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VGAASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEADYVRMWV QAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPFGELAKFLEMAAQAFTEVGE LIMKSAEAWAVGFVELITGLVNFEPWLVLTGMIDMFFATVGFALGVFVLVPLLEFAVVLELAILSIGWII SNIFGAIPVLGGPLLGALAAAVVPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLV SAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLADEFGDGAPVPMLPGSWGPDLVGVAG DGGLVSV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3021c | PPE47 | - | 100% (358) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | e-148 | 77.68% (354) | PPE family protein |
| M. tuberculosis H37Rv | Rv3738c | PPE66 | 1e-61 | 44.96% (347) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 0.0 | 98.59% (354) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-37 | 38.98% (295) | PPE protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 1e-30 | 31.45% (372) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 1e-37 | 29.83% (409) | PPE family protein |
| M. marinum M | MMAR_3006 | - | 2e-58 | 42.28% (369) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 3e-50 | 36.79% (405) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-44 | 34.35% (428) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-40 | 43.65% (252) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 2e-53 | 37.14% (420) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-48 | 34.57% (431) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
Rv3021c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
MMAR_3006|M.marinum_M ----------------MAAPPEVHAASLSTGPGPGPLQNAAAAWASLSAE
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
Rv3021c|M.tuberculosis_H37Rv -------------MVGA------------------------ASADSAAAA
Mb3047c|M.bovis_AF2122/97 YAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
MMAR_3006|M.marinum_M YASVAEELAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYAVMA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
. *. * *
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
Rv3021c|M.tuberculosis_H37Rv GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
Mb3047c|M.bovis_AF2122/97 GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
MMAR_3006|M.marinum_M AEHEAAAAEYVAALAAMPTLAELAINHAAHAVLLGTNFFGINTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
. :. *. * :** ***: ** *: * .*: ***:*:*:**** .*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGG-EANNLAA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
Rv3021c|M.tuberculosis_H37Rv ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
Mb3047c|M.bovis_AF2122/97 ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
MMAR_3006|M.marinum_M ADYARMWVQAATVMSVYEAGSTAALAAAPRGVPAPVVLKAGAAEG---VS
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
** ***::** *. *: : ::* ..* :: .. .
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQ-AGAAFDV-----------------------------
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAE-AGSALDL-----------------------------
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAE-SGSSLDL-----------------------------
TH_3569|M.thermoresistible__bu TTQQIGSQATAAD-SGTALNL-----------------------------
MAB_4783|M.abscessus_ATCC_1997 -------QDATKP-PPIVPDP-----------------------------
MAV_4867|M.avium_104 NAAQNSSG-------DWWQNF-----------------------------
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSDPWQLL-----------------------------
Rv3021c|M.tuberculosis_H37Rv AATITPFPFGELA-------------------------------------
Mb3047c|M.bovis_AF2122/97 AATITPFPFGELA-------------------------------------
MMAR_3006|M.marinum_M AAALP---------------------------------------------
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
Mflv_0325|M.gilvum_PYR-GCK ----SNIIADIIRLYGEVLRFLFEPIFNFLRDPIGNTFALITDFLTNPVQ
Mvan_0415|M.vanbaalenii_PYR-1 ----SNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTIKLITDFLTNPAQ
MSMEG_0619|M.smegmatis_MC2_155 ----SSIISDLLNQYLQGVPGGQ-AILDFLKDPLGNLGRLLTDFMTNPAG
TH_3569|M.thermoresistible__bu ----SDLIANLLQYYQDYLDQLFGPIVDFLRDPIGNLFQLIDDFLTNPAG
MAB_4783|M.abscessus_ATCC_1997 ----NDPIEMLLKNSQHFL-GMYRALKGLITDPVGTIVRIIIDFSTNPAA
MAV_4867|M.avium_104 ----IQQLS------------------QFFQN----IQKMLQDFWANLPA
MUL_1208|M.ulcerans_Agy99 ----WQLLQYLWNAYTGFNTWMFDLIWEFLQDPIGNTIKIIIAFLTNPLQ
Rv3021c|M.tuberculosis_H37Rv -----------------KFLEMAAQAFTEVGELIMKSAEAWAVGFVELIT
Mb3047c|M.bovis_AF2122/97 -----------------KFLEMAAQAFTEVGELIMKSAEAWAVGFVELIT
MMAR_3006|M.marinum_M ------------------------AAAAELPIIIVILIQIILV-LLEILY
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
. :
Mflv_0325|M.gilvum_PYR-GCK ALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVGQHLL
Mvan_0415|M.vanbaalenii_PYR-1 ALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVGAYLL
MSMEG_0619|M.smegmatis_MC2_155 ALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITGLVLL
