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MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASDLFSAASAFQSVVWGLTVGSWIGSSAGLMVAAA SPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAE YGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGGLLEQAAAVEEASDTAAANQLMNNVPQALQQ LAQPTQGTTPSSKLGGLWKTVSPHRSPISNMVSMANNHMSMTNSGVSMTNTLSSMLKGFAPAAAAQAVQT AAQNGVRAMSSLGSSLGSSGLGGGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAERG PGQMLGGLPVGQMGARAGGGLSGVLRVPPRPYVMPHSPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1196 | PPE18 | - | 100% (391) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1361c | PPE19 | 0.0 | 84.89% (397) | PPE family protein |
| M. tuberculosis H37Rv | Rv3478 | PPE60 | e-176 | 81.27% (395) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1228 | PPE18 | 0.0 | 98.98% (391) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-30 | 36.79% (212) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-76 | 41.53% (419) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 3e-31 | 36.10% (205) | PPE-family protein |
| M. marinum M | MMAR_4240 | - | 1e-121 | 56.82% (396) | PPE family protein, PPE18 |
| M. avium 104 | MAV_2924 | - | 8e-77 | 41.97% (417) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-30 | 35.00% (220) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 4e-32 | 40.72% (194) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0947 | - | 1e-120 | 56.57% (396) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 9e-33 | 38.21% (212) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
Rv1196|M.tuberculosis_H37Rv ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
Mb1228|M.bovis_AF2122/97 ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
MMAR_4240|M.marinum_M -------------MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVD
MUL_0947|M.ulcerans_Agy99 -------------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVD
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MAV_2924|M.avium_104 -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
: : .** :* : *.*...::.*. * :. :
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
Rv1196|M.tuberculosis_H37Rv LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
Mb1228|M.bovis_AF2122/97 LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
MMAR_4240|M.marinum_M LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATRAELAA
MUL_0947|M.ulcerans_Agy99 LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
MAV_2924|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
:* . : : : * :: ** *: : . *
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
Rv1196|M.tuberculosis_H37Rv AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
Mb1228|M.bovis_AF2122/97 AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
MMAR_4240|M.marinum_M NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MUL_0947|M.ulcerans_Agy99 NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MAV_2924|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
: :* ** :* . : *: * :*.:* *: ** *
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGV--------
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGV--------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGV--------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGV--------
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG---------
Rv1196|M.tuberculosis_H37Rv AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG--------
Mb1228|M.bovis_AF2122/97 AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG--------
MMAR_4240|M.marinum_M AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG--------
MUL_0947|M.ulcerans_Agy99 AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG--------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
MAV_2924|M.avium_104 AQYGEYWAQDAAAMYSYAG-QSASASKVTPFQKAPQVTNPSG--------
*:* . * * *::* * . .*
MSMEG_0619|M.smegmatis_MC2_155 --GEAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-
TH_3569|M.thermoresistible__bu --SEAADAMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFG
Mflv_0325|M.gilvum_PYR-GCK --GEAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFE
Mvan_0415|M.vanbaalenii_PYR-1 --GEAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFE
MAB_0669|M.abscessus_ATCC_1997 --GEARSDQSDVPGSPDQ---------------IMKMLQGFQQWFEKMG-
Rv1196|M.tuberculosis_H37Rv ----LLEQAAAVEEASDTAAANQLMNN------VPQALQQL--AQPT-QG
Mb1228|M.bovis_AF2122/97 ----LLEQAAAVEEASDTAAANQLMNN------VPQALQQL--AQPT-QG
MMAR_4240|M.marinum_M ----LVNQTAAVGQAIDSAAAGQLMSN------VPQALQQL--AAPAPQG
MUL_0947|M.ulcerans_Agy99 ----LVKQTAAVGQAIDSAAAGQLMSN------VPQALQQL--AATAPQG
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
MAV_2924|M.avium_104 ----QAAQSAAVSTATANSTSTNTTKALQS---LAQPASSSTTATKAATT
: .
MSMEG_0619|M.smegmatis_MC2_155 AILDFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWP
TH_3569|M.thermoresistible__bu PIVDFLRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWP
Mflv_0325|M.gilvum_PYR-GCK PIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 PIFDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASI
MAB_0669|M.abscessus_ATCC_1997 -FNPATSAVLAVIMLFLYDLLWYPY-----YASYLLPFLIPALSGLSG-L
Rv1196|M.tuberculosis_H37Rv TTP---SSKLGGLWKTVSP--HRSPISNMVSMANNHMSMT-----NSGVS
Mb1228|M.bovis_AF2122/97 TTP---SSKLGGLWKTVSP--HLSPISNMVSMANNHVSMT-----NSGVS
MMAR_4240|M.marinum_M AST---ATAPKSLLQSVTSSFSLSNLSTIVGMENTHLSMA-----NSGAS
MUL_0947|M.ulcerans_Agy99 AST---ATAPKSLLQSVTSSFSSSNLSTIVGMENTHLSMA-----NSGAS
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQ--HLSPINDTLSMINNHAGMA-----NAGLS
MAV_2924|M.avium_104 AASTTSTDPLSEIWFLLTG--QTSLPTNLGTLVNGYSPFAGLFYNTEGLP
. . .
