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NYAFLPPEVNSARMYSGPGPESLLAAAASWDMVAIELASTAEGYRSVISTLSGMYWWGPASAAMLAATGP FIDWLEITGALASETANQATAAAAAYEQAYAMTVPPIVVAANRALLAALIASNIFGQNTAAIEATEAEYA EMWAQDAGAMYDYAATSAMATALEPFPGPQQHTNPAGLPAQGAAVSKAAASSEEGSQSLLSQLIALVPQA LQVLGIWPILPEEFTLLDAIFAMYATVGMTADAVTIPVAIIAADNNLGLLGAASENPAELAPGALGVGAK LSSAEMGAARGAANAVTVSMSRAGSIGQLSVPPSWAAPSSGSASALSVSGLTTIPGTEVAEQGAPGVPGM PVGTGKRATSVIPRYGVRLTVMARPPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3465 | - | - | 100% (380) | PPE family protein, PPE51_3 |
| M. marinum M | MMAR_1514 | - | e-178 | 84.51% (381) | PPE family protein, PPE51_1 |
| M. marinum M | MMAR_0191 | - | e-124 | 61.10% (383) | PPE family protein, PPE51_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3159 | PPE50 | 1e-140 | 66.40% (381) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-29 | 28.73% (369) | PPE protein |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 1e-120 | 60.15% (389) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-45 | 33.41% (416) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 8e-31 | 32.52% (412) | PPE family protein |
| M. avium 104 | MAV_4015 | - | 3e-89 | 50.26% (382) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-32 | 38.60% (215) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-32 | 30.15% (408) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2737 | - | 1e-177 | 84.25% (381) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 9e-32 | 31.71% (410) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3465|M.marinum_M -------------MNYAFLPPEVNSARMYSGPGPESLLAAAASWDMVAIE
MUL_2737|M.ulcerans_Agy99 -------------MNYAFLPPEVNSARMYSGPGSASLLAAAASWDMVAIE
Mb3159|M.bovis_AF2122/97 -------------MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAE
Rv3136|M.tuberculosis_H37Rv -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
MAV_4015|M.avium_104 -------------MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** :*: : ***. .: .*. * :. .
MMAR_3465|M.marinum_M LASTAEGYRSVISTLSGMYWWGPASAAMLAATGPFIDWLEITGALASETA
MUL_2737|M.ulcerans_Agy99 LASAAEGYRSVISTLSGMYWWGPASAAMLAATGPFIGWLEITGALASETA
Mb3159|M.bovis_AF2122/97 LASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTA
Rv3136|M.tuberculosis_H37Rv LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
MAV_4015|M.avium_104 LSITAAVYESVLAGLTGLYWHGPASRAMAAGAAPYVGWLHTTAERAQQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : : * .: *: ** . .
MMAR_3465|M.marinum_M NQATAAAAAYEQAYAMTVPPIVVAANRALLAALIASNIFGQNTAAIEATE
MUL_2737|M.ulcerans_Agy99 NQAAAAAAAYEQAYAMTVPPIVVAANRALLVALVASNIFGQNTAAIEATE
Mb3159|M.bovis_AF2122/97 TQARAAAAAFEQAHAMTVPPALVTANRAELKALIASNLLGQNTAAIAAIE
Rv3136|M.tuberculosis_H37Rv IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
MAV_4015|M.avium_104 TQARAAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .** *. * : . : *: *: :*::* *: .* *
MMAR_3465|M.marinum_M AEYAEMWAQDAGAMYDYAATSAMAT-ALEPFPGPQQHTNPAGLP------
MUL_2737|M.ulcerans_Agy99 AEYAEMWAQDAGAMYDYAATSAMAT-ALVPFSAPGQDTNPAGLA------
Mb3159|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATTSAAAR-QLTPFSSPQQTTNPAGLA------
Rv3136|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPAGLT------
MAV_4015|M.avium_104 AQYAEYWAQDAAAMYAYSASSAAAA-QFSPFASPRRTTDPGGVT------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:*.. * * * :* * : * .
