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NFALQPPEITSAQLYTGPGAGPMLTAAAAWDALAAELQSAASSYAAVVNGLADEAWAGPSAAAMAAAAAP YVAWLSATSAQARTAAEQATAAASAFESAFAAVVPPAEIATNRARLAMLSASNVFGQNSAAIAAAEAEYG QMWAQDAAAMFGYASASAAATRLAPFTEPPKTTNDAGIAAQAAALGEATGRGAGTAAADATAPPSGIISQ LLEALGNASRGYMDFWDQVLNTLTGSPLAGTTWQNTFGILADIGRFSTVANDSMSPINLAMTEFKMFYKL PVEGLDIPKSALGAGLGLRSAGAGLTGAVSVGVGEANTVGRLSVPPTWASATPAIRLASGLAPATAAAAA PAAGIPAGLLGQMALGSVTGGALGAVAPHVGSGRGVRVRAAKPAEPVKLDDVIAKLQRQPEAVQHWNVDK AGLDDLLDRLSKKPGIHAVHVSSGGKPTVTLPDAGPAGSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2905 | - | - | 100% (461) | PPE family protein |
| M. avium 104 | MAV_3355 | - | e-109 | 49.02% (459) | PPE family protein |
| M. avium 104 | MAV_2909 | - | 7e-96 | 45.88% (473) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1830 | PPE30 | 1e-118 | 49.68% (473) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-34 | 31.12% (392) | PPE protein |
| M. tuberculosis H37Rv | Rv1809 | PPE33 | 1e-157 | 62.50% (464) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-47 | 33.49% (415) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 4e-34 | 31.37% (424) | PPE family protein |
| M. marinum M | MMAR_2685 | - | 1e-109 | 47.98% (471) | PPE family protein, PPE30 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-35 | 29.27% (410) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-35 | 37.28% (228) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3071 | - | 1e-105 | 46.92% (471) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-35 | 31.38% (392) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2905|M.avium_104 -------------MNFALQPPEITSAQLYTGPGAGPMLTAAAAWDALAAE
Rv1809|M.tuberculosis_H37Rv -------------MDFGLQPPEITSGEMYLGPGAGPMLAAAVAWDGLAAE
MMAR_2685|M.marinum_M -------------MFYAAFPPEINSGRMYTGPGSGPLLAAAAAWDAVAAE
MUL_3071|M.ulcerans_Agy99 -------------MFYAAFPPEINSGRVYTGPGSEPLLAAAAAWDAVAAE
Mb1830|M.bovis_AF2122/97 -------------MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .** * : ***. .:*:*. * :. .
MAV_2905|M.avium_104 LQSAASSYAAVVNGLADEAWAGPSAAAMAAAAAPYVAWLSATSAQARTAA
Rv1809|M.tuberculosis_H37Rv LQSMAASYASIVEGMASESWLGPSSAGMAAAAAPYVTWMSGTSAQAKAAA
MMAR_2685|M.marinum_M LQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVAPYVTWMGATAAQAAQAA
MUL_3071|M.ulcerans_Agy99 LQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVAPYVTWMGATATQAAQAA
Mb1830|M.bovis_AF2122/97 LQSTAADYGSVISVLT-GVWSGQSSGTMAAAAAPYVAWMSATAALAREAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
: * : : : * *: . :** *: : . *
MAV_2905|M.avium_104 EQATAAASAFESAFAAVVPPAEIATNRARLAMLSASNVFGQNSAAIAAAE
Rv1809|M.tuberculosis_H37Rv DQARAAVVAYETAFAAVVPPPQIAANRSQLISLVATNIFGQNTAAIAATE
MMAR_2685|M.marinum_M TQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAE
MUL_3071|M.ulcerans_Agy99 TQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAE
Mb1830|M.bovis_AF2122/97 AQASAAAAAYEAAFAATVPPPVVAANRAELAVLAATNIFGQNTGAIAAAE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: .*. *: :*:: . : *:: * :*.:* *: .* *
MAV_2905|M.avium_104 AEYGQMWAQDAAAMFGYASASAAAT-RLAPFTEPPKTTNDAGIAAQAAAL
