG_0619|M.smegmatis_MC2_155 LAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP-LAV
Mvan_0415|M.vanbaalenii_PYR-1 VATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQPSPAI
MAB_4783|M.abscessus_ATCC_1997 AGISIPLAITLAS---LSQMPEAPPVDAPAETVPARI------DQP-HAV
TH_3113|M.thermoresistible__bu VAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSG-----LAGLAGLT
Mflv_0768|M.gilvum_PYR-GCK QMMQGVTQPFQQLTQPLQQMSSLFGGMMNGDKGAQIGMVGATPFSNHPAI
:
MUL_1701|M.ulcerans_Agy99 GAAPAALGGAGPIGAGLGNASALG-KLSVPPSWPGSGLDVPPSV-SAGGP
MMAR_2516|M.marinum_M GAAPAALGGAGPIGAGLGNASALG-KLSVPPSWAGSGLDVPPSV-SAGGP
Mb1731c|M.bovis_AF2122/97 AAVGAAVGGTGPVSAGLGNAATIG-KLSVPPNWAGASPSLAPTVGSASAP
Rv1705c|M.tuberculosis_H37Rv AAVGAAVGGTGPVSAGLGNAATIG-KLSLPPNWAGASPSLAPTVGSASAP
MAV_2924|M.avium_104 GMLGGGAAAAHPVAA-LGGAGSIGGKLSVPVAWSG--APATPALGHAIP-
MLBr_01182|M.leprae_Br4923 GRGLLGSSSGGHVTAQLGRAASIG-SLRVPQTWTTASQPVTAATRALSPA
MSMEG_0619|M.smegmatis_MC2_155 GISPAGVPGSAATAAAPAPAPAGTTVAAPAP----AAATFVPYAVANRDP
Mvan_0415|M.vanbaalenii_PYR-1 AVSAPPPPSSAAATVGTVATGTAPAPGAPAA----ATASFVPYAVAGRDP
MAB_4783|M.abscessus_ATCC_1997 AMGGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGP
TH_3113|M.thermoresistible__bu AVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPP
Mflv_0768|M.gilvum_PYR-GCK GGTGPATGSGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPTSPVAVGAGA
. :
MUL_1701|M.ulcerans_Agy99 LASDIVNPPEAS-APGSLLGG-MPLAGGPGGAAAGAGPRYGFRVTVMARP
MMAR_2516|M.marinum_M LASDIVNPPEAS-APGSLLGG-MPLAGGPGGAAAGAGPRYGFRVTVMARP
Mb1731c|M.bovis_AF2122/97 LVSDIVEQPEAG-AAGNLLGG-MPLAG-SGTGTGGAGPRYGFRVTVMSRP
Rv1705c|M.tuberculosis_H37Rv LVSDIVEQPEAG-AAGNLLGG-MPLAG-SGTGTGGAGPRYGFRVTVMSRP
MAV_2924|M.avium_104 -VSSISAAPEAAGGPGNLLGG-MPLAGAGAGGHGAAGPKYGFRPTVMARP
MLBr_01182|M.leprae_Br4923 RVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRN
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MAB_4783|M.abscessus_ATCC_1997 GFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRG
TH_3113|M.thermoresistible__bu PAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPA
Mflv_0768|M.gilvum_PYR-GCK GPGAGVGLAPVGTGGGMGAGGPMGMFGQRGKSGGNKPGLNAPAPLDHDLG
. . .
MUL_1701|M.ulcerans_Agy99 PFAG----------------------------------------------
MMAR_2516|M.marinum_M PFAG----------------------------------------------
Mb1731c|M.bovis_AF2122/97 PFAG----------------------------------------------
Rv1705c|M.tuberculosis_H37Rv PFAG----------------------------------------------
MAV_2924|M.avium_104 PFAG----------------------------------------------
MLBr_01182|M.leprae_Br4923 PAAG----------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYE-EPDEDPAPQPEPRVRASE-RGSDAMGFTGTVTR-HDVTAA
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATE-RGAGPMGFAGTVSR-DAAQAG
MAB_4783|M.abscessus_ATCC_1997 YRHEYATMD---DHTPTGPQDPVTAVASGTGAGRLGFAGVHTATTAVEAT
TH_3113|M.thermoresistible__bu GSAAAAAAA---RESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAA
Mflv_0768|M.gilvum_PYR-GCK EDEDEEW-------------------------------------------
MUL_1701|M.ulcerans_Agy99 -----------------------------------------------
MMAR_2516|M.marinum_M -----------------------------------------------
Mb1731c|M.bovis_AF2122/97 -----------------------------------------------
Rv1705c|M.tuberculosis_H37Rv -----------------------------------------------
MAV_2924|M.avium_104 -----------------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 GLTTLTGDT-----FDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR
Mvan_0415|M.vanbaalenii_PYR-1 GLTTLPGDP-----FGGGPKAPMLPGTWDPDTEPDERHNHHDGKDSQ
MAB_4783|M.abscessus_ATCC_1997 GLSTLDGD-------AENRTIPMLPGTWDVTDDDR------------
TH_3113|M.thermoresistible__bu GIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN--
Mflv_0768|M.gilvum_PYR-GCK -----------------------------------------------