MMAR_3465|M.marinum_M ----------AQGAAVSKAAASSEEG------------------------
MUL_2737|M.ulcerans_Agy99 ----------AQSAAVSQAAGNAPAS------------------------
Mb3159|M.bovis_AF2122/97 ----------AQNAAVTQAATNSAGN------------------------
Rv3136|M.tuberculosis_H37Rv ----------AQAAAVSQATDP----------------------------
MAV_4015|M.avium_104 ----------AQQAAVAAAETG----------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVN------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MMAR_3465|M.marinum_M -------------SQSLLSQLIALVPQALQVLGIWP-ILPEEFT------
MUL_2737|M.ulcerans_Agy99 -------------AQSVWSQLTSLVPDALPSLSNWPNILPDDFS------
Mb3159|M.bovis_AF2122/97 -------------TPTALSQLSSFLSQAVEAPTGWPNILPDDFT------
Rv3136|M.tuberculosis_H37Rv -----------------LSLLIETVTQALQAL-TIPSFIPEDFT------
MAV_4015|M.avium_104 ------------------STGTDSGTQVIPPTAGAS-EIPLDFR------
MLBr_01182|M.leprae_Br4923 -------------EGMEATVVPQVDQQVNVDVATPQTAVPDSSSAA----
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
: :
MMAR_3465|M.marinum_M --------------LLDAIFAMYATVGMTADAVT------------IPVA
MUL_2737|M.ulcerans_Agy99 --------------MLDGIFAMYATVGVTQDVES------------FCAG
Mb3159|M.bovis_AF2122/97 --------------ILDGILAAYATVGVTQDIES------------ICAG
Rv3136|M.tuberculosis_H37Rv --------------FLDAIFAGYATVGVTQDVES------------FVAG
MAV_4015|M.avium_104 --------------ILDTILGAQTTFRSIFTTEG------------IPAG
MLBr_01182|M.leprae_Br4923 -------APQLWGGFAQHLSPINDTLSMINNHAG------------MANA
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
: :
MMAR_3465|M.marinum_M IIAADNNLG--LLGAASENPAELAPGALGVGAKLSSAEMG---------A
MUL_2737|M.ulcerans_Agy99 IIGAGNNLG--LLGAASENSAEVTPGALGLGAMFSSAERS---------A
Mb3159|M.bovis_AF2122/97 IIGAENNLG--LLGAASENPAELAPGAFGIDAALSSAEKG---------A
Rv3136|M.tuberculosis_H37Rv TIGAESNLG--LLNVGDENPAEVTPGDFGIGELVSATSPGGGVSASGAGG
MAV_4015|M.avium_104 IIQADKNLG--ILPNLATIPAALPR-----TPALSASPTG----------
MLBr_01182|M.leprae_Br4923 GLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRG--------LL
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
.
MMAR_3465|M.marinum_M ARGAANAVTVSMSRAGSIGQLSVPPSWAAPSS---GSASALSVSGLTTIP
MUL_2737|M.ulcerans_Agy99 VGGATNAVTVSMSRAGSIGQLSVPPSWAAPSS---GSASALSVSGLTTIP
Mb3159|M.bovis_AF2122/97 AASMHDAVLASAGRAGSIGPMSVPPSWATPSS---TPVSALSGAGLTTLD
Rv3136|M.tuberculosis_H37Rv AASVGNTVLASVGRANSIGQLSVPPSWAAPST---RPVSALSPAGLTTLP
MAV_4015|M.avium_104 ----LGRIDAVLARAARIGPMSVPAGWTAATG---NPVAAAPVTGWSEPS
MLBr_01182|M.leprae_Br4923 GSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVAT
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
. : :
MMAR_3465|M.marinum_M GTEVAEQG------------------------------APGVPGMP-VGT
MUL_2737|M.ulcerans_Agy99 GTEVAEQG------------------------------APGMPGMP-VGT
Mb3159|M.bovis_AF2122/97 GTDVAEHG------------------------------TPGLPGVP-AGT
Rv3136|M.tuberculosis_H37Rv GTDVAEHG------------------------------MPGVPGVP-VAA
MAV_4015|M.avium_104 AADARPGVT-----------------------------APGLPGIP-GAT
MLBr_01182|M.leprae_Br4923 ESESAPLLGGG---------------------------LPMAPMVPGGGS
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
.
MMAR_3465|M.marinum_M GKRATSVIPRYGVRLTVMARPPAAG-------------------------
MUL_2737|M.ulcerans_Agy99 GKRATSVIPRYGVRLTVMARPPAAG-------------------------
Mb3159|M.bovis_AF2122/97 DKRASGVIPRYGVRLTVMSRPPAAG-------------------------
Rv3136|M.tuberculosis_H37Rv G-RASGVLPRYGVRLTVMAHPPAAG-------------------------
MAV_4015|M.avium_104 LRRAALVVPRYGVRITVMARPPAAG-------------------------
MLBr_01182|M.leprae_Br4923 GTGGVNTALRLQPRAFVMPRNPAAG-------------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
: . .
MMAR_3465|M.marinum_M ---------------
MUL_2737|M.ulcerans_Agy99 ---------------
Mb3159|M.bovis_AF2122/97 ---------------
Rv3136|M.tuberculosis_H37Rv ---------------
MAV_4015|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------