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TTAYASALAAMPTLTELAANHTSHAVLLGTNFFGINTIPIALNEADYARMWIQAATTMSIYEGTSDAALA SAPQTTPAPVLFNGGAGVASALPAISAATLDPASIIGIIIEILIQLFLISLEILFAIVAYTIIIVLILPL VIFAYAIVFAVLAIIFGPPLLVIASPFVLTGSVIAVPTSLSTSLSTAVPIGVGQYLADLASADAQAIEVG LKTADVAPVAVRPAAAPPLRESAAVRPEARLVSAVAPAPAGTSASVLASDRGAGVLGFAGTAGKESVGRP AGLTTLAGGEFGGSPSVPMVPASWEQLVGAGEAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3738c | PPE66 | - | 100% (315) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3021c | PPE47 | 8e-62 | 44.96% (347) | PPE family protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 1e-59 | 45.43% (339) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 6e-62 | 44.99% (349) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 7e-40 | 34.31% (411) | PPE protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 1e-28 | 32.64% (337) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 2e-33 | 32.91% (398) | PPE family protein |
| M. marinum M | MMAR_3006 | - | 3e-82 | 54.28% (304) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 2e-44 | 35.36% (379) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 7e-39 | 32.27% (409) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-30 | 34.59% (292) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0492 | - | 9e-50 | 39.04% (333) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-40 | 32.28% (412) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVT---SPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MS---SPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MT---APIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
MAB_2230c|M.abscessus_ATCC_199 ----------MS---APIWMASPPEVHSALLSAGPGPGALLAAAAQWQAL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
Rv3738c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3006|M.marinum_M -------------------MAAPPEVHAASLSTGPGPGPLQNAAAAWASL
Mb3047c|M.bovis_AF2122/97 ----------MT---APVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
MLBr_00539|M.leprae_Br4923 -----------M---TNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWL
MUL_0492|M.ulcerans_Agy99 ----------MT---AIMWMASPPEVHSGLLSSGPGAGPMLASAAAWKSL
TH_3113|M.thermoresistible__bu -------------------MALPPEVHSTLLRTGPGPGALSAAADAWRML
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
MAB_2230c|M.abscessus_ATCC_199 SVQYTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
Rv3738c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3006|M.marinum_M SAEYASVAEELAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYA
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
MLBr_00539|M.leprae_Br4923 SAEYRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYM
MUL_0492|M.ulcerans_Agy99 SGEYASAAAELAGLVGAVP-QVWWGPAEQSYAAANERYLAWLTQVSADYA
TH_3113|M.thermoresistible__bu SDEYRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
MAB_2230c|M.abscessus_ATCC_199 TNAVLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
Rv3738c|M.tuberculosis_H37Rv --------MTTAYASALAAMPTLTELAANHTSHAVLLGTNFFGINTIPIA
MMAR_3006|M.marinum_M VMAAEHEAAAAEYVAALAAMPTLAELAINHAAHAVLLGTNFFGINTIPIA
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
MLBr_00539|M.leprae_Br4923 DVATQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIA
MUL_0492|M.ulcerans_Agy99 RQATLVDVVVAAYGAAVAAMPSLVELAANHTVHAVLSATNFFGVNTIPIA
TH_3113|M.thermoresistible__bu AAGAQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIA
.: : *: **: **: *: :..* .***:*:******
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGV-----
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGV-----
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGV-----
MAB_2230c|M.abscessus_ATCC_199 LNEADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG------
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG------
Rv3738c|M.tuberculosis_H37Rv LNEADYARMWIQAATTMSIYEGTSDAALASAPQTTPAPVLFNGG------
MMAR_3006|M.marinum_M LNEADYARMWVQAATVMSVYEAGSTAALAAAPRGVPAPVVLKAG------
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPG------
MLBr_00539|M.leprae_Br4923 LNEEEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDV
MUL_0492|M.ulcerans_Agy99 VNEMDYVRMWVQAAAVMGTYQMITQGELLAAPNIAPAPWILVL-------
TH_3113|M.thermoresistible__bu VNEADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTG----
:.* :* :**::**:.*. *. . : :.. ..* :.
