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AAPPEVHAASLSTGPGPGPLQNAAAAWASLSAEYASVAEELAGVLGGVQAQAWQGPSAASYVAAHLPYAA WLTKASADYAVMAAEHEAAAAEYVAALAAMPTLAELAINHAAHAVLLGTNFFGINTIPIALNEADYARMW VQAATVMSVYEAGSTAALAAAPRGVPAPVVLKAGAAEGVSAAALPAAAAELPIIIVILIQIILVLLEILY AIVAYTIILSIILPIIVVVEAFVLSVVAVILGTPILLVSSPFLLTGSLIGLTAGVPVSLATALPIGIPAY LADQSRRDELNDTDQEHVVFVGARAGMAPLLTASTAPAPAAGLASAGSAVPASNSVSTVASERGADMSSF AGTSTKGSVGQPAGLTALGGSEFEGGSREPMLPATWGPALVGVAN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3006 | - | - | 100% (396) | PPE family protein |
| M. marinum M | MMAR_3005 | - | e-175 | 79.40% (398) | PPE family protein |
| M. marinum M | MMAR_0787 | - | 2e-98 | 51.52% (396) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3043c | PPE46 | 2e-88 | 46.15% (442) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-64 | 41.89% (370) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 7e-88 | 46.17% (444) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 9e-55 | 36.27% (408) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 4e-62 | 39.02% (410) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 4e-74 | 40.38% (473) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-65 | 41.71% (398) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 8e-62 | 44.44% (306) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2247 | - | 9e-90 | 90.66% (182) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-70 | 37.96% (511) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3006|M.marinum_M -------------------MAAPPEVHAASLSTGPGPGPLQNAAAAWASL
MUL_2247|M.ulcerans_Agy99 -------------MTAAFWMAVPPEVHSALLSAGPGPGPLQEAATAWASL
Mb3043c|M.bovis_AF2122/97 ----------MSSHRTPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv -------------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_2230c|M.abscessus_ATCC_199 ----------MSA---PIWMASPPEVHSALLSAGPGPGALLAAAAQWQAL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
:* *****:: ** ***.*.: *. * :*
MMAR_3006|M.marinum_M SAEYASVAEELAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYA
MUL_2247|M.ulcerans_Agy99 SVEYASVAEDLAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYA
Mb3043c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_2230c|M.abscessus_ATCC_199 SVQYTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
* *: * :* :: . *:* :: :. :: ** ** : *. *
MMAR_3006|M.marinum_M VMAAEHEAAAAEYVAALAAMPTLAELAINHAAHAVLLGTNFFGINTIPIA
MUL_2247|M.ulcerans_Agy99 VMAAEQEVVAAEYVAALAAMPTLAELAGNHATHAVLLGTNFFGINTIPIA
Mb3043c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_2230c|M.abscessus_ATCC_199 TNAVLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* :. *: * :** ***:.**: *: * **: ***:********
MMAR_3006|M.marinum_M LNEADYARMWVQAATVMSVYEAGSTAALAAAPRGVPAPVVLKAGAAEGVS
MUL_2247|M.ulcerans_Agy99 LNEADYARMWVQAATVMSVYQAGSTAALAAAPRGMPAPVVLKAGAAEGD-
Mb3043c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_2230c|M.abscessus_ATCC_199 LNEADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSR
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEAN-
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* ** ***::** *..*: .: :.. .** :: .. *
MMAR_3006|M.marinum_M AAALPAAA------------------------------------------
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
Mb3043c|M.bovis_AF2122/97 AVAAATITPFPWH-------------------------------------
Rv3018c|M.tuberculosis_H37Rv AVAAATITPFPWH-------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLF--------
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLF--------
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ--------
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLF--------
MAB_2230c|M.abscessus_ATCC_199 MSADMSGMAAQAQAAESGMALDDS----------ESFFDKLM--------
MAV_4867|M.avium_104 ------NLAANAAQNSSG-----------------DWWQNFI--------
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
MMAR_3006|M.marinum_M ------------------------------------------------AE
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
Mb3043c|M.bovis_AF2122/97 ----------------------------------EIVQFLEETFAAYDQY
Rv3018c|M.tuberculosis_H37Rv ----------------------------------EIVQFLEETFAAYDQY
Mflv_0325|M.gilvum_PYR-GCK ---------------------------------EPIFNFLRDPIGNTFAL
Mvan_0415|M.vanbaalenii_PYR-1 ---------------------------------EPIFDFLRDPLGNTIKL
MSMEG_0619|M.smegmatis_MC2_155 ----------------------------------AILDFLKDPLGNLGRL
TH_3569|M.thermoresistible__bu ---------------------------------GPIVDFLRDPIGNLFQL
MAB_2230c|M.abscessus_ATCC_199 ---------------------------------RQIQEFFSDPLGTLQKI
MAV_4867|M.avium_104 ---------------------------------QQLSQFFQN----IQKM
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
MMAR_3006|M.marinum_M LPIIIVILIQIILVLLEILYAIVAYTIILSIILPIIVVVEAFVLSVV--A
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
Mb3043c|M.bovis_AF2122/97 LSALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAIN--A
Rv3018c|M.tuberculosis_H37Rv LSALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAIN--A
Mflv_0325|M.gilvum_PYR-GCK ITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLA
