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MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAEYRWVASEVEALLREVRSGGWQGQAVEMFVGS CMPFLAWLMKAAADYMDVATQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNEE EYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKDSRHDGHSHGGHASAMDRVFAD ILRNVSGGRLVWDPLNGTLNGLDYDDYVYPGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVV LDLPTHIVQLGTWLAEYPQLLLVALGGTIANLGAVTGLAGLSSGLSAGPSAAIPTVVPESAPIATVPAML AGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAPPGTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVS ESVSDSAVAEAAAQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTGSRVSDCGAGSFG FAGTVSKEAVVEVAGLTTLAGDDFGGGPTMPMVPGTWAPARESSDEGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00539 | PPE | - | 100% (538) | PPE-family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 2e-50 | 30.98% (581) | PPE-family protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 5e-47 | 30.71% (534) | PPE-family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1422 | PPE20 | 0.0 | 69.30% (544) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-69 | 35.52% (549) | PPE protein |
| M. tuberculosis H37Rv | Rv1387 | PPE20 | 0.0 | 69.49% (544) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 2e-75 | 38.15% (540) | PPE family protein |
| M. marinum M | MMAR_0538 | - | 1e-132 | 48.76% (525) | PPE family protein, PPE3 |
| M. avium 104 | MAV_4349 | - | 1e-110 | 43.60% (539) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-72 | 35.42% (542) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-51 | 33.94% (495) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-132 | 49.14% (525) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-75 | 36.02% (558) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
Mb1422|M.bovis_AF2122/97 -----------MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQ
Rv1387|M.tuberculosis_H37Rv -----------MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQ
MLBr_00539|M.leprae_Br4923 -----------MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
MMAR_0538|M.marinum_M ----------MVAPVWFASPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MAV_4349|M.avium_104 ----MTTVPAMTAPIWMASPPEVHSALLSSGPGPASVFAAAAAWSALGAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
:: ****:*::* *.* ..: .. *. .
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
Mb1422|M.bovis_AF2122/97 YAEAASEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMA
Rv1387|M.tuberculosis_H37Rv YAEAASEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
MMAR_0538|M.marinum_M YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MAV_4349|M.avium_104 YASAAEELSGLLASAQAGAWQGPSAASYVAAHGPYLAWLTRASAHSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* .* *: :: . . .*.* . :..: *:* ** : .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
Mb1422|M.bovis_AF2122/97 AQQHAVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINE
Rv1387|M.tuberculosis_H37Rv AQQHVVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
MMAR_0538|M.marinum_M AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MAV_4349|M.avium_104 AQHETAGTAYTAALAAMPTLPELAANHAVHGALVATNFFGINTIPIAVNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.* .. *:::*: *** **: *: ..*:.***:*:***** .*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLP---GVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAP---GVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKP---GVGEAGS
Mb1422|M.bovis_AF2122/97 AEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKS-DELLPDTGE
Rv1387|M.tuberculosis_H37Rv AEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKS-DELLPDTGE
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKS-NVLVDDVEK
MMAR_0538|M.marinum_M ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAA-PAAAHDHDH
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAA-PAAAHDHDH
MAV_4349|M.avium_104 ADYARMWVQAAGTMATYQAVSTAAVAAVPQPDPAPSILRS-TAAHDHDDH
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHDHGHDDHDH
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
:*..**::** **:**.: : *::: * . ..* :*
Mflv_0325|M.gilvum_PYR-GCK AAA----------------DMSAFAAQPMAAQAGAAFDVSNIIADIIRLY
Mvan_0415|M.vanbaalenii_PYR-1 AAA----------------DVTAFAAQAQAAEAGSALDLSNIIADLIRAY
MSMEG_0619|M.smegmatis_MC2_155 ASA----------------SVQQMSAQATAAESGSSLDLSSIISDLLNQY
Mb1422|M.bovis_AF2122/97 DSDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLD
Rv1387|M.tuberculosis_H37Rv DSDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLD
MLBr_00539|M.leprae_Br4923 DS-----RHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLD
MMAR_0538|M.marinum_M DHG----GDP--------TPIDYFVAEVLRIISGGRIIWDPAEGTVNGIP
MUL_1202|M.ulcerans_Agy99 DHG----GDP--------TPIDYFVAEVLRIISGGRIIWDPAEGTVNGIP
MAV_4349|M.avium_104 EHG----DDHDHDHG-FDSPLNQFVAQILRLFG---IDWDPVEGTLNGLP
MAB_0809c|M.abscessus_ATCC_199 EHG----HDD-----------------------------DHGHGDLD---
TH_3113|M.thermoresistible__bu TGAHVTAELR--------AAESRTLLDEINELIDRLFAPLFPPGFADALP
.
