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VSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSFASVTAGLAGQAWQGPAALAMAAAAA PYAGWLTAAAAQSAGAAGQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVY EEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVG TGGATASGGGVGYVGGGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPL ALAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVAAKAAPLSTTR VGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVRQDPKIQMRGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3168c | PPE52 | - | 100% (409) | PPE-family protein |
| M. bovis AF2122 / 97 | Mb3563c | PPE62 | 2e-83 | 55.88% (306) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3183c | PPE53 | 6e-79 | 54.36% (298) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-22 | 24.88% (410) | PPE protein |
| M. tuberculosis H37Rv | Rv3144c | PPE52 | 0.0 | 99.51% (409) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-29 | 44.08% (152) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 1e-23 | 37.27% (161) | PPE-family protein |
| M. marinum M | MMAR_1484 | - | 1e-120 | 58.00% (450) | PPE family protein |
| M. avium 104 | MAV_2905 | - | 9e-52 | 34.75% (423) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-26 | 36.00% (200) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-26 | 34.50% (200) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0902 | - | 6e-71 | 52.73% (275) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-26 | 25.43% (405) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3168c|M.bovis_AF2122/97 -------------MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEE
Rv3144c|M.tuberculosis_H37Rv -------------MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEE
MMAR_1484|M.marinum_M -------------MSFFVLPPEINSLRMFIGAGTAPMLEAAAAWQGLAEE
MUL_0902|M.ulcerans_Agy99 -------------MNFPMLPPEINSARMFAGAGSGPMLSAAMAWDGLAVE
MAV_2905|M.avium_104 -------------MNFALQPPEITSAQLYTGPGAGPMLTAAAAWDALAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .** * : *.*...:* *. * :. :
Mb3168c|M.bovis_AF2122/97 LGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAA
Rv3144c|M.tuberculosis_H37Rv LGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAA
MMAR_1484|M.marinum_M LSTAAQSFASVTAGLAGQAWQGSAAMAMASAAAPYAGWLAAAAAQSAGAA
MUL_0902|M.ulcerans_Agy99 LGSAAESFGSVTSGLVGSSWQGAAATAMSAAAAPYVSWLNAAAVRAGEAA
MAV_2905|M.avium_104 LQSAASSYAAVVNGLADEAWAGPSAAAMAAAAAPYVAWLSATSAQARTAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
:* : :: * :: ** ** :. . *
Mb3168c|M.bovis_AF2122/97 GQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAE
Rv3144c|M.tuberculosis_H37Rv GQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAE
MMAR_1484|M.marinum_M GNARAVASMFEAAQAATVLPTSISANRNAFVQLVMSNLFGQNAPAIAAAE
MUL_0902|M.ulcerans_Agy99 LQAKEVVSAFEAARAAMIHPLAVAANRNALVQLVLTNLFGQNAPAIAAAE
MAV_2905|M.avium_104 EQATAAASAFESAFAAVVPPAEIATNRARLAMLSASNVFGQNSAAIAAAE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
. .. : :* : : *: * :*.:* *: ** *
Mb3168c|M.bovis_AF2122/97 GVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPG----------
Rv3144c|M.tuberculosis_H37Rv GVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPG----------
MMAR_1484|M.marinum_M SIYEEMWAADVAAMSGYYSGVSAVAAQVVPWQSVLKGLPG----------
MUL_0902|M.ulcerans_Agy99 GSYEQMWAADVAAMLGYHGGASAAASGLASWQQALQGLAGPAASVILGLS
MAV_2905|M.avium_104 AEYGQMWAQDAAAMFGYAS-ASAAATRLAPFTEPPK--------------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGV--------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGV--------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGV--------
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGV--------
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG---------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVG--------
. * .** .::* * .