Mvan_0415|M.vanbaalenii_PYR-1 ITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLA
MSMEG_0619|M.smegmatis_MC2_155 LTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALA
TH_3569|M.thermoresistible__bu IDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAI
MAB_2230c|M.abscessus_ATCC_199 LQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPLWLP---
MAV_4867|M.avium_104 LQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAPFLLP---
MLBr_01828|M.leprae_Br4923 LAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMI
MMAR_3006|M.marinum_M VILGTPILLVSS------PFLLTGSLIGLTAGVPVSLATALPIGIPAYLA
MUL_2247|M.ulcerans_Agy99 -----------------------GAVVGGVN-------------------
Mb3043c|M.bovis_AF2122/97 SYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVA
Rv3018c|M.tuberculosis_H37Rv SYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVA
Mflv_0325|M.gilvum_PYR-GCK IVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPP
Mvan_0415|M.vanbaalenii_PYR-1 IVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPP
MSMEG_0619|M.smegmatis_MC2_155 ALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGV
TH_3569|M.thermoresistible__bu TLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------------
MAB_2230c|M.abscessus_ATCC_199 -LLLVGLAQLVN-PVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMPG
MAV_4867|M.avium_104 LLLGIGLSSLLAAPAE---IAPVAAPAAITPVLASNKPPTLPAAVALAPS
MLBr_01828|M.leprae_Br4923 LPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVP
MMAR_3006|M.marinum_M DQSRRDELNDTDQEHVVFVGARAGMAPL---------------LTASTAP
MUL_2247|M.ulcerans_Agy99 ---------------------RAGAG------------------------
Mb3043c|M.bovis_AF2122/97 GLAG-----VAGLAAVPAVGAAAGAPAA---------------LVGSVAP
Rv3018c|M.tuberculosis_H37Rv GLAG-----VAGLAALPAVGAAAGAPAA---------------LVGSVAP
Mflv_0325|M.gilvum_PYR-GCK PSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGRDPYEGFSPTVR
Mvan_0415|M.vanbaalenii_PYR-1 PSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGRDPGTGFSPTVR
MSMEG_0619|M.smegmatis_MC2_155 PGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANRDPGEGFTPTLG
TH_3569|M.thermoresistible__bu ----VRAEPQNPLPLTXXX-------------------------------
MAB_2230c|M.abscessus_ATCC_199 GGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQEDPPAARFGPTLN
MAV_4867|M.avium_104 VATPAGAPASTVAAGSGAAAAPGPAAAAGNFAYLVAFGGDPDTGVGPTLS
MLBr_01828|M.leprae_Br4923 PSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGY
MMAR_3006|M.marinum_M A------PAAGLASAGSAVPASNS--------------------------
MUL_2247|M.ulcerans_Agy99 -------GGTGLGWIG----------------------------------
Mb3043c|M.bovis_AF2122/97 VSGGVVSPQARLVSAVEPAPASTS--------------------------
Rv3018c|M.tuberculosis_H37Rv VSGGVVSPQARLVSAVEPAPASTS--------------------------
Mflv_0325|M.gilvum_PYR-GCK DSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYE
Mvan_0415|M.vanbaalenii_PYR-1 DSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYE
MSMEG_0619|M.smegmatis_MC2_155 NKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 EGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDPAPQFMDMNSPVD
MAV_4867|M.avium_104 GRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGFG
MLBr_01828|M.leprae_Br4923 LVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKV
MMAR_3006|M.marinum_M ------------VSTVASERGADMSSFAGTSTKGSVGQ--PAGLTALGGS
MUL_2247|M.ulcerans_Agy99 ---------------------------------GAGKQ--PG--------
Mb3043c|M.bovis_AF2122/97 ------------VSVLASDRGAGALGFVGTAGKESVGQ--PAGLTVLAD-
Rv3018c|M.tuberculosis_H37Rv ------------VSVLASDRGAGALGFVGTAGKESVGQ--PAGLTVLAD-
Mflv_0325|M.gilvum_PYR-GCK ELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQ---AGGLTTLAGD
Mvan_0415|M.vanbaalenii_PYR-1 PEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQ---AGGLTTLPGD
MSMEG_0619|M.smegmatis_MC2_155 E-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVT---AAGLTTLTGD
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 P-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIEREAAS
MAV_4867|M.avium_104 VPPDYG-AEEELAAAVASGQGAGTLGFAGTQQRRKAFQ--AAGLTKLADD
MLBr_01828|M.leprae_Br4923 TPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGP--ATGLVTLSNG
MMAR_3006|M.marinum_M EFEGGSREPMLPATWGPA---------LVGVAN------------
MUL_2247|M.ulcerans_Agy99 -FGGGF---------------------------------------
Mb3043c|M.bovis_AF2122/97 EFGDGAPVPMLPGSWGPD---------LVGVAGDGGLVSV-----
Rv3018c|M.tuberculosis_H37Rv EFGDGAPVPMLPGSWGPD---------LVGVAGDGGLVSV-----
Mflv_0325|M.gilvum_PYR-GCK SFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-----
Mvan_0415|M.vanbaalenii_PYR-1 PFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-----
MSMEG_0619|M.smegmatis_MC2_155 TFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR-----
TH_3569|M.thermoresistible__bu ---------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 EMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGERGAST
MAV_4867|M.avium_104 DFGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG------
MLBr_01828|M.leprae_Br4923 TFSDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE-----