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SFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAP YAGWLTAAAAQSAGAAGQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYE EMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGT GGATASGGGVGYVGSGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPLA LAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVAAKAAPLSTTRV GQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVRKDPKIQMRGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3144c | PPE52 | - | 100% (409) | PPE-FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3533c | PPE62 | 1e-83 | 55.88% (306) | PPE family protein |
| M. tuberculosis H37Rv | Rv3159c | PPE53 | 9e-80 | 54.03% (298) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3168c | PPE52 | 0.0 | 99.51% (409) | PPE-family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-22 | 24.88% (410) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-29 | 44.08% (152) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 1e-23 | 37.27% (161) | PPE-family protein |
| M. marinum M | MMAR_1484 | - | 1e-119 | 57.78% (450) | PPE family protein |
| M. avium 104 | MAV_2905 | - | 9e-52 | 37.53% (373) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-26 | 36.00% (200) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-26 | 34.50% (200) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0964 | - | 1e-70 | 48.44% (289) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-26 | 25.43% (405) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3144c|M.tuberculosis_H37Rv -------------MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEE
Mb3168c|M.bovis_AF2122/97 -------------MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEE
MMAR_1484|M.marinum_M -------------MSFFVLPPEINSLRMFIGAGTAPMLEAAAAWQGLAEE
MUL_0964|M.ulcerans_Agy99 -------------MNFMMLPPEVNSALMFTGAGSAPTLAAATAWDGLVAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
MAV_2905|M.avium_104 -------------MNFALQPPEITSAQLYTGPGAGPMLTAAAAWDALAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .** * : *.*... * *. * : :
Rv3144c|M.tuberculosis_H37Rv LGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAA
Mb3168c|M.bovis_AF2122/97 LGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAA
MMAR_1484|M.marinum_M LSTAAQSFASVTAGLAGQAWQGSAAMAMASAAAPYAGWLAAAAAQSAGAA
MUL_0964|M.ulcerans_Agy99 LGEAAEAFSSVTSGLASGSWQGPAAAAMAAAAAPYAGWLSAAATRALGAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
MAV_2905|M.avium_104 LQSAASSYAAVVNGLADEAWAGPSAAAMAAAAAPYVAWLSATSAQARTAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
:* : :: * :: . ** ** :: . *
Rv3144c|M.tuberculosis_H37Rv GQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAE
Mb3168c|M.bovis_AF2122/97 GQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAE
MMAR_1484|M.marinum_M GNARAVASMFEAAQAATVLPTSISANRNAFVQLVMSNLFGQNAPAIAAAE
MUL_0964|M.ulcerans_Agy99 TQAKAAAAVFESAQAATVHPELVLANRNQLVSLVLSNLFGQNAPAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
MAV_2905|M.avium_104 EQATAAASAFESAFAAVVPPAEIATNRARLAMLSASNVFGQNSAAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
. ..* : :* : : *: * :*.:* *: ** *
Rv3144c|M.tuberculosis_H37Rv GVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPG----------
Mb3168c|M.bovis_AF2122/97 GVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPG----------
MMAR_1484|M.marinum_M SIYEEMWAADVAAMSGYYSGVSAVAAQVVPWQSVLKGLPG----------
MUL_0964|M.ulcerans_Agy99 STYEELWAQDVAATVGYHGGASAVAAQLAPWQQAIQALPGRVAAMATTGP
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
MAV_2905|M.avium_104 AEYGQMWAQDAAAMFGYASASAAATRLAPFTEPPKTTNDAG---------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVG--------
. * .:* .:: * .
