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DFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATP YVGWLAATAALAKETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQAEYA EMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAAATQAAGAGAVADAQATLAQLPPGILSD ILSALAANADPLTSGLLGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHI GLYGNAGGLGPTQGHPLSSATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQAT PTFSSSAGADPTALNGMPAGLLSGMALASLAARGTTGGGGTRSGTSTDGQEDGRKPPVVVIREQPPPGNP PR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0915c | PPE14 | - | 100% (423) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 8e-77 | 44.70% (396) | PPE family protein |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 2e-76 | 44.58% (406) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0939c | PPE14 | 0.0 | 100.00% (423) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-34 | 40.19% (209) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-46 | 33.73% (424) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 6e-33 | 28.88% (367) | PPE family protein |
| M. marinum M | MMAR_2534 | - | 1e-150 | 71.68% (392) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 1e-75 | 42.34% (411) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-33 | 29.85% (459) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-36 | 31.45% (442) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4463 | - | 1e-109 | 53.02% (430) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-37 | 33.67% (392) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0915c|M.tuberculosis_H37Rv -------------MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAE
Mb0939c|M.bovis_AF2122/97 -------------MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAE
MMAR_2534|M.marinum_M -------------MDFGLLPPEVNSGRMYTGPGPESMLAAAAAWDTVAAE
MUL_4463|M.ulcerans_Agy99 ----------MLATDFGALPPEVNSGLLYAGPGAAPMLTAATAWDGLATV
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.**.:* : *.*. .: :*. :* :.
Rv0915c|M.tuberculosis_H37Rv LTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETA
Mb0939c|M.bovis_AF2122/97 LTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETA
MMAR_2534|M.marinum_M LSAAAVSYGSVVSALILEPWMGSAAAAMTAAATPYVGWLAATAAQVKETA
MUL_4463|M.ulcerans_Agy99 LNSAAASYASVVSGLTLESRMGPASASMAAAAAPYATWLAVANEQARQTA
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
: * : : * .: *: * ..
Rv0915c|M.tuberculosis_H37Rv TQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQ
Mb0939c|M.bovis_AF2122/97 TQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQ
MMAR_2534|M.marinum_M YQARMAASAFATAFASTVPPPRIAANRSRLMSLVAANILGQNSPAIAAIQ
MUL_4463|M.ulcerans_Agy99 AQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQ
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* ** *. *:: . : *:: *: :*.:* *: .* :
Rv0915c|M.tuberculosis_H37Rv AEYAEMWAQDAAVMYSYEG-ASAAASALPPFTPPVQGTGPAG-PAAAAAA
Mb0939c|M.bovis_AF2122/97 AEYAEMWAQDAAVMYSYEG-ASAAASALPPFTPPVQGTGPAG-PAAAAAA
MMAR_2534|M.marinum_M AEYAEMWAQDAAAMHSYLG-ASATAATLTPFTEPIQSTDPPGSMAEAAAV
MUL_4463|M.ulcerans_Agy99 AEYAEMWAQDAAVMYQYSA-ASEAASTLAAFTSPVQSTDPSR-----AQA
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAA-ASAAAAELTPFTEPPRTTESSAAARQSAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVG---LAQEV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* .** * *:.* * . : . .
Rv0915c|M.tuberculosis_H37Rv TQAAGAGAVADAQAT-----------------------------------
Mb0939c|M.bovis_AF2122/97 TQAAGAGAVADAQAT-----------------------------------
MMAR_2534|M.marinum_M AQAAGAAAPTITATR-----------------------------------
MUL_4463|M.ulcerans_Agy99 STAAGAAAAGTTAQT-----------------------------------
MAV_2906|M.avium_104 AQSA-ASDLPAQLST-----------------------------------
MLBr_01182|M.leprae_Br4923 VEEVVEEVVEEVVEA-----------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG----------EVLRFLF
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG----------ELLRFLF
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLD-LSSIISDLLNQYL----------QGVPGG-
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPD-PNDPIEMLLKNS-----------QHFLGMY
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Rv0915c|M.tuberculosis_H37Rv ------------LAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQV
Mb0939c|M.bovis_AF2122/97 ------------LAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQV
MMAR_2534|M.marinum_M ------------LAELFPGDLADSLSTLTTAADPLTSGLLGIATSLNPQL
MUL_4463|M.ulcerans_Agy99 ------------TASQPTTAATDTAQGLAAEVPTIPAG---------SDL
MAV_2906|M.avium_104 ------------LIDVTPTMLQGLATTPSAAAATPAASIIEAIYPITAAL
MLBr_01182|M.leprae_Br4923 ------------EQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