TH_3569|M.thermoresistible__bu ALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAGLVMI
MAB_4783|M.abscessus_ATCC_1997 AIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP---AAGISIPLAITLASL
MAV_4867|M.avium_104 FLAANGPLLFFVAYQVFFNAVGWPTWGAILTAP---FLLPLLLGIGLSSL
MUL_1208|M.ulcerans_Agy99 AIITYGPLLFALSYQIFFNLVGWPTWALILSSP---FLLPAALGLALSAI
Rv3021c|M.tuberculosis_H37Rv GLVNFEPWLVLTGMIDMFFATVGFALGVFVLVPLLEFAVVLELAILSIGW
Mb3047c|M.bovis_AF2122/97 GLVNFEPWLVLTGMIDMFFATVGFALGVFVLVPLLEFAVVLELAILSIGW
MMAR_3006|M.marinum_M AIVAYT--IILSIILPIIVVVEAFVLSVVAVI-LGTPILLVSSPFLLTGS
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
:
Mflv_0325|M.gilvum_PYR-GCK SLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANT
Mvan_0415|M.vanbaalenii_PYR-1 ENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGT
MSMEG_0619|M.smegmatis_MC2_155 IDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAP
TH_3569|M.thermoresistible__bu ADQAQP-----PAEEAAPEEDVAAP-------------------VRAEPQ
MAB_4783|M.abscessus_ATCC_1997 SQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSP
MAV_4867|M.avium_104 LAAPAEIAPVAAPAAITPVLASNKPPTLPAAVALAPSVATPAGAPASTVA
MUL_1208|M.ulcerans_Agy99 AFTPIQIAAEVPAAAAPLAAAAVTAKSVFPAASLASPGTGSAGAPASGAG
Rv3021c|M.tuberculosis_H37Rv IISNIFGAIPVLGGPLLGALAAAVVP----------------GVAGLAGV
Mb3047c|M.bovis_AF2122/97 IISNIFGAIPVLAGPLLGALAAAVVP----------------GVAGVTGL
MMAR_3006|M.marinum_M LIGLTAGVPVSLATALPIGIPAYLADQ---------------SRRDELND
MLBr_01828|M.leprae_Br4923 LTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSM
Mflv_0325|M.gilvum_PYR-GCK VSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGT-
Mvan_0415|M.vanbaalenii_PYR-1 VATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASG-
MSMEG_0619|M.smegmatis_MC2_155 APAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASG-
TH_3569|M.thermoresistible__bu NPLPLTXXX-----------------------------------------
MAB_4783|M.abscessus_ATCC_1997 ATPGSAPAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPS-
MAV_4867|M.avium_104 AGSGAAAAPGP-AAAAGNFAYLVAFGGDPDTGVGPTLSGRGGAKAPAAT-
MUL_1208|M.ulcerans_Agy99 AGAPGTAPPGPGAPAPASFLYAVGGSGDWGPSLGPTVGGRSGAKAPAVT-
Rv3021c|M.tuberculosis_H37Rv AGLAALPAVGAAAGAPAALV-------------GSVAPVSGGVVSPQAR-
Mb3047c|M.bovis_AF2122/97 AGLAAVPAVGAAAGAPAALV-------------GSVAPVSGGVVSPQAR-
MMAR_3006|M.marinum_M TDQEHVVFVGARAGMAPLLT-------------ASTAP------APAAG-
MLBr_01828|M.leprae_Br4923 PTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGYLVG
Mflv_0325|M.gilvum_PYR-GCK -IPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEEL-------P
Mvan_0415|M.vanbaalenii_PYR-1 -IPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPE-------P
MSMEG_0619|M.smegmatis_MC2_155 -VPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE--------P
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 -SAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATMDDH-------T
MAV_4867|M.avium_104 -IPAAGAAAPARAEARARRRRR----AALHDYSDEFLDMDSGF----GVP
MUL_1208|M.ulcerans_Agy99 -IPAAGAAAASRASARSRRRRR----TEMRDYGDEFLDMDAN-----GVT
Rv3021c|M.tuberculosis_H37Rv -LVSAVEPAPASTS------------------------------------
Mb3047c|M.bovis_AF2122/97 -LVSAVEPAPASTS------------------------------------
MMAR_3006|M.marinum_M -LASAGSAVPASNS------------------------------------
MLBr_01828|M.leprae_Br4923 RLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKVTPF
Mflv_0325|M.gilvum_PYR-GCK DDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGG
Mvan_0415|M.vanbaalenii_PYR-1 DDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGG
MSMEG_0619|M.smegmatis_MC2_155 DEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 PTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--
MAV_4867|M.avium_104 PDYGAEEELAAAVASGQGAGTLGFAGTQQRRKAFQAAGLTKLADDDFGGS
MUL_1208|M.ulcerans_Agy99 ---GPAATDDAARASERGAGQFGFAGTVSTEAVLQAAGLTELAVDEFGNG
Rv3021c|M.tuberculosis_H37Rv ---------VSVLASDRGAGALGFVGTAGKESVGQPAGLTVLAD-EFGDG
Mb3047c|M.bovis_AF2122/97 ---------VSVLASDRGAGALGFVGTAGKESVGQPAGLTVLAD-EFGDG
MMAR_3006|M.marinum_M ---------VSTVASERGADMSSFAGTSTKGSVGQPAGLTALGGSEFEGG
MLBr_01828|M.leprae_Br4923 DSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATGLVTLSNGTFSDS
Mflv_0325|M.gilvum_PYR-GCK PREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 PKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 PVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------------------------------
MAB_4783|M.abscessus_ATCC_1997 RTIPMLPGTWDVTDDDR------------------
MAV_4867|M.avium_104 PRMPMVPGTWEQDTQNG--------AHPTEPGKGG
MUL_1208|M.ulcerans_Agy99 PRMPMVPGSWDSPQEGR--------EDGLQSE---
Rv3021c|M.tuberculosis_H37Rv APVPMLPGSWGPDLVGVAG------DGGLVSV---
Mb3047c|M.bovis_AF2122/97 APVPMLPGSWGPDLVGVAG------DGGLVSV---
MMAR_3006|M.marinum_M SREPMLPATWGPALVGVAN----------------
MLBr_01828|M.leprae_Br4923 PRAPMLPRTWGADPTFCYNAADIGPAGGWDDE---