Rv3144c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3168c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1484|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 AASAAAALASGPAAALDIGNNGSGNFLSIGNIGNNNLGSGNTGSANLGGG
Mflv_0325|M.gilvum_PYR-GCK DMSA----------------------------------------------
Mvan_0415|M.vanbaalenii_PYR-1 DVTA----------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 SVQQ----------------------------------------------
TH_3569|M.thermoresistible__bu TTQQ----------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 DVPG----------------------------------------------
MAV_2905|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Rv3144c|M.tuberculosis_H37Rv ------LGAGATG----ATGGES---VGTGATGGES--VGTGGGESVG--
Mb3168c|M.bovis_AF2122/97 ------LGAGATG----ATGGES---VGTGATGGES--VGTGGGESVG--
MMAR_1484|M.marinum_M ------LASGLAG----GAGAGSGFAGGSGMVGGAAGSPGSQGGAGAGS-
MUL_0964|M.ulcerans_Agy99 NIGNGNLGSGNTGNVNLGNGNNGFFNFGNGNLGDTNFGSGNSGNLNLGSG
Mflv_0325|M.gilvum_PYR-GCK -FAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPIGN-
Mvan_0415|M.vanbaalenii_PYR-1 -FAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPLGN-
MSMEG_0619|M.smegmatis_MC2_155 -MSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPLGN-
TH_3569|M.thermoresistible__bu -IGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPIGN-
MAB_0669|M.abscessus_ATCC_1997 -SPDQ---------------IMKMLQGFQQWFEKMG--FNPATSAVLAV-
MAV_2905|M.avium_104 -IAAQAAALGEATGRGAGTAAADATAPPSGIISQLLEALGNASRGYMDFW
MLBr_01182|M.leprae_Br4923 ------------------LAQEVVEEVVEEVVEEVVEAEQAISQAALDQ-
Rv3144c|M.tuberculosis_H37Rv ------------------TGGATASG-----------------GGVGYVG
Mb3168c|M.bovis_AF2122/97 ------------------TGGATASG-----------------GGVGYVG
MMAR_1484|M.marinum_M -----------------DTAGANAGGD-----ASSSVVAGGGAGGAGLVG
MUL_0964|M.ulcerans_Agy99 NRFGSGNIGFGNRFGDGNFGSGNAGSYNFGTGNNGSFNIGSGNNGDSNIG
Mflv_0325|M.gilvum_PYR-GCK ---------------TFALITDFLTNPVQALITWGPFLLAVVYQAVSWVG
Mvan_0415|M.vanbaalenii_PYR-1 ---------------TIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVG
MSMEG_0619|M.smegmatis_MC2_155 ---------------LGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLV
TH_3569|M.thermoresistible__bu ---------------LFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLV
MAB_0669|M.abscessus_ATCC_1997 ---------------IMLFLYDLLWYPY-----YASYLLPFLIPALSGLS
MAV_2905|M.avium_104 D----------------QVLNTLTGSPLAGTTWQNTFGILADIGRFSTVA
MLBr_01182|M.leprae_Br4923 -----------------AVNEGMEATVVPQVDQQVNVDVATPQTAVPDSS
Rv3144c|M.tuberculosis_H37Rv SG-VASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATS---------
Mb3168c|M.bovis_AF2122/97 GG-VASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATS---------
MMAR_1484|M.marinum_M AGGYASGGGGADSGAMGAPG-GAVDGASSGVGGGGGGMAAS---------
MUL_0964|M.ulcerans_Agy99 FGNLGTNNLGFGNNGSNNIGFGLSGSNQIGIGGLNAGIGNMGFGNAGDNN
Mflv_0325|M.gilvum_PYR-GCK ASILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQS
Mvan_0415|M.vanbaalenii_PYR-1 ASILYPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSP
MSMEG_0619|M.smegmatis_MC2_155 GWPTWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEV
TH_3569|M.thermoresistible__bu GWPTWAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEED
MAB_0669|M.abscessus_ATCC_1997 G-LAALMHLRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSV
MAV_2905|M.avium_104 NDSMSPINLAMTEFKMFYKLPVEGLDIPKSALGAGLGLRSAGAGLTG---
MLBr_01182|M.leprae_Br4923 SAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMG-------
Rv3144c|M.tuberculosis_H37Rv -----------------------AHAGVVSPGFIG-------------AP
Mb3168c|M.bovis_AF2122/97 -----------------------AHAGVVSPGFIG-------------AP
MMAR_1484|M.marinum_M -----------------------AGAATPGMGAMA-------------MP