Mflv_0325|M.gilvum_PYR-GCK GEVLRFLFEPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAV
Mvan_0415|M.vanbaalenii_PYR-1 GELLRFLFEPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAV
MSMEG_0619|M.smegmatis_MC2_155 LQGVPGG-QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGV
Mb1422|M.bovis_AF2122/97 YDDYVYPGHAIWWLARG-LEFFQDGEQFGELLFTNPTGAFQFLLYVVVVD
Rv1387|M.tuberculosis_H37Rv YDDYVYPGHAIWWLARG-LEFFQDGEQFGELLFTNPTGAFQFLLYVVVVD
MLBr_00539|M.leprae_Br4923 YDDYVYPGQPIWWLARG-LEFFQDGEQFWELLFINPTAAFQFLLYIVVLD
MMAR_0538|M.marinum_M YDDYVNAAQPIWWLVRA-LEFGQDFQTFIKELFTNPIGAIEFMVELVLFD
MUL_1202|M.ulcerans_Agy99 YDDYVNAAQPIWWLVRA-LEFGQDFQTFIKELFTNPIGAIEFMVELVLFD
MAV_4349|M.avium_104 YEAYTSPADPLWWVVRA-LELFSDFQQFGALLQENPAAAFQFITELVLLD
MAB_0809c|M.abscessus_ATCC_199 ------PTDPEWWVHVA-GEMVEHFELLLNNLLTDP-AALLTNLPMVLAD
TH_3113|M.thermoresistible__bu DGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTG
. : :* : .:
Mflv_0325|M.gilvum_PYR-GCK VYQA----VSWVGASI-LYPSLFLLPLLATT--LAIVAGVGQHL--LSLL
Mvan_0415|M.vanbaalenii_PYR-1 AYQA----VSWVGASI-LYPSLLLLPLVATT--LAIVLGVGAYL--LENL
MSMEG_0619|M.smegmatis_MC2_155 AYQVFFNLVGWPTWGM-IFASPFLIPALAALGITGLVLLIDHVL--NNPV
Mb1422|M.bovis_AF2122/97 LPTHIAQIATWLGQY----PQLLSAALTGVIAHLGAITGLAGLS-GLSAI
Rv1387|M.tuberculosis_H37Rv LPTHIAQIATWLGQY----PQLLSAALTGVIAHLGAITGLAGLS-GLSAI
MLBr_00539|M.leprae_Br4923 LPTHIVQLGTWLAEY----PQLLLVALGGTIANLGAVTGLAGLSSGLSAG
MMAR_0538|M.marinum_M WPTHIAQIIQALAQS----PQLLAVALGGVVANLGAISGLAGLS-GLAGL
MUL_1202|M.ulcerans_Agy99 WPTHIAQIIQALAQS----PQLLAVALGGVVANLGAISGLAGLS-GLAGL
MAV_4349|M.avium_104 WPTHLAQLASWLPTQ----PQLLLVPALVAAAPFGALAGFAGVA-GQPPL
MAB_0809c|M.abscessus_ATCC_199 VAFHAAQLASTIGQFA---PALIQPALALAIANLGWAAGFAGLAGIQPSP
TH_3113|M.thermoresistible__bu VVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLT
. : . . .
Mflv_0325|M.gilvum_PYR-GCK NTPPAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAG
Mvan_0415|M.vanbaalenii_PYR-1 PAPAEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATG
MSMEG_0619|M.smegmatis_MC2_155 DVPAEDEAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAP
Mb1422|M.bovis_AF2122/97 PSAAIPAVVPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGA
Rv1387|M.tuberculosis_H37Rv PSAAIPAVVPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGA
MLBr_00539|M.leprae_Br4923 PSAAIPTVVPESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASA
MMAR_0538|M.marinum_M HS-AALPAAIAPIAPPMPPGVALAPTVATSVAAP--TPPSAPPSATSTVA
MUL_1202|M.ulcerans_Agy99 HS-AALPAAIAPIAPPMPPGVALAPTVAASVAAP--TPPSAPPSAASTVA
MAV_4349|M.avium_104 PAPVAEPATPSAAAPTGLPATAGATPIAASAAAS--VPAPTPAPTAATVS
MAB_0809c|M.abscessus_ATCC_199 EILAVEPGSVEDAPMAASAGTALAPSPPASAAAP-AAPASAPAPTASG-T
TH_3113|M.thermoresistible__bu AVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPP
. . . .