Mflv_0325|M.gilvum_PYR-GCK --------GEAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEV
Mvan_0415|M.vanbaalenii_PYR-1 --------GEAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGEL
MSMEG_0619|M.smegmatis_MC2_155 --------GEAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQG
MAB_2230c|M.abscessus_ATCC_199 --------GEMSRMSADMSGMAAQAQAAESGMALDDS----------ESF
MAV_4867|M.avium_104 --------GEANNLAAN----AAQNSSGD--------------------W
Rv3738c|M.tuberculosis_H37Rv -----------AGVASALPAISAATLDPAS-------------------I
MMAR_3006|M.marinum_M -----------AAEGVSAAALPAAAAELP---------------------
Mb3047c|M.bovis_AF2122/97 -----------ANEASNAVAAATITPFPFG-------------------E
MLBr_00539|M.leprae_Br4923 EKDSRHDGHSHGGHASAMDRVFADILRNVSGGRLVWD-----------PL
MUL_0492|M.ulcerans_Agy99 -----------GGEAAAVVGLAASAAAAT-------------------PP
TH_3113|M.thermoresistible__bu ---------ESATAAITGAHVTAELRAAESR-----------------TL
. :
Mflv_0325|M.gilvum_PYR-GCK LRFLFEPIFNFLRDPIGN--------------------TFALITDFLTNP
Mvan_0415|M.vanbaalenii_PYR-1 LRFLFEPIFDFLRDPLGN--------------------TIKLITDFLTNP
MSMEG_0619|M.smegmatis_MC2_155 VPGG-QAILDFLKDPLGN--------------------LGRLLTDFMTNP
MAB_2230c|M.abscessus_ATCC_199 FDKLMRQIQEFFSDPLGT--------------------LQKILQDFMRNP
MAV_4867|M.avium_104 WQNFIQQLSQFFQN------------------------IQKMLQDFWANL
Rv3738c|M.tuberculosis_H37Rv IGIIIEILIQLFLISL-----------------------EILF-AIVAYT
MMAR_3006|M.marinum_M --IIIVILIQIILVLL-----------------------EILY-AIVAYT
Mb3047c|M.bovis_AF2122/97 LAKFLEMAAQAFTEVG-----------------------ELIMKSAEAWA
MLBr_00539|M.leprae_Br4923 NGTLNGLDYDDYVYPGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFL
MUL_0492|M.ulcerans_Agy99 LAALIALIVAAIETPS-----IAT--------------VLAALVAIVAFP
TH_3113|M.thermoresistible__bu LDEINELIDRLFAPLFPPG-------------------FADALPDGLLGT
Mflv_0325|M.gilvum_PYR-GCK VQALITWGPFLLAVVYQA------VSWVGASILYPSLFLLPLLATT--LA
Mvan_0415|M.vanbaalenii_PYR-1 AQALITWGPFLAAVAYQA------VSWVGASILYPSLLLLPLVATT--LA
MSMEG_0619|M.smegmatis_MC2_155 AGALATWWPFLFGVAYQVFFNL--VGWPTWGMIFASPFLIPALAALGITG
MAB_2230c|M.abscessus_ATCC_199 LEALVAWGPLLFFIAYEAFFIP--FGFTFWGVMLSAPLWLP---------
MAV_4867|M.avium_104 PAFLAANGPLLFFVAYQVFFNA--VGWPTWGAILTAPFLLP---------
Rv3738c|M.tuberculosis_H37Rv I-IIVLILPLVIFAYAIVFA--------VLAIIFGPPLLVIA-------S
MMAR_3006|M.marinum_M I-ILSIILPIIVVVEAFVLS--------VVAVILGTPILLVS-------S
Mb3047c|M.bovis_AF2122/97 VGFVELITGLVNFEPWLVLTGMIDMFFATVGFALGVFVLVPL-------L
MLBr_00539|M.leprae_Br4923 LYIVVLDLPTHIVQLGTWLAE----YPQLLLVALGGTIANLG-------A
MUL_0492|M.ulcerans_Agy99 VQAVVFFFSTLLGQFFSWIP----------VISLSYAQIIIG-------Y
TH_3113|M.thermoresistible__bu LLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTG---VVH
Mflv_0325|M.gilvum_PYR-GCK IVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPP
Mvan_0415|M.vanbaalenii_PYR-1 IVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPP
MSMEG_0619|M.smegmatis_MC2_155 LVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP-LAVGISPAGVP
MAB_2230c|M.abscessus_ATCC_199 LLL-VGLAQLVNPVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMPGG
MAV_4867|M.avium_104 LLLGIGLSSLLAAP--AEIAPVAAPAAITPVLASNKPPTLPAAVALAPSV
Rv3738c|M.tuberculosis_H37Rv PFVLTGSVIAVPTSLSTS-LSTAVPIGVGQYLADLASADAQAIE---VGL
MMAR_3006|M.marinum_M PFLLTGSLIGLTAGVPVS-LATALPIGIPAYLADQSRRDELN------DT
Mb3047c|M.bovis_AF2122/97 EFAVVLELAILSIGWIISNIFGAIPVLAGPLLGALAAAVVPGVAGVTGLA
MLBr_00539|M.leprae_Br4923 VTGLAGLSSGLSAGPSAA-IPTVVPESAPIATVPAMLAGAGVAP----AV
MUL_0492|M.ulcerans_Agy99 FVGFLAAAPVLTSGAEIA-VPVSVPLGVGRHLYDVQMANADVAE----VE
TH_3113|M.thermoresistible__bu TTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVP
Mflv_0325|M.gilvum_PYR-GCK SGAPIAANTVSAGSPPAPGAPAAAAAT------FVPYVVAGRDPYEGFSP
Mvan_0415|M.vanbaalenii_PYR-1 SSAAATVGTVATGTAPAPGAPAAATAS------FVPYAVAGRDPGTGFSP
MSMEG_0619|M.smegmatis_MC2_155 GSAATAAAPAPAPAGTTVAAPAPAAAT------FVPYAVANRDPGEGFTP
MAB_2230c|M.abscessus_ATCC_199 GGAPATPANAPATPANAPASPAAAAATPA----YMVYAVQEDPPAARFGP
MAV_4867|M.avium_104 ATPAGAPASTVAAGSGAAAAPGPAAAAGN----FAYLVAFGGDPDTGVGP
Rv3738c|M.tuberculosis_H37Rv KTADVAPVAVRPAAAPPLRESAAVR-------------------------
MMAR_3006|M.marinum_M DQEHVVFVGARAGMAPLLTASTAPA-------------------------
Mb3047c|M.bovis_AF2122/97 GLAAVPAVGAAAGAPAALVGSVAPVSGGV---------------------
MLBr_00539|M.leprae_Br4923 VAPGASPSSAAPPASAASAAAAAPAPPGTGFGGFSPYLVDGRGPGVGFGS
MUL_0492|M.ulcerans_Agy99 RVAERSRE-----VLVSAHHAIAPQP------------------------
TH_3113|M.thermoresistible__bu AADGGASAAPVPAGGPSLPSGSSAPPAPTG----SAAPTTGTAPGGAGSP
.