Rv1809|M.tuberculosis_H37Rv AEYGEMWAQDTMAMFGYASSSATAS-RLTPFTAPPQTTNPSGLAGQAAAT
MMAR_2685|M.marinum_M SQYAEMWAQDATAMDGYASSSAAAS-EVTPFAEPPQVVNAAGLASQAAVV
MUL_3071|M.ulcerans_Agy99 SQYAEMWAQDATAMDGYASSSAAAS-EVTPVAEPRQVVNAAGLASQAAVV
Mb1830|M.bovis_AF2122/97 ARYAEMWAQDAAAMYGYAGSSSVAT-QVTPFAAPPPTTNAAGLATQGVAV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAAL-AATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAAL-AATPTATPAPFVLAPGVGEAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAV-AAAPVSAPAPFLLKPGVGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAV-MSAPASSPAPLLLAPGVSEAADAM
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVAL-ASAPPSTPPPSILHD---------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVG--------
: * .** * : :* * * . : *
MAV_2905|M.avium_104 G-------EATGRGAGTAAADATAP------PSGIISQLLEALGNASRGY
Rv1809|M.tuberculosis_H37Rv G-------QATALASGTNAVTTALSSAAAQFPFDIIPTLLQGLATLSTQY
MMAR_2685|M.marinum_M G-------QAAAASPAATVQD--------LLATGPISWLLQLGADLSTGY
MUL_3071|M.ulcerans_Agy99 G-------QAAAASPAATVQD--------LLATGPISWLLQLGADLSTGY
Mb1830|M.bovis_AF2122/97 A-------QAVGASAGN--------------ARSLVSEVLEFLATAGTNY
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDP
MAB_0809c|M.abscessus_ATCC_199 ---HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAGEM
MLBr_01182|M.leprae_Br4923 ------------------------------LAQEVVEEVVEEVVEEVVEA
MAV_2905|M.avium_104 MDFWDQVLNTLTGSPLAGTTWQN--TFGILADIGRFSTVANDSMSPINLA
Rv1809|M.tuberculosis_H37Rv TQLMGQLINAIFG-PTGATTYQN--VFVTAANVTKFSTWANDAMSAPNLG
MMAR_2685|M.marinum_M TAAVTALLNGLFG-PSGATTYLT--LYNAIKTPLNFTTGFNDIGLLINFP
MUL_3071|M.ulcerans_Agy99 TAAVTALLNGLFG-PSGATTYLT--LYNAIKTPLNFTTGFNDIGLLINFP
Mb1830|M.bovis_AF2122/97 NKTVASLMNAVTGVPYASSVYNS--MLGLGFAESKMVLPANDTVISTIFG
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLP
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLP
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
TH_3569|M.thermoresistible__bu IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASP
MAB_0809c|M.abscessus_ATCC_199 VEHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQP
MLBr_01182|M.leprae_Br4923 EQAISQAALDQAVNEGMEATVVP-----QVDQQVNVDVATPQTAVPDSSS
MAV_2905|M.avium_104 MTEFKMFY------------------KLPVEGLDIPKSALGAGLGLRS-A
Rv1809|M.tuberculosis_H37Rv MTEFKVFW------------------QPPPA-PEIPKSSLGAGLGLRSGL
MMAR_2685|M.marinum_M ASQFLKFA-----------------PHPGLGP--LPKDALGGGLGLAPHW
MUL_3071|M.ulcerans_Agy99 ASQLLKFA-----------------PHPGLGP--LPKDALGGGLGLAPHW
Mb1830|M.bovis_AF2122/97 MVQFQKFFN----------------PVTPFNPDLIPKSALGAGLGLRSAI
Mflv_0325|M.gilvum_PYR-GCK LLATTLAIV----AGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LVATTLAIV----LGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAAL----GITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQ
TH_3569|M.thermoresistible__bu VLIPLAITL----GVAGLVMIADQAQP-----PAEEAAPEEDVAAP----
MAB_0809c|M.abscessus_ATCC_199 ALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAP
MLBr_01182|M.leprae_Br4923 AAAPQLWGG-----------------------FAQHLSPINDTLSMINNH
.
