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LDFAQLPPEVNSALMYAGPGSGPMLAAAAAWEALAAELQTTASTYDALITGLADGPWQGSSAASMVAAAT PQVAWLRSTAGQAEQAGSQAVAAASAYEAAFFATVPPPEIAANRALLMALLATNFLGQNTAAIAATEAQY AEMWAQDAAAMYGYAGASAAATQLSPFNPAAQTINPAGLASQAASVGQAVSGAANAQALTDIPKALFGLS GIFTNEPPWLTDLGKALGLTGHTWSSDGSGLIVGGVLGDFVQGVTGSAELDASVAMDTFGKWVSPARLMV TQFKDYFGLAHDLPKWASEGAKAAGEAAKALPAAVPAIPSAGLSGVAGAVGQAASVGGLKVPAVWTATTP AASPAVLAASNGLGAAAAAEGSTHAFGGMPLMGSGAGRAFNNFAAPRYGFKPTVIAQPPAGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3621c | PPE65 | - | 100% (413) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 6e-85 | 46.32% (421) | PPE family protein |
| M. tuberculosis H37Rv | Rv1039c | PPE15 | 3e-80 | 44.63% (410) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 7e-85 | 46.56% (421) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 5e-32 | 39.90% (203) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-45 | 32.34% (436) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 3e-33 | 30.79% (406) | PPE family protein |
| M. marinum M | MMAR_5121 | - | 1e-171 | 73.73% (415) | PPE family protein |
| M. avium 104 | MAV_0535 | - | 1e-119 | 56.43% (420) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 9e-34 | 29.06% (437) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 5e-36 | 32.39% (426) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4195 | - | 1e-108 | 50.71% (420) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-36 | 32.18% (435) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3621c|M.tuberculosis_H37Rv ------------MLDFAQLPPEVNSALMYAGPGSGPMLAAAAAWEALAAE
MMAR_5121|M.marinum_M ------------MLDFAQLPPEVNSALMYSGPGSGPMLTAAAAWDVLAAE
MAV_0535|M.avium_104 -------MLNFGQLDFAQLPPEINSGLMYSGPGAGPLLAAAAAWNGLAAE
MUL_4195|M.ulcerans_Agy99 ------------MLDFALLPPKVNSTLMYSGPGSGSMLAAAAAWQALGAE
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.*: :* : *.*...: :*. * *. :
Rv3621c|M.tuberculosis_H37Rv LQTTASTYDALITGLADGPWQGSSAASMVAAATPQVAWLRSTAGQAEQAG
MMAR_5121|M.marinum_M LQATASTYDALVTELTDGPWQGPSAANMVAAAMPQVEWLRNTAALAEQAG
MAV_0535|M.avium_104 LRSAAASFGSVITGVGDAGWQGPAASSMMAAAAPQLAWLSGTAGRAELAA
MUL_4195|M.ulcerans_Agy99 LQCTADSYRSLLSGLVSGPWSGPAAAAMSAAAAPHLAWLSATAAQAEQVG
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : * .: * *: : . .
Rv3621c|M.tuberculosis_H37Rv SQAVAAASAYEAAFFATVPPPEIAANRALLMALLATNFLGQNTAAIAATE
MMAR_5121|M.marinum_M SQAVAAAGAYEAAFVATVPPPVIAANRALLMALMATNFLGQNTGAIAATE
MAV_0535|M.avium_104 GQALAAVSAYETAFAETVPPPVIAANRALLLQLLATNFLGQNTPAIADVE
MUL_4195|M.ulcerans_Agy99 RQAAAAASAYEAAFAGMVPPAVVAANRAMLATLVATNLFGQNTPAIAVVE
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.:. *: :*: . : *: *: :*.:* *: .** *
Rv3621c|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYAGASAAATQLSPFNPAAQTINPAGLASQAASVG
MMAR_5121|M.marinum_M AQYGEMWAQDAAAMYGYAGSSAAAAQLAPFDPAAQTVSAAGLANQAAAVG
MAV_0535|M.avium_104 AQYGEMWAQDAAAMYGYALASAAASTLPPFEPAKPATDPAGLARQAAATA
MUL_4195|M.ulcerans_Agy99 AEYAKMWAQDANAMYQYAATAAAAADLTSFVPPRPATTANGPAAQAAAVG
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAATQLTPFTEPVQTTNASGLAAQSAAIA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSRMSA
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* .** * * :* * * .
