For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAENYGSVIARLTGMHWWGPASTSMLAMSA PYVEWLERTAAQTKQTATQARAAAAAFEQAHAMTVPPALVTGIRGAIVVETASASNTAGTPP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3135 | PPE50 | - | 100% (132) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 4e-38 | 57.25% (131) | PPE family protein |
| M. tuberculosis H37Rv | Rv0915c | PPE14 | 5e-37 | 61.02% (118) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3159 | PPE50 | 2e-61 | 88.55% (131) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-19 | 39.83% (118) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-20 | 44.04% (109) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 5e-17 | 38.14% (97) | PPE family protein |
| M. marinum M | MMAR_3465 | - | 2e-42 | 61.07% (131) | PPE family protein, PPE51_3 |
| M. avium 104 | MAV_4015 | - | 2e-39 | 61.07% (131) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-19 | 39.68% (126) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-20 | 46.53% (101) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2737 | - | 7e-42 | 62.60% (131) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-20 | 42.37% (118) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3135|M.tuberculosis_H37Rv -------------MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAE
Mb3159|M.bovis_AF2122/97 -------------MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAE
MMAR_3465|M.marinum_M -------------MNYAFLPPEVNSARMYSGPGPESLLAAAASWDMVAIE
MUL_2737|M.ulcerans_Agy99 -------------MNYAFLPPEVNSARMYSGPGSASLLAAAASWDMVAIE
MAV_4015|M.avium_104 -------------MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .** :*: : ***. .:*.*. * :. .
Rv3135|M.tuberculosis_H37Rv LASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTA
Mb3159|M.bovis_AF2122/97 LASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTA
MMAR_3465|M.marinum_M LASTAEGYRSVISTLSGMYWWGPASAAMLAATGPFIDWLEITGALASETA
MUL_2737|M.ulcerans_Agy99 LASAAEGYRSVISTLSGMYWWGPASAAMLAATGPFIGWLEITGALASETA
MAV_4015|M.avium_104 LSITAAVYESVLAGLTGLYWHGPASRAMAAGAAPYVGWLHTTAERAQQTA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: :* : : : * :: *: ** . *
Rv3135|M.tuberculosis_H37Rv TQARAAAAAFEQAHAMTVPPALVTGIRGAIVVETAS--------------
Mb3159|M.bovis_AF2122/97 TQARAAAAAFEQAHAMTVPPALVTANRAELKALIASNLLGQNTAAIAAIE
MMAR_3465|M.marinum_M NQATAAAAAYEQAYAMTVPPIVVAANRALLAALIASNIFGQNTAAIEATE
MUL_2737|M.ulcerans_Agy99 NQAAAAAAAYEQAYAMTVPPIVVAANRALLVALVASNIFGQNTAAIEATE
MAV_4015|M.avium_104 TQARAAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: .** *: * : . : : :
Rv3135|M.tuberculosis_H37Rv --------------------------------------------------
Mb3159|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATTSAAARQLTPFSSPQQT------TNPAGLAA
MMAR_3465|M.marinum_M AEYAEMWAQDAGAMYDYAATSAMATALEPFPGPQQH------TNPAGLPA
MUL_2737|M.ulcerans_Agy99 AEYAEMWAQDAGAMYDYAATSAMATALVPFSAPGQD------TNPAGLAA
MAV_4015|M.avium_104 AQYAEYWAQDAAAMYAYSASSAAAAQFSPFASPRRT------TDPGGVTA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPF------LLKPGVGE
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPL------LLAPGVSE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPS------VLLPGVGE
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPF------VLAPGVGE
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPS------ILHD----
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Rv3135|M.tuberculosis_H37Rv --------ASNTAGTPP---------------------------------
Mb3159|M.bovis_AF2122/97 QNAAVTQAATNSAGNTPTALSQLSSFLSQAVEAPTGWPNILPDDFTILDG
MMAR_3465|M.marinum_M QGAAVSKAAASSEEGSQSLLSQLIALVPQALQVLGIWP-ILPEEFTLLDA
MUL_2737|M.ulcerans_Agy99 QSAAVSQAAGNAPASAQSVWSQLTSLVPDALPSLSNWPNILPDDFSMLDG
MAV_4015|M.avium_104 QQAAVAAAETGSTGTDSG-----TQVIPPTAGAS-----EIPLDFRILDT
MSMEG_0619|M.smegmatis_MC2_155 AGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILD
TH_3569|M.thermoresistible__bu AADAMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVD
Mflv_0325|M.gilvum_PYR-GCK AGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFN
Mvan_0415|M.vanbaalenii_PYR-1 AGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFD
MAB_0809c|M.abscessus_ATCC_199 --------HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVH
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
Rv3135|M.tuberculosis_H37Rv --------------------------------------------------
Mb3159|M.bovis_AF2122/97 ILAAYATVGVTQDIESICAGIIGAENNLGLLGAASENPAELAPGAFGIDA
MMAR_3465|M.marinum_M IFAMYATVGMTADAVTIPVAIIAADNNLGLLGAASENPAELAPGALGVGA
MUL_2737|M.ulcerans_Agy99 IFAMYATVGVTQDVESFCAGIIGAGNNLGLLGAASENSAEVTPGALGLGA
MAV_4015|M.avium_104 ILGAQTTFRSIFTTEGIPAGIIQADKNLGILPNLATIPAALPR-----TP
MSMEG_0619|M.smegmatis_MC2_155 FLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGM
TH_3569|M.thermoresistible__bu FLRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAM
Mflv_0325|M.gilvum_PYR-GCK FLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPS
Mvan_0415|M.vanbaalenii_PYR-1 FLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPS
MAB_0809c|M.abscessus_ATCC_199 VAGEMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAP
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGS
Rv3135|M.tuberculosis_H37Rv --------------------------------------------------
Mb3159|M.bovis_AF2122/97 ALSSAEKGAAASMH------------------------DAVLASAGRAGS
MMAR_3465|M.marinum_M KLSSAEMGAARGAA------------------------NAVTVSMSRAGS
MUL_2737|M.ulcerans_Agy99 MFSSAERSAVGGAT------------------------NAVTVSMSRAGS
MAV_4015|M.avium_104 ALSASPTGLGR-----------------------------IDAVLARAAR
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAAL----GITGLVLLIDHVLNNPVDVPAEDEAPQEVAAA
TH_3569|M.thermoresistible__bu ILASPVLIPLAITL----GVAGLVMIADQAQP-----PAEEAAPEEDVAA
Mflv_0325|M.gilvum_PYR-GCK LFLLPLLATTLAIV----AGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPS
Mvan_0415|M.vanbaalenii_PYR-1 LLLLPLVATTLAIV----LGVGAYLLENLPAP-AEDAPAEEPAASSPAPT
MAB_0809c|M.abscessus_ATCC_199 ALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAG
MLBr_01182|M.leprae_Br4923 AMKSLAPTTTKAAES-AFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAAS
Rv3135|M.tuberculosis_H37Rv --------------------------------------------------
Mb3159|M.bovis_AF2122/97 IGPMSVPPSWATPSSTPVSALSGAGLT--TLDGTDVAEHG-TPGLPGVPA
MMAR_3465|M.marinum_M IGQLSVPPSWAAPSSGSASALSVSGLT--TIPGTEVAEQG-APGVPGMPV
MUL_2737|M.ulcerans_Agy99 IGQLSVPPSWAAPSSGSASALSVSGLT--TIPGTEVAEQG-APGMPGMPV
MAV_4015|M.avium_104 IGPMSVPAGWTAATGNPVAAAPVTGWS--EPSAADARPGVTAPGLPGIPG
MSMEG_0619|M.smegmatis_MC2_155 PRTDQPLAVGISPAGVPGSAATAAAPA--PAPAGTTVAAPAPAAATFVPY
TH_3569|M.thermoresistible__bu P-------------------VRAEPQN--PLPLTXXX-------------
Mflv_0325|M.gilvum_PYR-GCK RPDQQSFPATMSAPPPPSGAPIAANTV--SAGSPPAPGAPAAAAATFVPY
Mvan_0415|M.vanbaalenii_PYR-1 RADQPSPAIAVSAPPPPSSAAATVGTV--ATGTAPAPGAPAAATASFVPY
MAB_0809c|M.abscessus_ATCC_199 TALAPSPPASAAAPAAPASAPAPTASG--TAPAPPSPPPVGDPGFSFPYA
MLBr_01182|M.leprae_Br4923 IGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPM
Rv3135|M.tuberculosis_H37Rv --------------------------------------------------
Mb3159|M.bovis_AF2122/97 GTDKRASGVIPRYGVRLTVMSRPPAAG-----------------------
MMAR_3465|M.marinum_M GTGKRATSVIPRYGVRLTVMARPPAAG-----------------------
MUL_2737|M.ulcerans_Agy99 GTGKRATSVIPRYGVRLTVMARPPAAG-----------------------
MAV_4015|M.avium_104 ATLRRAALVVPRYGVRITVMARPPAAG-----------------------
MSMEG_0619|M.smegmatis_MC2_155 AVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKG
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK VVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQK
Mvan_0415|M.vanbaalenii_PYR-1 AVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQK
MAB_0809c|M.abscessus_ATCC_199 VGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDK
MLBr_01182|M.leprae_Br4923 VPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-------------------
Rv3135|M.tuberculosis_H37Rv --------------------------------------------------
Mb3159|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3465|M.marinum_M --------------------------------------------------
MUL_2737|M.ulcerans_Agy99 --------------------------------------------------
MAV_4015|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 AQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK EEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG
Mvan_0415|M.vanbaalenii_PYR-1 DEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD
MAB_0809c|M.abscessus_ATCC_199 GKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKT
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Rv3135|M.tuberculosis_H37Rv --------------------------------------------------
Mb3159|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3465|M.marinum_M --------------------------------------------------
MUL_2737|M.ulcerans_Agy99 --------------------------------------------------
MAV_4015|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 DVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR--
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDG
Mvan_0415|M.vanbaalenii_PYR-1 AAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDG
MAB_0809c|M.abscessus_ATCC_199 GATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD-------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Rv3135|M.tuberculosis_H37Rv ----
Mb3159|M.bovis_AF2122/97 ----
MMAR_3465|M.marinum_M ----
MUL_2737|M.ulcerans_Agy99 ----
MAV_4015|M.avium_104 ----
MSMEG_0619|M.smegmatis_MC2_155 ----
TH_3569|M.thermoresistible__bu ----
Mflv_0325|M.gilvum_PYR-GCK KEKP
Mvan_0415|M.vanbaalenii_PYR-1 KDSQ
MAB_0809c|M.abscessus_ATCC_199 ----
MLBr_01182|M.leprae_Br4923 ----