MAV_2905|M.avium_104 GAGLTG------AVSVGVGEANTVGRLSVPPTWASATPAIRLASGLAPAT
Rv1809|M.tuberculosis_H37Rv SAGLAH------AASAGLGQANLVGDLSVPPSWASATPAVRLVANTLPAT
MMAR_2685|M.marinum_M NQGTLFSAIQPEAMTPHWGRGTLVGKLTVPPSWAAATPTIRTVAAALSAA
MUL_3071|M.ulcerans_Agy99 NQGTLFSAIQPEAMTPHWGRGTLVGKLTVPPSWAAATPTIRTVAAALSAA
Mb1830|M.bovis_AF2122/97 SSGLGSTAPAISAGASQAGS---VGGMSVPPSWAAATPAIRTVAAVFSST
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 PLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
TH_3569|M.thermoresistible__bu ---------------VRAEPQNPLPLTXXX--------------------
MAB_0809c|M.abscessus_ATCC_199 SPPASAAAPAAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPRL
MLBr_01182|M.leprae_Br4923 AGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGS
MAV_2905|M.avium_104 AAAAAPAAGIPAG-LLGQMALGSVTGGALGAVAPHVGSGRGVRVRA----
Rv1809|M.tuberculosis_H37Rv SLAAAPATQIPAN-LLGQMALGSMTGGALGAAAPAIYTGSGARARAN---
MMAR_2685|M.marinum_M GPEAVPAAALGEGGLLSSMAVAGMLGSAFGAGAPDAYKRAGVRSRLTPLK
MUL_3071|M.ulcerans_Agy99 GPEAVPAAALGEGGLLSSMAVAGMLGSAFGAGAPDAYKRAGVRSRLTPLK
Mb1830|M.bovis_AF2122/97 GLQAVPAAAISEGSLLSQMALASVAGGALGGAAARATGGFLGGGRVTAVK
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 GTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG
MLBr_01182|M.leprae_Br4923 SSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATR-------------
MAV_2905|M.avium_104 ---AKPAEPVKLDDVIAKLQRQPEAVQHWNVDKAGLDDLLDRLSKKPG--
Rv1809|M.tuberculosis_H37Rv -GGTPSAEPVKLEAVIAQLQKQPDAVRHWNVDKADLDGLLDRLSKQPG--
MMAR_2685|M.marinum_M D-LKDATSPEKLKRLVAQISEKPESVQHHTVDQEGLDSLLEQLAKKPG--
MUL_3071|M.ulcerans_Agy99 D-LKDATSPEKLKRLVAQISEKPESVQHHTVDQEGLDSLLEQLAKKPG--
Mb1830|M.bovis_AF2122/97 KSLKDSDSPDKLRRVVAHMMEKPESVQHWHTDEDGLDDLLAELKKKPG--
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGL
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGL
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGL
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 -----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGL
MLBr_01182|M.leprae_Br4923 ----------ALSPARVAVATESESAPLLG-GGLPMAPMVPGGGSGTG--
MAV_2905|M.avium_104 --IHAVHVSSGGKPTVTLPDAGPAGSA--------------------
Rv1809|M.tuberculosis_H37Rv --IHAVHVSNGDKPKVALPDT-QLGSH--------------------
MMAR_2685|M.marinum_M --IHAVHLSKGDKAKVVPTDA-QPG----------------------
MUL_3071|M.ulcerans_Agy99 --IHAVHLSKGDKAKVVPTDA-QPG----------------------
Mb1830|M.bovis_AF2122/97 --IHAVHMAGGNKAEIAPTIS-ESG----------------------
Mflv_0325|M.gilvum_PYR-GCK TTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TTLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 TTLT-GDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 AMLSRDDDLFEGVRAPMVPNTWDPEHGRQD-----------------
MLBr_01182|M.leprae_Br4923 ---GVNTALRLQPRAFVMPRNPAAG----------------------