Rv3621c|M.tuberculosis_H37Rv QAVS-GAAN-AQALTDIP-------------------------KALF-GL
MMAR_5121|M.marinum_M QALN-GAVD-SQALAEIP-------------------------KALS-QL
MAV_0535|M.avium_104 QAAGTGAGDSAQGLGAAP-------------------------QSMS-TL
MUL_4195|M.ulcerans_Agy99 RATGDLLAGDAQSLQQLV-------------------------EQLPNAL
Mb1836|M.bovis_AF2122/97 HATGASAGAQQTTLSQLI-------------------------AAIPSVL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQ-------------------------AALDQAV
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_2230c|M.abscessus_ATCC_199 DMSGMAAQAQAAESGMALDDSESFFDKLMR----------QIQEFFSDPL
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGLL
:
Rv3621c|M.tuberculosis_H37Rv SGIFT-NEPPWLTDLGKALGLTGHTWSSDGSG------------------
MMAR_5121|M.marinum_M AGIS--NEPPWLTDLTGAIGLTGHAWNSNGDG------------------
MAV_0535|M.avium_104 AAGT--NNPPAAN---PGFSLGGISLNPEGDG------------------
MUL_4195|M.ulcerans_Agy99 RGLSEAALVPSLERILRALGLIGWKWTPNGDG------------------
Mb1836|M.bovis_AF2122/97 QGLSSSTAATSASGPSGLLGILGSGSSWLDKL------------------
MLBr_01182|M.leprae_Br4923 NEGMEATVVPQVDQQVNVDVATPQTAVPDSSS------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_2230c|M.abscessus_ATCC_199 GTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPL
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP----------AYLFPVLV
.
Rv3621c|M.tuberculosis_H37Rv -----------LIVGGVLGDFVQGVTGSAELDASVAMDTFGKWVSPARLM
MMAR_5121|M.marinum_M -----------IIVGGALGDIVQGVTGSAEVDAGVFMDTFSKWVSPARLA
MAV_0535|M.avium_104 -----------LVIGGPLGDLLEGLTGSQTLDASTPFDAFIRLISPTRLF
MUL_4195|M.ulcerans_Agy99 -----------IVLSGALGALIAGPTGSSTLDASTLSNTYIRLVSPFRLT
Mb1836|M.bovis_AF2122/97 -----------WALLDPNSNFWNTIASSGLFLPSNTIAPFLGLLG-----
MLBr_01182|M.leprae_Br4923 -----------AAAPQLWGGFAQHLS--PINDTLSMINNHAGMANAG---
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_2230c|M.abscessus_ATCC_199 WLPLLLVG---------LAQLVNPVPV-EADAPADEPAPQQARVERSSPQ
TH_3113|M.thermoresistible__bu YLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLA
:
Rv3621c|M.tuberculosis_H37Rv VTQFKDYFGLAH-DLPKWASEGAKAAGEAAKALPAAVP-----------A
MMAR_5121|M.marinum_M VTQFKDYVGLAH-DLPKFAQEGAKAAAEAAKELPAVLP-----------S
MAV_0535|M.avium_104 TTSFKDIQGIAQGMMPAAKSAGEGVAKAAEAVLPAAVPG---------AG
MUL_4195|M.ulcerans_Agy99 TTALKDIDGLSHSLFPAAAHAGQEAA-KAVEALPQALPK---------LS
Mb1836|M.bovis_AF2122/97 --------GVAA-ADAAGDVLGEATSGGLGGALVAPLG-----------S
MLBr_01182|M.leprae_Br4923 -LSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGR---------GL
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGR
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGR
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANR
MAB_2230c|M.abscessus_ATCC_199 QQPFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQED
TH_3113|M.thermoresistible__bu GLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPTG---SAAPTTGT
. .