Mflv_0325|M.gilvum_PYR-GCK SPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTG--AKAPAGTIPA
Mvan_0415|M.vanbaalenii_PYR-1 TAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTS--AKAPASGIPA
MSMEG_0619|M.smegmatis_MC2_155 AGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQ--VAAPASGVPA
Mb1422|M.bovis_AF2122/97 TAAGPTPPATGFGGFPPYLVGGGGPGIGFGSG-QSAHA---KAAASDSAA
Rv1387|M.tuberculosis_H37Rv TAAGPTPPATGFGGFPPYLVGGGGPGIGFGSG-QSAHA---KAAASDSAA
MLBr_00539|M.leprae_Br4923 AAAAPAPPGTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVSESVSDSAV
MMAR_0538|M.marinum_M NAAPPPPPAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPDS
MUL_1202|M.ulcerans_Agy99 NAAPPPPPAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPDS
MAV_4349|M.avium_104 SPAPPAPPAPGAAPFAPPYAVPP-PGVGFGSKARASVDTRAKSKSPQPDS
MAB_0809c|M.abscessus_ATCC_199 APAPPSPPPVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAR
TH_3113|M.thermoresistible__bu PAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPA
.*
Mflv_0325|M.gilvum_PYR-GCK AASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAP-
Mvan_0415|M.vanbaalenii_PYR-1 AASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEP-
MSMEG_0619|M.smegmatis_MC2_155 AASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEP-
Mb1422|M.bovis_AF2122/97 AESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQP
Rv1387|M.tuberculosis_H37Rv AESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQP
MLBr_00539|M.leprae_Br4923 AEAAAQASAREQARAWRR-RSAAKERGYREEVITMNTGFDAAIPSPVDQT
MMAR_0538|M.marinum_M AALAAAAAAREEARRRRR--KRKTERGYGEEFMDVEV--DPDWGGPRDD-
MUL_1202|M.ulcerans_Agy99 AALAAAAAVREEARRRRR--KRKTERGYGEEFMDVEV--DPDWGGPLDD-
MAV_4349|M.avium_104 NAVGAGSAVREAAHARRR--QRSRRR--GEEFMDMNVGVDPDWDEP----
MAB_0809c|M.abscessus_ATCC_199 EQAAAAETAAARQARRRR--DKGKQQGRGIEYMDMNATARCEEPAP----
TH_3113|M.thermoresistible__bu GSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPAS----------MSA
. : *: :
Mflv_0325|M.gilvum_PYR-GCK RVTASTRGAGPMGFAGTVSRGDEQ-AGGLTTLAG-DSFGGGPREPMLPGT
Mvan_0415|M.vanbaalenii_PYR-1 RIAATERGAGPMGFAGTVSRDAAQ-AGGLTTLPG-DPFGGGPKAPMLPGT
MSMEG_0619|M.smegmatis_MC2_155 RVRASERGSDAMGFTGTVTRHDVT-AAGLTTLTG-DTFDDRPVTPMLPGT
Mb1422|M.bovis_AF2122/97 GARASDCGAGPIGFAGTVRKEAVVKAAGLTTLAG-DDFGGGPTMPMMPGT
Rv1387|M.tuberculosis_H37Rv GARASDCGAGPIGFAGTVRKEAVVKAAGLTTLAG-DDFGGGPTMPMMPGT
MLBr_00539|M.leprae_Br4923 GSRVSDCGAGSFGFAGTVSKEAVVEVAGLTTLAG-DDFGGGPTMPMVPGT
MMAR_0538|M.marinum_M EPVASTQGAGRLGFAGTVHSESAATAAGLTTLVA-DEFGGGPKMPMLPGT
MUL_1202|M.ulcerans_Agy99 EPVASTQGAGRLGFAGTVHSESAATAAGLTTLVA-DEFGGGPKMPMLPGT
MAV_4349|M.avium_104 ATTASPRGAGNLGFAGTAPRETVA-AAGMTQLAG-DEFGGGAGMPLLPGS
MAB_0809c|M.abscessus_ATCC_199 DTTASHRGAGTMGFAGTVIKTGAT-ASGLAMLSRDDDLFEGVRAPMVPNT
TH_3113|M.thermoresistible__bu ATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGD-------PTEPSSPTD
: * :* :* . * *
Mflv_0325|M.gilvum_PYR-GCK WDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 WDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 WDGDENPAP------SPDDPEGGPRR
Mb1422|M.bovis_AF2122/97 WTHD------------QGVFDEHR--
Rv1387|M.tuberculosis_H37Rv WTHD------------QGVFDEHR--
MLBr_00539|M.leprae_Br4923 WAPA------------RESSDEGR--
MMAR_0538|M.marinum_M WDTD------------SDAPSD----
MUL_1202|M.ulcerans_Agy99 WDTD------------SDAPSD----
MAV_4349|M.avium_104 WAPP------------DPRDSGV---
MAB_0809c|M.abscessus_ATCC_199 WDPE------------HGRQD-----
TH_3113|M.thermoresistible__bu RAHR------------PAEPN-----
.