MSMEG_0619|M.smegmatis_MC2_155 TWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAA
TH_3569|M.thermoresistible__bu TWAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAA
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPS
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPT
MAB_0669|M.abscessus_ATCC_1997 AALMHLRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPS
Rv1196|M.tuberculosis_H37Rv MTNT-LSSMLKGFAPAAAAQAVQTAAQNGVRAMSSLGSSLGSSGLGGGVA
Mb1228|M.bovis_AF2122/97 MTNT-LSSMLKGFAP-AAAQAVETAAQNGVRAMSSLGSSLGSSGLGGGVA
MMAR_4240|M.marinum_M IFKT-MGDSVKGFIP-SASKAAETAVEHAARNAVSMVGGGGPAGIGGWAP
MUL_0947|M.ulcerans_Agy99 ILKT-MGDSVKGFIP-SASKAAETAVEHAARNAVSMVGGGGPAGIGGWAP
MLBr_01182|M.leprae_Br4923 LVNG-MGSAMKSLAP-TTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVT
MAV_2924|M.avium_104 YFSTGMANTFTQIAKSVGAIGGAAPAAAKALPGLGGLGGMLGGGAAAAHP
: . .
MSMEG_0619|M.smegmatis_MC2_155 PRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAV
TH_3569|M.thermoresistible__bu P-------------------VRAEPQNPLPLTXXX---------------
Mflv_0325|M.gilvum_PYR-GCK RPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVV
Mvan_0415|M.vanbaalenii_PYR-1 RADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAV
MAB_0669|M.abscessus_ATCC_1997 GG---------------SSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLV
Rv1196|M.tuberculosis_H37Rv AN-----------LGRAASVG-SLSVPQAWAAANQAVTPAARALPLTSLT
Mb1228|M.bovis_AF2122/97 AN-----------LGRAASVG-SLSVPQAWAAANQAVTPAARALPLTSLT
MMAR_4240|M.marinum_M QGG----------VGQALSVG-GLKVPQAWAEANQSVVPAARALPISPVT
MUL_0947|M.ulcerans_Agy99 QGG----------VGQALSVG-GLKVPQAWAEANQAVVPAARALPISPVT
MLBr_01182|M.leprae_Br4923 AQ-----------LGRAASIG-SLRVPQTWTTASQPVTAATRALSPARVA
MAV_2924|M.avium_104 VAA----------LGGAGSIGGKLSVPVAWSGA-PATPALGHAIPVSSIS
MSMEG_0619|M.smegmatis_MC2_155 ANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQ
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEE
Mvan_0415|M.vanbaalenii_PYR-1 AGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDE
MAB_0669|M.abscessus_ATCC_1997 P---PGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKNKAE
Rv1196|M.tuberculosis_H37Rv SAAERGPGQ--MLGG-LPVGQMGARAGGGLSGV---LRVPPRPYVMPHSP
Mb1228|M.bovis_AF2122/97 SAAERGPGQ--MLGG-LPVGQMGARAGGGLSGV---LRVPPRPYVMPHSP
MMAR_4240|M.marinum_M GAVEGAHGA--PLPG-MPFGQLAGNGGNGVSGV---LRVTPKAYVMPRPP
MUL_0947|M.ulcerans_Agy99 GAVEGAHGA--PLPG-MPFGQLAGNGGNGVSGV---LRVTPKAYVMPRPP
MLBr_01182|M.leprae_Br4923 VATESESAP--LLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNP
MAV_2924|M.avium_104 AAPEAAGGPGNLLGG-MPLAGAG-AGGHGAAGP----KYGFRPTVMARPP
MSMEG_0619|M.smegmatis_MC2_155 IEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDV
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK IKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDE
Mvan_0415|M.vanbaalenii_PYR-1 IAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAA
MAB_0669|M.abscessus_ATCC_1997 AGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAGTAPAAAS
Rv1196|M.tuberculosis_H37Rv AAG-----------------------------------------------
Mb1228|M.bovis_AF2122/97 AAG-----------------------------------------------
MMAR_4240|M.marinum_M AAG-----------------------------------------------
MUL_0947|M.ulcerans_Agy99 AAG-----------------------------------------------
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
MAV_2924|M.avium_104 FAG-----------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 TAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR-----
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK QAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 QAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MAB_0669|M.abscessus_ATCC_1997 THVAATVRLS-SDEARQVIPMLPSTWDADGGDQN----------------
Rv1196|M.tuberculosis_H37Rv --------------------------------------------------
Mb1228|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4240|M.marinum_M --------------------------------------------------
MUL_0947|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAV_2924|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 -
TH_3569|M.thermoresistible__bu -
Mflv_0325|M.gilvum_PYR-GCK P
Mvan_0415|M.vanbaalenii_PYR-1 Q
MAB_0669|M.abscessus_ATCC_1997 -
Rv1196|M.tuberculosis_H37Rv -
Mb1228|M.bovis_AF2122/97 -
MMAR_4240|M.marinum_M -
MUL_0947|M.ulcerans_Agy99 -
MLBr_01182|M.leprae_Br4923 -
MAV_2924|M.avium_104 -