Rv3621c|M.tuberculosis_H37Rv IPSAG-LSGVAGAVGQAASVGGLKVPAVWTATTPAASPAVLAASN-GLGA
MMAR_5121|M.marinum_M LPGVG-LGGITGAVGKAASVTGLSVPTSWMNSVGAAANPAIVTVN-SLG-
MAV_0535|M.avium_104 LGSLGSLGSIGGSVGKAASIGGLSVPASWASAAPTP-PSVAVALN-GATT
MUL_4195|M.ulcerans_Agy99 LSGVS--SGLGG-IGRAAQIGGLSVPNAWASSMPGLGRVATVPLSSVAAA
Mb1836|M.bovis_AF2122/97 AGGLG--GTVAAGLGNAATVGTLSVPPSWTAAAPLASPLGSALGG-----
MLBr_01182|M.leprae_Br4923 LGSSS-GGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAV
Mflv_0325|M.gilvum_PYR-GCK DPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKG
Mvan_0415|M.vanbaalenii_PYR-1 DPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAG
MSMEG_0619|M.smegmatis_MC2_155 DPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEE
MAB_2230c|M.abscessus_ATCC_199 PPAARFGPTLNEGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDPA
TH_3113|M.thermoresistible__bu APGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPG-VARRSAGA
* .
Rv3621c|M.tuberculosis_H37Rv AAAAEGSTHAFGGMPLMG-S-GAGRAFN-NFAAPRYGFKPTVIAQPP---
MMAR_5121|M.marinum_M AAAAEPAQAAVGGVPLMPAS-GVGRGMAAHFAAPRYGFKPTMVVHPP---
MAV_0535|M.avium_104 AGAAEHAASAVGGVPMMPAG-AAGRGAGAHFVVPRYGFKPTVIAQPP---
MUL_4195|M.ulcerans_Agy99 AAAADPSQHVFGGLPAHG---TPARGFAASAAPPRYGFHPRVMTRPP---
Mb1836|M.bovis_AF2122/97 TPMVAPPPAVAAGMPGMP-F-GTMGGQGFGRAVPQYGFRPNFVARPP---
MLBr_01182|M.leprae_Br4923 ATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNP---
Mflv_0325|M.gilvum_PYR-GCK RGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQ
Mvan_0415|M.vanbaalenii_PYR-1 RAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQ
MSMEG_0619|M.smegmatis_MC2_155 RGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VT
MAB_2230c|M.abscessus_ATCC_199 PQFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTS
TH_3113|M.thermoresistible__bu RRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPAS-MS
Rv3621c|M.tuberculosis_H37Rv AGG-----------------------------------------------
MMAR_5121|M.marinum_M AGG-----------------------------------------------
MAV_0535|M.avium_104 AGG-----------------------------------------------
MUL_4195|M.ulcerans_Agy99 AAG-----------------------------------------------
Mb1836|M.bovis_AF2122/97 AAG-----------------------------------------------
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AGGLTT-LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 AGGLTT-LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MSMEG_0619|M.smegmatis_MC2_155 AAGLTT-LTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPR
MAB_2230c|M.abscessus_ATCC_199 AAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPG
TH_3113|M.thermoresistible__bu AATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPA
*.
Rv3621c|M.tuberculosis_H37Rv ------
MMAR_5121|M.marinum_M ------
MAV_0535|M.avium_104 ------
MUL_4195|M.ulcerans_Agy99 ------
Mb1836|M.bovis_AF2122/97 ------
MLBr_01182|M.leprae_Br4923 ------
Mflv_0325|M.gilvum_PYR-GCK P-----
Mvan_0415|M.vanbaalenii_PYR-1 Q-----
MSMEG_0619|M.smegmatis_MC2_155 R-----
MAB_2230c|M.abscessus_ATCC_199 ERGAST
TH_3113|M.thermoresistible__bu EPN---