Mflv_0325|M.gilvum_PYR-GCK EPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 EPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_4783|M.abscessus_ATCC_1997 RALKGLIT---DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
Rv0915c|M.tuberculosis_H37Rv GS--AQPIVIPTPIG--ELDVIA-LYIASIATG--------------SIA
Mb0939c|M.bovis_AF2122/97 GS--AQPIVIPTPIG--ELDVIA-LYIASIATG--------------SIA
MMAR_2534|M.marinum_M TT--AAAMTVPTPIG--ELDVLA-LYIAAVATG--------------SIA
MUL_4463|M.ulcerans_Agy99 AA--PAAISIPTPVG--ELDLLA-AYIAVAATA--------------SLS
MAV_2906|M.avium_104 RPFFAAVTGAYSPIG--AIILPGGWWLLSLQAL--------------GLA
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINN--------------HAG
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ---HLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT--LAIVLGVGA---YLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGITGLVLLIDH---VLNNPVDVPAEDEA
MAB_4783|M.abscessus_ATCC_1997 -TFAVMGTPIYAAIMGPAAGISIPLAITLAS------LSQMPEAPPVDAP
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
Rv0915c|M.tuberculosis_H37Rv LAITNTARPW-HIGLYGNA----GGLGPTQGHPLSSATDEPEPHWGPFGG
Mb0939c|M.bovis_AF2122/97 LAITNTARPW-HIGLYGNA----GGLGPTQGHPLSSATDEPEPHWGPFGG
MMAR_2534|M.marinum_M LSVTNTFRPWNYYGSDAHG----GGSNPTHGGAISSTRKEDATDWGPFGG
MUL_4463|M.ulcerans_Agy99 LSAVNTARPWSYSTNNDHAQPNGGGVAPTQGNTLGTERPDAEVLVSAPN-
MAV_2906|M.avium_104 QNAPGVAELLGGGKAIAGG---LSPLAPLRGGYVSAVTPDAG--------
MLBr_01182|M.leprae_Br4923 MANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSS
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSP-----P
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTA-----P
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAG-----T
MAB_4783|M.abscessus_ATCC_1997 AETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSA-----P
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
Rv0915c|M.tuberculosis_H37Rv AAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTA
Mb0939c|M.bovis_AF2122/97 AAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTA
MMAR_2534|M.marinum_M AAPVTVGVGHAALVGSLSVPHGWTTAAPEIQLAVEAMRTGASSR-VDSTA
MUL_4463|M.ulcerans_Agy99 VVPTSAFVGHAALVGALSVPHSWAMAAPEIRLAVESLPSAGGLSAPAGPD
MAV_2906|M.avium_104 --GVAGSMGRSTLVGSLSVPPGWTTAAPVLRTVASVLPAASSATAAAMPA
MLBr_01182|M.leprae_Br4923 GGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESES
Mflv_0325|M.gilvum_PYR-GCK APGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGI
Mvan_0415|M.vanbaalenii_PYR-1 APGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGV
MSMEG_0619|M.smegmatis_MC2_155 TVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGV
MAB_4783|M.abscessus_ATCC_1997 AP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEPAGSAAAAA
. :
Rv0915c|M.tuberculosis_H37Rv LNGMP-----------------------------------------AGLL
Mb0939c|M.bovis_AF2122/97 LNGMP-----------------------------------------AGLL
MMAR_2534|M.marinum_M LNGMS-----------------------------------------AGLL
MUL_4463|M.ulcerans_Agy99 MGGVAP----------------------------------------TGLL
MAV_2906|M.avium_104 SGGAVFGE------------------------------------MAAASL
MLBr_01182|M.leprae_Br4923 APLLG---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTAST
Mvan_0415|M.vanbaalenii_PYR-1 AASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATE
MSMEG_0619|M.smegmatis_MC2_155 AASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASE
MAB_4783|M.abscessus_ATCC_1997 LACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-----------AATAPSA
Rv0915c|M.tuberculosis_H37Rv SGMALASLAARGTTGGGG-TRSGTSTDGQEDGRKPPVVVIREQPPPGNPP
Mb0939c|M.bovis_AF2122/97 SGMALASLAARGTTGGGG-TRSGTSTDGQEDGRKPPVVVIREQPPPGNPP
MMAR_2534|M.marinum_M GGAALAGWAARGTIGGG---RS-SATD------KNPHPVW----------
MUL_4463|M.ulcerans_Agy99 SGMALASLAGRGATGAGSRSPSESATNEDEQPQRKPTVVVIQKPPPAGGP
MAV_2906|M.avium_104 AGRALAGAGVR-TVGNG---TTGAATAAAADGAATTATIIVVPAD-----
MLBr_01182|M.leprae_Br4923 GGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-----------
Mflv_0325|M.gilvum_PYR-GCK RGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATD
Mvan_0415|M.vanbaalenii_PYR-1 RGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEP
MSMEG_0619|M.smegmatis_MC2_155 RGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENP
MAB_4783|M.abscessus_ATCC_1997 TGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDD
TH_3113|M.thermoresistible__bu AGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRAHRPAEPN-
*
Rv0915c|M.tuberculosis_H37Rv R------------------
Mb0939c|M.bovis_AF2122/97 R------------------
MMAR_2534|M.marinum_M -------------------
MUL_4463|M.ulcerans_Agy99 PAARP--------------
MAV_2906|M.avium_104 -------------------
MLBr_01182|M.leprae_Br4923 -------------------
Mflv_0325|M.gilvum_PYR-GCK DRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 D------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 R------------------
TH_3113|M.thermoresistible__bu -------------------