Mflv_0325|M.gilvum_PYR-GCK TVRDSTGAKAPAGTIPAAASGIAASAAERRKRR--RRQKEEIKGRGYADA
Mvan_0415|M.vanbaalenii_PYR-1 TVRDSTSAKAPASGIPAAASGVAASAAERRKRR--RRQKDEIAGRAYADA
MSMEG_0619|M.smegmatis_MC2_155 TLGNKSQVAAPASGVPAAASGVAASLASRRKRR--RKKGAQIEERGYADA
MAB_2230c|M.abscessus_ATCC_199 TLNEGSGAKAPAAGISAAAAAAAS-ARSRARRK--RGARIKDPAPQFMDM
MAV_4867|M.avium_104 TLSGRGGAKAPAATIPAAGAAAPARAEARARRR--RRAALHDYSDEFLDM
Rv3738c|M.tuberculosis_H37Rv ----------PEARLVSAVAPAPAGTSAS---------------------
MMAR_3006|M.marinum_M ----------PAAGLASAGSAVPASNSVS---------------------
Mb3047c|M.bovis_AF2122/97 --------VSPQARLVSAVEPAPASTSVS---------------------
MLBr_00539|M.leprae_Br4923 GRQSAYANKVSESVSDSAVAEAAAQASAREQARAWRRRSAAKERGYREEV
MUL_0492|M.ulcerans_Agy99 ---------LSDSVSTVASVDVPAVAPS----------------------
TH_3113|M.thermoresistible__bu PPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPG---VARRSAGARRAASI
. . . .
Mflv_0325|M.gilvum_PYR-GCK YADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSR-GDEQAGG--LT
Mvan_0415|M.vanbaalenii_PYR-1 YADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSR-DAAQAGG--LT
MSMEG_0619|M.smegmatis_MC2_155 YMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTR-HDVTAAG--LT
MAB_2230c|M.abscessus_ATCC_199 NSPVDPDFSEP-ATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIE
MAV_4867|M.avium_104 DSGFGVPPDYG-AEEELAAAVASGQGAGTLGFAGTQQRRKAFQAAG--LT
Rv3738c|M.tuberculosis_H37Rv -------------------VLASDRGAGVLGFAGTAGKESVGRPAG--LT
MMAR_3006|M.marinum_M -------------------TVASERGADMSSFAGTSTKGSVGQPAG--LT
Mb3047c|M.bovis_AF2122/97 -------------------VLASDRGAGALGFVGTAGKESVGQPAG--LT
MLBr_00539|M.leprae_Br4923 ITMNTGFDAAIPSPVDQTGSRVSDCGAGSFGFAGTVSKEAVVEVAG--LT
MUL_0492|M.ulcerans_Agy99 -----------------------DQGAGPWGFVSTASKGIVAQPSG--LT
TH_3113|M.thermoresistible__bu VEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAAT-APS
. .. : .
Mflv_0325|M.gilvum_PYR-GCK TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-----
Mvan_0415|M.vanbaalenii_PYR-1 TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-----
MSMEG_0619|M.smegmatis_MC2_155 TLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPRR-----
MAB_2230c|M.abscessus_ATCC_199 REAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGERGAST
MAV_4867|M.avium_104 KLADDDFGGSPRMPMVPGTWEQDTQNG-------AHPTE---PGKGG---
Rv3738c|M.tuberculosis_H37Rv TLAGGEFGGSPSVPMVPASW-EQLVGA-------GEAG------------
MMAR_3006|M.marinum_M ALGGSEFEGGSREPMLPATWGPALVGV-------AN--------------
Mb3047c|M.bovis_AF2122/97 VLAD-EFGDGAPVPMLPGSWGPDLVGV-------AGDGGLVSV-------
MLBr_00539|M.leprae_Br4923 TLAGDDFGGGPTMPMVPGTWAPARESS-------DEGR------------
MUL_0492|M.ulcerans_Agy99 TLAGAEVGDGPAMPMLPATWGPALATV-------AG--------------
TH_3113|M.thermoresistible__bu AAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN---
. . . :