Mb3168c|M.bovis_AF2122/97 ----------------------------LGAGATG----ATGGES---VG
Rv3144c|M.tuberculosis_H37Rv ----------------------------LGAGATG----ATGGES---VG
MMAR_1484|M.marinum_M ----------------------------LASGLAG----GAGAGSGFAGG
MUL_0902|M.ulcerans_Agy99 IGNTGVGNLSIGNIGVFNLGGGNAGNLNLGGGNTGNANLGSGNNGFFNLG
MAV_2905|M.avium_104 -----------------------------TTNDAGIAAQAAALGEATGRG
Mflv_0325|M.gilvum_PYR-GCK ---------------------------GEAGRAAADMSAFAAQPMAAQAG
Mvan_0415|M.vanbaalenii_PYR-1 ---------------------------GEAGRAAADVTAFAAQAQAAEAG
MSMEG_0619|M.smegmatis_MC2_155 ---------------------------GEAGSASASVQQMSAQATAAESG
TH_3569|M.thermoresistible__bu ---------------------------SEAADAMATTQQIGSQATAADSG
MAB_0669|M.abscessus_ATCC_1997 ---------------------------GEARSDQSDVPGSPDQ-------
MLBr_01182|M.leprae_Br4923 ----------------------------LAQEVVEEVVEEVVEEVVEAEQ
Mb3168c|M.bovis_AF2122/97 TGATGGES--VGTGGGESVG--TGGAT--------ASG------------
Rv3144c|M.tuberculosis_H37Rv TGATGGES--VGTGGGESVG--TGGAT--------ASG------------
MMAR_1484|M.marinum_M SGMVGGAAGSPGSQGGAGAGSDTAGAN--------AGGDASSSVVAGGGA
MUL_0902|M.ulcerans_Agy99 SGNTGNTNFGNGNRGNLNWGSGNLGNANVGFGNFLGQGNFGFGNRVGDAN
MAV_2905|M.avium_104 AGTAAADATAPPSGIISQLLEALGNAS---------RGYMDFWDQVLNTL
Mflv_0325|M.gilvum_PYR-GCK AAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPIGNTFALITDFLTNPV
Mvan_0415|M.vanbaalenii_PYR-1 SALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTIKLITDFLTNPA
MSMEG_0619|M.smegmatis_MC2_155 SSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPLGNLGRLLTDFMTNPA
TH_3569|M.thermoresistible__bu TALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPIGNLFQLIDDFLTNPA
MAB_0669|M.abscessus_ATCC_1997 --------IMKMLQGFQQWFEKMG--FNPATSAVLAVIMLFLYDLLWYPY
MLBr_01182|M.leprae_Br4923 AISQAALDQAVNEGMEATVVPQVDQQVN---------------VDVATPQ
Mb3168c|M.bovis_AF2122/97 GGVGYVGGG-VASAGL-----AAGDPAHGSVGQGNFGGGDVGAGDVV---
Rv3144c|M.tuberculosis_H37Rv GGVGYVGSG-VASAGL-----AAGDPAHGSVGQGNFGGGDVGAGDVV---
MMAR_1484|M.marinum_M GGAGLVGAGGYASGGG-----GADSGAMGAPG-GAVDGASSGVGGGG---
MUL_0902|M.ulcerans_Agy99 LGSGNLGNANFGNGNLGDTNLGSGNNGFSNVGFGNLGSNNLGFGNNGDNN
MAV_2905|M.avium_104 TGSPLAGTTWQNTFGI-----LADIGRFSTVANDSMSPINLAMTEFK---
Mflv_0325|M.gilvum_PYR-GCK QALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVGQHL
Mvan_0415|M.vanbaalenii_PYR-1 QALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVGAYL
MSMEG_0619|M.smegmatis_MC2_155 GALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITGLVL
TH_3569|M.thermoresistible__bu GALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAGLVM
MAB_0669|M.abscessus_ATCC_1997 -----YASYLLPFLIPALSGLSG-LAALMHLRPAAPGPVPAAALSPGDRP
MLBr_01182|M.leprae_Br4923 TAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMG
.
Mb3168c|M.bovis_AF2122/97 ---------------------------ASSATS-----------------
Rv3144c|M.tuberculosis_H37Rv ---------------------------ASSATS-----------------
MMAR_1484|M.marinum_M ---------------------------GGMAAS-----------------
MUL_0902|M.ulcerans_Agy99 IGFGLTGNNQVGINFAGLNGGIGNIDLGNSGDNNVGFFNSGSNNVGFFNS
MAV_2905|M.avium_104 ---------------------------MFYKLP-----------------
Mflv_0325|M.gilvum_PYR-GCK --------------------------LSLLNTP-----------------
Mvan_0415|M.vanbaalenii_PYR-1 --------------------------LENLPAP-----------------
MSMEG_0619|M.smegmatis_MC2_155 --------------------------LIDHVLNN----------------
TH_3569|M.thermoresistible__bu --------------------------IADQAQP-----------------
MAB_0669|M.abscessus_ATCC_1997 --------------------------IRRPTQHV----------------
MLBr_01182|M.leprae_Br4923 -------------------------SAMKSLAP-----------------
Mb3168c|M.bovis_AF2122/97 -------AHAGVVSPGFIGAPLA------------------LAALGQMAR
Rv3144c|M.tuberculosis_H37Rv -------AHAGVVSPGFIGAPLA------------------LAALGQMAR
MMAR_1484|M.marinum_M -------AGAATPGMGAMAMPIAGM----------------AAARAAMAA
MUL_0902|M.ulcerans_Agy99 GDRNFGFANSGDTNTGFWNAGRVNTGFGNGGNFNLGFGNGGAANVGVGNG