MUL_0964|M.ulcerans_Agy99 VGFFNSGSNNIGFFNSGDGNFGFAHAGSTNTGFWNSGGTNTGFGNGGSLN
Mflv_0325|M.gilvum_PYR-GCK APSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPG---------AP
Mvan_0415|M.vanbaalenii_PYR-1 APTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPG---------AP
MSMEG_0619|M.smegmatis_MC2_155 AAAPRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVA---------AP
TH_3569|M.thermoresistible__bu VAAP-------------------VRAEPQNPLPLTXXX------------
MAB_0669|M.abscessus_ATCC_1997 VPSGG---------------SSVPVSTPTAPAHTVSSVP---------AP
MAV_2905|M.avium_104 -----------------------AVSVGVGEANTVGRLS--------VPP
MLBr_01182|M.leprae_Br4923 -----------------------SAMKSLAPTTTKAAES----------A
Rv3144c|M.tuberculosis_H37Rv LA--LAALGQMARG-------------GTNSAPGTATESARAPEPAASAP
Mb3168c|M.bovis_AF2122/97 LA--LAALGQMARG-------------GTNSAPGTATESARAPEPAASAP
MMAR_1484|M.marinum_M IAGMAAARAAMAAG-------------GGQSGPVNAGPPVRETAPAAPEP
MUL_0964|M.ulcerans_Agy99 FGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGFSNAAETN
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 SAAISYAIPGLVP---PGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQ
MAV_2905|M.avium_104 TWASATPAIRLASG---------LAPATAAAAAPAAGIPAGLLGQMALGS
MLBr_01182|M.leprae_Br4923 FKAMGSAVQSTGRG---------------LLGSSSGGHVTAQLGRAASIG
Rv3144c|M.tuberculosis_H37Rv ---------------------PEAVVEVPELEVPAMGVLPTVDPKVAAKA
Mb3168c|M.bovis_AF2122/97 ---------------------PEAVVEVPELEVPAMGVLPTVDPKVAAKA
MMAR_1484|M.marinum_M E-------------------AAAPAPEEAEAPVPQMAVLPTADPGIAAAA
MUL_0964|M.ulcerans_Agy99 TGWENSGNVNTGGYNSGGLNTGIGSPDTQAGPNSGFGHSGSGNSGFFNSG
Mflv_0325|M.gilvum_PYR-GCK ERRKR---------------RRRQKEEIKGRGYADAYADYEELPDDGPPE
Mvan_0415|M.vanbaalenii_PYR-1 ERRKR---------------RRRQKDEIAGRAYADAYADYEPEPDDEPPV
MSMEG_0619|M.smegmatis_MC2_155 SRRKR---------------RRKKGAQIEERGYADAYMDYEE-PDEDPAP
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 ARRRL---------------RGKNKAEAGGR--RHEYLEETAGMGAT-AT
MAV_2905|M.avium_104 VTGGA---------------LGAVAPHVGSGRGVRVRAAKPAEPVKLDDV
MLBr_01182|M.leprae_Br4923 SLRVP-----------------QTWTTASQPVTAATRALSPARVAVATES
Rv3144c|M.tuberculosis_H37Rv APLS----TTRVGQSAG-SGIPESTLRTAQG-------------QQASET
Mb3168c|M.bovis_AF2122/97 APLS----TTRVGQSAG-SGIPESTLRTAQG-------------QQASET
MMAR_1484|M.marinum_M APGS----KPQATRATGTTGIPASPLRSSPAGTESKRSAPTQDQQDGAEQ
MUL_0964|M.ulcerans_Agy99 DGNSGFENSNTCVSANGHSGVRNSGDATNVG------FSNSGSNNTGIFN
Mflv_0325|M.gilvum_PYR-GCK QPAPRVTASTRGAGPMGFAGTVSRGDEQAGG-------LTT-LAGDSFGG
Mvan_0415|M.vanbaalenii_PYR-1 RQEPRIAATERGAGPMGFAGTVSRDAAQAGG-------LTT-LPGDPFGG
MSMEG_0619|M.smegmatis_MC2_155 QPEPRVRASERGSDAMGFTGTVTRHDVTAAG-------LTT-LTGDTFDD
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 ADVPAYAATGRGTGPLGFAGTAPAAASTHVA-------ATVRLSSD--EA
MAV_2905|M.avium_104 IAKLQRQPEAVQHWNVDKAGLDDLLDRLSKK--------PGIHAVHVSSG
MLBr_01182|M.leprae_Br4923 ESAPLLGGGLPMAPMVPGGGSGTGGVNTALR------------------L
Rv3144c|M.tuberculosis_H37Rv SAAEETAPSLRPEAAAGQLRPRVRKDPKIQMRGG------
Mb3168c|M.bovis_AF2122/97 SAAEETAPSLRPEAAAGQLRPRVRQDPKIQMRGG------
MMAR_1484|M.marinum_M TAAEDTVVPLRPEAVAGELRSRVQEPSGIQMRGG------
MUL_0964|M.ulcerans_Agy99 TGTFNTGIANSGSDSSGLLISGTNSSGALNSGDDQSGFNN
Mflv_0325|M.gilvum_PYR-GCK GPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP----
Mvan_0415|M.vanbaalenii_PYR-1 GPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ----
MSMEG_0619|M.smegmatis_MC2_155 RPVTPMLPGTWDGDENPA------PSPDDPEGGPRR----
TH_3569|M.thermoresistible__bu ----------------------------------------
MAB_0669|M.abscessus_ATCC_1997 RQVIPMLPSTWDAD-----------------GGDQN----
MAV_2905|M.avium_104 GKPTVTLPDAGPAGSA------------------------
MLBr_01182|M.leprae_Br4923 QPRAFVMPRNPAAG--------------------------