MAV_2905|M.avium_104 -------VEGLDIPKSALGAGLG------------------LRSAGAGLT
Mflv_0325|M.gilvum_PYR-GCK -----PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVS
Mvan_0415|M.vanbaalenii_PYR-1 -----AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVA
MSMEG_0619|M.smegmatis_MC2_155 -----PVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPAP
TH_3569|M.thermoresistible__bu ---------PAEEAAPEEDVAAP-------------------VRAEPQNP
MAB_0669|M.abscessus_ATCC_1997 -----EPNLAALPLPTSSVVPSGG---------------SSVPVSTPTAP
MLBr_01182|M.leprae_Br4923 -----TTTKAAESAFKAMGSAVQSTG---------------RGLLGSSSG
Mb3168c|M.bovis_AF2122/97 GGTNSAPGTATESARAPEPAASAP--PEAVVEVPELEVPAMGVLP-----
Rv3144c|M.tuberculosis_H37Rv GGTNSAPGTATESARAPEPAASAP--PEAVVEVPELEVPAMGVLP-----
MMAR_1484|M.marinum_M GGGQSGPVNAGPPVRETAPAAPEPEAAAPAPEEAEAPVPQMAVLP-----
MUL_0902|M.ulcerans_Agy99 GGGNLGFGNSGTENTGSFNSGGDNGRNGGNTGSFNSGYVNTGFFNSGSTN
MAV_2905|M.avium_104 GAVSVGVGEANTVGRLSVPPTWASATPAIRLASGLAPATAAAAAP-----
Mflv_0325|M.gilvum_PYR-GCK AGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAG----
Mvan_0415|M.vanbaalenii_PYR-1 TGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPAS----
MSMEG_0619|M.smegmatis_MC2_155 APAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPAS----
TH_3569|M.thermoresistible__bu LPLTXXX-------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 AHTVSSVPAPSAAISYAIPGLVP---PGVSFGPKSTEKSSESAVDT----
MLBr_01182|M.leprae_Br4923 GHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATE----
Mb3168c|M.bovis_AF2122/97 -------TVDPKVAAK-AAPLSTTRVG-QSAG-SGIPEST------LRTA
Rv3144c|M.tuberculosis_H37Rv -------TVDPKVAAK-AAPLSTTRVG-QSAG-SGIPEST------LRTA
MMAR_1484|M.marinum_M -------TADPGIAAA-AAPGSKPQAT-RATGTTGIPASP------LRSS
MUL_0902|M.ulcerans_Agy99 TGLFNAGSVNTGIGSPDTQPGSISGFGNTGAGVSGFNNSGDATSGFMNVA
MAV_2905|M.avium_104 -----AAGIPAGLLGQMALGSVTGGALGAVAPHVGSGRGVR-----VRAA
Mflv_0325|M.gilvum_PYR-GCK -------TIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELP
Mvan_0415|M.vanbaalenii_PYR-1 -------GIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEP
MSMEG_0619|M.smegmatis_MC2_155 -------GVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-P
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 -------VAAVAAARGAVAAQARRRLRGKNKAEAGGR--RHEYLEETAGM
MLBr_01182|M.leprae_Br4923 -------SESAPLLGGGLPMAP----------------------------
Mb3168c|M.bovis_AF2122/97 QG-------------QQASETSAAEETAPSLRPEAAAGQLRPRVRQD---
Rv3144c|M.tuberculosis_H37Rv QG-------------QQASETSAAEETAPSLRPEAAAGQLRPRVRKD---
MMAR_1484|M.marinum_M PAGTESKRSAPTQDQQDGAEQTAAEDTVVPLRPEAVAGELRSRVQEP---
MUL_0902|M.ulcerans_Agy99 TTFGFASGINNVGDYQVGLFNTGFGNAGIANSGNATFGIANSGALSSGIS
MAV_2905|M.avium_104 KPAEPVKLDDVIAKLQRQPEAVQHWNVDKAGLDDLLDRLSKKPGIHAVHV
Mflv_0325|M.gilvum_PYR-GCK DDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTT-LAGDSFGGG
Mvan_0415|M.vanbaalenii_PYR-1 DDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTT-LPGDPFGGG
MSMEG_0619|M.smegmatis_MC2_155 DEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTT-LTGDTFDDR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 GAT-ATADVPAYAATGRGTGPLGFAGTAPAAASTHVAATVRLSSD--EAR
MLBr_01182|M.leprae_Br4923 -------------MVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-----
Mb3168c|M.bovis_AF2122/97 -PKIQMRGG--------------------------
Rv3144c|M.tuberculosis_H37Rv -PKIQMRGG--------------------------
MMAR_1484|M.marinum_M -SGIQMRGG--------------------------
MUL_0902|M.ulcerans_Agy99 NSGTNSSGGFNTGDDQSGFFN--------------
MAV_2905|M.avium_104 SSGGKPTVTLPDAGPAGSA----------------
Mflv_0325|M.gilvum_PYR-GCK PREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 PKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 PVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------------------------------
MAB_0669|M.abscessus_ATCC_1997 QVIPMLPSTWDAD-----------------GGDQN
MLBr_01182|M.leprae_Br4923 -----------------------------------